Author: Jinfiniti Science

5 Daily Practices to Support Mitochondrial Health

Written by Jinfiniti Science on April 28, 2025. Posted in Mitochondrial Dysfunction. No Comments on 5 Daily Practices to Support Mitochondrial Health

Ever feel like your body’s batteries need recharging? That’s essentially what your mitochondria do all day long.

These tiny cellular power plants transform what you eat and breathe into the energy that keeps you moving, thinking, and thriving.

When they work well, you feel energized and clear headed. When they struggle, so do you.

Luckily, science has uncovered daily practices that can supercharge these microscopic energy factories.

Read on to discover how simple lifestyle adjustments can support mitochondrial function and revitalize your cellular batteries.

Key Takeaways

Mitochondria generate 90% of your body’s energy and play crucial roles in cell repair and immune function
Exercise stimulates the creation of new mitochondria, improving energy production capacity
Quality sleep and stress management are essential for mitochondrial maintenance and repair
Intermittent fasting activates pathways that enhance mitochondrial performance and cleanup
A diet rich in antioxidants and healthy fats protects mitochondria from damage and supports function

Why is Mitochondrial Function Important?

What exactly runs the show deep inside your cells? Meet the mitochondria. They are essential for your health at the most basic level.

Most known for energy production, they generate about 90% of the ATP your body needs.¹ This is the fundamental fuel for life’s processes.

However, their influence stretches much further. Mitochondria are critical multitaskers:

Powering You: Creating cellular energy (ATP)

Cellular Maintenance: Playing a key role in cellular repair signals²

Immune Guardians: Helping regulate immune responses³

Calming Inflammation: Assisting in controlling inflammation⁴

Over time, their performance can naturally decline. This slowdown contributes directly to common signs of aging like fatigue and reduced mental clarity.

Strengthening mitochondrial function offers real benefits. Research shows it can combat age related decline.⁵ It boosts energy and overall physical resilience.

Ultimately, supporting mitochondria means supporting your body’s core ability to function well and repair itself. It’s a cornerstone of lasting wellness and longevity.

Common Signs of Mitochondrial Dysfunction

Feeling constantly tired? Having trouble thinking clearly? Your mitochondria might be trying to tell you something.

When these cellular powerhouses aren’t working well, your body feels it. Most people don’t realize their mitochondria are struggling until several symptoms start adding up.

Watch for these warning signs:

Feeling exhausted even after a full night’s sleep

Struggling to focus or remember things

Muscles that feel weak or take forever to recover

Getting winded easily during exercise

Feeling older than your actual age

If this sounds like you, don’t worry. Supporting your mitochondrial health can boost your energy, mental clarity, and overall vitality. Your body has an amazing ability to bounce back when you give it what it needs at the cellular level.

5 Practices to Boost Your Mitochondrial Health

Give your cellular powerhouses the support they need with these simple but effective daily habits that enhance energy production at the most fundamental level.

1. Optimize Your Diet for Mitochondrial Support

Want to give your mitochondria a boost? Start with what’s on your plate!

Your mitochondria thrive when you feed them the right nutrients:

Load up on antioxidants from berries, leafy greens, and even dark chocolate. These natural defenders protect your mitochondria from the damaging byproducts of energy production.⁶

Embrace healthy fats like omega-3s found in salmon, walnuts, and flaxseeds. They keep mitochondrial membranes flexible and functioning well.

Choose quality proteins from eggs, lean meats, and legumes to provide the building blocks your body needs for mitochondrial repair.

Don’t forget micronutrients that power energy production: B vitamins from greens and nuts, magnesium from seeds and whole grains, and CoQ10 from fatty fish.⁷ ⁸

Simple food swaps like adding spinach to your morning smoothie or snacking on blueberries can energize your cells from the inside out!

Bonus Read: While food should be your foundation, our guide to the best evidence-based mitochondrial health supplements options explores additional ways to nourish your cellular energy systems when diet alone may not be enough.

2. Exercise for Mitochondrial Biogenesis

Regular exercise triggers your body to make new mitochondria and upgrade existing ones. Here’s how to get the most benefit:

Go long with cardio. Activities like brisk walking, cycling, or swimming for 30 minutes daily can increase your muscle cells’ mitochondrial volume by up to 40%!⁹ This means more energy production with less effort.

Try HIIT for efficiency. Short bursts of intense activity (30 seconds all-out, 90 seconds recovery) are particularly effective at boosting mitochondrial function.¹⁰ Just 2-3 sessions weekly can deliver impressive results in minimal time.

Don’t skip strength training. Resistance exercises improve how your mitochondria process proteins and respond to insulin, both crucial for cellular energy.¹¹

Remember to recover properly with good hydration, quality sleep, and even foam rolling, which surprisingly may help support mitochondrial formation by improving circulation.

Your mitochondria respond quickly to movement, making exercise one of the most powerful tools for cellular health.

Precision Testing for Mitochondrial Function

At Jinfiniti, our AgingSOS® panels provide precise measurements of your mitochondrial function through multiple biomarkers. This data reveals exactly where your energy production systems need support – information impossible to get from symptoms alone.

Athletes using AgingSOS® testing have identified specific biomarkers limiting their performance. Others have discovered hidden inflammation sabotaging their mitochondria despite perfect nutrition and training.

Take the first step toward optimal cellular energy. Test your mitochondrial function with AgingSOS® and build your health optimization plan on measurable data, not assumptions.

3. Prioritize Sleep and Stress Management

Your mitochondria can’t perform at their best when you’re exhausted and stressed out. Here’s why rest and recovery matter so much.

When you sleep deeply, your body runs essential maintenance, clearing out damaged mitochondria and building fresh ones. But missing those precious hours means this cleanup crew never shows up for work.

Meanwhile, stress hormones flooding your system create a toxic environment where mitochondria struggle to function.

These simple daily habits can improve your mitochondrial health:

For better sleep: Create a cool (65-68°F), dark bedroom sanctuary without electronic devices. Stick to consistent sleep times and give yourself a screen-free wind-down period before bed.

For stress relief: Even brief practices make a difference. Try the 4-7-8 breathing technique (inhale 4, hold 7, exhale 8) to quickly shift your nervous system into recovery mode.

For recovery: Surprisingly, massage has been scientifically shown to stimulate new mitochondrial growth by activating specific cellular pathways.¹² Other relaxing activities like stretching or warm baths support mitochondrial health too.

Remember: your energy at the cellular level depends on how well you balance activity with recovery. Just 5-10 minutes of daily relaxation can create significant benefits over time.

4. Practice Intermittent Fasting

Giving your digestive system a break can supercharge your cellular energy factories! Intermittent fasting creates powerful shifts in your metabolism that help your mitochondria work better.

What happens when you fast:

Your body activates cellular pathways that boost mitochondrial performance.¹³ Fasting increases important proteins called sirtuins that regulate cellular health and raises levels of NAD+, a crucial molecule your mitochondria need for energy production.¹⁴ Your body also starts producing ketones, a clean alternative fuel that your mitochondria love.

Even more importantly, fasting triggers “mitophagy,” your body’s way of removing damaged mitochondria and replacing them with healthy new ones.¹⁵ Think of it as regular maintenance that keeps your cellular power plants running efficiently.

As a bonus, studies show fasting helps reduce inflammation and oxidative stress that can damage mitochondrial membranes.¹⁶

Easy ways to start:

Try a simple 12-hour overnight fast (finish dinner by 7 PM, eat breakfast at 7 AM)

Once comfortable, explore the 16/8 method (16 hours fasting, 8 hours eating)

For a different approach, consider the 5:2 method (eat normally five days, reduce calories to 500-600 on two non-consecutive days)

Start with shorter fasting periods and gradually extend them as your body adapts. Monitor how you feel to find what works best for your unique system. The goal is to support your cellular energy, not create additional stress!

5. Minimize Toxic Exposure

Your mitochondria are sensitive to toxins that can damage them and reduce their efficiency.¹⁷

Here’s how to create a cleaner environment for optimal cellular energy:

Avoid hidden toxins:

Check household cleaners, cosmetics, and food containers for harmful chemicals

Replace products containing parabens, phthalates, and BPA with natural alternatives

Choose BPA-free containers and toxin-free personal care items

Support natural detoxification:

Stay well-hydrated to help flush toxins from your system

Eat plenty of fiber to remove waste through your digestive tract

Include detox-supporting foods like leafy greens, berries, and cruciferous vegetables

Nurture your gut microbiome:

Feed beneficial bacteria with prebiotics found in garlic and onions

Add fermented foods like yogurt and kefir for probiotics

Remember: a healthy gut supports healthy mitochondria!

Your cellular power plants work best in a clean environment. Simple changes make a big difference!

Your Mitochondrial Support Plan: Putting It All Together

Matured couple planning for their mitochondrial support

Improving mitochondrial function isn’t about quick fixes, it’s about creating healthy habits that work together. Here’s how to build your own mitochondrial health plan:

Start small and build gradually:

Choose just one practice to begin with

Add a handful of antioxidant-rich foods to your meals

Try a 20-minute daily walk or commit to consistent sleep times

Begin with a manageable 12-hour overnight fast

Watch for signs of improvement:

Increased energy and mental clarity

Better exercise performance and recovery

Improved mood and skin health

Reduced inflammation and fatigue

Remember these key principles:

Each practice enhances the others—they work better together

Consistency matters more than perfection

Small daily habits create powerful cellular changes over time

For deeper insights into your progress, consider the AgingSOS Advanced Longevity Panel from Jinfiniti, which measures key biomarkers of cellular health and aging. This test provides actionable information to help you fine-tune your mitochondrial support plan.

Your mitochondria respond quickly to positive changes! By implementing these five practices, you’re supporting the fundamental energy systems that power every cell in your body.

Referenced Sources:

Secrets to Longevity: 50 Easy Habits for a Longer Life

Written by Jinfiniti Science on April 28, 2025. Posted in Longevity, Health Conditions.

The quest to maintain a healthy lifestyle and live a long life is something we all share.

While genetics influences lifespan, research shows our daily habits matter even more for longevity.

Studies reveal only about 25% of aging comes from our genes.¹ This gives you real power to shape your health path and potentially add decades of active living.

If you want to live to be 100, adopting some of these habits can be an important step toward excellent health and well-being.

The Power of Simple Habits for Healthy Aging

Studies show that when healthy habits are combined, they can dramatically increase your life expectancy.

A 30-year Harvard study discovered that people who maintained five key habits lived significantly longer²:

Eating a healthy diet
Exercising regularly
Maintaining a healthy weight
Drinking alcohol in moderation
Not smoking

These habits added an impressive 14 extra years of life for women and 12 for men.

Even more impressive, a study of U.S. veterans found that adopting eight healthy habits by middle age was linked to living 21 to 24 years longer compared to those who adopted none.³

You don’t need to completely overhaul your lifestyle all at once. Small, consistent changes can yield big health benefits over time.

Centenarians who live past 100 years often have many simple yet impactful lifestyle habits that contribute to healthy aging and longevity.

The more healthy habits you adopt, the greater your potential for a longer, healthier life.

50 Easy Habits That Promote Longevity

Here are 50 evidence-based habits that require minimal effort yet may help you live longer.

Movement & Physical Activity

Take the stairs instead of elevators or escalators when possible.
Park farther away from your destination to add extra steps to your day.
Stand up during phone calls to break up prolonged sitting periods.
Go for a 10-minute brisk walk daily to boost heart health and mood.
Do calf raises during downtime while waiting for water to boil or during TV commercials.
Stretch for 5 minutes after waking to improve flexibility and blood flow.
Take short, active breaks by standing and moving every hour if sitting for long periods.
Try simple balance exercises like standing on one leg while brushing teeth.
Set a daily step goal using a pedometer or smartphone app, starting with 5,000 steps.
Try a fun, active hobby like dancing, gardening, or swimming that you genuinely enjoy.
Add simple bodyweight exercises like squats, lunges, or wall push-ups twice weekly.

Nutrition & Eating Habits

Assorted fruits and vegetables on green surface

Drink a glass of water upon waking to replenish fluids and support vital organs.
Add one extra fruit or vegetable serving daily to boost essential nutrients.
Swap one sugary drink for water to reduce empty calories and sugar intake.
Eat a small handful of nuts several times weekly for heart health benefits.
Choose whole grains instead of refined options when possible.
Eat until 80% full, paying attention to hunger and satiety cues.
Add herbs and spices instead of salt to flavor food while reducing sodium intake.
Opt for fish or beans once a week to replace red or processed meat.
Use olive oil for cooking or salad dressings instead of less healthy fats.
Eat meals mindfully without distractions like TV or phones.
Avoid large meals before bed to prevent digestive discomfort that interferes with sleep.
Stay hydrated throughout the day by sipping water consistently between meals.

Sleep Quality

Woman sleeping in a bed of white flowers

Go to bed 15 minutes earlier to increase total sleep time toward the recommended 7-9 hours.
Avoid screens an hour before bed to prevent suppression of sleep hormone melatonin.
Keep a consistent wake-up time, even on weekends, to reinforce natural sleep-wake cycles.
Keep the bedroom cool, dark, and quiet for optimal sleep conditions.
Avoid caffeine after 2 p.m. to prevent interference with falling asleep.
Create a relaxing pre-sleep ritual like taking a warm bath, light stretching, or reading.
Get morning sunlight shortly after waking to regulate your internal body clock.

Stress Management & Mental Well-Being

Woman practicing mindfulness meditation in the forest

Practice 5 minutes of deep breathing when feeling stressed.
Do 5 minutes of mindfulness daily, focusing on the present moment without judgment.
Practice gratitude daily by identifying something you’re thankful for.
Listen to calming music when needing to unwind.
Learn to say “no” sometimes to prevent overwhelm and manage stress.
Engage in a hobby regularly for stress relief and fulfillment.

Social Connection & Cognitive Health

Friends cheersing their water cups at a social picnic

Call or message a friend/family member daily to maintain social ties.
Read for 15 minutes daily to engage your brain and potentially slow cognitive decline.
Do a crossword or sudoku puzzle a few times weekly to challenge your brain.
Schedule a weekly social meetup in person or virtually.
Learn one new thing each week to promote lifelong learning and mental stimulation.
Volunteer occasionally for a cause you care about.
Take a different route when walking or commuting to introduce novelty.
Engage in thought-provoking conversation to exercise cognitive functions.

Preventative Health Habits

Moderate alcohol intake or consider abstaining for optimal health.
Practice good hand hygiene to reduce infection risk.
Protect skin from the sun with sunscreen, protective clothing, or seeking shade.
Maintain a healthy weight within the recommended BMI range of 18.5-24.9 kg/m².
Get regular checkups as recommended by healthcare providers.
If smoking, seek help to quit – this provides substantial health benefits at any age.

These habits collectively help you add years to your life and reduce risk of premature death, especially important for older adults who want to stay independent and maintain a healthy life.

The Science of Interconnected Habits

A game board with interconnected multi-colored pieces

Healthy habits don’t exist in isolation. They build on each other to improve your overall health.

How Habits Support Each Other

Regular physical activity does more than strengthen your heart. It improves sleep quality, reduces stress, and sharpens thinking. Quality sleep, in turn, helps regulate stress hormones, manage appetite, and maintain mental clarity.

Beyond Physical Health

This network extends to your mental and social wellbeing. Strong relationships, effective stress management, and a sense of purpose significantly impact your physical health by regulating inflammation, balancing hormones, and supporting brain health. These are all keys to longevity.

The Compound Effect

When you combine these habits, they work better as a team than they do alone. Remember that Harvard study? It confirmed this combined approach could potentially add ten healthy years to your life.

The Power of Consistency

Longevity isn’t achieved through occasional big efforts but through small, consistent daily choices that help prevent serious conditions like heart disease, diabetes, cancer, and dementia.

Starting Your Longevity Journey with Jinfiniti

The secrets of longevity aren’t really secrets at all – they’re accessible, evidence-based habits that anyone can add to their daily routine.

Start small with just one or two habits you like. Once they become part of your routine, slowly add more. Your future self will thank you for adding not just more years to your life, but more life to your years.

While these daily habits build a good foundation for living longer, understanding your body’s unique needs can help you get even better results.

After building these healthy habits, consider these science-backed approaches from Jinfiniti:

Test your cellular NAD+ levels with our Intracellular NAD Test to see where you stand and track your progress.
Check your aging markers with our AgingSOS Longevity Panel to find issues that regular blood tests miss.
Boost your cellular energy with Vitality↑ NAD+ Booster, our supplement designed to restore NAD+ levels that decline with age.
Clear out harmful old cells with our senolytic supplement complex SenoAid, which targets “zombie cells” that build up as you age and cause inflammation.

At Jinfiniti Precision Medicine, we’re dedicated to optimizing health, performance, and longevity through advanced biomarker testing and targeted supplementation. Our TAO (Test, Act, Optimize) approach helps individuals extend their years of healthy, vibrant living by addressing the cellular foundations of aging and wellness.

Referenced Sources

A woman with stylish short blonde-gray hair is smiling broadly while looking to the side on a plain background

NAD+ Supplements: Forms, Benefits, Side Effects and Safety

Written by Jinfiniti Science on April 25, 2025. Posted in NAD+, NAD, NAD+ Precursors, Supplements.

In 1513, Ponce de León sought the Fountain of Youth. In the 1920s, it was radium-infused water. The 1970s brought megadose vitamins. Now, NAD+ has become the latest anti-aging trend.

NAD+ levels decline with age, prompting claims that supplements can reverse aging.

Unlike past trends, NAD+ has real biological importance in metabolism and cellular function. But the jump from laboratory studies to costly supplements deserves healthy skepticism.

This article examines what we know, what remains unproven, and whether these increasingly popular NAD+ supplements are worth the price and promises.

Key Takeaways

NAD+ is a critical molecule for cellular health and energy production that naturally declines up to 50% by middle age
Human studies confirm NMN and NR supplements effectively raise NAD+ levels with minimal side effects
Research shows benefits for muscle strength, brain function, metabolism, and cardiovascular health in aging adults
Quality matters: choose supplements with third-party testing, proper certifications, and transparent manufacturing
Testing NAD+ levels before and after supplementation provides the most personalized approach

NAD+ and Its Role in the Body

Nicotinamide adenine dinucleotide (NAD+) is a key molecule in your body that supports over 500 enzyme reactions.

NAD+ is essential for:

Creating cellular energy
Repairing DNA
Signaling between hormones
Managing inflammation

Your cells are like busy kitchens with ingredients moving everywhere. NAD+ is the head chef who decides which ingredients go into which dishes, when to turn up the heat, and how to transform raw materials into energy your body can use.

The molecule also plays other important roles in your body:

Powers sirtuins (known as “longevity genes”) that affect how you age
Keeps your internal body clock ticking on time
Supports your mitochondria, the powerhouses of your cells¹

Aging and Decline of NAD+

What makes NAD+ so interesting is how our body’s relationship with this molecule changes as we age.

Mouse studies show NAD+ levels fall by about half in middle age.¹ In humans, NAD levels vary based on age, sex, lifestyle, and health status.²

When NAD+ becomes limited, it impacts cells in critical ways:

Mitochondrial function declines, reducing energy production
DNA repair mechanisms weaken
Cells become less resilient and metabolically efficient

These changes can contribute to many signs of aging like lower cognitive function, metabolic disorders and inflammation.³

This has lead researchers to study NAD+ precursors as potential supplements to safely increase NAD in older adults.

Since NAD+ patterns vary among individuals, the most effective approaches may need to be personalized.

Tissue-Specific NAD+ Decline

Rodent Studies

Human Studies

Skeletal Muscle

15-65% Decline

Consistent decrease with age in rodents, particularly in the gastrocnemius muscle.

Liver Tissue

10-50% Decline

Variable patterns with age. Most studies report decline in aged rodents with some exceptions.

Cardiac Tissue

0-65% Decline

Highly variable pattern. Study differences likely reflect species, strains, and methodological approaches.

Brain Regions

Variable by Region

Declines earlier than other tissues. Different brain regions show distinct patterns.

Skin Tissue

≥50% Decline

Substantial reductions with age. Strong negative correlations between NAD+ levels and age in both genders.

Brain & Cerebrospinal Fluid

10-25% Decline

Approximately 14% decrease in subjects older than 45 years compared to younger subjects.

Blood NAD+ Levels

Decline before age 50

More pronounced decline in men than women, especially in middle age (40-49 years).

Types of NAD+ Supplements

NAD+ supplements come in several forms, each containing specific compounds that serve as building blocks for NAD+ production in the body.

NAD+ Precursors

Nicotinamide Riboside (NR): This advanced vitamin B3 form directly converts to NAD+. Research shows that daily supplementation can increase NAD+ by up to 2.7 times.⁴
Nicotinamide Mononucleotide (NMN): Another direct precursor shown to boost NAD+ levels in human studies.⁴
Niacin and Nicotinamide: Traditional vitamin B3 forms that help make NAD+, but may have different side effects than newer options.
Trigonelline: A natural alkaloid related to niacin that can increase NAD+ levels in the body.⁵
NADH: A direct form of the coenzyme that can be supplemented orally, though absorption efficiency is still being studied.

Supplement Forms

Oral Supplements: Simple capsules, tablets, or powders you swallow. The most common and easy-to-use option for daily use.
Sublingual Products: These dissolve under your tongue for potentially faster results.
Liposomal Delivery: These liquids use tiny fat bubbles to help your body absorb NAD+, but remain unproven.
IV Therapy: Delivers NAD+ directly to your bloodstream, though research shows the large molecules have trouble getting into your cells.⁶
Alternative Methods: Includes skin creams, patches, and nasal sprays.

Supplement Safety Note

Supplements receive minimal FDA regulation and may not be safe for everyone. They can interact with medications and other supplements. Always consult your doctor before starting any supplement regimen.

Potential Benefits of NAD+ Supplements

Here is what current human research suggests about the benefits of NAD supplements.

Benefit	How NAD+ Helps	Notes on Human Research
1. Raises NAD+ levels	Restores age-related NAD+ decline in blood and tissues	Proven in multiple clinical studies
2. Supports muscle strength	Improves grip strength, walking speed, muscle health	Shown in older adults
3. Protects brain and memory	May slow memory decline, supports cognition, reduces brain inflammation	Shown in people with mild memory loss
4. Improves metabolism and energy	Enhances sugar/fat use, supports energy production	Beneficial for aging and metabolism issues
5. Reduces inflammation	Lowers markers of chronic inflammation	Key in aging populations
6. Supports heart and blood vessels	Better heart function, lower blood pressure, healthy vessels	Backed by heart health studies
7. May improve fertility in older women	Helps egg cell quality in women >35	Early research; more studies needed

1. Boosts NAD+ Levels That Decline with Age

Both NMN and NR are effective at increasing NAD+ levels in the human body, helping to restore what is lost with aging.⁷

Increased NAD+ means your cells can produce more energy and work better, supporting overall wellness and vitality.

In multiple research studies, people who took NMN or NR had measurable increases in NAD+ in their blood, brains, and muscles.⁸

2. Supports Physical Strength and Muscle Function

NMN and NR supplementation may help keep your muscles stronger as you age.

In trials with older adults, taking NMN improved muscle strength and made walking easier, which is important for staying independent and active.⁹

NR also helps increase the energy capacity in muscle cells by supporting mitochondria, laying the foundation for better physical performance.¹⁰

3. Helps Maintain a Healthy Brain and May Support Memory

NAD+ is important for brain health, and raising NAD+ levels with NR and NMN can help support memory and mental sharpness.

Some research on NR showed it could reduce certain markers linked to Alzheimer’s disease in older adults, and there have been small improvements in activity and step counts in people with early memory loss.¹¹

NMN and NR may also decrease inflammation in the brain, helping protect your brain as you age.¹²

4. Improves Metabolism and Energy Levels

Studies indicate that NR and NMN supplements help the body handle sugar and fats better, supporting energy production and metabolic health.¹³

Older adults and people with metabolic challenges may find these supplements particularly helpful for weight management and avoiding metabolism-related complications.

5. Reduces Inflammation in the Body

Chronic inflammation can quietly damage your health over time and increase the risk for many diseases.

Both NMN and NR have demonstrated an ability to lower inflammation markers in the body, especially in older adults who tend to have higher baseline inflammation.¹⁴

Studies observed that taking NR can reduce levels of cytokines like IL-6, which are signs of inflammation in the body.¹⁵

6. Supports Heart and Blood Vessel Health

NAD+ supplements may help protect your heart and improve circulation.

NMN and NR have shown promise in boosting cardiovascular function, enhancing flexible blood vessels, and sometimes reducing blood pressure.¹⁶

By supporting the metabolism of heart cells and blood vessels, NMN and NR could help lower the risk of age-related heart concerns.

7. May Improve Fertility in Older Women

There is early evidence that NMN might improve egg health and reproduction potential in women over the age of 35, a group that typically experiences a drop in fertility linked to declining NAD+.

Supplementing with NMN can help boost oocyte (egg cell) quality, increasing the chances of a healthy pregnancy for women in this age group.¹⁷

Infographic showing 5 NAD+ supplement benefits

Safety and Side Effects of NAD+ Supplements

One of the most reassuring findings from many human studies is that NMN and NR supplements are safe for most people and well tolerated even at higher doses.¹⁸

Reported side effects are typically mild and rare, such as slight stomach upset or headache, and no serious events have been shown in clinical research up to doses of 2000 mg/day for NR and 900 mg/day for NMN.¹⁹

Common Side Effects

Feeling tired or weak at first
Digestive problems (nausea, constipation, diarrhea)
Short-term headaches
Feeling more irritable than usual
Possible sleep issues, muscle aches, or nervous system effects

Precautions

Watch for allergic reactions (rare but serious)
Avoid during pregnancy or while breastfeeding
Not studied enough for use in children
Use with caution if you have liver or kidney issues

Other Considerations

Antidepressants might decrease NAD+ effectiveness²⁰
Insulin users should monitor blood sugar closely
Other longevity supplements like curcumin, quercetin and CoQ10 might amplify NAD+ effects

How to Safely Take NAD Supplements

Optimal dosages for NAD+ precursors are still being studied. Here’s what we know from clinical trials:

Compound	Typical Effective Dosage Range
NMN	250-500mg daily
NR	300-1,000mg daily
Nicotinamide	500-1,500mg daily
Niacin	100-500mg daily*

*Higher doses of niacin require medical supervision.

Important Note: A healthcare professional should help determine the right amount and form of NAD supplement for you.

Choosing a Quality Supplement

When selecting NAD+ supplements, consumers should consider:

Independent testing: Look for products that have undergone third-party testing for purity and potency.
Manufacturing standards: GMP-certified and NSF-certified products may offer greater quality assurance.
Regulatory limitations: The FDA does not regulate supplements as strictly as prescription drugs, making quality variability a concern.

Our Research-Validated NAD+ Formulations

At Jinfiniti, we go beyond basic quality assurance by scientifically validating our formulations. Our Vitality ↑® NAD+ Booster Powder combines NMN with D-ribose, niacinamide, and creatine monohydrate in a formula that targets multiple pathways for NAD+ production.

This synergistic approach produces better results than single-ingredient supplements. Our Pure NMN Powder offers >99.5% purity for those who prefer a direct NAD precursor without additional ingredients.

What sets our products apart is their connection to our testing services. We back our supplements with our Intracellular NAD® Test, allowing you to verify your results with objective measurements. This creates accountability that few supplement makers offer.

Our formulations are developed by Dr. Jin-Xiong She, who brings decades of scientific expertise in cellular health and aging. We conduct our own research rather than simply following market trends, ensuring you receive products based on solid scientific principles.

Intracellular NAD Test promotional image

Takeaway on NAD+ Supplementation

Taking NAD+ supplements can be a convenient way to help your cells stay energized and support key aspects of health as you age.

These supplements offer benefits in boosting energy, muscle strength, brain and heart function, and may even support healthy aging and fertility.

Human studies consistently report safety and good tolerability, making NMN and NR promising options to help people age more healthfully.

However, everyone is different, so consult your healthcare provider before starting new supplements, especially if you have underlying health conditions or take regular medications.

Referenced Sources

DNA double helix structure with green stems forming the spiraling backbone, featuring pink and light purple roses and blood sample test tubes along the structure in a dramatic gradient pattern

Longevity Testing Guide: 15 Biomarkers for Healthy Aging

Written by Jinfiniti Science on April 25, 2025. Posted in At-Home Testing, Longevity.

Longevity testing shifts the focus from treating illness to proactively managing health as you age. These tests examine your body’s internal aging processes to help you improve your healthspan—the quality of your years, not just the quantity.

Analyzing biomarkers linked to aging pathways lets you detect early signs of metabolic dysfunction, oxidative stress, or cellular senescence. This knowledge empowers you to address potential issues before they become serious, putting you in control.

This guide details 15 essential biomarkers for healthy aging. Learn their roles, why they matter for longevity, and how your results can inform targeted lifestyle choices for lasting health.

Key Takeaways

Longevity tests measure biological markers that reveal your internal aging process, helping you tackle health issues before they become major problems.
Key biomarkers including albumin, NAD+, and inflammatory markers provide vital information about organ function, cell energy, and body stress. This helps identify aging signs before symptoms show up.
Advanced tests like Jinfiniti’s AgingSOS® panels study multiple biomarkers to create a complete view of your aging status and health risks.
Regular biomarker testing allows you to make personalized health decisions using actual data rather than guesswork, potentially increasing your healthy lifespan.

What is Longevity Testing?

A longevity test is a blood test that analyzes key biomarkers to predict how your body is aging. The primary goal is health,span optimization, which means maximizing the years you live in good health with full functional capacity.

This proactive approach differs from traditional tests that mainly focus on diagnosing illnesses that are already present.

Modern lab tests typically include:

Markers of oxidative stress (e.g., 8 OHdG)

Indicators of metabolic health (e.g., HbA1c, lipid profiles)

Signs of inflammation, known as inflammatory mediators (e.g., hs CRP, IL 6)

Biomarkers for cellular aging (e.g., Klotho, senescence associated β galactosidase)

Many of these markers are combined in advanced longevity blood panels like Jinfiniti’s AgingSOS®. Our test evaluates 22 biomarkers tied to mitochondrial health, inflammation, and gene regulation.

By closely examining these biomarkers, you can catch potential issues early and take targeted action to support long-term health and slow biological aging.

15 Key Longevity Blood Test Biomarkers

Here are 15 key biomarkers in a longevity blood test that may help predict health outcomes and promote overall wellness.

1. Albumin

Albumin is a protein made by the liver that helps regulate blood volume and keeps fluids in your bloodstream. It also transports hormones and binds to toxins, helping your body stay balanced and functioning properly.

When albumin levels are low, it can signal issues like chronic inflammation, malnutrition, or liver problems.¹ These low levels often lead to increased frailty and slower recovery, especially as we age.

A study in BMC Geriatrics found that many centenarians maintain healthy albumin levels well into their later years.² This suggests strong liver function and the body’s ability to keep up with protein production and repair.

2. ALP (Alkaline Phosphatase) & ALT (Alanine Aminotransferase)

ALP (Alkaline Phosphatase) and ALT (Alanine Aminotransferase) are key enzymes that give clues about liver and bone health.

ALP helps break down proteins and supports bone growth and repair, while ALT is mainly found in the liver and rises when liver cells are damaged.

Elevated ALP can point to bone disorders or bile duct problems, while high ALT levels often signal liver inflammation or stress.³ Tracking both markers helps spot potential issues before they become serious.

ALT usually drops with age, but that doesn’t always mean better liver health.⁴ Centenarians with stable ALT levels likely have good liver detox functions, which may be key to their long, healthy lives.

3. Creatinine (CRE)

Creatinine (CRE) is a waste product filtered out by the kidneys, and its levels reflect how well your kidneys are functioning.⁵

Lower creatinine levels usually indicate that the kidneys filter waste efficiently and that muscle mass is well-preserved.

As we get older, creatinine levels usually go up because kidney function naturally declines. But studies on centenarians in Springer Link showed that they often keep their creatinine levels low, suggesting their kidneys remain strong.⁶

Moreover, reduced creatinine levels in older adults can signal a slower kidney decline. This is a key indicator of healthy aging and longevity.

4. Creatine Kinase (CK)

Elevated CK (Creatine Kinase) levels can indicate muscle damage or metabolic stress from intense activity, injury, or inflammation.⁷

While it’s not always directly linked to aging, CK’s role in muscle health is crucial. Maintaining muscle mass and strength is key to staying mobile and independent as we age.

Optimal muscle function reduces fall risk, improves balance, and maintains physical vitality, making CK monitoring valuable for health and longevity.⁸

5. Reactive Oxygen Metabolite (ROM)

Reactive Oxygen Metabolite (ROM) levels measure the burden of oxidative stress on the body. High ROM levels can accelerate DNA damage and contribute to cellular aging.⁹

Consistently elevated ROM is a sign of the body’s struggle to manage oxidative stress. Luckily, antioxidants like vitamin E help reduce ROM levels, protecting against oxidative damage.¹⁰

Keeping ROM levels in check may help slow aging and reduce the risk of chronic diseases. This is why antioxidants are crucial for healthy aging and longevity.

6. Total Antioxidant Capacity (TAC)

Total Antioxidant Capacity (TAC) measures how well your body fights oxidative stress.¹¹ Low TAC levels suggest weaker defenses, which may increase your risk of chronic diseases.

TAC shows the balance between oxidative stress and your body’s repair systems. An imbalance toward too much stress speeds up aging and increases risk of disease.

High TAC levels are essential for healthy aging. They indicate your body effectively protects itself from free radical damage, supporting long term health and longevity.

7. DNA Damage (8-OHdG)

DNA Damage (8-OHdG) is a biomarker that indicates oxidative damage to your DNA.¹² Higher levels, especially in older individuals, suggest that the body’s repair mechanisms are slowing down.

When DNA repair isn’t functioning properly, it can lead to accelerated aging and increased disease risk. The good news is that nutritional interventions like zinc and vitamin E can help lower 8-OHdG levels.¹³

8. Intracellular NAD+

NAD+ is crucial for mitochondrial function and activating sirtuins, which help regulate energy metabolism and support cellular health. Unfortunately, as we age, NAD+ levels naturally decline.¹⁴

This decline in NAD+ is linked to various age-related health issues, including fatigue and metabolic dysfunction. Research has explored supplementation with NAD+ precursors as a potential way to reverse these effects.¹⁵

Jinfiniti’s Intracellular NAD+ Test is designed to accurately test your cellular NAD+ levels and provide actionable insights for restoring them.

9. Vitamin D

Vitamin D helps regulate immune function and supports bone health. When you have low levels, it increases your risk for chronic diseases and shortens your healthspan.¹⁶

Maintaining optimal vitamin D levels supports the immune system and reduces the risk of frailty, especially as we age.¹⁷ It helps your body fight infections and keeps your bones strong, which is essential for overall health.

10. Glycated Serum Protein (GSP)

Glycated Serum Protein (GSP) shows your short term blood sugar management. Used alongside HbA1c, it helps assess your diabetes risk.¹⁸ GSP specifically reflects glucose levels over a more recent period.

Maintaining stable blood sugar levels, or glycemic control, is essential for health. It protects against vascular and neurological damage.¹⁹

Monitoring both GSP and HbA1c provides a clearer view of your potential for diabetes. This allows you to take steps to safeguard your health.

11. Blood Lipids (HDL, LDL, Triglycerides)

Blood lipids such as HDL, LDL, and triglycerides play important roles in heart health. HDL helps protect the heart, while high levels of LDL and triglycerides signal greater risk for cardiovascular disease.

Research in The Lancet found that people who live past 100 typically have lower cholesterol levels, suggesting healthier lipid profiles support cardiovascular health.²⁰

Keeping track of your lipids can guide you toward a heart-healthy lifestyle that promotes a longer, healthier life.

12. Uric Acid

Uric acid forms when the body breaks down purines. Too much of it can lead to gout, kidney stones, or signal metabolic issues.²¹

On the flip side, uric acid also acts as an antioxidant in small amounts.²² It helps neutralize free radicals and may play a role in protecting cells from oxidative stress.

Centenarians often maintain lower yet balanced levels, suggesting they benefit from its protective effects without the downsides.²³

Keeping uric acid in check can help you avoid metabolic risks and support healthy aging.

13. Klotho

Klotho is an anti-aging protein that supports kidney function, mineral balance, and brain health while regulating key longevity processes.²⁴

As we get older, Klotho levels naturally decline, which may contribute to faster aging and greater disease risk.

A study published in Metabolites showed that people with higher Klotho levels tend to age more slowly and stay healthier longer.²⁵

Monitoring Klotho gives you insight into your biological age beyond just life expectancy. Supporting healthy levels may help resist age-related decline.

14. Inflammation (hs-CRP, IL-1β, IL-6, IL-8, TNF-α)

Chronic inflammation strongly affects aging and disease risk. It quietly chips away at health over time, often without early symptoms.

Markers like hs-CRP, IL-6, IL-1β, IL-8, and TNF-α reveal how much immune stress your body is under.²⁶ When these stay elevated, they can damage tissues and fuel issues like heart disease, diabetes, and cognitive decline.

This long term, low intensity inflammation called “inflammaging” is a critical target for healthy aging.²⁷

Regular exercise, omega 3 consumption, and stress management practices can effectively keep it under control.

15. Senescence-Associated β-Galactosidase (SABG or β-gal)

Senescence-Associated β-Galactosidase (SABG or β-gal) is a marker that identifies senescent cells, which stop multiplying but stay alive in the body. These “zombie” cells build up over time and release harmful substances that cause inflammation and damage tissues.²⁸

Research shows that this accumulation leads to chronic disease as we age.²⁹ Senolytic treatments may work to remove these cells and improve tissue health.

Clinical Applications and Future Trends

An image showing the clinical applications of longevity testing

Longevity testing is entering an exciting new phase due to advances in omics and AI biomarker discovery. These technologies help measure biological aging more accurately than just tracking calendar years.

Epigenetic clocks such as DNAmAge and PhenoAge are leading this trend.³⁰ They estimate your biological age and predict future health risks with greater precision than traditional methods.

Another important tool is GlycanAge.³¹ It tracks glycosylation patterns that influence immune function and overall health resilience, giving valuable insights into your potential lifespan.

These health assessments are becoming part of everyday life. Biomarkers help us track how our bodies respond to nutrition, exercise, and stress on a regular basis.

This provides actual data that can guide personalized health decisions rather than relying on guesswork.

Test Your Biomarkers with Jinfiniti’s AgingSOS Panel

An image of a man tracking longevity biomarkers

Tracking your longevity biomarkers can transform how you age. These key health indicators help you make better choices and prevent potential health problems before they appear.

Jinfiniti’s AgingSOS panels make it easy to track these biomarkers. The starter panel gives you a solid foundation by measuring essential markers, while the advanced panel dives deeper with a complete selection of blood biomarkers. Armed with this data, you can take action today for optimal health and well-being tomorrow.

Start your journey to healthier aging today. Whether you’re just getting started or want a comprehensive analysis, Jinfiniti has a panel that fits your needs.

Referenced Sources:

A man with chronic fatigue holds his face in exasperation

Chronic Fatigue Supplements: What Science Actually Says

Written by Jinfiniti Science on April 22, 2025. Posted in Energy and Fatigue, Creatine, NAD+, Supplements.

Chronic fatigue syndrome, also called ME/CFS, impacts millions of lives around the world. People with this condition often find everyday activities incredibly difficult.

The lack of FDA-approved treatments leads many patients to try supplements. But is there good evidence that these supplements help?

This guide looks at the science behind supplements for chronic fatigue, giving you clear facts without exaggerated claims.

While supplements may help manage symptoms, they’re not a cure for ME/CFS. Always work with healthcare providers familiar with your condition for a comprehensive treatment plan.

Key Takeaways

CoQ10 combined with NADH shows the strongest evidence for reducing fatigue in ME/CFS patients
Mitochondrial support supplements (NAD+ precursors, L-carnitine) may address energy production issues at the cellular level
Research quality is generally low to moderate with small sample sizes and methodological limitations
Response to supplements varies widely between individuals, highlighting the need for personalized approaches

What is Chronic Fatigue Syndrome?

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has several key symptoms:

Unexplained, persistent fatigue that doesn’t improve with rest
Post-exertional malaise (worsening of symptoms after physical or mental effort)
Unrefreshing sleep
Cognitive impairment (often called “brain fog“)
Orthostatic intolerance (symptoms that worsen when standing up)

Despite affecting millions worldwide, the cause is unknown. Researchers have proposed several theories:

Immune dysfunction
Mitochondrial problems
Infectious triggers
Oxidative stress
Neuroendocrine imbalances

Why Many Turn to Supplements

Since there are no FDA approved treatments for ME/CFS, 35-68% of patients use nutritional supplements to try to reduce their symptoms.¹

Current treatments mainly manage symptoms, with less than 5% of patients ever getting back to their pre-illness activity levels.²

This gap in treatment has led patients and researchers to look for alternatives that address the various physiological pathways involved in the condition.

Supplement Safety Note

Most Promising Supplements for Chronic Fatigue

A short-haired woman with fatigue holding her forehead

People with chronic fatigue syndrome may find relief through certain supplements. Here’s what research shows about the most promising options for improving energy levels.

1. CoQ10 and NADH: The Top Contenders

Coenzyme Q10 (CoQ10) and nicotinamide adenine dinucleotide hydride (NADH) stand out as some of the most promising supplements for patients with chronic fatigue syndrome.

Multiple studies show positive results when these supplements are used together. Researchers found that taking CoQ10 (200 mg daily) with NADH (20 mg daily) significantly reduced fatigue in ME/CFS patients over 2-3 months.³

In the study with 73 participants, this combination lowered maximum heart rate during exercise tests and reduced how tired patients felt at each check-up.⁴

Research reviews have consistently found that CoQ10 reduces fatigue, especially when paired with NADH, though many studies have been relatively small.⁵

Why they help: Both supplements are key players in how cells produce energy through mitochondrial processes, potentially improving the reduced energy production seen in ME/CFS patients.

2. NAD+ and Its Precursors

NAD+ is an essential coenzyme that exists in all living cells. It’s important for many biological functions, including how your body creates energy, repairs DNA damage, regulates genes, and sends calcium signals.

In the electron transport chain, NAD+ helps transform nutrients into ATP through oxidative phosphorylation, which is how cells generate energy.

Studies show that NAD+ decreases with aging and in various diseases. This reduction may cause lower energy levels and impaired cell function.⁶

Clinical Evidence:

A review of clinical research examined if NAD+ and NADH supplements help people with various conditions, including CFS. Looking at ten studies with 489 participants, researchers found that those with CFS experienced less intense fatigue, better sleep quality, and improved overall wellbeing.⁷
A study by Forsyth and colleagues found that CFS patients who took 10 mg of NADH daily for four weeks experienced significant relief from fatigue symptoms.⁸

NMN and NR (nicotinamide mononucleotide and nicotinamide riboside) are drawing interest as possible CFS treatments. Unlike direct NAD+ supplements, these precursor compounds are better absorbed and more effectively transported into cells, resulting in higher NAD+ levels.

By improving NAD+ metabolism, these compounds might help repair the kynurenine pathway, which scientists believe is involved in ME/CFS.⁹

3. L-carnitine: Mixed But Promising Results

L-carnitine moves fatty acids into mitochondria for energy production. Research shows it might help with fatigue, but results vary.

In a key 2004 study by Vermeulen and colleagues, 90 chronic fatigue syndrome patients took either acetyl-L-carnitine (2 grams daily), propionyl-L-carnitine (2 grams daily), or both for 24 weeks.¹⁰

The acetyl form improved mental tiredness, while the propionyl form reduced overall fatigue.

Another study with older adults found that acetyl-L-carnitine lowered both physical and mental fatigue and boosted brain function and daily activities.¹¹

Not all research agrees, though. Larger studies, particularly those on cancer-related fatigue, show inconsistent benefits, suggesting that more condition-specific studies are needed.

4. Creatine: Supporting Brain Energy

Research has identified low levels of creatine in brain areas relevant to CFS symptoms, including regions involved in cognition and energy regulation.¹²

In a recent study, CFS patients took creatine supplements for six weeks. Patients experienced reduction in fatigue, better reaction time on cognitive tests, and stronger grip strength.¹³

Another study looked at creatine for post-COVID-19 fatigue, which is similar to CFS. After six months, participants had more creatine in several brain regions and muscles, along with less fatigue and improvements in breathing, body pain, headaches, and concentration.¹⁴

Safety and Dosing: Creatine supplementation appears generally well-tolerated in CFS patients. Typical dosing protocols include a loading phase of approximately 16g daily, followed by a maintenance dose of 3-5g daily.

To better understand how creatine may support brain health, see our detailed article covering the nootropic properties of creatine.

5. Oxaloacetate: Promising But Preliminary

Oxaloacetate is a newer supplement with promising early results.

A small study of 52 ME/CFS patients found that oxaloacetate reduced fatigue in 80% of participants. Some people reported up to 80% less fatigue.¹⁵

Higher doses (1000 mg three times daily) worked better than lower doses, suggesting the effect depends on the amount taken.

Oxaloacetate helps the Krebs cycle, which supports cellular energy production. While these results were described as “striking and surprising,” larger controlled studies are needed to confirm the findings.

6. Vitamins and Minerals: Mixed Evidence

Research on vitamins and minerals for ME/CFS shows mixed results:

Vitamin D may help with general fatigue, but there’s limited evidence specifically for ME/CFS patients. One study found that vitamin D supplements improved fatigue symptoms in people with stable chronic conditions.¹⁶
Vitamin C (500 mg daily) significantly reduced fatigue in obese adults during a small controlled trial, but studies focusing on ME/CFS patients are still needed.¹⁷
Zinc supplements (30 mg daily for 70 days) reduced fatigue in elderly people and increased their zinc blood levels.¹⁸ Another study is currently testing if zinc combined with melatonin helps ME/CFS symptoms.¹⁹
B vitamins, especially thiamine (B1), have shown promise in reducing chronic fatigue in patients with multiple sclerosis and inflammatory bowel disease. Sulbutiamine, a man-made form of thiamine, significantly decreased fatigue scores in multiple sclerosis patients.²⁰
A research review found ME/CFS patients had lower vitamin E levels than healthy individuals, though this finding disappeared when analyzing only the most reliable studies.¹ More research on vitamin E supplementation is needed.

7. Melatonin and Zinc: Ongoing Research

A new clinical trial is testing “MelatoZinc,” which combines melatonin (1 mg) and zinc (10 mg) as a potential treatment for ME/CFS.¹⁹

This carefully designed study will compare the supplement to a placebo in 106 patients who have ME/CFS according to official 2011 guidelines. Researchers will measure if the supplement reduces fatigue and is safe to use.

Scientists believe this combination might help because melatonin helps control sleep cycles, while zinc supports immune function and manages oxidative stress. Both of these processes may be involved in ME/CFS.

8. Panax Ginseng: Limited Evidence

Panax Ginseng has been used traditionally to combat fatigue, with research confirming these effects.²¹ The herb likely helps by enhancing how the body processes energy and through its antioxidant and anti-inflammatory qualities. Research specifically examining its effects on ME/CFS is still limited.

How Nutritional Supplements May Work

A photo of a woman with high energy playing in the autumn leaves, having overcome her chronic fatigue

Several plausible mechanisms may explain why certain dietary supplements show benefits in ME/CFS:

Boosting Mitochondrial Function: People with ME/CFS often have problems with their mitochondria making enough ATP. Many mitochondrial health supplements support energy production.
Reducing Oxidative Stress: Studies show oxidative stress contributes to ME/CFS. Antioxidant supplements including CoQ10 and vitamins C and E may lower oxidative damage and related symptoms.
Balancing Immune Function: Immune dysregulation is a proposed mechanism in ME/CFS. Certain supplements (zinc, vitamin D, some herbal preparations) may help normalize immune function and reduce inflammatory markers.

Safe Supplement Use for Chronic Fatigue Relief

When you have chronic fatigue, supplements can help but safety always comes first. Before adding any supplements to your chronic fatigue plan, consult with a healthcare provider who knows your medical history.

Consider these safety guidelines when adding supplements to manage chronic fatigue:

Start with one supplement and use it for 2-3 weeks before adding another. Fatigue symptoms can fluctuate so give each supplement time to see what it does.
Start with half the recommended dose on the label especially if you’re sensitive to medications or have multiple health conditions. You can increase to full dose if needed and tolerated.
Take supplements with the same meal every day to establish routine and help you track changes in your energy levels or symptoms.
Keep a symptom journal of your fatigue levels, other symptoms and when you take supplements. This will help you identify patterns and see which supplements are working for you.
Be patient. Some supplements that support energy production and reduce fatigue may take weeks to show benefits. Quick fixes are rare with chronic fatigue and sustainable improvements take time.

Because ME/CFS affects everyone differently, personalized treatment of chronic fatigue works best. When possible, supplements should target specific deficiencies.

Testing to Guide Supplementation

While general supplement recommendations are helpful, personalized testing is more targeted for ME/CFS patients. Functional testing helps identify specific deficiencies and imbalances that may be contributing to your symptoms.

Key benefits of testing before supplementation:

Establish a baseline to track progress over time
Avoid unnecessary supplements that may not address your specific needs
Optimize dosages based on your biochemistry

For people with chronic fatigue, comprehensive biomarker testing that looks at multiple systems can be valuable. Jinfiniti’s AgingSOS® Advanced Longevity Panel looks at all the interconnected systems that impact energy production and cellular health, including mitochondrial function, oxidative stress, inflammation and micronutrient status – all of which are involved in ME/CFS.

This type of testing gives you and your healthcare provider actionable information to develop a more precise supplementation strategy, potentially improving outcomes and reducing trial and error.

Remember to always interpret test results with a knowledgeable healthcare provider who understands ME/CFS.

When to Seek Help for Chronic Fatigue

Chronic fatigue requires medical attention when it significantly impacts your daily life.

Consult a healthcare provider if you experience:

Fatigue that persists for six months or longer despite adequate rest
Extreme exhaustion after physical or mental activities that previously caused no issues
Unrefreshing sleep or worsening fatigue despite increasing rest
New symptoms like joint pain, cognitive difficulties, or recurring sore throat
Depression, anxiety, or mood changes accompanying your fatigue
Fatigue that prevents you from fulfilling work, family, or social responsibilities

Early intervention can lead to more effective management strategies and help identify any underlying conditions that may be contributing to your symptoms.

For additional support and information, visit trusted resources such as the CDC ME/CFS Patient Toolkit, the Solve ME/CFS Initiative, or the Bateman Horne Center to better understand your symptoms and prepare for medical appointments.

Supportive Lifestyle Practices

Beyond supplements, these lifestyle approaches can help manage chronic fatigue:

Gentle, consistent movement: Light exercise like walking, swimming, or yoga can gradually improve energy levels when practiced regularly but without pushing to exhaustion
Energy pacing: Planning activities around your energy levels and taking rest breaks before becoming completely depleted
Sleep hygiene: Maintaining consistent sleep and wake times, creating a restful bedroom environment, and limiting screen time before bed
Stress management: Incorporating mindfulness, meditation, or breathing exercises to reduce the energy-draining effects of chronic stress
Nutrition focus: Emphasizing nutrient-dense whole foods that provide sustained energy while limiting processed foods, caffeine and alcohol that can worsen fatigue patterns

These foundational practices create a supportive framework that can enhance the effectiveness of any supplements you add to your routine.

Woman in pink tank top stretching arm outdoors at sunset

Limitations of Supplements for ME/CFS

Research on supplements for ME/CFS shows promise but faces significant limitations.

Studies typically involve small sample sizes (under 100 participants) with design issues including bias risks and short follow-up periods.

Standardization problems persist across studies, with inconsistent diagnostic criteria, symptom measurements and supplement protocols.

Publication bias favors positive results, while adverse effects and dropout rates often go unreported.

A 2017 systematic review concluded there is “insufficient evidence” for nutritional supplements and dietary interventions for ME/CFS, highlighting these methodological weaknesses.

Future Research Needs

Larger studies with more patients
Standard diagnosis and measurement methods
Longer follow-up periods
Research on which patients benefit from specific supplements
Investigation of combination supplement approaches

Takeaway

The research on supplements for ME/CFS shows mixed results.

Some supplements look promising, including CoQ10 with NADH, NAD+ precursors, L-carnitine, and creatine. However, research limitations make it hard to draw firm conclusions about most supplements.

The quality of evidence varies greatly, and no single supplement works for all ME/CFS patients.

If you have ME/CFS and want to try supplements, work with healthcare providers who understand your condition. Focusing on supplements that address your specific deficiencies or symptoms may lead to better results.

Scientists must continue conducting careful research to learn which supplements truly help ME/CFS patients and how they work. This research is essential for developing better treatments.

Remember that supplements might ease symptoms but cannot cure ME/CFS. Always work with knowledgeable healthcare providers to develop your full treatment plan.

Referenced Sources

An image of healthy man and woman with good cellular health

The 7 Best Supplements to Support Cellular Repair

Written by Jinfiniti Science on April 21, 2025. Posted in Vitamin B, Creatine, NMN, Vitamin C. No Comments on The 7 Best Supplements to Support Cellular Repair

Every second, our cells repair damage from free radicals and natural metabolism, directly influencing how we age and resist disease.

Supporting cellular nutrition is fundamental to slowing cellular aging and maintaining overall health throughout your lifespan.

Research supports certain vitamins and supplements that work through distinct pathways to promote repair processes and protect against damage.

This guide explores the science behind these cellular repair supplements and their potential health benefits.

Always consult your healthcare provider before adding new supplements, especially if you take medications or have health conditions.

7 Supplements That Promote Cellular Health:

Creatine
B Vitamins
Nicotinamide Mononucleotide (NMN)
Curcumin
Magnesium
CoQ10
Vitamin C

What is Cellular Repair?

Cellular repair is your body’s way of fixing damage at the microscopic level, keeping cells healthy and functioning properly.

Every day, your cells endure stress from metabolism, toxins, and radiation. This causes thousands of tiny injuries, especially to DNA, which holds the instructions for everything your body does.¹

Your body has built-in repair mechanisms to handle this. Cells use special processes to correct DNA damage, restore proteins, and maintain healthy mitochondria (your cells’ energy producers).

When these repair systems work well, damaged cells are either fixed or removed. But if they fail, faulty cells can stick around, increasing the risk of diseases like cancer.²

Your body relies on specialized DNA repair pathways. These include base excision repair (fixing small DNA changes), mismatch repair (correcting errors during DNA replication), and recombinational repair (fixing broken DNA strands).³

Cellular repair extends beyond DNA. Your body also repairs proteins, cell membranes, and organelles to maintain optimal cellular function.

Why is Cellular Health Important?

Your health starts at the cellular level. With around 37 trillion cells working behind the scenes, their ability to function properly determines how well your organs, tissues, and entire body operate.⁴

When cells take on too much damage and can’t repair themselves, they face three possible fates:⁵

Becoming dormant (senescence)

Self-destructing (apoptosis)

Dividing uncontrollably (which can lead to tumors)

Over time, damaged cells accumulate, making it harder for your body to function optimally. This speeds up aging and increases the risk of chronic diseases.

One of the most important factors in cellular health is DNA repair. Research shows that many of the genes linked to longer lifespans are directly involved in fixing DNA damage.⁶

Supporting your body’s natural repair mechanisms with the right nutrients and lifestyle choices can promote healthy aging, improve recovery, strengthen immunity, and lower disease risk.

Supplement Safety Note

Top 7 Supplements for Healthy Cellular Function

An image of different kinds of supplements

Here are 7 supplements have been scientifically shown to support different aspects of cellular repair and regeneration.

1. Creatine

Creatine is a key supplement for boosting cellular energy, especially when your body is under stress.

It helps replenish ATP, the energy that powers your cells, supporting everything from muscle function to immune response.

Beyond energy, creatine supports cell protection and repair, improving cellular metabolism and reducing the impact of injuries and disease.

Creatine also enhances immune cell functions, like cytokine production and phagocytosis, helping your body fight infections more effectively.⁷

For best results, creatine monohydrate is the go-to form. A daily dose of 3-5 grams is effective, but if you’re looking for maximum absorption, you can start with a loading phase of 20 grams split into four 5-gram doses per day.⁸

2. B Vitamins

B vitamins serve as essential building blocks for cellular repair, with B12 playing a particularly vital role in maintaining DNA health.

These nutrients enable one-carbon metabolism, which protects genetic material and supports your body’s constant regeneration processes.

Research shows B12 consumption increases during repair activities, highlighting its importance in cellular recovery mechanisms.⁹

Through epigenetic regulation, B12 helps ensure genes are expressed correctly, preventing errors that could compromise cell function.¹⁰

B vitamins work collaboratively within your cells, making comprehensive B complexes more effective than isolated supplements.

3. Nicotinamide Mononucleotide (NMN)

NMN supports cellular repair by boosting NAD+, a crucial molecule that powers nearly all cellular functions. NAD+ levels start declining in early adulthood, falling to approximately 50% by middle age.¹¹

This significant drop compromises your cells’ ability to repair damage and maintain energy production. Taking NMN provides the building blocks to help restore more youthful NAD+ levels.

Research published in Integrative Medicine identifies several benefits of NMN supplementation:¹²

Supporting insulin sensitivity

Enhancing mitochondrial function

Promoting vascular health

Maintaining muscle strength and endurance

Protecting heart and brain function

Potentially extending lifespan

Most adults see benefits with 250-500 mg daily before age 60, with higher NMN dosages often recommended for seniors.

4. Curcumin

Curcumin may provide comprehensive cellular support by combating inflammation, neutralizing free radicals, and protecting genetic material.

It targets specific inflammatory pathways such as NF-κB and JAK/STAT that can interfere with normal cellular repair.¹³

This powerful compound shields DNA from damage while activating enzymes that repair genetic breaks and mutations.

A study published in Frontiers in Oncology demonstrates curcumin enhances multiple DNA repair mechanisms that maintain genetic integrity and slow aging processes.¹⁴

5. Magnesium

Magnesium functions as a cellular repair catalyst, protecting DNA structure and enabling repair enzymes to function properly.

Insufficient magnesium leads to increased DNA damage and compromised repair capacity.

Your cells require magnesium to create Mg-ATP, the activated form of cellular energy that powers all repair activities.¹⁵

This mineral drives autophagy, the natural process that removes cellular damage before it can accumulate.¹⁶

Scientists have discovered that higher magnesium levels correlate with longer telomeres, the protective caps on chromosomes that indicate cellular age.¹⁷

6. CoQ10

CoQ10, located in the mitochondria, helps produce ATP by transferring electrons in the electron transport chain.¹⁸

This process powers your cells, keeping them functioning optimally.

But its benefits go beyond energy production. Research in Nutrients showed that it also helps protect cells from oxidative damage under conditions of cellular stress.¹⁹

CoQ10 doses typically range from 60 to 500 mg a day. Absorption also improves when taken with meals that contain fat.

7. Vitamin C

Vitamin C provides essential support for immune function and cellular protection systems.

It acts as a potent water-soluble antioxidant that intercepts and neutralizes harmful free radicals.

Beyond direct antioxidant action, vitamin C helps regenerate depleted antioxidants including glutathione and vitamin E.²⁰

Unlike most antioxidants, vitamin C can strategically switch to pro-oxidant action when needed.²¹

This remarkable flexibility allows it to trigger specific repair pathways during oxidative stress or recovery periods.

How to Choose the Best Cellular Health Supplement

Navigating the world of supplements for cellular health can be tricky. To make sure you choose wisely, ask these important questions:

Is the Quality Confirmed? Look for evidence of third-party testing on the label or website. This independent check helps ensure the supplement meets quality standards for purity and ingredient amounts.

What Form is the Nutrient In? Pay attention to the specific form listed. Different forms have vastly different absorption rates, affecting how much of the nutrient your body can actually use. Research suggests forms like glycinate (for magnesium) and methylcobalamin (for B12) are often better absorbed.

How Might It Interact with Other Supplements? Consider what else you’re taking. Some supplements compete (like iron and calcium, which shouldn’t be taken together), while others assist each other (like vitamin C helping iron absorption). Knowing these interactions helps you optimize your supplement routine.

Everyday Habits for Healthy Cells

An image of adults building healthy habits for healthy cells

Your daily habits play a crucial role in supporting cellular health, working alongside any supplements you might take. Here’s what matters most:

Move Your Body

Regular exercise stimulates cellular repair mechanisms throughout your body.

High-intensity interval training (HIIT) is particularly effective, boosting production of proteins essential for mitochondria and ribosomes—key players in energy production and aging resistance.²²

Even moderate activities like walking or cycling improve blood flow, reduce inflammation, and enhance tissue regeneration in vital organs.

Prioritize Sleep

During quality sleep, your body activates critical repair processes:²³

Produces proteins needed for tissue regeneration

Clears cellular waste products

Reduces oxidative stress

Poor sleep does the opposite—increasing cellular damage, especially in your digestive system.

Eat for Cellular Health

Your diet provides the raw materials for cellular nutrition:

Protein supplies essential building blocks for repair

Omega-3 fatty acids strengthen cell membranes and manage inflammation

Antioxidant-rich foods protect against cellular damage

By combining these three foundational habits, you create the optimal environment for your cells to thrive, repair, and regenerate effectively.

Final Thoughts

An image of a woman with healthy lifestyle

Research shows your cell health and wellness may benefit from quality supplements like creatine, B vitamins, NMN, curcumin, magnesium, CoQ10, and vitamin C. Be sure to select third-party tested, bioavailable options for maximum effectiveness.

Pair these supplements with exercise, quality sleep, and a nutrient-rich diet to enhance your body’s natural repair processes.

For personalized insights into your cellular health status, Jinfiniti’s advanced AgingSOS® longevity panel can identify your specific needs and help you track improvements as you optimize your supplement regimen.

This data-driven approach ensures you’re addressing your unique cellular health requirements rather than guessing.

Referenced Sources:

Woman holding a bowl of strawberries by the water

Fisetin: Benefits, Longevity Potential & Side Effects

Written by Jinfiniti Science on April 18, 2025. Posted in Longevity, Nutrition, Supplements.

Could a natural compound found in fruits like strawberries and apples help you live healthier and longer?

Fisetin is a flavonoid found in fruits and vegetables making waves in the wellness world for its potential health benefits.

Why is it interesting? Fisetin is a strong antioxidant and studies suggest it could help support healthy aging and cellular function.

But what does the research really show?

We’ll get into the evidence for fisetin’s benefits, list the natural food sources, discuss supplements and what you need to know before trying it.

Key Takeaways

Fisetin is a natural flavonoid found in fruits and vegetables (like strawberries and apples) with strong antioxidant and senolytic properties, helping clear out old, damaged cells.
Research suggests fisetin supports healthy aging by reducing inflammation, protecting against oxidative stress, and potentially benefiting brain, heart, and metabolic health.
Studies, notably in aged mice, link fisetin to increased longevity and improved healthspan, largely attributed to its senolytic (clearance of aged cells) activity.
While present in foods, fisetin supplements are often used to achieve potentially therapeutic doses due to low natural concentrations and bioavailability; taking it with fat enhances absorption.

What Is Fisetin?

Fisetin is a type of flavonoid which is part of a larger group of natural plant compounds called polyphenols. It’s what gives the yellow color to foods like strawberries, apples, persimmons and onions.

But fisetin offers more than just color, it’s a strong antioxidant that protects cells from damage known as oxidative stress.¹

Research also shows fisetin has other benefits like helping control inflammation, promoting cellular homeostasis (keeping cells stable), and acting as a natural senolytic – meaning it might help clear out old, aged cells from tissues.

Key Benefits of Fisetin

Infographic showing 5 anti-aging benefits of Fisetin

Fisetin may offer a wide range of benefits that support healthy aging and overall wellness. Let’s break down the key research behind this powerful senolytic compound.

Senolytic Activity

During aging, the body accumulates senescent cells: damaged cells that stop dividing but stick around. These cells create issues by releasing inflammatory compounds that disrupt normal tissue function.

Fisetin acts as a senolytic, meaning it selectively targets these troublesome senescent cells for removal.² Getting rid of these cells helps create a healthier internal environment, supporting cellular health and tissue regeneration.

As a result, fisetin may help slow down age-related decline, improve vitality, and potentially increase healthspan through better cell function and decreased inflammation.³

Antioxidant Protection

As a powerful antioxidant, fisetin fights off free radicals that cause oxidative stress and cell damage.⁴ It enhances the body’s natural defenses like glutathione and superoxide dismutase.

These properties help shield cells from environmental stressors, protect DNA, and maintain cellular health, making fisetin valuable in preventing oxidative damage.

Anti-inflammatory Effects

Fisetin tackles inflammation by interacting with important cellular pathways like NF-κB and MAPK.⁵ These pathways are responsible for producing molecules that trigger inflammation.

Fisetin helps lower the levels of these molecules, specifically pro-inflammatory cytokines. This action supports joint health, promotes a balanced immune system, and contributes to overall well-being.

Neuroprotective Properties

Fisetin also shows promise for brain health by fighting oxidative stress and neuroinflammation, two factors linked to cognitive decline.⁶ Research indicates it may shield neurons from damage, boost memory, and improve communication between brain cells.

These neuroprotective effects of fisetin make it a potential tool for maintaining mental clarity and cognitive performance with age.⁷

Metabolic and Cardiovascular Support

Fisetin may help manage blood sugar levels and reduce the risk of insulin resistance, which is a major factor in metabolic disorders.⁸

It has also been shown to protect the heart by fighting oxidative stress and improving blood vessel function.⁹ These benefits may contribute to better circulation, healthier metabolism, and improved cardiovascular health.

Fisetin’s Role in Longevity and Anti-Aging

An image of a woman consulting to a doctor about longevity and anti-aging

When it comes to healthy aging, fisetin stands out as one of nature’s most promising compounds. Research continues to reveal exciting possibilities for this plant-derived flavonoid’s impact on the aging process.

According to key findings from the Mayo Clinic:¹⁰

Aged mice (equivalent to 75-year-old humans) receiving fisetin lived approximately 10% longer than control groups

Benefits occurred even when fisetin was administered late in life

Mice maintained better health during their extended lifespan, improving both lifespan and healthspan

Building on our earlier discussion of fisetin’s senolytic properties, the Mayo Clinic research confirmed that by clearing these problematic senescent cells, fisetin helps restore tissue balance and reduce age-related decline across multiple organs.

A separate study demonstrated fisetin’s ability to reverse signs of premature aging in mice with shortened telomeres (protective DNA caps that diminish with age).¹¹ Researchers identified it as a “potent senolytic drug capable of reversing premature aging signs” by:

Suppressing specific aging markers

Reducing collagen fiber buildup in tissues

Inhibiting cellular pathways that contribute to aging

Ready to add fisetin to your wellness routine? Jinfiniti’s SenoAid offers a targeted approach. It’s our premium senolytic supplement providing a scientifically backed blend, including fisetin, formulated to support cellular vitality and longevity.

Dietary Sources of Fisetin

Fisetin is found in various foods with strawberries containing the highest concentration. Here’s a comparison of the best sources:

Food	Fisetin Content (μg/g)	Amount in Typical Serving
Strawberries	160	16,000 μg (100g)
Apples	26.9	4,035 μg (1 medium)
Persimmons	10.6	1,590 μg (1 fruit)
Lotus root	5.8	580 μg (100g)
Onions	4.8	528 μg (1 medium)

While adding these foods to your diet is beneficial, food sources alone may be insufficient because:

Even strawberries would require large daily quantities to reach research-effective doses

Poor bioavailability limits absorption

Seasonal availability affects consistent intake

Dietary restrictions may limit consumption

Supplementation may provide a more reliable source for those seeking fisetin’s potential benefits, particularly its senolytic effects.

Fisetin Supplements: Dosage Guidelines

Dosage: Most supplements provide 100-200 mg daily for inflammation. Some clinical trials use higher doses (~20 mg/kg body weight). Many enthusiasts follow an intermittent “hit and run” approach with periodic higher doses instead of daily use.

Fisetin is often combined with quercetin for complementary senolytic effects. Jinfiniti’s SenoAid offers a premium formulation with both compounds in optimized ratios.

Bioavailability Challenges: Fisetin’s poor bioavailability (water-insoluble and rapidly metabolized) may limit its effectiveness. Some approaches include combining with fenugreek galactomannans (claimed to increase bioavailability up to 25x), liposomal encapsulation, and nanoparticle delivery systems.

Because Fisetin has low bioavailability and metabolizes quickly in the body, you may need to take it more frequently to achieve its therapeutic effects.

How to Take Fisetin Effectively

Fisetin is a fat-soluble compound, meaning it dissolves in fats rather than water. This characteristic is key to absorbing it well.

Taking fisetin with a meal containing healthy fats significantly boosts how much your body can actually use. Foods like avocados, nuts, olive oil, or fatty fish consumed alongside your supplement help increase its bioavailability.

Taking fisetin with food generally, rather than on an empty stomach, also helps prevent digestive discomfort. For timing, consuming it with breakfast or lunch is a popular choice, allowing your body to process it during your active hours.

Potential Side Effects and Safety

A graphic image written with "side effects"

Fisetin is generally safe but can cause mild side effects. These are usually stomach issues like nausea or diarrhea, especially at higher doses. Taking fisetin with food can help minimize these and improve absorption.

Allergies to fisetin are rare but can happen, showing up as itching, swelling or rashes. Fisetin may also interact with certain medications by affecting liver enzymes and altering drug effectiveness.

Long term human studies are still being done. Consult with a healthcare provider before starting fisetin supplement especially if you’re pregnant, breastfeeding or have existing health conditions.

Final Thoughts on Fisetin

Fisetin is a naturally occurring flavonoid with remarkable potential for supporting healthy aging, cellular health, and overall wellness.

Its senolytic properties, antioxidant effects, and ability to promote cellular renewal make it an exciting addition to longevity-focused routines.

While fisetin-rich foods like strawberries can provide small amounts, supplementation offers a more reliable way to achieve beneficial levels.

As research continues to uncover fisetin’s full capabilities, it remains a promising tool for enhancing vitality and healthspan. Whether through diet or supplements like SenoAid, incorporating fisetin into your routine may be a step toward optimizing your wellness journey.

Referenced Sources:

Two brown supplement bottles labeled 'NR' and 'NAM' sitting on a clean white marble countertop with soft natural light coming through a window.

Nicotinamide Riboside vs. Niacinamide: Which is Better?

Written by Jinfiniti Science on April 16, 2025. Posted in NAD+, NAD+ Precursors.

When it comes to Vitamin B3 supplements, the options can get confusing. You’ve probably heard about niacin, but what about nicotinamide riboside (NR) and niacinamide (NAM)?

These less-familiar forms of Vitamin B3 have been gaining attention for their potential health benefits. Research suggests they might support cellular energy, improve skin health, and potentially promote longevity.

But which one is right for you? Let’s break down the similarities and differences between these two NAD+ precursors to help you make an informed choice.

Key Takeaways

Both NR and NAM are forms of Vitamin B3 that boost NAD+ levels, but they work through different metabolic pathways
Niacinamide (NAM) has stronger clinical evidence for skin health benefits, with decades of research backing its effectiveness
Nicotinamide Riboside (NR) shows promising potential for anti-aging and metabolic health, but human clinical evidence is still emerging
Your choice should depend on your goals: NAM for established skin benefits at lower cost, NR for potential metabolic and anti-aging benefits at premium pricing

What Are NR and NAM?

Nicotinamide riboside and niacinamide are both forms of Vitamin B3. Your body uses these to make NAD+ (nicotinamide adenine dinucleotide), a molecule vital for energy production.

Niacinamide (NAM) is the amide form of nicotinic acid found naturally in foods like meat, fish, beans, nuts, and grains. “Niacinamide” and “nicotinamide” refer to the same molecule. Beauty products usually use “niacinamide,” while research papers and supplements use “nicotinamide.”
Nicotinamide Riboside (NR) is a more advanced form of Vitamin B3. It combines a nicotinamide molecule with a ribose sugar. Small amounts exist in cow’s milk, yeast, and beer, but most people get it from supplements.

The key difference is simple: NR contains that extra ribose component, which makes it structurally closer to NAD+.

Infographic showing the differences between Nicotinamide Riboside and Niacinamide

Why NAD+ Matters

Before comparing supplements, we should understand why NAD+ is important enough to consider boosting it.

NAD+ is a coenzyme found in every cell of your body and serves several key functions:

Energy Production: NAD+ helps your cells convert food into energy through processes like glycolysis and mitochondrial oxidative phosphorylation.
DNA Repair: NAD+ supports enzymes that repair DNA damage, helping maintain genetic stability.
Signaling and Regulation: NAD+ is used by enzyme families called sirtuins that regulate metabolism, stress responses, and possibly influence aging.

Research shows our NAD+ levels tend to drop as we get older. This decrease may contribute to various age-related conditions.

The decline happens because our bodies either produce less NAD+ or use more of it due to factors such as DNA damage and inflammation.

How They Work: Different Paths to the Same Goal

NR and NAM both help create NAD+, but they follow different metabolic pathways to accomplish their goal.

Niacinamide Pathway

NAM creates NAD+ through what scientists call the “salvage pathway.”

This is how it happens:

An enzyme called Nicotinamide Phosphoribosyltransferase (NAMPT) converts NAM to Nicotinamide Mononucleotide (NMN).
Enzymes called Nicotinamide Mononucleotide Adenylyltransferases (NMNATs) then convert NMN to NAD+.

NAMPT is the rate-limiting enzyme in this process. This means it can become a bottleneck that slows down NAD+ production. This problem may get worse as we age because NAMPT activity often decreases over time.

Nicotinamide Riboside Pathway

NR follows a different route:

Enzymes called Nicotinamide Riboside Kinases (NRKs) add a phosphate group to NR, creating Nicotinamide Mononucleotide (NMN).
Like in the NAM pathway, NMNAT enzymes then convert NMN to NAD+.

The main advantage of NR is that it skips the NAMPT step, potentially offering a more direct path to NAD+.

However, it is important to know that NR can also be broken down into NAM in the body, which would then go through the standard NAM pathway.

Brown Wooden Path Surrounded With Green Grass Near Mountain

Benefits of Nicotinamide Riboside vs Niacinamide

Now for the big question: Which one is better? The answer isn’t straightforward and depends largely on what health goals you’re trying to achieve.

Nicotinamide Riboside Benefits

Research on NR has largely focused on cellular energy, mitochondrial function, and potential anti-aging effects:

NAD+ Boosting: Human studies consistently show that oral NR supplementation effectively increases NAD+ levels in the blood, with increases ranging from 40-90% with regular dosing.¹
Mitochondrial Function: Studies highlight NR’s capacity to enhance mitochondrial function and potentially promote mitochondrial biogenesis (creation of new mitochondria).²
Sirtuin Activation: NR is associated with activation of sirtuins, particularly SIRT1 and SIRT3, which are involved in regulating metabolism and longevity pathways.³
Promising Preclinical Evidence: Animal studies suggest benefits for metabolic health, neurodegenerative diseases, muscle disorders, and even potential lifespan extension in some models.⁴
Mixed Human Evidence: While NR reliably increases blood NAD+ levels in humans, clinical evidence for downstream health benefits has been inconsistent. Some studies show modest improvements in blood pressure or aortic stiffness in specific populations⁵, potential neuroprotective effects in Parkinson’s disease⁶, and possible benefits for conditions like non-alcoholic fatty liver disease (NAFLD) when combined with other compounds.⁷

Niacinamide Benefits

NAM has a longer history of research and established applications, particularly in dermatology:

Skin Health: NAM has well-documented benefits for skin, supported by numerous clinical studies using both topical and oral forms:
- Acne: Topical NAM (4% creams/gels) has shown effectiveness comparable to topical antibiotics.⁸
- Rosacea: Its anti-inflammatory effects help manage redness and inflammation.⁹
- Skin Aging: Topical application (5% concentration) improves various signs of photoaging, including reducing fine lines, wrinkles, and hyperpigmentation.¹⁰
- Skin Cancer Prevention: A landmark clinical trial (ONTRAC) demonstrated that oral NAM (500mg twice daily) significantly reduced the rate of new non-melanoma skin cancers in high-risk individuals.¹¹
Other Potential Benefits:
- Osteoarthritis: Higher doses (3g/day) may improve joint flexibility and reduce pain and swelling.¹²
- Type 1 Diabetes: May help slow disease progression in newly diagnosed individuals by preserving pancreatic beta-cell function.¹³
- Hyperphosphatemia: Can help lower high blood phosphate levels in kidney failure patients on dialysis.¹⁴

A critical distinction emerges when comparing the evidence. NAM has established human clinical data, including large randomized controlled trials, supporting its use for specific conditions.

In contrast, while NR shows promising results in preclinical models and reliably boosts NAD+ in humans, strong clinical evidence confirming specific health outcomes in humans is often lacking or inconsistent.

Bioavailability and Safety Profiles

Bioavailability

Both NR and NAM are effective at increasing NAD+ levels, but there are some differences in how efficiently they do so:

NR: Human studies show that NR supplementation (100-1000 mg daily) effectively raises blood NAD+ levels, with increases ranging from 40-90%. However, a significant portion of orally ingested NR may be converted to NAM in the digestive tract or circulation.
NAM: Readily absorbed, primarily in the small intestine, and is generally considered more bioavailable than niacin (NA) due to its more direct pathway to NAD+.

One interesting finding is that NR supplementation leads to substantial increases in a molecule called NAAD, even when NAD+ levels don’t show a significant rise. This suggests NR undergoes unique metabolic processing, the implications of which are still being investigated.

Safety and Side Effects

Both supplements are generally considered safe, but they have different characteristics at higher doses:

NR:

Generally well-tolerated up to 1000-2000 mg/day in studies
Typical side effects, when they occur, include nausea, bloating, fatigue, headache, diarrhea, and skin discomfort
May lower blood pressure, requiring caution for those on antihypertensive medications
Long-term safety data in humans is still relatively limited compared to NAM

NAM:

Excellent tolerability, particularly at nutritional and common therapeutic doses
A major advantage over nicotinic acid (niacin) is the lack of the uncomfortable “niacin flush”
At typical supplement doses (up to 900-1500 mg/day), side effects are usually mild and may include stomach discomfort, dizziness, headache, or rash
High doses (>3 g/day) may cause reversible liver issues, increased blood sugar, or worsen gallbladder disease or peptic ulcers

Dosage Recommendations from Human Studies

The effective dosage depends on what you’re trying to achieve:

NR:

For NAD+ boosting: 250-1000 mg per day
250 mg/day has been shown to increase blood NAD+ by about 40%
500 mg/day increased blood NAD+ by approximately 90%
1000 mg/day increased NAD+ in white blood cells by about 60%
Higher doses (2000 mg/day) have been used in studies on obesity/insulin resistance and heart failure

NAM:

Basic nutritional needs (RDA): 14-16 mg per day for adults
Skin cancer prevention: 500 mg once or twice daily (total 500-1000 mg/day)
Osteoarthritis: 3 grams per day, typically divided into multiple doses
Acne (oral): 750 mg per day
Topical applications: Usually 4-5% concentration in creams or serums

Making Your Choice: Which is Better for You?

The “better” option really depends on your specific health goals:

Consider NR if:

You’re primarily interested in boosting overall NAD+ levels for potential metabolic, mitochondrial, or “anti-aging” benefits
You’re specifically interested in sirtuin activation (NAM can actually inhibit sirtuins at higher doses)
You’re willing to pay more for a supplement with promising preclinical evidence but less established human clinical outcomes
You’re comfortable with a newer supplement that has less long-term safety data

Consider NAM if:

You’re focused on skin health (acne, rosacea, photoaging, hyperpigmentation)
You’re at high risk for non-melanoma skin cancers and looking for preventive measures
You’re seeking a more budget-friendly option with a longer history of use
You prefer a supplement with more established clinical evidence for specific conditions
You’re concerned about long-term safety and want a more extensively studied option

Takeaway on Niacinamide vs Nicotinamide Riboside

Both nicotinamide riboside and niacinamide are valuable forms of Vitamin B3 that can boost NAD+ levels, albeit through different pathways.

They share the fundamental goal of supporting cellular NAD+ pools but have distinct profiles regarding established benefits, research evidence, and cost.

NAM boasts a longer history of use, established clinical benefits (particularly for skin health), and a well-understood safety profile at a more affordable price point.

NR offers a theoretically more direct pathway to NAD+ and promising preclinical evidence for metabolic and anti-aging benefits, but at a higher cost and with less definitive human outcome data.

For those looking to optimize their NAD+ levels, a comprehensive approach may be most effective. Jinfiniti’s Vitality ↑® NAD+ Booster offers a clinically validated formula combining NMN (another NAD+ precursor) with niacinamide, D-ribose, and creatine monohydrate.

This synergistic blend is designed to support NAD+ levels, boost energy production, and improve sleep quality and overall cellular function.

What sets this approach apart is the combination of multiple pathways to NAD+ enhancement, rather than relying on a single precursor.

The inclusion of niacinamide provides the established benefits discussed throughout this article, while the additional ingredients work together to maximize cellular energy production.

Remember that supplements should complement, not replace, a healthy lifestyle. Proper nutrition, regular exercise, quality sleep, and stress management remain the foundations of health and may themselves support healthy NAD+ levels.

As with any supplement, it’s always advisable to consult with a healthcare professional before starting either NR or NAM, especially if you have existing health conditions or are taking medications.

FAQs

Are nicotinamide and niacinamide the same thing?

Nicotinamide and niacinamide refer to the exact same molecule. The terms are often used interchangeably, with “niacinamide” being more common in cosmetics and skincare products, while “nicotinamide” is more frequently used in research and supplement nomenclature.

Why is nicotinamide riboside so much more expensive than niacinamide?

Nicotinamide riboside is more expensive primarily because it’s a newer, more complex compound that requires special manufacturing processes. The higher cost also reflects marketing around NR’s potential anti-aging benefits and the costs of ongoing research.

Can I take both nicotinamide riboside and niacinamide together?

While the document doesn’t specifically address taking both supplements together, there’s no indication that combining them would be harmful. However, since NR can be converted to NAM in the body anyway, taking both might be redundant. As with any supplement combination, it’s best to consult with a healthcare provider before starting such a regimen.

Does niacinamide cause flushing like niacin?

No, unlike niacin (nicotinic acid), niacinamide does not cause the uncomfortable “niacin flush” – a skin reaction characterized by redness, warmth, and itching. This is one of the major advantages of niacinamide over niacin. Nicotinamide riboside also doesn’t cause flushing.

Which form of Vitamin B3 is best for anti-aging purposes?

Based on current research, nicotinamide riboside has more theoretical potential for overall “anti-aging” benefits due to its efficient NAD+ boosting capabilities and association with sirtuin activation.

However, for specific skin anti-aging benefits (reducing wrinkles, hyperpigmentation, etc.), topical niacinamide (at 4-5% concentration) has stronger clinical evidence.

For internal anti-aging effects, NR shows promise in animal studies, but conclusive human evidence is still emerging.

Fresh strawberries and blueberries arranged in a perfect symmetrical pattern on a light background

Quercetin vs. Fisetin: Differences and Combined Benefits

Written by Jinfiniti Science on April 14, 2025. Posted in Quercetin, Longevity. No Comments on Quercetin vs. Fisetin: Differences and Combined Benefits

When it comes to longevity and cellular health, two compounds found in fruits and vegetables have been making waves: quercetin and fisetin. Both offer potent antioxidant and anti-inflammatory action, yet possess unique strengths.

Quercetin is known for boosting immune function and cardiovascular health. Fisetin earns distinction for its superior senolytic ability, clearing aged cells linked to inflammation.

Which should you choose, or is there advantage in combining them?

In this Jinfiniti article, we’ll break down the key differences between quercetin and fisetin, explore their individual benefits, and uncover how they may work even better together.

Key Takeaways

Quercetin and fisetin are powerful natural senolytics that work in different ways—quercetin shines with its anti-inflammatory effects, while fisetin excels at clearing out harmful senescent cells (the “zombie” cells that age us).
When taken together, quercetin and fisetin provide stronger anti-cancer effects and more protection against age-related decline than if taken separately.
The right approach for each differs—quercetin benefits from daily doses (500-1,000mg), while fisetin may be most effective with an intermittent “pulse” (500-1,000mg over 2-3 days a month).

What Are Quercetin and Fisetin?

Bowl of Strawberries and Berries next to Apples on Chopping Board

Quercetin and fisetin are flavonoid compounds that function as natural senolytics, compounds capable of selectively eliminating senescent cells from the body.

Although related as flavonoids, they function differently inside the body. Both act as powerful antioxidants, meaning they neutralize destructive free radicals. These free radicals can damage cells and accelerate the aging process.

Quercetin is much more common in our diet, found easily in foods like apples and onions. Fisetin is less common; it’s mainly found in strawberries, with smaller amounts also in apples and cucumbers.

Differences Between Quercetin and Fisetin

As related flavonoids, quercetin and fisetin share some similarities but differ in their structures and how they benefit the body. Quercetin works best as an antioxidant and inflammation fighter, while fisetin’s specialty is its senolytic effect—removing aging cells that can cause problems in the body.

See the table below for a detailed comparison:

Property	Quercetin	Fisetin
Chemical Structure	Flavonol with 5 hydroxyl groups	Flavonol with 4 hydroxyl groups
Natural Sources	Abundant in onions, apples, berries, tea, red wine, broccoli, citrus fruits	Found in strawberries, apples, persimmons, cucumbers, onions, grapes
Bioavailability	Lower bioavailability (1-10%)	Slightly higher bioavailability
Primary Benefits	Strong antioxidant, anti-inflammatory, antihistamine properties	Potent senolytic (removes senescent cells), neuroprotective properties
Senolytic Potency	Has senolytic properties but appears less potent compared to fisetin	Strong senolytic effect
Supplement Usage	Often combined with vitamin C or bromelain to enhance absorption	Often taken in liposomal form to improve bioavailability
Common Dosage	500-1000 mg daily	100-500 mg daily
Side Effects	Generally well-tolerated; possible headache, tingling, nausea at high doses	Generally well-tolerated; fewer reported side effects

Quercetin’s Primary Health Benefits

Quercetin’s antioxidant, anti-inflammatory, allergy-relieving, and immune-supporting properties have made it a popular supplement.

1. Antioxidant Defense and Anti-Inflammatory Action

Quercetin acts as a strong antioxidant, defending your cells against damage from unstable molecules called free radicals.¹ This reduction in oxidative stress is crucial for important parts of your cells:

DNA: Your genetic blueprint

Proteins: The building blocks and workers within cells

Mitochondria: The cell’s power generators; damage here can speed up aging

Quercetin also has powerful anti-inflammatory effects. Research highlighted in journals like Biomolecules shows that it works deep within cells to:

Inhibit key inflammatory enzymes: Blocking the molecules that kickstart the inflammation process

Reduce pro-inflammatory cytokines: Lowering the levels of chemical messengers that signal and spread inflammation²

2. Natural Allergy Relief

Quercetin works as a natural antihistamine by:

Stabilizing mast cells that normally release histamine during allergies

Reducing common symptoms like itchy eyes and stuffy nose

Controlling inflammation without causing drowsiness

Research published in Allergy, Asthma & Clinical Immunology found that quercetin helps manage allergy symptoms by changing how the body responds to triggers, unlike conventional antihistamines that often make you sleepy.³

3. Heart Health

Research shows quercetin supports your heart through these mechanisms:

Blood vessel support: Improves how your blood vessels function and helps them relax, which supports normal blood pressure⁴

Cholesterol protection: Reduces oxidation of LDL cholesterol, addressing a major factor in artery blockage⁵

Improved circulation: Helps prevent excessive blood platelet sticking, promoting better blood flow without some of the drawbacks of conventional medications⁶

Fisetin’s Benefits for Longevity

Strawberry fruit on brown wooden surface

Fisetin supplements stand out due to targeted effects on key cellular processes associated with aging.

1. Senolytic Properties

Fisetin is a notable longevity supplement for its powerful senolytic action. This means it helps your body get rid of old, non-functioning cells often called “zombie cells.”

What are zombie cells? These are aged cells that have stopped dividing but haven’t died off

Why are they bad? They release inflammatory compounds that can harm healthy cells nearby

Fisetin’s Role: Research, including a study in eBioMedicine, found that fisetin is very effective at clearing out these troublesome senescent cells compared to many other natural compounds, helping address a key part of the aging process⁷

2. Support for Cognitive Health

Fisetin stands out because it readily passes through the blood-brain barrier, delivering neuroprotective benefits directly to brain tissue – something many supplements can’t do.⁸ A study in Neurochemistry International highlighted this effectiveness.

Key brain-supporting functions of fisetin include:

Direct neuroprotection: Acts inside the brain to safeguard neurons

Combats oxidative damage: Helps defend brain cells against harmful oxidative stress

Boosts mitochondrial health: Supports the energy production centers within brain cells

Maintains neuroplasticity: Helps preserve the brain’s ability to rewire itself and form new neural pathways

Disrupts harmful protein aggregation: Helps prevent the accumulation of tangled tau proteins – a hallmark of many neurodegenerative conditions.⁹

Together, these properties contribute to fisetin’s role in cognitive support and protecting against age-related mental decline.

3. Anti-Aging Effects

Fisetin is gaining attention for its potential role in promoting a longer healthspan – the period of life spent in good health. It appears to achieve this by impacting the biology of aging in several ways:

Promoting autophagy: Helping your cells perform essential “housekeeping” by recycling old or damaged components¹⁰

Balancing cell signals: Influencing the activity of pathways like mTOR (related to growth) and AMPK (related to energy sensing)

Calming inflammation: Working to decrease persistent, low-grade inflammation that contributes to the aging process

These effects on the core processes of aging make fisetin a top contender for anyone looking to age well.

Combined Benefits of Quercetin and Fisetin

While Quercetin and Fisetin are beneficial on their own, they might pack an even bigger punch when working as a team.

Here’s a quick look at their combined power:

Stronger Antioxidant Protection: Provides increased anti-inflammatory and antioxidant action, fighting the damaging oxidative stress linked to many chronic diseases.¹¹

Cancer Research Synergy: Studies suggest a potentially greater effect when combined in slowing the growth and spread of specific cancer cells (like breast cancer). Animal research also shows promise for shrinking tumors.¹²

Nerve Pain Medication Support: May improve the effectiveness of certain drugs for neuropathic pain (like pregabalin), potentially allowing patients to use lower doses.¹³

Combined Antiviral Effects: The combination shows potential for working together to inhibit certain viruses (e.g., dengue virus) and decrease related inflammation.¹⁴

Think of them as a dynamic duo. Working in tandem, Quercetin and Fisetin show potential for amplified health benefits in several key areas.

SenoAid Senolytic Supplement Complex promotional image

Quercetin vs. Fisetin: Which Flavonoid is Better?

Rather than seeing quercetin and fisetin as rivals, think of them as flavonoids that work well together.

Quercetin stands out for its strong anti-inflammatory properties and is generally more easily absorbed by the body than similar compounds. It helps protect cells and is found in common foods like onions and apples.

Fisetin excels at targeting senescent cells (aging cells), which is especially important for brain health.

Instead of choosing one over the other, using both may be most effective. Together, they can address multiple aspects of aging.

Infographic showing the differences between Quercetin vs. Fisetin

Should You Take Fisetin and Quercetin Together?

Combining fisetin and quercetin is backed by research that shows they work better together than alone.

Studies indicate this pair more effectively fights major aging factors like senescent cells, inflammation, and oxidative stress. Together, they have a stronger impact on cell health.

Jinfiniti’s Senolytic Supplement Complex SenoAid™ is formulated based on this synergy. It includes carefully selected doses of both fisetin and quercetin.

To optimize their potential, the formula also incorporates bromelain, green tea extract, and piperine, ingredients known to support the absorption and bioavailability of flavonoids.

This aligns with Jinfiniti’s focus on creating evidence-based supplements for measurable health outcomes.

Recommended Dosages

Woman taking quercetin supplements with a glass of water

The right dosages for fisetin and quercetin depend on your goals and individual health needs.

Quercetin Dosage Guidelines

For general health, quercetin is usually safe in doses up to 1,000mg daily for up to 12 weeks.¹⁵

How well your body absorbs quercetin depends on the form used, with the dihydrate form showing the best bioavailability, followed by glycosides, aglycone, and rutinoside forms.

Fisetin Dosage Guidelines

For fisetin, a typical daily dose for general wellness is 100–500mg, based on human studies.¹⁶

But for senolytic (anti-aging) benefits, intermittent “pulse” dosing is recommended—around 1,400mg (20mg per kg of body weight) taken 1–2 times a month.¹⁷

This approach is thought to work better at clearing senescent cells without continuous dosing.

Combined Supplementation

Jinfiniti’s SenoAid™ supplement combines the two flavonoids in just the right amounts to maximize their benefits. The formula makes it easy to get the right doses without any extra hassle.

Understanding Side Effects and Safety Profiles

Both quercetin and fisetin are generally safe for most people, but there are a few precautions to keep in mind.

For quercetin, it’s considered safe for short-term use, with studies showing minimal side effects at doses up to 1 gram daily for 12 weeks.¹⁸

However, long-term safety at higher doses isn’t fully established. Some things to watch out for:

Pregnancy and breastfeeding: Prenatal exposure to quercetin may impact fetal iron metabolism, so it’s best to avoid quercetin during these times.¹⁹

Kidney conditions: If you have kidney disease, quercetin could make things worse, so avoid it.

Medication interactions: Quercetin may interact with antibiotics (like quinolones) and immunosuppressants, potentially altering their effects.

As for fisetin, while animal studies show promise, there are fewer human trials, so we don’t know as much about its long-term safety.

A few things to note:

Bioavailability: Fisetin doesn’t absorb well on its own, but taking it with fats can help boost absorption.²⁰
Special populations: Pregnant or breastfeeding women, and children, should be cautious due to limited research on these groups.

As with any supplement, it’s always smart to check with a healthcare provider, especially if you have health conditions or are on medication.

The Future of Senolytic Research

Research on quercetin and fisetin is advancing quickly with several promising directions.

AI tools like the Segment Anything Model now provide more accurate data on quercetin’s role in healing diabetic wounds.²¹

Current studies explore these compounds’ effects on DNA methylation, epigenetic age, and immune cell function.

Researchers are solving bioavailability problems through innovative delivery systems. These include quercetin-rosemary oil nanoemulsions for wound healing and photothermal nanodrugs for cancer treatment.²²

Scientists are also studying how these flavonoids interact with other compounds to enhance their anti-aging and disease-fighting potential.

With all the progress in quercetin and fisetin research, it’s clear these compounds could help us age gracefully and improve our health, offering a hopeful outlook for the future.

Referenced Sources:

An image of a woman consulting a doctor for weight loss

A Guide to NMN and Weight Loss

Written by Jinfiniti Science on April 11, 2025. Posted in NMN. No Comments on A Guide to NMN and Weight Loss

Having trouble losing weight despite eating well and exercising? Your age-related metabolism changes might be the reason, not your habits.

As people get older, their nicotinamide adenine dinucleotide (NAD+) levels naturally decline. This reduces how efficiently cells convert food into energy. The slowdown in metabolism makes burning fat more challenging, even with careful eating and regular exercise.

NMN (nicotinamide mononucleotide) functions as a direct precursor to NAD+. It helps enhance the energy production in cells and supports healthy metabolism.

This guide examines the science behind NMN’s weight loss benefits, exploring how it can complement your weight management strategy when conventional approaches fall short.

Key Takeaways

NAD+ decline slows metabolism with age. By 50, NAD+ levels drop significantly, making it harder to burn fat and maintain a healthy weight.
NMN supports metabolism on multiple levels. It boosts mitochondrial function, enhances fat burning through SIRT1 activation, improves insulin sensitivity, and may help regulate appetite.
A well-rounded approach delivers the best results. Pairing NMN with a nutrient-dense diet, strength training, good sleep, and stress management maximizes its benefits for long-term metabolic health.

What Is NMN and Why Does It Matter?

NMN (nicotinamide mononucleotide) is a molecule found naturally within human cells and in some foods. Its primary role is creating NAD+, the essential coenzyme that powers cellular energy production throughout the body.

Here’s the challenge: NAD+ levels naturally decline with age.¹ By the time a person reaches 50, they typically have less than half the NAD+ they had in their youth.

This decline disrupts metabolism, leading to:

Slower energy production

Reduced fat burning efficiency

Unfavorable changes in body composition

NAD+ helps manage weight as people age by keeping cellular functions operating efficiently. It assists the body in processing nutrients, burning fat, and maintaining energy balance.

As a direct precursor to NAD+, NMN helps replenish declining NAD+ levels. Unlike other precursors, it skips unnecessary conversion steps, making it one of the most effective ways to boost NAD+ inside your cells.²

For an in-depth exploration, check out our complete guide to NMN.

Can NMN Really Help You Lose Weight?

Research indicates NMN may support weight management. Harvard researchers found overweight participants taking 2,000 mg of NMN daily for one month lost an average of 4 pounds.³

The body converts NMN into NAD+, which then activates proteins called sirtuins. These proteins control metabolism and energy usage, potentially helping the body burn calories more effectively.

While NMN isn’t a quick fix for weight loss, it may influence key cellular processes that affect body composition by increasing NAD+ levels and restoring metabolic function.

How Does NMN Support Weight Loss?

NMN works on your cellular powerhouses called mitochondria. Higher NAD+ levels make these energy factories more efficient, which can increase calorie burning even when you are resting.⁴

SIRT1, a key metabolic protein, gets switched on by NMN.⁵ This protein basically tells your body “burn fat, don’t store it,” helping shrink both the dangerous fat around your organs and the stubborn fat under your skin.⁶

NMN also helps with insulin sensitivity. This means cells respond better to insulin, preventing extra glucose from being stored as fat and keeping blood sugar stable.⁷

Another benefit is that NMN can activate brown fat.⁸ Unlike white fat that stores energy, brown fat burns calories to create heat, increasing overall calorie burning and speeding up metabolism.

Even your brain’s hunger control center—the hypothalamus—needs NAD+ to function.⁹ By supporting healthy NAD+ levels, NMN helps normalize those hunger signals so you’re less likely to overeat.

What Does the Research Say About NMN?

Research suggests that NMN may help with weight management by affecting metabolism, energy balance, and body composition.

What Have Animal Studies Shown?

Animal studies consistently show NMN supports metabolism and weight management.

In a Scientific Reports study, mice given NMN had less fat and burned more energy.¹⁰ Even as they aged, these mice maintained healthier bodies with better insulin sensitivity and blood sugar control.

A study in IUBMB Life examined obese mice given NMN. These mice gained less weight and fat while showing improved glucose processing.¹¹ NMN also increased fat-burning genes, helping mice use fat for energy more efficiently.

These studies suggest NMN may help fight the metabolic slowdown caused by aging and obesity by improving mitochondrial function.

What Did the Harvard Study Actually Find?

A 2023 Harvard study revealed promising results when 21 overweight adults took 2,000 mg of NMN daily for 28 days.

The results were significant. Participants lost an average of 4.2 pounds without changing diet or exercise. They also showed improved insulin sensitivity and smaller waists, suggesting NMN supports multiple aspects of metabolic health.¹²

This study confirms previous animal research findings, though its small scale is notable. Future research with larger groups over longer periods will help confirm these effects and identify optimal dosages.

Benefits of NMN Supplementation Beyond Weight Loss

An image of a woman on a weight loss journey

The benefits of NMN supplementation go beyond just helping you lose weight. By boosting NAD+ levels, it supports many vital bodily processes for better overall health:

Heart Health: Lowers bad cholesterol, improves blood flow, reduces arterial stiffness, and fights inflammation that contributes to heart disease¹³

Inflammation Reduction: Activates SIRT1 to fight chronic inflammation, reducing harmful cytokines and improving insulin sensitivity¹⁴

Liver Support: Reduces fat buildup, helping prevent fatty liver disease and supporting better blood sugar control¹⁵

Healthy Aging: Enhances DNA repair, cellular stress resistance, and protein maintenance, helping prevent metabolic disorders as you age¹⁶

NMN Supplement Dosage for Weight Management

Finding the right NMN dosage for weight management is still evolving, but here’s what we know:

Most supplements offer 250-1,000mg per serving, shown to be safe and effective for energy and body composition¹⁷

Higher doses generally mean stronger effects, but with diminishing returns beyond certain levels

Your ideal dose depends on age, metabolic health, and lifestyle—older adults may need more than active younger people

Start with 250-500mg daily and increase gradually while monitoring your response—some see results at 1,000mg, while others may benefit from up to 2,000mg

Fitting NMN into a Complete Weight Management Plan

NMN works best as part of a comprehensive approach to weight management. Here’s how to integrate it effectively:

Healthy Diet: Pair NMN with low-inflammatory eating patterns like the Mediterranean diet and consider intermittent fasting, which naturally boosts NAD+ levels

Exercise: Physical activity increases NAD+ while NMN improves mitochondrial function, enhancing endurance, recovery, and fat burning—prioritize strength training to maintain metabolism-boosting muscle

Quality Sleep: Aim for 7-8 hours nightly, as poor sleep disrupts metabolism and increases inflammation, both processes that NMN helps regulate

Stress Management: Practice meditation, deep breathing, or daily walks to lower cortisol, which depletes NAD+ and promotes fat storage

Always consult your healthcare provider before adding NMN to your routine, especially if you take medications or have health conditions.

Takeaway: Is NMN Right for Your Weight Loss Journey?

NMN offers a scientific approach to weight management through its effects on cellular metabolism, addressing factors that diet and exercise alone might miss. While research shows promise, more comprehensive studies are needed to understand its effectiveness across different populations.

Before starting NMN, think about your overall health. If you have conditions like diabetes or heart disease, talk to your doctor first to make sure NMN is safe for you.

The quality of NMN supplements also matters. Choosing a high-purity option like Jinfiniti’s Pure NMN Powder can improve how well your body absorbs and uses it. Look for products with third-party testing and purity certifications.

Additionally, testing your NAD+ levels before and during supplementation shows whether NMN is working for you.

The Intracellular NAD Test can identify deficiencies and help you optimize your levels. Since NAD+ production changes based on age, lifestyle, and health, tracking these levels helps you adjust your dosage for best results.

NMN is an investment in long-term health. It can benefit metabolism, energy, and aging, but consider if ongoing supplementation fits your health goals and budget.

If you want a science-based, long-term approach to support your weight goals, NMN could be worth trying as part of a complete, healthy lifestyle.