Author: Jinfiniti Science

My NAD+ Story: After Three Months, I Feel 30 Years Younger!

Written by Jinfiniti Science on August 10, 2024. Posted in Energy and Fatigue, Guest Blog, NAD, NAD+.

Breakthrough formula restores health and vitality on the cellular level

You may not be aware of this, but a revolution in health sciences is happening, because of discoveries surrounding a compound called nicotinamide adenine dinucleotide, abbreviated as NAD+.

This molecule, as it turns out, is essential for virtually every function of human cells, and not only do we not get enough of it, but aging, stress, and poor lifestyle choices cause a depletion of NAD+ at the cellular level.

NAD+ depletion leads to a wide range of metabolic and age-related disorders, including chronic inflammation, insulin resistance, type II diabetes, cardiovascular disease, chronic fatigue, cancer, and on and on, seemingly ad infinitum.

The good news is that scientists, most notably Dr. Jin-Xiong She in Augusta, Georgia, have developed effective ways to boost intracellular levels of NAD+, thereby restoring youthful vigor and deterring a slew of adult-onset illnesses.

Now, if you’re thinking this pitch sounds too good to be true, I can hardly blame you. As a fourth grader reading about Ponce de Leon, I had to laugh at the gullible rube who was searching Florida for the Fountain of Youth.

And, as you might have read, I’m appalled by corrupt practices in modern medicine¹. But when it comes to all-natural methods of improving my health, I’ll try just about anything once. So, three-plus months ago, I started taking Dr. She’s NAD+ supplement, Vitality ↑® NAD+ Booster, and am I ever happy I did!

SHOP NAD+ BOOSTER

Where did I go wrong?

A little personal background. When I was six, I suffered a nasty whiplash accident that left me with a misaligned spine and a sacrum that was ever-so-slightly out of the socket. My family’s quack doctor said to rest, and I’d been fine.

But I wasn’t fine, and he did nothing to help. As a result, I grew up with atrocious posture and sleeping problems that hampered my growth and left me chronically exhausted.

I was in fairly constant pain, which fluctuated between dull and excruciating, and I had to deal with ever-increasing metabolic health problems, which included a panoply of allergies, tinnitus, “sinus headaches,” a “nervous stomach,” hypoglycemia, and low-level asthma. I was rarely my best self, underperformed at school, lived under constant stress, and simply didn’t have the energy to pursue my life’s goals.

Now, I don’t want to paint a picture of abject misery. I’ve done a lot in my life and have known a great deal of joy and contentment.

And I feel like I’ve earned those moments. I fought for them, exploring every potential avenue to restore my health: chiropractic, Atkins’ diet, cytotoxic four-day rotation diet, nutrient supplementation, meditation, crystals, acupuncture, traditional Chinese herbs, complete abstention from sugar and alcohol, massage therapy, electrical muscle stimulation, and regular exercise.

I poured my meager earnings into expensive treatments that for a time allowed me to feel better before the exhaustion and the pain crept back in.

For the amount of exercise I put in, I should have had a chiseled physique, but I never made the progress others made, and pushing my boundaries resulted in exhaustion, inflammation, and more pain.

Chronic pain/fatigue has been my cross to bear. It’s a lighter cross than many others have endured, and for that I’m grateful.

But it nevertheless has limited my success personally and professionally.

I could recite a litany of times I ended a relationship or made a career change because I was just too tired to move forward.

When I was trying to break in as an actor, a common observation from the agents who interviewed me was, “You need to have more energy.”

As a singer, I never fully developed my voice, because the energy I lacked stunted the development of my vocal instrument.

As a writer, I’ve had a million stories bouncing around in my head that I just haven’t had the time—make that energy—to put down on paper.

So, at age 63, I perceive a huge chasm between my potential, based on an honest assessment of my talent and intelligence, and my accomplishments. Augh, so much spilt milk.

Saved from managed decline by NAD+!

The good news came about four or five months ago when my friend Greta asked if I wanted to do a little marketing writing for a product she was involved with.

At that time, I was feeling every bit of my age. I’d wake up every morning with a song in my heart, but it went something like this:

“Why does everything hurt, hurt, hurt?

Why does everything hurt, hurt, hurt?

Why does every little thing crackle and ping

When I take off my shirt?

It’s a day above dirt,

But why does everything hurt?”

Here’s a brief list of the symptoms I was struggling with:

Asthma
Allergies
Brain fog
Lethargy
Insomnia
Peripheral neuropathy
Swollen feet
Inflammation everywhere
Sciatica and piriformis syndrome
Shoulder impingement syndrome
Tinnitus
Neck pain
Restless leg syndrome and night cramps
Afternoon slump a la Rip Van Winkle

I dutifully exercised for an hour each day to keep these symptoms from worsening, but I was clearly managing my decline, not recovering.

So, then Greta introduced me to Dr. Jin-Xiong She, a molecular biologist who had founded Jinfiniti Precision Medicine.

Dr. She has been studying cellular functions relative to age-related diseases for decades.

His studies confirm that there is one essential nutrient that operates as a cofactor in virtually every cellular function, including the production of energy, a compound called NAD+.

People lose NAD+ with age, leading to a decline in our cells’ ability to perform, which opens the door to various maladies. Supplementing NAD+ can restore cellular performance to peak levels, so we build healthier tissues, bones, and organs.

Dr. She also confirmed through his studies that NAD+ is a difficult nutrient to supplement. Because it’s such a large molecule, it does not penetrate the gut barrier, and even if given intravenously, NAD+ is too large to pass through the vacuoles in the cell membranes.

Thus, the way to boost NAD+ levels is to supplement the precursor molecules, the building blocks of NAD+, and let them enter the cells where the organelles in the cell will use them to create NAD+.

Dr. She claims to have developed the most efficacious NAD+ supplement on the market, and after three months of taking it, I have no reason to doubt him.

Dr. She is a very data-driven scientist, so the first thing he wanted to do with me was draw some blood and measure my levels of essential biomarkers.

Not surprisingly, my NAD+ level was that of a mid-70s man.

The way I figure it, constant stress depleted my levels, and even the strict diet and exercise regimen I’ve been on for decades was not enough to replenish this vital nutrient.

I was also deficient in creatine, which could explain the muscle soreness I experienced after exercising, and I had poor biomarkers for inflammation and antioxidant levels.

Armed with this information, I started taking Dr. She’s NAD+ supplement, Vitality ↑® NAD+ Booster, along with creatine, anti-inflammatory supplements, and antioxidants.

What three months on Vitality ↑® NAD+ Booster has done

I’m now on my third jar of Vitality ↑® NAD+ Booster, and as I wrote at the beginning, I feel like I’m back in my mid-30s. Now, my mid-30s might translate to a fit individual’s early 50s, but I’ll take it, because here’s what I’m experiencing:

Vastly improved overall energy
Deeper sleep
Allergies are milder
Mental fog gone
Better mood
Tightness in my trapezius and neck during computer work/piano playing greatly diminished
Tenderness in the shoulder greatly diminished
Pain/swelling in my feet and lower legs greatly diminished
Sciatica and piriformis pain barely noticeable
Greater flexibility, greater ability to stretch muscles and hold deep stretches longer
Hardly any muscle soreness after exercise
Easier, quicker workouts
Singing is easier with better airflow, greater range, and more power

This is after only three months. Dr. She says he’s been taking Vitality ↑® NAD+ Booster for two years and is still discovering new benefits.

Is NAD+ a real hope for humanity?

In my research, I’ve found that NAD+ optimization is proven or suspected to be beneficial for an incredible number of conditions related to faulty metabolism, genetic mutations, poor neural signaling, and aging, such as:

Addiction
Age-related macular degeneration
Allergies and asthma
Alzheimer’s and Parkinson’s diseases
Autism
Cancer
Cardiovascular disease
Chronic fatigue syndrome
Depression
Female infertility
Insomnia
Low libido
Obesity
PTSD
Type II diabetes and insulin resistance

Now here’s where I offer my disclaimer. Because of my own experience, the mounting hard scientific evidence, and enthusiastic anecdotal testimony, I am sold on Vitality ↑® NAD+ Booster and am excited to share what I know with anyone who could benefit.

So, I asked Dr. She to make me an affiliate marketer for Jinfiniti Precision Medicine.

I think what Dr. She has accomplished is amazing, and the word has to get out to the public. Just thinking about all the unhealthy, suffering people in this country who could benefit and turn their lives around…it makes my head spin.

Get started on NAD+ today and start feeling younger!

So, I invite you, dear reader, to explore Jinfiniti Precision Medicine and make it your source for NAD+ supplementation. If you decide to make a purchase, enter the offer code kevinrush20 for a 20 percent discount off your first purchase, and 10 percent off every subsequent purchase.

If you are suffering from any sort of systemic illness, you need to give your system the fuel it needs to fight back. And if you’re feeling the decline that comes with age, NAD+ can help you turn back the clock and get a youthful spring back in your step.

I’ll continue to keep you updated on this blog about my progress and any new NAD+ discoveries. Until then, good luck and good health!

Update: Get started with NAD+ for only $28!

Vitality ↑® NAD+ Booster has never been more cost-effective than now, because Dr. She is offering an introductory, one-month supply for only $28 dollars with a monthly subscription. That’s a savings of 76 percent, and you can cancel the subscription any time, if you’re not thrilled with the results. Just follow this link: Start for $28!

If you routinely struggle to get a good night’s sleep, you know how insomnia is undermining your health. Do yourself a tremendous favor and order Vitality ↑® NAD+ Booster today. You’ll be very happy you did.

SHOP NAD+ BOOSTER

Kevin Rush is an award-winning playwright and screenwriter. He’s the author of three novels, including The Lance and the Veil, an adventure in the time of Christ (which Kirkus Reviews calls “a big, bold Biblical saga to fire the Christian imagination”) and The Wedding Routine, (hailed by Online Book Club as a 4/4 Star romantic comedy delivering “nothing but comic gold”). Learn more at www.kevinrush.us.

Referenced Sources:

https://kevinrush.us/2022/08/27/twilight-of-a-quack-tony-fauci-at-sunset/ ↩︎

A Master Key to Health & Longevity: NAD Optimization Utilizing TAO Wisdom

Written by Jinfiniti Science on July 31, 2024. Posted in NAD+, Longevity, NAD, Popular.

What if you could age without facing common health issues like brittle bones, memory loss, fatigue, heart disease, diabetes, and other chronic conditions that often come with getting older?

Recent breakthrough research suggests this is possible, thanks to Nicotinamide Adenine Dinucleotide (NAD). This coenzyme, naturally found in our cells, is the key to maintaining a vibrant, healthy life as we age.

But what exactly is NAD, and how can it help you stay healthy as you get older? Read on to learn how NAD might transform the aging process and help you live a longer, healthier life.

In this article, we discuss:

How NAD can turn back the clock on age-related health issues, boosting both your lifespan and healthspan.
7 powerful ways NAD can transform your health from the inside out.
2 key strategies to tackle oxidative stress, DNA damage, blood sugar imbalances, chronic inflammation, metabolic dysfunction, and cellular senescence.
The T-A-O (Test, Act, Optimize) method, a proven approach to optimizing your health and longevity as you age.

In the pursuit of wellness and longevity, NAD has emerged as the most important area of interest among scientists and consumers.

Nicotinamide Adenine Dinucleotide (NAD) is a coenzyme found in all living cells, playing a crucial role in over 500 cellular processes. The most important one is the production of cellular energy, ATP, that all cells need to function. NAD is also responsible for many chronic diseases like obesity, diabetes, cardiovascular diseases, and neurodegenerative disorders.

NAD supplementation has been widely recommended by doctors and used by millions of consumers. However, it is still not widely known that the full benefits of NAD are only realized when your NAD levels are optimized.

How can you optimize your NAD so that you achieve your full potential and live healthier and longer? There is only one approach that works. That is TAO: test, act and optimize.

Read this blog and download our free eBook guide on NAD, you will appreciate more the science, the benefits and more importantly the how to get all the benefits of optimized NAD levels.

What Is NAD Optimization?

NAD optimization involves strategies to increase and maintain optimal levels of NAD in the body.

As we age, our cells experience a decline in NAD levels.

This decline contributes to various aspects of aging, including cellular dysfunction, mitochondrial dysfunction, and DNA damage.

Both research studies and extensive consumer data have shown that replenishing NAD levels can slow down or reverse many age-related health conditions, definitely extending health span, the period of life without major diseases or injuries, and likely extending lifespan via extended improved health.

Role of NAD in Cellular Function

One of the most important roles of NAD is its involvement in cellular energy production.

NAD is a key player in the process of cellular respiration¹, where it helps convert nutrients into ATP, the cell’s primary energy source.

Additionally, NAD is involved in DNA repair, gene expression, and the regulation of over 500 different cellular processes partly through its interaction with sirtuins, a class of proteins involved in longevity and aging.

Boosting NAD levels can also improve mitochondrial function, increase energy production, and improve many health biomarkers such as liver function, kidney function, and insulin sensitivity, just to name a few.

For example, a study published in the Journal of Springer Nature shows that mice administered with NAD precursors like NAD+ precursor can improve mitochondrial function, enhance muscle function, and increase lifespan².

Human studies on NAD supplementation are increasing and have shown encouraging results.

A clinical trial from the Journal of Sciences Advances found that supplementation with NR increased NAD levels in healthy adults and improved markers of mitochondrial function³.

Other studies from the Journal of Nutrients also show that supplementation could have benefits for age-related conditions such as cardiovascular disease, neurodegenerative diseases, and metabolic disorders.⁴

Data from tens of thousands of our customers clearly indicate that over 80% of people who have optimized NAD by our NAD supplement, the Vitality ↑® NAD+ Booster, have seen health benefits in various areas including but not limited to more energy, better sleep, better mental clarity, higher performance and recovery.

7 Top Benefits of Healthy NAD Levels

Enhanced Energy Production:

Maintaining healthy NAD levels is essential for optimal cellular metabolism, as NAD is a key player in cellular respiration. This process converts nutrients into energy, leading to increased ATP production.

With higher NAD levels, cells can produce energy more efficiently, resulting in enhanced overall energy levels and reduced fatigue. Additionally, NAD supports mitochondrial health⁵, ensuring that these cellular powerhouses function effectively and produce less toxic substances, namely free radicals.

Improved Metabolic Health:

NAD plays a crucial role in regulating metabolism⁶, including glucose and lipid metabolism. Healthy NAD levels help maintain stable blood sugar and cholesterol levels, reducing the risk of metabolic disorders.

By supporting metabolic efficiency, NAD can aid in weight management and combat obesity, and reduce insulin resistance and risk for diabetes, making it a vital component of overall metabolic health.

Enhanced Cellular Repair:

NAD is essential for DNA repair and maintaining genomic stability⁷. It activates enzymes like PARPs, which repair damaged DNA, protecting cells from mutations and preserving their function.

Healthy NAD levels support these repair processes, extending the lifespan of cells and tissues and contributing to overall cellular longevity.

Cognitive Function:

Healthy NAD levels are crucial for brain health, as NAD is a neurotransmitter and supports the production of ATP in brain cells, ensuring they have the energy needed to function optimally.

NAD also plays a role in neuroprotection,⁸ helping to safeguard neurons from damage and potentially reducing the risk of neurodegenerative diseases, thereby enhancing cognitive function and memory.

Athletic Performance:

For athletes, maintaining healthy NAD levels can significantly improve physical performance.⁹ NAD enhances energy production and reduces muscle fatigue, leading to increased endurance.

It also helps in faster recovery by reducing muscle soreness and inflammation after intense exercise, allowing athletes to train harder and longer with quicker recovery times.

Aging Optimization:

NAD levels naturally decline with age, contributing to various age-related declines in function. By maintaining healthy NAD levels, it is possible to support cellular health and slow down the aging process.¹⁰

This includes improved skin health, where NAD helps maintain skin elasticity and reduce the appearance of wrinkles, promoting a more youthful appearance.

Immune System Support:

NAD is vital for a robust immune system¹¹, as it is involved in the production and function of immune cells. Healthy NAD levels enhance the immune response, helping the body to fight off infections and diseases more effectively.

Additionally, NAD helps regulate inflammatory responses, reducing chronic inflammation that can contribute to various health issues, thereby supporting overall immune health. NAD can also reduce symptoms of allergies and asthma in many individuals.

With all these benefits, how can you optimize your NAD levels and live a healthy, fulfilling life?

How Jinfiniti Can Optimize Your NAD Levels

At Jinfiniti, we aim to alleviate debilitating conditions such as oxidative stress, DNA damage, blood sugar imbalances, chronic inflammation, metabolic dysfunction, and cellular senescence through two key approaches:

1. Finding & Tackling the Root Causes

2. Adhering to the 8 Pillars of TAO for Optimal Health

Taoism (道) is an ancient Chinese philosophy that explains the workings of the universe, emphasizing the balance and harmony of Yin and Yang, two opposite but interconnected forces.

To achieve health and longevity, one must maintain cellular harmony through a holistic approach.

The Jinfiniti Approach

We use the Intracellular NAD test to provide precise data, avoiding guesswork and optimizing your NAD levels.

This test, the first and most reliable one on the market, helps determine NAD deficiency, assess supplement effectiveness, and find the optimal dosage for your needs.

It also provides actionable data to adjust the dosage of NAD supplements or other NAD products, optimizing your NAD levels and helping manage chronic diseases.

Based on the test results, we prescribe customized approaches to manage symptoms and chronic diseases at the cellular level.

After 3 to 4 weeks of action, take a second test to assess your new levels. You’ll likely see significant changes, especially if you follow our protocol and use our products.

With the results of the Intracellular NAD test, you’ll know which actions yield progress.

Repeat these actions consistently for optimal health and longevity.

Why should you optimize your NAD levels?

1. How is an optimal level of NAD defined?

Like any biomarker, defining the optimal range is a critical but difficult process. This range may change slightly as additional data becomes available. There are major differences between the normal ranges that medical organizations usually use and the optimal range that functional medicine or health optimization organizations prefer to use.

Normal ranges are values that we see in the vast majority of people who appear to be healthy, while optimal ranges are values within which you can perform the best and maximize your health span and lifespan.

For Intracellular NAD, Jinfiniti conducted extensive studies and proposed to define the lower end of the optimal range as the 75th percentile of NAD levels we see in teenagers, meaning that NAD levels are higher than the value in 75% of teenagers. This value is 40µM (micromolar).

2. Too low NAD level is bad for health

It turned out that young individuals with NAD levels less than 40µM often have certain health or subhealth issues such as autism, autoimmune diseases, and allergies.

We also found that individuals who can increase their NAD levels to above 40µM, especially above 50µM, usually experience significant health benefits including more energy, better sleep, improved mental focus, and reduced symptoms related to allergy, asthma, arthritis, diabetes, blood pressure, and others.

In an extreme case, a baby boy in a coma for six months was cured by our NAD product.

We shall emphasize that the dosage required by each person to optimize his or her NAD is different. If you do not take enough, you may not increase your NAD level at all and do not gain any health benefits.

Therefore, you must take a NAD test at least after supplementation to determine whether your action is producing the result you need and deserve. Otherwise, you may be just wasting your money and time.

3. Too high level of NAD is also bad.

Accumulating evidence suggests that one should not elevate their NAD level above 100µM, a threshold beyond which it may become harmful. Known harm includes an increase in vascular inflammation and cardiovascular disease. We see about 5% of the individuals overdosing on their NAD supplements in our large dataset.

To summarize, the optimal NAD range is 40-100µM. One shall not guess, test!

Two Steps to Optimize your NAD levels

If you want to optimize your NAD levels and combat age-related chronic diseases, here are two things you need to do:

Step 1: Order the Intracellular NAD test today.

Order the Intracellular NAD test today and use it as soon as it arrives. This test can help you determine if you are deficient in NAD, assess the effectiveness of your NAD supplement, and find the optimal dosage for your needs.

Additionally, the test provides actionable data to help you adjust the dosage of Vitality ↑® NAD+ Booster, optimizing your NAD levels and helping you manage chronic fatigue.

TEST YOUR NAD LEVELS TODAY

Step 2: Take the Vitality ↑® NAD+ Booster

When it comes to boosting your NAD levels, there’s nothing quite like Vitality ↑® NAD+ Booster.

This patented supplement is meticulously formulated by two world-class scientists in cellular health to provide a potent blend of natural ingredients that work synergistically to enhance your vitality and combat chronic diseases proactively.

It is a clinically validated formulation consisting of multiple NAD precursors, NAD+ precursor, D-Ribose and Nicotinamide as well as Creatine monohydrate that stores your ATP when you do not need them. These ingredients have their own health benefits and in the golden ratio work synergistically to help:

Manage fatigue
Boost energy and improve performance
Improve sleep quality
Support inflammation, muscle, and joint pains
Support healthy allergic and asthmatic symptoms
Improve mental clarity and dementia symptoms
Support functions of many organs (liver, kidney, heart, thyroid, fertility)…

In other words, Vitality ↑® NAD+ Booster supports healthy NAD levels to revitalize your cells, optimize your mitochondria, and improve your energy so you can do things you love!

SHOP NAD+ BOOSTER

To save even more, you can take advantage of the NAD Optimization® Bundles, where you can get…

2 Intracellular NAD® tests
1 Vitality ↑® NAD+ Booster supplement
one free supplement and…
a free consultation.

Start by using the first Intracellular NAD® test to reveal your current NAD levels. Then, take Vitality ↑® NAD+ Booster for a month.

After 3-4 weeks, use the second Intracellular NAD® test to identify your new, optimized levels after taking our NAD supplements. You’ll be pleasantly surprised by how much your levels have improved.

If you’re unsure about what to do or have questions about how to start or interpret your results, you can book your free consultation.

Grab the NAD Optimization® Bundles here — SAVE $178 today.

If you want to manage your chronic fatigue and boost your energy…

Order Vitality ↑® NAD+ Booster and Intracellular NAD® Test, or Grab the NAD Optimization® Bundles here to save even more.

Subscribe and Save

For our returning customers, Jinfiniti offers multiple subscription options. Take advantage of our special offer reserved for readers of this blog to get your first bottle of our NAD supplement for $38 for the first month, a 65% saving, and automatically receive a monthly shipment for only $108.

Go to the Vitality ↑® NAD+ Booster page, add a monthly subscription to the cart, and then enter VB38 in the coupon field to receive this special offer.

Our Money-Back Guarantee

It turned out that many young people with f our Vitality ↑® NAD+ Booster fails to increase your NAD levels, just send us a message within 60 days and we will gladly refund your supplement purchase.

Please note that tests are non-refundable.

Referenced Sources:

What Happened During Dave Asprey’s 10th Annual Biohacking Conference?

Written by Jinfiniti Science on June 19, 2024. Posted in NAD+, Longevity, NAD.

Four days might seem like plenty of time to cover a conference dedicated to health and longevity, but the recent Asprey event at the Sheraton Dallas proved otherwise.

The event could have been divided into three separate areas: the exhibition hall, breakout rooms, and main stage speaking area, each deserving its four-day exploration.

Main Stage Highlights

The Main Stage hosted world-class authorities such as Dr. Joseph Mercola, Dr. Nathan Bryan, Dr. Daniel Amen, Dr. Patrick Porter, and Bryan Johnson.

These experts delivered their insights to large, attentive audiences.

Meanwhile, the Breakout Rooms were buzzing with activity, offering multiple presentations simultaneously to smaller yet equally engaged groups.

Exhibit Hall Experience

Dave Asprey’s 10th Annual Biohacking Conference

I spent most of my time in the Exhibit Hall, interacting with attendees and observing their biohacking interests firsthand. Here are my key takeaways:

Youthful Attendance

A significant proportion of the biohacker attendees were surprisingly young.

Unlike other anti-aging and longevity conferences that tend to attract middle-aged and older individuals, this event saw a larger turnout of younger biohackers.

The Silver Seniors were present but in much smaller numbers.

Lack of NAD Awareness

Despite focusing on living longer and healthier lives, many attendees were unaware of NAD and its role as a foundational, effective biohack supplement.

Over 70% of those I spoke with needed to learn about NAD.

If you are not familiar with NAD (Nicotinamide Adenine Dinucleotide), it is a vital coenzyme found in every cell of the body.

It plays a crucial role in energy production, DNA repair, and regulating cellular processes.

As we age, NAD levels decline, which can contribute to various age-related health issues.

Boosting NAD levels can enhance energy metabolism, improve brain function, support healthy aging, and promote longevity.

By maintaining optimal NAD levels, you can potentially reduce the risk of chronic diseases and improve overall well-being.

Importance of Biomarker Tests

I emphasized the availability of biomarker tests to the mainstream public.

Biohacking requires measurable baseline data and ways to assess and compare results over time.

Many attendees were unaware of such tests, especially the Intracellular NAD test and Aging SOS full panel offered by Jinfiniti, which measure 22 important factors related to aging.

TEST YOUR NAD LEVELS TODAY

Cost of Tests vs. Medical Bills

Some attendees balked at the price of biomarker tests.

However, I pointed out that the cost of medical bills, expensive drugs, and diminished quality of life when one is ill far outweighs the expense of discovering or predicting potential health issues.

Additionally, tests can determine if a current NAD supplement is effective or if one is wasting time and money.

Risks of Random Supplementation

Many biohackers were surprised to learn that indiscriminately taking a variety of supplements can harm their health.

Functional medicine and anti-aging practices have noted increasing kidney and liver damage in individuals who purchase and use all the “latest” supplements without understanding how they interact or if they are necessary for their wellness.

We saw that the number of supplements taken does not always correlate with optimal health.

Addressing Serious Health Issues

Perhaps most satisfying was helping attendees with serious health issues that their current medical professionals could not resolve.

At least five visitors to our booth explained conditions that limited their daily functioning. In each case, we discovered sub-optimal intracellular NAD levels as a contributing factor.

We look forward to following these new customers on their NAD optimization journey, which promises more energy, better mental focus, improved sleep, less inflammation, and other health benefits.

TAO: Harnessing Biomarker Testing Data for Biohacking Success

During my talk, I discussed the critical role of NAD in biohacking safely.

When I asked the audience if they believed they could live up to 80 years old or even delay and avoid death, the majority raised their hands, showing a keen interest in longevity.

I introduced them to an ancient Chinese philosophy of Taoism, which I have adapted into the TAO steps for optimizing health. These steps are:

Test: Identify abnormalities or deficiencies in your body.
Act: Define and implement interventions to bring levels within optimal ranges.
Optimize: Continuously evaluate the efficacy of these interventions, adjusting actions and dosages for safety and maximum benefit.

By following TAO, you can:

Pinpoint specific health issues.
Set and achieve optimal health targets.
Regularly assess and refine your approach for better outcomes.

In other words, regular testing is key to optimizing NAD levels and your overall health. Repeat testing ensures that your interventions are effective and safe.

If you want to learn more about living a healthier and longer life, you can watch my talk for free below.

⇒ TAO: Harnessing Biomarker Data for Biohacking Success

Takeaway

Dave Asprey’s 10th Annual Biohacking Conference was an enlightening event that brought together experts and enthusiasts focused on health and longevity.

The Exhibit Hall experience highlighted the importance of educating biohackers about foundational supplements like NAD and the necessity of biomarker tests for personalized health tracking.

The conference underscored the need for informed supplement use and the potential for optimizing health through targeted interventions.

TEST YOUR NAD LEVELS TODAY

How NAD Therapy Can Combat Chronic Fatigue

Written by Jinfiniti Science on May 10, 2024. Posted in NAD+, Energy and Fatigue, NAD.

Chronic fatigue is a debilitating condition that affects millions of people worldwide.

According to the Centers for Disease Control and Prevention (CDC), around 2.5% of adults in the United States report experiencing fatigue that is severe enough to interfere with their daily lives.¹

People with chronic fatigue often describe feeling exhausted and worn out, even after getting plenty of rest.

This persistent fatigue can significantly impact their quality of life, making it difficult to work, socialize, or even perform simple tasks.

In fact, in 2022, 13.5% of adults aged 18 and older reported feeling very tired or exhausted most days or every day in the past three months², according to CDC.

Fatigue is a common reason for seeking medical care and a source of considerable economic burden.

Just take a look at the graph below:

Among men, the percentage was highest among those aged 18–44 years, followed by those aged 45–64 years, and then those aged 65 years and older (8.9%).

Among women, the decline in the percentage with age was steeper, decreasing from 20.3% to 15.3% (45–64 years) and to 11.5% (65 years and older).

The percentage of adults who felt tired or exhausted most days or every day was higher for women compared with men in each age group.

AND… those who are tired all the time seem to die more likely, as suggested by the lower percentages in those older than 65 years.

There are several reasons why people may experience chronic fatigue. Here are the top three:

3 Major Reasons For Chronic Fatigue

Stress

Stress is a complex phenomenon that can have profound effects on the body, including contributing to the development and exacerbation of chronic fatigue. This is due to several factors:

First, stress activates the HPA axis, leading to the release of cortisol, the body’s primary stress hormone.

Chronic stress can dysregulate the HPA axis, resulting in abnormal cortisol levels. A study published in the Journal of Psychiatric Research found that individuals with chronic fatigue syndrome (CFS) often exhibit abnormalities in the HPA axis³, suggesting a link between stress and fatigue in these individuals.

Chronic stress can also lead to systemic inflammation and immune dysregulation, which have been implicated in the pathophysiology of chronic fatigue.

A study published in Psychoneuroendocrinology (PMID: 18614268) found that stress-induced increases in inflammatory markers were associated with increased fatigue severity in patients with chronic fatigue syndrome.⁴

Moreover, chronic stress can also lead to alterations in neuroendocrine function, including changes in neurotransmitter levels and receptor sensitivity.

These neuroendocrine changes can affect mood, energy levels, and fatigue.

A study published in Psychological Medicine) found that alterations in the serotonin system, which is involved in mood regulation, were associated with increased fatigue in people.⁵

In conclusion, stress can contribute to chronic fatigue through various mechanisms, including HPA axis dysregulation, inflammation and immune dysregulation, and neuroendocrine changes.

Poor Sleep Quality

Poor sleep quality is a common complaint among people with chronic fatigue and plays a significant role in the development and exacerbation of fatigue.

Research has identified several ways in which poor sleep quality can contribute to chronic fatigue:

Poor sleep quality often manifests as sleep fragmentation, characterized by frequent awakenings throughout the night.

A study published in the Journal of Clinical Sleep Medicine found that sleep fragmentation disrupts the normal sleep cycle⁶, leading to non-restorative sleep and increased fatigue.

Another way poor sleep quality contributes to chronic fatigue is through alterations in sleep architecture, such as reduced slow-wave sleep and disturbances in rapid eye movement (REM) sleep.

A study published in Sleep Medicine Reviews (PMID: 26298830) found that alterations in sleep architecture can lead to daytime sleepiness and fatigue⁷ in CFS patients.

Poor sleep quality can also result from underlying sleep disorders, such as obstructive sleep apnea (OSA) or insomnia⁸. These sleep disorders can disrupt the normal sleep pattern and lead to poor sleep quality and fatigue.

A study published in the Journal of Clinical Sleep Medicine found that treating comorbid sleep disorders in individuals with CFS led to improvements in fatigue levels⁹.

Therefore if you want to manage chronic fatigue, you have to address your sleep disorders.

Addressing poor sleep quality is crucial in managing chronic fatigue.

Cognitive-behavioral therapy for insomnia (CBT-I)¹⁰ is a highly effective intervention for improving sleep quality and reducing fatigue in individuals with CFS.

You can also practice good sleep hygiene by sleeping in a cool room and turning off your phone, TV, or any gadgets at least an hour before bedtime to help improve the quality of your sleep.

Low NAD Levels

One often overlooked factor is the role of nicotinamide adenine dinucleotide (NAD) levels in the body.

NAD is a coenzyme found in every cell of the body and plays a crucial role in energy production. It helps convert the food we eat into the energy our cells need to function properly.

When NAD levels are low, our cells may not have enough energy to perform their essential functions, leading to fatigue and other health issues.

Optimizing NAD levels can help improve chronic fatigue in several ways.

How NAD Can Improve Chronic Fatigue

First, NAD helps regulate the body’s circadian rhythm, which is crucial for healthy sleep patterns.¹¹ By supporting NAD levels, individuals may experience improved sleep quality, which can reduce fatigue.

Second, NAD is involved in repairing damaged DNA and maintaining the health of our cells¹². By optimizing NAD levels, individuals may experience improved cellular function, which can lead to increased energy levels and reduced fatigue.

Third, and most importantly, NAD plays a vital role in mitochondrial function.¹³

Mitochondria are often referred to as the powerhouse of the cell, as they are responsible for producing ATP, the primary source of energy for the body.

When NAD levels are low, mitochondrial function can be compromised, leading to decreased energy production and increased fatigue.

In conclusion, chronic fatigue is a complex condition with various contributing factors.

While stress and poor sleep quality are commonly recognized causes, low NAD levels can also play a significant role.

By optimizing NAD levels through lifestyle changes and supplementation, you may experience improvements in your energy levels and overall quality of life.

Two Steps to Manage Chronic Fatigue

Step 1: Order the Intracellular NAD test today.

Additionally, the test provides actionable data to help you adjust the dosage of Vitality ↑® NAD+ Booster, optimizing your NAD levels and helping you manage chronic fatigue.

TEST YOUR NAD LEVELS TODAY

Step 2: Take Vitality ↑® NAD+ Booster

When it comes to boosting your energy levels, there’s nothing quite like Vitality ↑® N A D+ Booster.

This supplement is meticulously formulated to provide a potent blend of natural ingredients that work synergistically to enhance your vitality and combat chronic fatigue.

It is a clinically validated formulation consisting of NAD precursor, Creatine monohydrate, D-Ribose, and Nicotinamide that work synergistically to help:

Manage fatigue
Boost energy and improve performance
Improve sleep quality
Support inflammation, muscle, and joint pains
Support healthy allergic and asthmatic symptoms
Improve mental clarity and dementia symptoms
Support functions of many organs (liver, kidney, heart, thyroid, fertility)…

But don’t just take our word for it. See how Vitality ↑® NAD+ Booster improved Melissa’s chronic fatigue issues.

I started using this product about 3 weeks ago and I can honestly say that by week 2 the need for a Power Nap daily has decreased, my energy level has increased, and I am exercising more.

Chronic fatigue has been a negative factor in my life since my early 40s so I was willing to give this a try. So far I’m very pleased and I’m only taking 1 scoop a day! Give this product a try

~Melissa

Vitality ↑® NAD+ Booster supports healthy NAD levels to revitalize your cells, optimize your mitochondria, and improve your energy so you can do things you love!

Whether you’re feeling fatigued from a busy lifestyle or struggling with chronic fatigue syndrome,

Vitality ↑® NAD+ Booster can help restore your energy levels and improve your overall well-being.

SHOP NAD+ BOOSTER

To save even more, you can take advantage of the NAD Optimization® Bundles, where you can get…

2 Intracellular NAD® tests
1 Vitality ↑® NAD+ Booster supplement
one free supplement and…
a free consultation.

Start by using the first Intracellular NAD® test to reveal your current NAD levels. Then, take Vitality ↑® NAD+ Booster for a month.

Afterwards, use the second Intracellular NAD® test to identify your new, optimized levels after taking our NAD supplements. You’ll be pleasantly surprised by how much your levels have improved.

If you’re unsure about what to do or have questions about how to start or interpret your results, you can book your free consultation.

Grab the NAD Optimization® Bundles here — SAVE $178 today.

If you want to manage your chronic fatigue and boost your energy…

Order Vitality ↑® NAD+ Booster and Intracellular NAD® Test, or Grab the NAD Optimization® Bundles here to save even more.

Our Money-Back Guarantee

If our Vitality ↑® NAD+ Booster fails to increase your NAD levels, just send us a message within 60 days and we will gladly refund your supplement purchase.

Please note that tests are non-refundable.

Referenced Sources:

5 Ways to Manage Chronic Pain and Improve Your Mobility

Written by Jinfiniti Science on April 29, 2024. Posted in NAD+, Arthritis and Pain, Inflammation, NAD.

Living with chronic pain can significantly impact daily life, affecting your mobility, mood, and overall well-being. Simple tasks become more challenging, and the persistent discomfort can take a toll on your mental health.

For example, imagine waking up each day feeling like your body is weighed down, making every movement a struggle.

Tasks that were once routine, like sitting or standing, become uncomfortable.

This can lead to decreased physical activity, which can further worsen the pain.

Chronic pain can also affect your mood, causing feelings of frustration, anxiety, and even depression.

The constant battle against pain can be mentally exhausting, leading to a loss of enjoyment in daily activities and impacting overall quality of life.

Despite these challenges, there are ways to manage chronic pain and improve quality of life.

But first, let’s identify the reason for your chronic pain.

Why Do You Have Chronic Pain

Chronic pain often stems from a combination of factors, with inflammation and aging playing significant roles.

Inflammation, a key driver of many chronic pain conditions, can arise from various sources such as arthritis, autoimmune diseases, or repetitive injuries.

This inflammatory response triggers the release of mediators that sensitize nerves, amplifying pain signals.

Over time, this chronic inflammatory state can lead to tissue damage, further exacerbating pain.

Aging also contributes to chronic pain by causing changes in the musculoskeletal system, including cartilage loss, joint degeneration, and decreased muscle mass.

These age-related changes can increase the risk of conditions like osteoarthritis, characterized by joint pain and stiffness.

Understanding the connection between inflammation and aging in chronic pain is essential for developing effective treatment strategies and improving the quality of life for individuals affected by these conditions.

Fortunately, there are natural and effective ways you can experience relief from exacerbating pain.

5 Ways to Manage Chronic Pain

Heat and cold therapy

Pain often occurs due to inflammation, muscle tension, or injury.

Heat therapy, such as applying a warm compress or using a heating pad, works by increasing blood flow to the affected area.

This helps to relax muscles, reduce stiffness, and promote healing.

Cold therapy, on the other hand, works by constricting blood vessels, which can reduce swelling and numb the area, thereby reducing pain.

A study published in the Journal of Clinical and Diagnostic Research in 2014 investigated the effectiveness of heat and cold therapy for lower back pain.

The study found that both heat and cold therapy were effective in reducing pain and improving function in patients with acute lower back pain.¹

Heat therapy was found to be more effective for improving flexibility, while cold therapy was more effective for reducing inflammation and swelling.

This study suggests that both heat and cold therapy can be beneficial for managing pain, depending on the nature of the pain and the desired outcome.

Exercise and stretching

Lack of exercise or movement can contribute to muscle tension and stiffness.

Regular exercise and stretching can help alleviate pain by improving muscle strength and flexibility.

Strengthening muscles around the affected area can provide better support and reduce strain.

On the other hand, stretching helps improve flexibility and reduce muscle tightness, which can relieve pain and improve mobility.

A study published in the Journal of Physical Therapy Science in 2018 investigated the effects of stretching on lower back pain.

The study found that participants who performed stretching exercises experienced a significant reduction in lower back pain² compared to those who did not stretch.

This only shows that incorporating stretching exercises into a routine can be effective in reducing pain and improving function, particularly for lower back pain.

Mind-body techniques

Pain perception can be influenced by emotional and psychological factors, such as stress, anxiety, and mood.

Chronic stress, for example, can lead to muscle tension and increased sensitivity to pain.

Mind-body techniques, such as meditation, yoga, and deep breathing exercises, can help reduce stress and promote relaxation.

By calming the mind and reducing stress levels, these techniques can help alleviate muscle tension, improve mood, and reduce pain perception.

A study published in the Journal of Pain Research in 2014 showed that participants who underwent mindfulness meditation training experienced a significant reduction in pain intensity and pain-related interference³ compared to a control group.

In other words, mind-body techniques, such as mindfulness meditation, can be beneficial for managing chronic pain by reducing stress and improving coping mechanisms.

Massage therapy

Massage therapy works by manipulating the soft tissues of the body, including muscles, tendons, and ligaments. This can help improve blood flow, reduce muscle tension, and promote relaxation.

Massage therapy also stimulates the release of endorphins, which are natural painkillers produced by the body.

It also helps alleviate pain by reducing muscle tension and improving circulation.

By targeting specific areas of pain or discomfort, massage can help relax muscles, reduce inflammation, and promote healing.

Massage therapy can also help improve range of motion and flexibility, which can further reduce pain and improve overall function.

A study published in the Journal of Pain and Symptom Management in 2002 found that patients who received massage therapy experienced a significant reduction in pain and anxiety⁴ compared to those who did not receive massage.

NAD supplementation

Pain can be associated with various factors, including inflammation, oxidative stress, and cellular damage.

NAD plays a crucial role in cellular metabolism and energy production, as well as in DNA repair and anti-inflammatory processes.

However, NAD levels decline with age, which may contribute to age-related conditions, including pain.

NAD supplementation can help alleviate pain by supporting cellular repair mechanisms, reducing inflammation, and improving mitochondrial function.

By increasing NAD levels, supplementation may enhance cellular energy production and repair processes, which can help reduce pain and promote overall health.

A study published in the journal Pain Medicine in 2020 investigated the effects of NAD supplementation on pain in patients with fibromyalgia, a condition characterized by widespread musculoskeletal pain.

The study found that participants who received NAD supplementation experienced a significant reduction in pain intensity and improvement in quality of life compared to those who received a placebo.⁵

It is also safe and well-tolerated, with potential benefits for managing pain in fibromyalgia patients.

Therefore, NAD supplementation may be a promising approach for managing pain, particularly in conditions associated with cellular dysfunction and inflammation.

When it comes to NAD supplementation, Vitality ↑® NAD+ Booster is our trusted choice for supporting healthy NAD levels and alleviating chronic pain that may be affecting your quality of life.

We also recommend checking your NAD levels with our Intracellular NAD test to determine if they are within the normal range, low, or high. This information can help you adjust the amount of Vitality ↑® NAD+ Booster to take for optimal results.

Are you ready to find relief from your pain and regain a sense of normalcy in your life?

Your Next Steps…

Step 1: Order the Intracellular NAD test today.

Additionally, the test provides actionable data to help you adjust the dosage of Vitality ↑® NAD+ Booster optimizing your NAD levels and potentially alleviating your chronic pain.

TEST YOUR NAD LEVELS TODAY

Step 1: Take Vitality ↑® NAD+ Booster.

This clinically validated formulation includes NAD precursor, Creatine monohydrate, D-Ribose, and Nicotinamide, which synergistically work to:

Revitalize your cells
Optimize your mitochondria
Improve your pain levels, helping you regain your normal life.

Just imagine being able to stand up from sitting without back pain…

To climb the stairs without troublesome leg pain, or…

To do household chores without paying the price later.

Taking Vitality ↑® NAD+ Booster can make these possibilities a reality for you.

SHOP NAD+ BOOSTER

To save even more, you can take advantage of the NAD Optimization® Bundles, where you can get…

2 Intracellular NAD® tests
1 Vitality ↑® NAD+ Booster supplement
one free supplement and…
a free consultation.

Start by using the first Intracellular NAD® test to reveal your current NAD levels. Then, take Vitality ↑® NAD+ Booster for a month.

Afterwards, use the second Intracellular NAD® test to identify your new, optimized levels after taking our NAD supplements. You’ll be pleasantly surprised by how much your levels have improved, just like Kevin and Adrianus…

“I’ve finished two jars of Vitality ↑® NAD+ Booster and my sleep is deeper, head-to-toe aches and pains have vanished, I’ve got more energy throughout the day, my workout takes less effort, I’m more flexible and have greater strength, I can do deeper stretches and hold them far longer, my mood is better and my outlook more positive. It’s like I’ve turned back the clock 20 years. Thank you, Jin!“

~ Kevin Rush

“Vitality ! taken twice daily has turned my health around and after six months continues to do so. As a 79-year-old I’ve experienced less aches and pains and feel more energetic than before I started taking the supplement. I highly recommend to try it for yourself.“

~Adrianus Slootjes

If you’re unsure about what to do or have questions about how to start or interpret your results, you can book your free consultation.

Grab the NAD Optimization® Bundles here — Save $178 today.

Get relief from your chronic pain and live a normal life again with Vitality ↑® NAD+ Booster!

Referenced Sources:

How NAD Can Support Children on the Autism Spectrum: Strategies and Success Stories

Written by Jinfiniti Science on April 14, 2024. Posted in NAD+, Autism, NAD.

Autism is a developmental disorder that affects communication and behavior.

According to the Centers for Disease Control and Prevention (CDC), autism affects an estimated 1 in 36 children in the United States¹, making it more common than previously thought.

The disorder can manifest in various ways, from mild social challenges to significant communication difficulties and repetitive behaviors.

What’s striking about autism is its indiscriminate nature. It knows no boundaries of wealth, fame, or social status.

Families from all walks of life, including public figures like Elon Musk, Sylvester Stallone, Holly Robinson Peete, Amanda Seyfried, Dylan Dreyer, and Nicole Shanahan, can find themselves navigating the challenges of raising a child with autism.

In this article, we explore…

Groundbreaking strategies that can help improve the lives of children with autism.

How NAD support might be a game-changer in the treatment and support of autism spectrum disorder.

A transformative case study of Corbin, a 3-year-old whose behavior, engagement, and communication skills have dramatically improved after NAD treatment.

Autism Intervention

One of the key issues in the autism community is the need for early detection and intervention.

Research shows that early diagnosis and intervention can significantly improve outcomes for individuals with autism.

However, many families face barriers to timely diagnosis and intervention services, highlighting the importance of raising awareness and ensuring that all children have access to quality care.

Another challenge faced by families affected by autism is the stigma and misconceptions surrounding the disorder.

Many people still hold outdated beliefs about autism, leading to discrimination and social isolation for individuals with autism and their families.

As the exact causes of autism remain not fully understood, research indicates that a combination of genetic and environmental factors contribute to its development.

One emerging area of research focuses on the role of NAD (nicotinamide adenine dinucleotide) deficiency in autism phenotypes².

Autism and NAD

NAD is a coenzyme found in all living cells and plays a crucial role in various cellular processes³, including energy production, DNA repair, and gene expression.

Our research here in Jinfiniti has shown that individuals with autism may have lower levels of NAD compared to neurotypical individuals.

This deficiency could potentially impact mitochondrial function, oxidative stress levels, and neurotransmitter signaling, all of which are involved in the development of autism.

Furthermore, NAD deficiency may also affect other cellular processes, such as immune function and inflammation, which have been linked to autism.

Jinfiniti’s Advocacy on Autism

At Jinfiniti, our mission is to provide innovative treatment for children with autism using NAD.

In fact, we have exciting updates from our ongoing study, showing promising results.

For example, Corbin, a 3-year-old diagnosed with Autism Spectrum Disorder (ASD) following routine childhood vaccinations, has shown remarkable improvement after participating in testing protocols and using the Vitality formulation.

Here are some of the notable improvements observed in Corbin:

Increased focus and engagement: Corbin has been able to sit attentively during therapy sessions and activities and with his teacher during meal times.
Improved fine motor skills: He has demonstrated the ability to put individual popsicle sticks inside a toothbrush holder, indicating progress in his fine motor abilities.
Enhanced communication skills: Despite being non-speaking, Corbin has shown progress in communication by interrupting his teacher to get her attention and indicating his wants and needs more clearly.
Increased independence: Corbin has started opening his lunch snack containers and lunch boxes, showing improved independence in daily tasks.
Improved responsiveness: He now responds with “yeah” when asked if he wants something, indicating better understanding and communication.
Better understanding of verbal commands: Corbin can now follow verbal commands like putting his shoes on, demonstrating improved listening skills.
Increased affection and social engagement: He has been more affectionate and cuddly, initiating play more often with his parents and seeking approval through eye contact.
Expanded vocabulary: Corbin has started saying new words and phrases like “Peek-a-boo,” “I wake up,” and “I pee-pee,” showing progress in his language development.
Improved behavior in public settings: He displayed patience and waiting behavior at the splash pad, a notable improvement from previous behaviors of attempting to run away.

Corbin’s improvements show that the Vitality formulation could be really helpful for kids with autism.

SHOP NAD+ BOOSTER

4 Ways Vitality ↑® NAD+ Booster Can Support Children With Autism

Vitality ↑® NAD+ Booster is a clinically tested blend of NAD precursor, Creatine monohydrate, D-Ribose, and Nicotinamide that work together to boost NAD levels, rejuvenating cells and the body.

This formulation is particularly beneficial for children with autism, helping improve their behavior and cognitive function in four key ways.

Supports Mitochondrial Function

Mitochondria are often called the “powerhouses” of cells because they produce most of the cell’s adenosine triphosphate (ATP), a molecule that stores and transports energy within cells.

NAD (nicotinamide adenine dinucleotide) is a coenzyme that plays a critical role in mitochondrial function⁴ by shuttling electrons in the electron transport chain, a process that generates ATP.

Research suggests a potential link between mitochondrial dysfunction and autism spectrum disorder (ASD).

Mitochondrial dysfunction can lead to reduced ATP production, affecting cellular processes crucial for brain development and function⁵. This dysfunction may contribute to the development or severity of ASD symptoms.

Boosting NAD levels could theoretically improve mitochondrial function by providing more of the coenzyme needed for efficient ATP production.

This could enhance cellular energy production and potentially support better brain function in individuals with ASD.

Manages Oxidative Stress

Oxidative stress occurs when there is an imbalance between free radicals and antioxidants in the body.

Free radicals are highly reactive molecules that can cause damage to cells and tissues if their levels are not controlled by antioxidants.

Research has shown that individuals with ASD may experience higher levels of oxidative stress⁶ compared to typically developing individuals.

A study published in the journal Clinical Biochemistry and Nutrition found that children with ASD had significantly higher levels of oxidative stress markers and lower levels of antioxidants compared to typically developing children⁷.

Another study published in the journal Redox Report suggested that oxidative stress may play a role in the development and progression of ASD.

By boosting NAD levels, it is believed that the body’s ability to manage oxidative stress may be enhanced.

This could potentially lead to improved overall health and cognitive function in individuals with ASD.

Supporting NAD levels through supplementation or other means may help mitigate the effects of oxidative stress and improve outcomes for individuals with autism.

Supports Neurotransmitter Signaling

Neurotransmitters are essential for communication between neurons in the brain.

Imbalances in neurotransmitter signaling have been associated with neurological disorders, including autism.⁸

For example, a study published in the journal Frontiers in Psychiatry found alterations in the levels of certain neurotransmitters, such as serotonin and dopamine, in individuals with autism spectrum disorder (ASD)⁹.

By boosting NAD levels, the brain’s ability to maintain proper neurotransmitter balance may be enhanced.

This could lead to improved communication between neurons and potentially enhance cognitive function and overall brain health in individuals with autism.

A study published in the journal Molecular Psychiatry suggested that NADH (a form of NAD) supplementation could modulate dopamine levels in the brain¹⁰, which is important for regulating mood and behavior.

Another study published in the Journal of Neuroscience Research found that NADH supplementation improved cognitive function in a mouse model of Alzheimer’s disease¹¹, which is characterized by neurotransmitter imbalances.

The potential of NAD to restore balance in neurotransmitter signaling is crucial for individuals with autism, as disruptions in this balance can lead to cognitive and behavioral issues.

By supporting NAD levels, it may be possible to help restore this balance and improve communication between neurons, which could have positive effects on cognitive function in individuals with autism.

Supports Healthy Immune Function and Inflammation

Dysregulation of the immune system and chronic inflammation have been linked to various health conditions, including autism.¹²

For example, a study published in the Journal of Neuroinflammation found that children with autism had altered levels of certain immune markers compared to typically developing children¹³.

Another study published in the Journal of Neuroimmunology reported elevated levels of inflammatory markers in the brains of individuals with autism¹⁴.

By boosting NAD levels, it’s possible to modulate immune function and reduce inflammation. This could have several benefits for individuals with autism, including improved overall health and well-being.

One study published in the journal Nature Communications found that NAD supplementation reduced inflammation and oxidative stress in a mouse model of multiple sclerosis¹⁵, a condition characterized by immune dysregulation and inflammation.

That’s why we recommend Vitality ↑® NAD+ Booster for children with autism to support their overall health and well-being.

Vitality ↑® NAD+ Booster is specially formulated with ingredients that work synergistically to promote energy levels, cognitive function, and overall vitality, which can be beneficial for children with autism who may have specific nutritional needs.

It can help support healthy growth and development, as well as provide essential nutrients that may be lacking in their diet.

By incorporating Vitality ↑® NAD+ Booster into their daily routine, children with autism can potentially experience improved energy levels, cognitive function, and overall health, helping them to thrive and reach their full potential.

SHOP NAD+ BOOSTER

Referenced Sources:

7 Common Symptoms of Autoimmune Diseases You Shouldn’t Ignore

Written by Jinfiniti Science on April 8, 2024. Posted in NAD+, Autoimmune Disease, NAD.

Do you struggle with an autoimmune disease that affects your health and daily life?

Autoimmune diseases are more common than you might think.

In fact, approximately 8% of people in the United States are diagnosed with autoimmune diseases¹, affecting virtually any part of their body, from the joints and skin to the organs and nervous system.

78% of autoimmune disease sufferers are women, especially during their childbearing years.

While the precise reasons for this gender imbalance remain unclear, researchers suggest that sex hormones may influence the development and progression of these conditions.

What is evident is that the immune system is behaving abnormally, deviating from its usual function.

The Immune System

The immune system is a complex network of cells and chemicals² that work together to protect the body from harmful invaders such as bacteria, viruses, and other pathogens.

Under normal circumstances, the immune system can distinguish between foreign substances and the body’s cells, launching an attack only when necessary to maintain health.

However, in the case of autoimmune diseases, this delicate balance is disrupted³.

The immune system mistakenly identifies your tissues and organs as foreign invaders and mounts an attack against them.

This misguided immune response leads to the production of autoantibodies, proteins that target and attack healthy cells, causing inflammation, tissue damage, and a range of symptoms.

Some autoimmune diseases, such as type 1 diabetes⁴, specifically target one organ, while others, like systemic lupus erythematosus (lupus)⁵, can affect multiple systems throughout the body.

Despite ongoing research efforts, the exact cause of autoimmune diseases remains unknown.

However, several factors are believed to contribute to their development, including genetic predisposition, environmental triggers, and lifestyle factors such as smoking and obesity.

Antibodies vs Autoantibodies

Antibodies and autoantibodies are critical components of the immune system, but they have distinct roles and functions in the body’s defense against pathogens and its response to autoimmune diseases.

Antibodies, also known as immunoglobulins⁶, are proteins produced by specialized white blood cells called B cells. Their primary function is to recognize and neutralize foreign invaders, such as bacteria, viruses, and other harmful substances known as antigens.

When an antigen enters the body, it triggers B cells to multiply and differentiate into plasma cells. These plasma cells secrete large quantities of antibodies circulating in the bloodstream and other body fluids.

Antibodies specifically target antigens by binding to them, marking them for destruction by other immune cells, or rendering them harmless.

On the other hand, autoantibodies are antibodies that mistakenly target and attack the body’s tissues and cells⁷.

Unlike antibodies, which target foreign invaders, autoantibodies target normal proteins in the body’s cells, leading to inflammation, tissue damage, and a range of symptoms.

The presence of autoantibodies in the blood is often used as a diagnostic marker for autoimmune diseases⁸, as it indicates an immune response against the body’s tissues.

Most individuals naturally have low levels of autoantibodies. However, elevated levels often suggest the presence of an autoimmune disease.

Diagnosing an autoimmune disease can be challenging.

According to Ana-Maria Orbai, M.D., M.H.S., a rheumatologist at the Johns Hopkins Arthritis Center, diagnosing the condition requires a combination of symptoms, specific blood markers, and sometimes even a tissue biopsy.⁹

Speaking of symptoms, below are seven of the common symptoms people with autoimmune diseases experience.

Fatigue

Fatigue is a common and often debilitating symptom experienced by individuals with autoimmune diseases.

Unlike normal tiredness, fatigue associated with autoimmune diseases is not relieved by rest and can significantly affect daily life.

People with autoimmune diseases have an overactive immune system resulting in elevated levels of cytokines and increased inflammation,¹⁰ which can contribute to fatigue.

Cytokines are vital proteins that regulate the growth and function of immune system cells and blood cells¹¹.

When these proteins are released, they act as signals that prompt the immune system to carry out its functions.

This includes the regulation of the growth of various blood cells and other cells involved in the body’s immune and inflammatory responses.

In a recent survey conducted by the Autoimmune Association, it showed the profound impact of fatigue on individuals with autoimmune diseases.

Over 1,000 respondents reported that fatigue negatively affects their quality of life¹², family relationships, mental health, and ability to work and parent.

The constant immune activity in autoimmune diseases can be exhausting, making simple tasks challenging.

Additionally, fatigue can impair cognitive function, affecting concentration and memory.

The neuroendocrine system, which regulates energy metabolism and stress response, can also be disrupted in autoimmune diseases, contributing to fatigue.

Sleep disturbances, such as insomnia, are common in autoimmune diseases and can further exacerbate fatigue.

Malabsorption and nutrient deficiencies, which are prevalent in autoimmune diseases, can also contribute to the feeling of extreme tiredness.

Joint Pain and Stiffness

Joint pain and stiffness are hallmark symptoms of autoimmune diseases, stemming from the immune system’s misdirected attack on the body’s tissues.

In autoimmune conditions, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), the immune system targets the synovium¹³, a thin membrane lining the joints, leading to inflammation and subsequent pain and stiffness.

As the autoimmune response persists, the inflammation can damage the cartilage and bone within the joint.

Cartilage, which cushions the ends of bones, can deteriorate, leading to friction between bones and further exacerbating pain and stiffness.

Additionally, chronic inflammation can promote the formation of osteophytes, or bone spurs¹⁴, which can impede joint movement and cause additional discomfort.

The nervous system also plays a role in the experience of joint pain and stiffness in autoimmune diseases.

The immune response can disrupt the normal function of nerves in the joints, resulting in heightened sensitivity to pain and altered pain perception.

That’s why you can experience severe pain if you have autoimmune joint conditions.

Skin Changes

Skin changes are a common manifestation of autoimmune diseases, reflecting the complex interplay between the immune system and skin cells.

Autoimmune skin conditions are characterized by an overactive immune response that targets the skin’s cells, resulting in inflammation and the formation of skin lesions.

These lesions can vary in appearance and severity, ranging from red, scaly patches in psoriasis to butterfly-shaped rashes across the cheeks and nose in lupus.

The mechanisms underlying skin changes in autoimmune diseases are multifactorial.

In psoriasis, for example, immune cells called T cells become overactive, leading to the rapid turnover of skin cells and thick, scaly plaques.¹⁵

In lupus, the immune system produces antibodies that target the skin, leading to inflammation and tissue damage.

Skin changes in autoimmune diseases can also be influenced by genetic and environmental factors.

Certain genetic variations can predispose individuals to develop autoimmune skin conditions, while environmental factors such as sunlight exposure and stress can trigger or exacerbate symptoms.

Digestive Issues

Digestive issues are a common concern for individuals grappling with autoimmune diseases, impacting the gastrointestinal tract and manifesting in a spectrum of symptoms.

These symptoms can include abdominal pain, bloating, diarrhea, constipation, nausea, vomiting, and difficulty swallowing, along with fluctuations in weight.

A variety of autoimmune diseases can affect the digestive system, such as Inflammatory Bowel Disease (IBD), including Crohn’s disease and ulcerative colitis¹⁶, which cause inflammation along the digestive tract.

Celiac Disease, triggered by gluten ingestion, damages the small intestine¹⁷.

Autoimmune Hepatitis targets liver cells¹⁸, leading to inflammation and damage.

Primary Biliary Cholangitis (PBC) and Primary Sclerosing Cholangitis (PSC)¹⁹ are chronic autoimmune conditions affecting the bile ducts in the liver.

The immune system’s assault on the gastrointestinal tract underpins these digestive symptoms, resulting in inflammation, tissue harm, and functional impairment.

Several mechanisms contribute to these symptoms:

Chronic inflammation in the digestive tract can damage the intestinal lining, affecting nutrient and water absorption, and causing issues like diarrhea, malabsorption, and nutrient deficiencies.

Alterations in the gut microbiota, the community of bacteria in the gut, can also lead to inflammation and digestive symptoms.

Moreover, autoantibodies in some autoimmune diseases target proteins in the digestive tract, leading to tissue damage and dysfunction. For instance, in celiac disease, autoantibodies attack the lining of the small intestine in response to gluten.

Disruption of the gut-brain axis, which regulates gut motility, sensation, and secretion, can also occur in autoimmune diseases, contributing to digestive symptoms.

Muscle Weakness

Muscle weakness is a common symptom in autoimmune diseases, arising from the immune system’s attack on healthy muscle tissue.

This immune response triggers inflammation, which can damage muscles and hinder their normal function.

This damage can culminate in muscle weakness and fatigue over time.

As a result, simple everyday activities like walking, climbing stairs, or lifting objects can become unmanageable due to muscle weakness.

Additionally, tasks requiring precision become a challenge due to compromised fine motor skills.

Beyond physical limitations, muscle weakness can exact a psychological toll, leading to feelings of frustration, loss of independence, and diminished quality of life.

Chronic inflammation can also impede muscle function, fostering muscle weakness²⁰. It can also inflict damage on muscle fibers, disrupting their usual structure and operation, leading to weakness and diminished strength.

Furthermore, autoimmune diseases can interfere with energy production in muscle cells, precipitating fatigue and weakness²¹, particularly during periods of physical exertion.

Fever and Inflammation

Fever, an elevation in body temperature often accompanied by sweating, chills, and fatigue is a common symptom in autoimmune diseases.

Inflammation, the body’s response to injury or infection, characterized by redness, swelling, heat, and pain, is also prevalent in these conditions.

Both fever and inflammation arise from the immune system’s misguided attack on healthy tissues.

Generally, these symptoms result from immune system dysfunction, producing inflammatory proteins known as cytokines.

These cytokines can provoke inflammation throughout the body²², manifesting as fever, swelling, and pain.

Additionally, external factors such as infections can trigger fever and inflammation in autoimmune diseases by stimulating the immune system.

When the immune system erroneously attacks the body’s tissues as foreign and launches an immune response against them. This process entails the production of autoantibodies and the activation of immune cells like T cells and macrophages.

Immune cells release pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)²³.

In response to inflammation, the liver produces acute-phase proteins like C-reactive protein (CRP) and fibrinogen.

While these proteins help modulate the immune response and facilitate tissue repair, they can also contribute to fever and inflammation.

Brain Fog and Cognitive Issues

Brain fog and cognitive issues in autoimmune diseases are thought to stem from inflammation, immune system dysfunction, and neurotransmitter imbalances.

The immune system can erroneously attack healthy tissues, resulting in chronic inflammation.

This inflammation can compromise the blood-brain barrier²⁴, a protective barrier that regulates the passage of substances between the bloodstream and the brain.

When the blood-brain barrier is compromised, immune cells and inflammatory molecules can enter the brain,²⁵ triggering an inflammatory response that impairs cognitive function.

Additionally, imbalances in neurotransmitters—chemical messengers that transmit signals between nerve cells in the brain—have been implicated in brain fog and cognitive issues.

Moreover, microglia, immune cells in the brain, play a crucial role in the brain’s immune response.

If you have autoimmune diseases, your microglia can become overactivated, releasing pro-inflammatory cytokines²⁶ and other molecules that damage neurons and disrupt normal brain function.

This neuroinflammation is believed to contribute to cognitive problems such as brain fog and memory loss.

NAD and Autoimmune Diseases

NAD (nicotinamide adenine dinucleotide) is a coenzyme found in all living cells and is essential for various biological processes, including energy metabolism, DNA repair, and gene expression.

Recent research has highlighted the potential connection between NAD levels and autoimmune diseases.

One emerging area of interest is the role of NAD in regulating immune responses.

NAD levels have been linked to the function of immune cells, such as T cells and macrophages²⁷, which play a crucial role in the development and progression of autoimmune diseases.

Studies suggest that NAD may influence immune cell activation, proliferation, and cytokine production²⁸, all of which are key factors in autoimmune responses.

Additionally, NAD is involved in regulating the activity of sirtuins²⁹, a class of proteins that play a role in cellular stress responses, inflammation, and aging.

Sirtuins have been implicated in autoimmune diseases, and their activity may be influenced by NAD levels.

Some research suggests that boosting NAD levels or activating sirtuins could have therapeutic potential in treating autoimmune diseases by modulating immune responses and reducing inflammation.

To help optimize your NAD levels to support a healthy immune system and minimize or avoid the symptoms associated with autoimmune disease, here are two things you can do:

1. Optimize your NAD Levels

First, you need to identify your NAD levels, whether they’re low, borderline, or high, so you can get actionable data to help you find an effective and affordable product and the correct dosage to optimize your NAD level.

The Intracellular NAD® Test is the first and only NAD test that can help you determine if you are deficient in NAD, if your NAD supplement is working, or if you are taking the optimal dosage for your supplement.

This test provides you with the information you need to optimize your NAD levels without the guessing game.

TEST YOUR NAD LEVELS TODAY

2. The Only NAD Supplement We Trust

Second, if there’s one supplement we trust to support healthy levels of NAD in your body, it’s none other than Vitality ↑® NAD+ Booster by Jinfiniti.

Vitality ↑® NAD+ Booster is a clinically validated formulation consisting of NAD precursor, Creatine monohydrate, D-Ribose, and Nicotinamide that work synergistically.

This supplement supports healthy NAD levels to revitalize your cells and body, just as it did for Mia, who began taking Vitality ↑® NAD+ Booster to address her autoimmune issues.

“I’ve struggled with autoimmune issues from a young age, trying numerous supplements that were both costly and ineffective. Despite various treatments, blood draws, and hospital visits, we couldn’t find a solution that worked for my body.

A few months ago, I started taking Boost and noticed an immediate increase in energy. My sleep improved, and I felt more energized during workouts and throughout the day. My lab results also saw a significant improvement, which hadn’t happened with any other treatment.”

Vitality ↑® NAD+ Booster is a patent-pending NAD formulation guaranteed to optimize NAD and contains four high-purity and natural ingredients, to help you…

Boost energy and improve performance
Improve sleep quality
Support inflammation, muscle, and joint pains
Support healthy allergic and asthmatic symptoms
Improve mental clarity and dementia symptoms
Support functions of many organs (liver, kidney, heart, thyroid, fertility)…

Therefore, if you’re looking to support a healthy immune system to avoid the risk of autoimmune diseases or finally break free from the symptoms that are trapping you from living a normal life…

You can also try out Intracellular NAD® Test and Vitality ↑® NAD+ Booster.

The NAD Optimization® Bundles — 2 Intracellular NAD® tests and 1 Accuri® Vitality ↑® NAD+ Booster supplement — and get 1 free supplement and free consultation.

This package allows you to reveal your current NAD level, the optimal dosage for NAD+ precursor supplements, and health benefits from optimized NAD levels.

We work with you to optimize your NAD level.

If you want to avoid the risk of autoimmune diseases or finally break free from the symptoms that are stopping you from living a normal life…

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Referenced Sources:

RFK Jr.’s VP Pick: Nicole Shanahan, A Voice for Autism

Written by Jinfiniti Science on March 28, 2024. Posted in NAD+, Autism, NAD.

In a move that solidifies his commitment to addressing pressing health issues, Robert F. Kennedy Jr. has chosen Nicole Shanahan as his vice-presidential pick.

What sets Shanahan apart is not just her professional prowess but also her journey as a mother of a child with autism.

This choice highlights the growing prevalence of autism spectrum disorder (ASD) and the need for greater awareness and support for affected families.

Autism is a developmental disorder that affects communication and behavior.

According to the Centers for Disease Control and Prevention (CDC), autism affects an estimated 1 in 36 children in the United States, making it more common than previously thought.

The disorder can manifest in various ways, from mild social challenges to significant communication difficulties and repetitive behaviors.

What’s striking about autism is its indiscriminate nature.

It knows no boundaries of wealth, fame, or social status.

Families from all walks of life can find themselves navigating the challenges of raising a child with autism.

This reality is exemplified by Shananhan’s experience, showing that even those in the public eye are not immune to the disorder’s impact.

Shananhan’s journey as a mother has led her to become a vocal advocate for autism awareness and support.

She has used her platform to raise awareness about the challenges faced by families affected by autism and to advocate for policies that improve access to resources and services for individuals with autism.

In her interview with People Magazine, Shanahan revealed that she had been in discussions with Elon Musk about leveraging technology developed by his Neuralink company.

Neuralink is known for creating an implantable brain-computer interface.

Shanahan expressed interest in exploring how this technology could potentially benefit her daughter, who has autism.

She also shared that a significant portion of her time, over 60%, is dedicated to researching autism and engaging with scientists in discussions about the topic.

“…in part because I am hopeful of helping my daughter overcome her autism, whatever that might look like, whether it be in five years not having a diagnosis anymore, or having all of the tools to navigate the challenges that her diagnosis has produced in her life.”

“This has led me into fields of science that have been utterly fascinating.

“I talk to two scientists a week, typically, whether they’re neurosurgeons or neurologists or mitochondrial experts. Then I spend an equal amount of time after meeting with them trying to digest my notes.

I chat with a lot of other mothers of autistic children because I think mothers are some of the most well-educated and researched.

They’re having to show up for their child every hour of every single day. They’re trying some of these autism interventions and they’re able to tell you with greater accuracy than any published medical paper what they’re seeing in their children.”

Autism Intervention

One of the key issues in the autism community is the need for early detection and intervention.

Research shows that early diagnosis and intervention can significantly improve outcomes for individuals with autism.

However, many families face barriers to accessing timely diagnosis and intervention services, highlighting the importance of raising awareness and ensuring that all children have access to quality care.

Another challenge faced by families affected by autism is the stigma and misconceptions surrounding the disorder.

Many people still hold outdated beliefs about autism, leading to discrimination and social isolation for individuals with autism and their families.

Shananhan’s advocacy work aims to challenge these misconceptions and promote a more inclusive and understanding society.

In addition to raising awareness, Shanahan has also been a strong proponent of increased research funding for autism.

She has supported the University of California Davis Mind Institute through donations, aiding their research and care efforts for individuals with autism and other neurodevelopmental conditions.

As the exact causes of autism remain not fully understood, research indicates that a combination of genetic and environmental factors contribute to its development.

One emerging area of research focuses on the role of NAD (nicotinamide adenine dinucleotide) deficiency in autism phenotypes.

Autism and NAD

NAD is a coenzyme found in all living cells and plays a crucial role in various cellular processes, including energy production, DNA repair, and gene expression.

Our research here in Jinfiniti has shown that individuals with autism may have lower levels of NAD compared to neurotypical individuals.

This deficiency could potentially impact mitochondrial function, oxidative stress levels, and neurotransmitter signaling, all of which are involved in the development of autism.

Furthermore, NAD deficiency may also affect other cellular processes, such as immune function and inflammation, which have been linked to autism.

Jinfiniti’s Advocacy on Autism

At Jinfiniti, our mission is to provide innovative treatment for children with autism using NAD.

In fact, we have exciting updates from our ongoing study, showing promising results.

Here are some of the notable improvements observed in Corbin:

Increased focus and engagement: Corbin has been able to sit attentively during therapy sessions and activities, as well as with his teacher during meal times.
Improved fine motor skills: He has demonstrated the ability to put individual popsicle sticks inside a toothbrush holder, indicating progress in his fine motor abilities.
Enhanced communication skills: Despite being non-speaking, Corbin has shown progress in communication by interrupting his teacher to get her attention and indicating his wants and needs more clearly.
Increased independence: Corbin has started opening his lunch snack containers and lunch boxes, showing improved independence in daily tasks.
Improved responsiveness: He now responds with “yeah” when asked if he wants something, indicating better understanding and communication.
Better understanding of verbal commands: Corbin can now follow verbal commands like putting his shoes on, demonstrating improved listening skills.
Increased affection and social engagement: He has been more affectionate and cuddly, initiating play more often with his parents and seeking approval through eye contact.
Expanded vocabulary: Corbin has started saying new words and phrases like “Peek-a-boo,” “I wake up,” and “I pee-pee,” showing progress in his language development.
Improved behavior in public settings: He displayed patience and waiting behavior at the splash pad, a notable improvement from previous behaviors of attempting to run away.

Corbin’s improvements show that the Vitality formulation could be really helpful for kids with autism.

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4 Ways Vitality ↑® NAD+ Booster Can Support Children With Autism

Vitality ↑® NAD+ Booster is a clinically tested blend of NAD precursor, Creatine monohydrate, D-Ribose, and Nicotinamide that work together to boost NAD levels, rejuvenating cells and the body.

This formulation is particularly beneficial for children with autism, helping improve their behavior and cognitive function in four key ways.

Supports Mitochondrial Function

Mitochondria are often called the “powerhouses” of cells because they produce most of the cell’s adenosine triphosphate (ATP), a molecule that stores and transports energy within cells.

NAD (nicotinamide adenine dinucleotide) is a coenzyme that plays a critical role in mitochondrial function by shuttling electrons in the electron transport chain, a process that generates ATP.

Research suggests a potential link between mitochondrial dysfunction and autism spectrum disorder (ASD).

Mitochondrial dysfunction can lead to reduced ATP production, affecting cellular processes crucial for brain development and function. This dysfunction may contribute to the development or severity of ASD symptoms.

Boosting NAD levels could theoretically improve mitochondrial function by providing more of the coenzyme needed for efficient ATP production.

This could enhance cellular energy production and potentially support better brain function in individuals with ASD.

Manages Oxidative Stress

Oxidative stress occurs when there is an imbalance between free radicals and antioxidants in the body.

Free radicals are highly reactive molecules that can cause damage to cells and tissues if their levels are not controlled by antioxidants.

Research has shown that individuals with ASD may experience higher levels of oxidative stress compared to typically developing individuals.

Another study published in the journal Redox Report suggested that oxidative stress may play a role in the development and progression of ASD.

By boosting NAD levels, it is believed that the body’s ability to manage oxidative stress may be enhanced.

This could potentially lead to improved overall health and cognitive function in individuals with ASD.

Supporting NAD levels through supplementation or other means may help mitigate the effects of oxidative stress and improve outcomes for individuals with autism.

Supports Neurotransmitter Signaling

Neurotransmitters are essential for communication between neurons in the brain.

Imbalances in neurotransmitter signaling have been associated with neurological disorders, including autism.

By boosting NAD levels, the brain’s ability to maintain proper neurotransmitter balance may be enhanced.

This could lead to improved communication between neurons and potentially enhance cognitive function and overall brain health in individuals with autism.

A study published in the journal Molecular Psychiatry suggested that NADH (a form of NAD) supplementation could modulate dopamine levels in the brain, which is important for regulating mood and behavior.

Another study published in the Journal of Neuroscience Research found that NADH supplementation improved cognitive function in a mouse model of Alzheimer’s disease, which is characterized by neurotransmitter imbalances.

The potential of NAD to restore balance in neurotransmitter signaling is crucial for individuals with autism, as disruptions in this balance can lead to cognitive and behavioral issues.

Supports Healthy Immune Function and Inflammation

Dysregulation of the immune system and chronic inflammation have been linked to various health conditions, including autism.

For example, a study published in the Journal of Neuroinflammation found that children with autism had altered levels of certain immune markers compared to typically developing children.

Another study published in the Journal of Neuroimmunology reported elevated levels of inflammatory markers in the brains of individuals with autism.

One study published in the journal Nature Communications found that NAD supplementation reduced inflammation and oxidative stress in a mouse model of multiple sclerosis, a condition characterized by immune dysregulation and inflammation.

That’s why we recommend Vitality ↑® NAD+ Booster for children with autism to support their overall health and well-being.

It can help support healthy growth and development, as well as provide essential nutrients that may be lacking in their diet.

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Understanding the Fundamental Hallmarks of Aging – A Closer Look

Written by Jinfiniti Science on March 17, 2024. Posted in Premature Aging, Epigenetic, Senescence.

Aging is a natural process that all living organisms experience. As you age, your body undergoes a series of changes that can impact your health and quality of life. To better understand these changes, scientists have identified nine fundamental hallmarks of aging. These hallmarks provide valuable insights into the underlying mechanisms of aging and offer potential targets for interventions to promote healthy aging.

“Intrinsic aging is due to genetic factors, while extrinsic aging can be attributed to lifestyle choices like alcohol consumption, smoking, diet, exercise and stress management.” Dr. Neil Paulvin, Regenerative Medicine Doctor

The Science Behind Aging

Aging is a complex and multifactorial process influenced by a combination of genetic and environmental factors. At the cellular level, aging is characterized by a gradual decline in the function of various biological processes. Understanding the biological mechanisms of aging is crucial for developing strategies to mitigate its negative effects.

Aging is not a simple linear process; rather, it involves a progressive decline in the ability of cells, tissues, and organs to maintain physiological homeostasis. This decline is influenced by a range of factors, including DNA damage, protein dysfunction, and cellular senescence. Over time, these cellular changes can lead to the development of age-related diseases.

One of the key factors contributing to aging is DNA damage. With age, the DNA becomes more susceptible to damage from various sources, such as environmental toxins, radiation, and oxidative stress. This damage can result in mutations and errors in DNA replication, leading to cellular dysfunction and ultimately contributing to aging.

Another important aspect of aging is protein dysfunction. Proteins are essential for the proper functioning of cells, and their misfolding or aggregation can have detrimental effects. As you age, the quality control mechanisms responsible for maintaining proper protein folding and function become less efficient, leading to the accumulation of damaged proteins. This protein accumulation can disrupt cellular processes and contribute to the overall decline in cellular function associated with aging.

Cellular senescence is also a significant contributor to the aging process. Senescence refers to a state in which cells lose their ability to divide and function properly. This can occur due to various factors, including DNA damage, telomere shortening, and cellular stress. Senescent cells can accumulate in tissues over time, secreting harmful molecules that can promote inflammation and tissue dysfunction. The presence of senescent cells has been linked to age-related diseases and overall aging.

The Role of Genetics in Aging

Genetics plays a significant role in determining an individual’s rate of aging. Certain genes have been identified as key regulators of the aging process. For example, variations in genes involved in DNA repair mechanisms can impact an individual’s susceptibility to age-related diseases.

One such gene is the tumor suppressor gene p53, which plays a crucial role in DNA repair and cell cycle regulation. Mutations in the p53 gene can impair its function, leading to an increased risk of DNA damage accumulation and accelerated aging. On the other hand, certain genetic variations in genes involved in antioxidant defense mechanisms, such as the superoxide dismutase gene, have been associated with increased longevity and reduced risk of age-related diseases.

It is important to note that while genetics can influence the rate of aging, it is not the sole determinant. Environmental factors also play a significant role in the aging process.

Environmental Factors Influencing Aging

In addition to genetics, environmental factors also contribute to the aging process. Factors such as diet, exercise, and exposure to toxins can modulate the rate of aging.

Dietary choices have a profound impact on aging. A diet rich in fruits, vegetables, whole grains, and lean proteins provides essential nutrients and antioxidants that can help protect against cellular damage and promote healthy aging. On the other hand, a diet high in processed foods, saturated fats, and sugar can contribute to inflammation, oxidative stress, and accelerated aging.

Regular physical activity is another crucial factor in healthy aging. Exercise has been shown to have numerous benefits, including improved cardiovascular health, enhanced cognitive function, and reduced risk of age-related diseases. Exercise can also stimulate the production of growth factors and hormones that promote cellular repair and regeneration¹.

Exposure to toxins and pollutants in the environment can also accelerate the aging process. Air pollution, cigarette smoke, and certain chemicals can induce oxidative stress and inflammation, leading to cellular damage and premature aging. Minimizing exposure to these harmful substances and adopting protective measures, such as wearing sunscreen and avoiding smoking, can help mitigate their negative effects on aging.

In conclusion, aging is a complex process influenced by a combination of genetic and environmental factors. Understanding the biological mechanisms of aging and the role of genetics and environmental factors is crucial for developing strategies to promote healthy aging and mitigate the negative effects of aging-related diseases.

The Nine Hallmarks of Aging

Scientists have identified nine hallmarks that contribute to the aging process. These hallmarks encompass a range of cellular and molecular changes that occur during aging.

Understanding these hallmarks is crucial for developing interventions that can slow down or reverse the aging process, ultimately improving health and extending lifespan.

1. Genomic Instability

Genomic instability refers to the increased susceptibility of DNA to damage and mutation. As we age, our DNA becomes more prone to errors and breaks, leading to genomic instability. This instability can result in the accumulation of genetic mutations, contributing to the development of age-related diseases, such as cancer.

Various factors, including exposure to environmental toxins, radiation, and oxidative stress, can cause genomic instability. These factors can induce DNA damage and impair the repair mechanisms, leading to the accumulation of mutations over time.

2. Telomere Attrition

Telomeres are protective caps at the ends of chromosomes that shorten with each cell division. Telomere attrition is a hallmark of aging, as the progressive shortening of telomeres limits the replicative capacity of cells. Ultimately, this can lead to cellular senescence and tissue deterioration.

During cell division, the enzyme telomerase adds repetitive DNA sequences to the telomeres, counteracting the shortening process. However, telomerase activity is low in most somatic cells, resulting in gradual telomere attrition over time.

Shortened telomeres can trigger DNA damage responses and cellular senescence, limiting the regenerative potential of tissues and contributing to age-related diseases.

3. Epigenetic Alterations

Epigenetic alterations are changes in gene expression patterns that do not involve changes to the underlying DNA sequence. Epigenetic modifications can accumulate over time and impact gene regulation. These alterations can influence the aging process by altering the expression of genes involved in various cellular functions.

Epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNA molecules, play a crucial role in regulating gene expression. With aging, there is a progressive alteration in the epigenetic landscape, leading to changes in gene expression patterns. These epigenetic changes can affect cellular processes, including DNA repair, inflammation, and cellular senescence, contributing to the aging phenotype and age-related diseases².

4. Loss of Proteostasis

Proteostasis refers to the cellular mechanisms responsible for maintaining protein homeostasis. With aging, there is a decline in the ability of cells to properly fold and degrade proteins. This can lead to the accumulation of misfolded proteins, which are associated with the onset of neurodegenerative diseases.

Protein quality control systems, including chaperones and proteases, help maintain the proper folding and degradation of proteins. However, with age, these systems become less efficient, leading to the accumulation of misfolded or aggregated proteins.

The accumulation of misfolded proteins can disrupt cellular function and promote the formation of toxic protein aggregates, contributing to age-related neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease.

5. Deregulated Nutrient Sensing

The body’s ability to sense and respond to changes in nutrient availability is crucial for maintaining metabolic homeostasis. During aging, there is a dysregulation in nutrient-sensing pathways, such as insulin and mTOR signaling. These alterations can contribute to metabolic dysfunction and age-related diseases, including diabetes.

Nutrient sensing pathways are vital in coordinating cellular responses to nutrient availability. Insulin signaling, for example, regulates glucose uptake and metabolism, while mTOR signaling controls protein synthesis and cell growth.

With aging, these nutrient-sensing pathways become dysregulated, leading to impaired glucose metabolism, increased insulin resistance, and altered protein synthesis. These changes can contribute to metabolic disorders and age-related diseases, such as type 2 diabetes and cardiovascular diseases.

6. Mitochondrial Dysfunction

Mitochondria are the powerhouses of our cells, responsible for producing energy in the form of adenosine triphosphate (ATP). With aging, mitochondrial function declines, leading to decreased energy production and increased production of reactive oxygen species (ROS). This mitochondrial dysfunction can contribute to cellular damage and aging-associated diseases.

Mitochondrial dysfunction can occur due to various factors, including oxidative stress, mitochondrial DNA mutations, and impaired mitochondrial biogenesis. These factors can disrupt the electron transport chain and impair ATP production.

Furthermore, dysfunctional mitochondria produce higher levels of ROS, which can damage cellular components, including DNA, proteins, and lipids. This oxidative damage can contribute to cellular senescence and the development of age-related diseases, such as cardiovascular disease and neurodegenerative disorders.

7. Cellular Senescence

Cellular senescence is a state in which cells lose their ability to divide and function properly. Senescent cells accumulate with age and secrete pro-inflammatory molecules, a phenomenon known as the senescence-associated secretory phenotype (SASP). The accumulation of senescent cells and the associated inflammation contribute to tissue dysfunction and age-related pathologies.

Various factors, including DNA damage, telomere attrition, and oncogene activation can trigger cellular senescence. Once senescence is induced, cells enter a state of irreversible growth arrest. Senescent cells secrete a variety of pro-inflammatory molecules, such as cytokines, chemokines, and growth factors. This SASP can promote chronic inflammation, disrupt tissue homeostasis, and contribute to the development of age-related diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.

8. Stem Cell Exhaustion

Stem cells are responsible for tissue regeneration and repair. However, with aging, the regenerative capacity of stem cells declines. This is due to a combination of factors, including changes in their microenvironment and the accumulation of DNA damage. Stem cell exhaustion can impair tissue repair and increase the risk of age-related diseases.

Stem cells reside in specialized niches within tissues and can differentiate into various cell types. They play a crucial role in tissue homeostasis and repair by replenishing damaged or lost cells. With aging, the stem cell niche changes, leading to a decline in stem cell function. Additionally, stem cells can accumulate DNA damage over time, impairing their regenerative potential.

These changes result in reduced tissue repair and regeneration, contributing to age-related diseases, such as impaired wound healing, muscle loss, and degenerative conditions.

9. Altered Intercellular Communication

Effective communication between cells is essential for maintaining tissue homeostasis. During aging, there is a disruption in intercellular communication, leading to chronic inflammation and the impaired functioning of tissues. This altered communication can contribute to the development of age-related diseases, such as Alzheimer’s disease.

Cells communicate with each other through various signaling pathways, including direct cell-to-cell contact and the release of signaling molecules, such as cytokines and growth factors.

With aging, there is a dysregulation in intercellular communication, leading to chronic low-grade inflammation, often referred to as inflammation. This chronic inflammation can contribute to tissue dysfunction and the development of age-related diseases, including neurodegenerative disorders like Alzheimer’s disease.

Understanding and targeting the mechanisms underlying altered intercellular communication may offer potential therapeutic strategies for mitigating age-related pathologies.

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The Impact of Aging on the Human Body

Aging and the Cardiovascular System

Aging is associated with structural and functional changes in the cardiovascular system. As you age, blood vessels become stiffer and less elastic, increasing the risk of hypertension and cardiovascular disease. Additionally, the heart muscle changes, leading to decreased cardiac output and increased susceptibility to heart failure.

Aging and the Nervous System

The aging process affects the nervous system, leading to various cognitive and motor changes. Age-related neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, are characterized by the accumulation of protein aggregates and the degeneration of specific neuronal populations. These diseases can significantly impact an individual’s quality of life.

Aging and the Musculoskeletal System

With aging, there is a gradual loss of muscle mass and strength, a condition known as sarcopenia. This loss of muscle mass can affect mobility and increase the risk of falls and fractures. Additionally, aging is associated with changes in bone density, leading to an increased risk of osteoporosis.

Aging and the Digestive System

The digestive system undergoes age-related changes that can impact nutrient absorption and gastrointestinal motility. Aging can lead to a decrease in the production of digestive enzymes, making it more challenging to digest certain foods. These changes can contribute to gastrointestinal disorders, including constipation and malnutrition.

Conclusion

The nine fundamental hallmarks of aging provide valuable insights into the biological processes underlying aging. Understanding these hallmarks can help researchers develop strategies to promote healthy aging and mitigate the negative effects of aging. By adopting a holistic approach that addresses both genetic and environmental factors, you can strive to age gracefully and maintain your health and well-being as you grow older. Extend your health span by increasing your NAD+ levels with Vitality ↑® NAD+ Booster by Jinfiniti.

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Lastly, if you’re interested in going deeper into health-related content, here are a few of our recent posts that you may want to read:

Referenced Sources:

Understanding the Varied Symptoms of DNA Damage: A Comprehensive Guide

Written by Jinfiniti Science on March 17, 2024. Posted in Oxidative Stress, DNA Damage.

DNA damage might not always be visible, but it can have a significant impact on your overall health.

From the subtle signs to more noticeable symptoms, understanding DNA damage is key to taking proactive steps toward better health.

In this article, you’ll learn about…

The fundamental concepts of DNA damage and why it matters for your health.

The various forms of DNA damage and their surprising effects on your body.

How to detect the telltale signs and symptoms that might reveal DNA damage.

The science behind your body’s natural repair processes and how they keep your cells in top shape.

An image of a DNA, showing its double-helix pattern

“Biology is the most powerful technology ever created. DNA is software, protein are hardware, cells are factories.“

Arvind Gupta, Inventor (Health/Medical Technology) and Author

What is DNA Damage?

DNA damage refers to any alteration or modification to the structure of DNA molecules within cells. It can occur due to various factors, such as exposure to harmful chemicals, radiation, or errors during DNA replication. When DNA is damaged, it can impact the functioning and stability of cells, potentially leading to health issues.

The Role of DNA in the Body

DNA, which stands for deoxyribonucleic acid, is a molecule that carries the genetic information of living organisms. It acts as a blueprint for the development, growth, and maintenance of cells and tissues. DNA is composed of nucleotides and is organized into chromosomes within the nucleus of cells.

Every living organism, from the tiniest microbe to the largest mammal, relies on the integrity of its DNA for survival and proper functioning.

The intricate structure of DNA allows it to store and transmit genetic information from one generation to the next, ensuring the continuity of life.

However, damage to DNA can disrupt the accurate transmission of this genetic information, leading to various symptoms and health complications. Understanding the role of DNA in the body helps you grasp the significance of protecting it from such damage.

Common Causes of DNA Damage

Numerous factors can lead to DNA damage, including:

Exposure to harmful chemicals such as tobacco smoke, pesticides, and industrial pollutants.
Ionizing radiation from sources like X-rays, gamma rays, and radioactive materials.
Ultraviolet (UV) radiation from the sun or tanning beds.
Genetic predisposition to DNA repair deficiencies.
Errors during DNA replication or failure of DNA repair mechanisms.

These causes of DNA damage can profoundly affect individuals’ health and well-being.

For example, exposure to harmful chemicals can introduce mutations in DNA, leading to the development of cancer. Similarly, UV radiation from the sun can cause DNA damage in skin cells, increasing the risk of skin cancer.

It is important to note that the human body has evolved intricate mechanisms to repair DNA damage. However, these repair mechanisms are not foolproof and can sometimes fail, allowing damaged DNA to persist and potentially cause harm.

Understanding these common causes of DNA damage is crucial in taking preventive measures and minimizing the risk.

By being aware of the factors that can harm your DNA, you can make informed choices to protect yourself and promote a healthier future.

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Different Types of DNA Damage

Single-Strand Breaks

A single-strand break occurs when one of the two strands of DNA is disrupted. This type of damage can result from exposure to radiation, oxidative stress, or chemical agents. Single-strand breaks can be repaired by specific DNA repair mechanisms, ensuring the integrity of the DNA sequence.

When DNA is exposed to ionizing radiation, such as X-rays or gamma rays, it can cause ionization of the atoms within the DNA molecule. This ionization can lead to the formation of free radicals, highly reactive molecules that can damage DNA. These free radicals can break the sugar-phosphate backbone of one strand of the DNA double helix, resulting in a single-strand break.

Oxidative stress, which occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to detoxify them, can also cause single-strand breaks. ROS, such as hydrogen peroxide and superoxide radicals, can react with the DNA molecule and cause damage, including the formation of single-strand breaks.

Chemical agents, such as certain chemotherapy drugs or environmental pollutants, can also induce single-strand breaks in DNA. These agents can directly damage the DNA molecule or interfere with the DNA replication process, leading to the formation of single-strand breaks.

Fortunately, cells have specific DNA repair mechanisms¹ to deal with single-strand breaks. One of the most common repair pathways is the base excision repair (BER) pathway. In BER, specialized enzymes recognize and remove the damaged DNA base, creating a gap in the DNA strand. This gap is then filled with the correct nucleotide sequence by other enzymes, restoring the integrity of the DNA.

Double-Strand Breaks

Double-strand breaks are considered more severe than single-strand breaks as they affect both strands of DNA. This type of damage can occur due to exposure to ionizing radiation, certain chemicals, or errors during DNA replication. Double-strand breaks require intricate repair processes to maintain the stability of the genome.

Ionizing radiation, such as high-energy X-rays or radioactive particles, can directly cause double-strand breaks by breaking both strands of the DNA double helix. These breaks can be induced by the ionization of atoms within the DNA molecule or by the formation of free radicals, similar to single-strand breaks.

Certain chemicals, such as some chemotherapy drugs or environmental toxins, can also cause double-strand breaks. These chemicals can directly damage the DNA molecule or interfere with the DNA replication process, leading to the formation of double-strand breaks.

Errors during DNA replication can also result in the formation of double-strand breaks. DNA replication is a highly complex process, and sometimes mistakes can occur. If these mistakes are not corrected, they can lead to the formation of double-strand breaks.

Repairing double-strand breaks is crucial for maintaining the stability of the genome. One of the main repair pathways for double-strand breaks is called homologous recombination (HR). In HR, the intact DNA strand from the sister chromatid or homologous chromosome is used as a template to repair the broken DNA strands. This process requires a series of enzymatic steps and is tightly regulated to ensure accurate repair.

DNA Crosslinks

DNA crosslinks refer to the formation of covalent bonds between DNA strands or DNA molecules and other cellular components. They can be induced by exposure to chemicals or reactive oxygen species. DNA crosslinks can hinder DNA replication and transcription, leading to cellular dysfunction.

Chemicals, such as certain anticancer drugs or environmental toxins, can form covalent bonds with DNA, resulting in DNA crosslinks. These crosslinks can physically block the progression of DNA replication or transcription machinery, preventing the accurate duplication or expression of genetic information.

Reactive oxygen species, such as hydroxyl radicals, can also induce DNA crosslinks. These reactive molecules can react with the DNA molecule and form covalent bonds between DNA strands or between DNA and other cellular components, impairing normal DNA functions.

Cells have evolved various mechanisms to repair DNA crosslinks. One of the repair pathways is the nucleotide excision repair (NER) pathway. In NER, specialized enzymes recognize and remove the DNA crosslinks, creating a gap in the DNA strand. This gap is then filled with the correct nucleotide sequence by other enzymes, restoring the integrity of the DNA.

Recognizing the Symptoms of DNA Damage

Physical Symptoms

Physical symptoms of DNA damage can manifest in different ways, depending on the affected cells and tissues. Some common physical symptoms include:

Skin abnormalities² include premature aging, sun sensitivity, and increased risk of skin cancer due to UV-induced damage.
Neurological symptoms like cognitive decline, memory loss, and increased susceptibility to neurodegenerative diseases.
Recurrent infections and impaired immune function due to DNA damage in immune cells.

If you experience any of these physical symptoms, it is important to consult a healthcare professional for further evaluation and guidance.

Cellular Symptoms

At the cellular level, DNA damage can lead to dysfunctional cell processes and impairments in cellular functions. This can result in various cellular symptoms, including:

Cell cycle abnormalities, such as uncontrolled cell growth and proliferation.
Increased levels of DNA mutations increase the risk of cancer development.
Activation of cellular stress responses and DNA repair pathways to maintain cellular homeostasis.
Potential cell death if the damage exceeds the repair capacity, leading to tissue dysfunction.

These cellular symptoms highlight the importance of maintaining DNA integrity to ensure proper cellular function and overall health.

Long-Term Health Implications

DNA damage can have significant long-term health implications. If left unaddressed, it can contribute to the development of various diseases, including:

Cancer: Unrepaired or mis-repaired DNA damage can lead to the accumulation of mutations, which can trigger the uncontrolled growth of cells, ultimately resulting in cancer.
Aging-related diseases: DNA damage is one of the major causes of aging and age-related diseases, such as neurodegenerative disorders and cardiovascular diseases.
Reproductive disorders: DNA damage in germ cells can result in infertility, genetic disorders in offspring, and pregnancy complications.

Understanding the long-term health implications of DNA damage can emphasize the importance of preventive measures and early detection for better health outcomes.

The Science Behind DNA Repair Mechanisms

The Importance of DNA Repair

DNA repair mechanisms play a crucial role in maintaining the integrity of the genome. They are responsible for detecting and correcting DNA damage to prevent the accumulation of mutations and maintain the stability of genetic information.

Proper functioning of DNA repair mechanisms is essential for cellular health and overall well-being.

Natural DNA Repair Processes

There are several natural DNA repair processes that cells utilize to repair damaged DNA. These include:

Base excision repair (BER): This repair mechanism targets DNA damage caused by oxidative stress or chemical modifications. It removes the damaged base and replaces it with a correct one.
Nucleotide excision repair (NER): NER repairs bulky DNA lesions induced by environmental agents such as UV radiation or certain chemicals. It removes the damaged portion of DNA and synthesizes a new, intact strand.
Mismatch repair (MMR): MMR corrects errors that occur during DNA replication, ensuring the accuracy of the genetic code.
Double-strand break repair (DSBR): DSBR mechanisms, including non-homologous end joining (NHEJ) and homologous recombination (HR), repair double-strand breaks by joining the broken ends or using a homologous template.

These natural DNA repair processes work together to address various types of DNA damage, ensuring genomic stability and minimizing the potential detrimental effects.

Limitations and Failures of DNA Repair

While DNA repair mechanisms are highly efficient, they are not infallible. Factors such as the extent and complexity of DNA damage, genetic variations, and aging can affect the efficiency and effectiveness of DNA repair processes.

In some cases, the repair mechanisms may fail, leading to the accumulation of DNA damage and potential health consequences. Understanding these limitations and failures is important to develop strategies for enhancing DNA repair capacity and minimizing the risk of disease development.

Conclusion

In conclusion, understanding the varied symptoms of DNA damage is crucial for assessing its impact on your health.

By grasping the basics of DNA damage, recognizing its varied symptoms, and comprehending the underlying science of DNA repair mechanisms, you can take proactive steps to mitigate risks and promote overall well-being.

Through ongoing research and advancements in the field, scientists can continue to deepen an understanding of DNA damage, repair mechanisms, and their implications for therapeutic interventions and disease prevention.

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