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The Crucial Role of Optimizing NAD in Treating, & Reversing Long Covid

Long Covid has emerged as a significant health concern for individuals who have recovered from the acute phase of Covid-19 but continue to experience debilitating symptoms. While the exact mechanisms behind Long Covid are not yet fully understood, scientists and researchers have been investigating various potential treatments. One avenue of investigation is the role of NAD+ in managing Long Covid.

What is Long Covid?

Long Covid, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), refers to a condition where individuals experience persistent symptoms after recovering from the initial phase of COVID-19. These symptoms can include fatigue, shortness of breath, cognitive impairment, and joint pain, among others. The duration of Long Covid can vary from a few weeks to several months, significantly impacting individuals’ quality of life.

Long Covid is a complex and multifaceted condition that continues to puzzle medical professionals and researchers alike. The long-lasting effects of the virus on the body can manifest in various ways, making it challenging to pinpoint a specific set of symptoms that define Long Covid. However, understanding the symptoms and impact of this condition is crucial in providing appropriate care and support to those affected.

Symptoms and Impact of Long Covid

The symptoms of Long Covid can be diverse and affect multiple organ systems. While fatigue is the most commonly reported symptom, individuals with Long Covid may also experience neurological symptoms such as brain fog and difficulties with memory and concentration. These cognitive impairments can be frustrating and debilitating, affecting individuals’ ability to perform daily tasks and engage in work or social activities.

Respiratory symptoms like persistent cough and shortness of breath are also frequently reported among Long Covid patients. These symptoms can persist long after the initial infection has resolved, making it difficult for individuals to regain their pre-COVID level of physical activity and overall well-being. The constant feeling of breathlessness can be distressing and limit an individual’s ability to exercise or perform simple tasks.

In addition to cognitive and respiratory symptoms, individuals with Long Covid may experience musculoskeletal symptoms, such as joint and muscle pain. These symptoms can be persistent and affect mobility, making it challenging for individuals to engage in physical activities they once enjoyed. Furthermore, Long Covid can also present cardiovascular symptoms like heart palpitations, adding another layer of complexity to the condition.

Long Covid can profoundly impact individuals’ lives, preventing them from returning to work, participating in daily activities, and maintaining relationships. The lingering symptoms can lead to a decreased quality of life and mental health issues, including depression and anxiety. The frustration and uncertainty surrounding Long Covid can also contribute to feelings of isolation and helplessness.

Prevalence and Demographics of Long Covid

The prevalence of Long Covid varies, with estimates ranging from 10% to 80% of people who have had Covid-19. This wide range can be attributed to various factors, including the severity of the initial infection, age, underlying health conditions, and vaccination status. While Long Covid is more commonly observed in individuals who had severe initial infections, it can also affect those with mild or even asymptomatic cases of Covid-19.

Long Covid does not discriminate and can affect individuals of all ages, genders, and ethnic backgrounds. It is not limited to a specific demographic group, highlighting the need for comprehensive research and support for all those affected. The long-term consequences of Long Covid on individuals’ physical and mental well-being emphasize the importance of early detection, proper management, and ongoing care.

Further research is necessary to identify risk factors and potential treatments for Long Covid. The medical community is actively investigating the underlying mechanisms of this condition, exploring potential therapies, and developing strategies to support individuals on their journey to recovery.

An Overview of NAD+

NAD+”…also helps enzymes that repair DNA and prevent damage to our cells.” Kathryn Piper, Registered Dietician/Nutritionist

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the body that plays a crucial role in various biological processes. It is involved in energy production, DNA repair, cellular signaling, and regulation of gene expression. NAD+ levels naturally decline with age, and this decline has been associated with various age-related conditions.

The Biological Role of NAD+

NAD+ is a key player in cellular energy metabolism. It is involved in the conversion of nutrients into adenosine triphosphate (ATP), the primary fuel for cellular processes. NAD+ also functions as a cofactor for enzymes involved in DNA repair, assisting in maintaining genomic integrity. Furthermore, NAD+ is involved in regulating cellular processes related to aging, inflammation, and stress response.

One fascinating aspect of NAD+ is its ability to modulate the activity of sirtuins, a class of proteins that have been linked to longevity and healthspan. Sirtuins require NAD+ as a cofactor to carry out their enzymatic activities, and their function is thought to be influenced by NAD+ availability. These proteins play diverse roles in regulating cellular metabolism, aging, and stress response. By interacting with sirtuins, NAD+ can have a profound impact on cellular health and homeostasis.

Research has shown that NAD+ levels can be influenced by various factors, including diet, exercise, and certain molecules like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). Strategies that boost intracellular NAD+ levels have gained attention for their potential role in promoting health and disease prevention.

Turn to NAD instead of the normal medicines to treat Long Covid

NAD+ and Cellular Health

NAD+ is essential for maintaining cellular health and homeostasis. It plays a pivotal role in cellular processes such as DNA repair, mitochondrial function, and cellular defense mechanisms. By supporting these critical processes, NAD+ can help optimize cellular function and protect against various stresses.

Furthermore, NAD+ has been implicated in the regulation of cellular aging. As we age, NAD+ levels naturally decline, leading to a decline in cellular function and an increased susceptibility to age-related conditions. By replenishing NAD+ levels, it may be possible to slow down the aging process and promote healthier aging.

Emerging research has also suggested a potential link between NAD+ and Long Covid, a condition characterized by persistent symptoms following a Covid-19 infection. It is hypothesized that NAD+ supplementation could help alleviate some of the symptoms associated with Long Covid by supporting cellular function and promoting recovery.

In conclusion, NAD+ is a vital coenzyme that plays a crucial role in various biological processes. Its involvement in energy production, DNA repair, cellular signaling, and regulation of gene expression highlights its significance in maintaining cellular health and homeostasis. Understanding the intricate mechanisms by which NAD+ influences cellular processes opens up exciting possibilities for therapeutic interventions and disease prevention.

The Connection Between NAD+ and Long Covid

Emerging evidence suggests that NAD+ may play a crucial role in the management of Long Covid. Several mechanisms have been proposed to explain this connection. Long Covid, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), refers to the persistent symptoms experienced by some individuals even after recovering from the acute phase of COVID-19. These symptoms can include fatigue, brain fog, shortness of breath, and muscle weakness, among others. Understanding the underlying mechanisms of Long Covid is essential for developing effective treatments.

The Impact of NAD+ on Immune Response

The immune system plays a vital role in combating viral infections, including SARS-CoV-2. NAD+ has been shown to influence immune cell function and response. It can regulate the production of pro-inflammatory cytokines, which are involved in the immune response to viral infections. By modulating immune cell activity, NAD+ may help optimize immune response and reduce the severity and duration of Long Covid symptoms.

Moreover, NAD+ is involved in the repair and maintenance of DNA, which is crucial for the proper functioning of immune cells. Adequate levels of NAD+ can support the immune system’s ability to recognize and eliminate viral particles, preventing the persistence of the virus and the subsequent development of Long Covid symptoms.

NAD+ and Viral Infections

Research has indicated that NAD+ may have antiviral properties and can enhance the immune response against viral infections. NAD+ can activate various cellular defense mechanisms, including the production of antiviral proteins and enhancing the activity of natural killer cells. These effects suggest that boosting NAD+ levels may support the body’s ability to fight viral infections, including the persistent nature of Long Covid.

In addition to its direct antiviral effects, NAD+ also plays a role in mitochondrial function. Mitochondria are the powerhouses of cells and are responsible for generating energy. Viral infections, including SARS-CoV-2, can disrupt mitochondrial function, leading to cellular dysfunction and the persistence of symptoms. NAD+ supplementation has been shown to improve mitochondrial function and restore cellular energy production, potentially alleviating the symptoms of Long Covid.

Furthermore, NAD+ is involved in the regulation of inflammation, a key component of the immune response. Excessive inflammation can contribute to tissue damage and the development of chronic conditions. By modulating the inflammatory response, NAD+ may help prevent the long-term consequences of COVID-19, reducing the risk of developing Long Covid.

Overall, the connection between NAD+ and Long Covid is an area of active research. 

Understanding the role of NAD+ in immune response, viral infections, and mitochondrial function can provide valuable insights into potential therapeutic strategies for managing Long Covid. Further studies are needed to elucidate the precise mechanisms involved and to determine the optimal approaches for NAD+ supplementation in Long Covid patients.

Potential Benefits of NAD+ for Long Covid Patients

The potential benefits of NAD+ supplementation for Long Covid patients are being explored in clinical and preclinical studies.

Improving Energy Levels and Reducing Fatigue

Fatigue is one of the most common and debilitating symptoms of Long Covid. NAD+ plays a vital role in cellular energy production, and its decline with age or illness can contribute to fatigue and reduced stamina. By replenishing NAD+ levels, it is possible that energy production can be enhanced, leading to improved energy levels and reduced fatigue in Long Covid patients.

Enhancing Cognitive Function

Cognitive impairment, often referred to as “brain fog,” is another prominent symptom of Long Covid. NAD+ is involved in maintaining brain health, supporting neuronal function, and facilitating neurotransmitter synthesis. By optimizing NAD+ levels, cognitive function may be improved, potentially alleviating the cognitive impairments experienced by Long Covid patients.

Current Research and Future Perspectives

Current research is actively investigating the role of NAD+ in managing Long Covid, aiming to provide more insights into its potential benefits and limitations.

Ongoing Studies on NAD+ and Long Covid

Several clinical and preclinical studies are underway to evaluate the efficacy of NAD+ supplementation or NAD+ precursor molecules in managing Long Covid. These studies aim to determine the optimal dosage, treatment duration, and potential side effects of NAD+ interventions in Long Covid patients. The results of these studies have the potential to guide future treatment strategies.

Potential Challenges and Limitations

While NAD+ shows promise in managing Long Covid, some challenges and limitations need to be addressed. The optimal dosage and treatment duration have yet to be determined, and the long-term effects of NAD+ supplementation are not fully understood. Additionally, further research is needed to identify potential interactions with other medications and treatments commonly used in Long Covid management.


In conclusion, understanding the role of NAD+ in managing Long Covid is a relevant and promising avenue of research. NAD+ plays a crucial role in cellular health, mitochondrial function, immune response, and energy production. Its potential benefits in managing Long Covid, such as improving energy levels, reducing fatigue, and enhancing cognitive function, make it an intriguing area of exploration. Raise your NAD levels and improve energy and performance with Accuri® Vitality Boost

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Why Optimized, Precision Medicine is the Future
  2. Andrew Huberman is Wrong About NAD, NMN & Longevity
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. What Does Peak Performance Look Like? 

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order)

NAD Optimization: Real People, Real Results

Over the last 30 days we’ve received amazing messages, reviews, and conversations with customers over text, social media, email and comments added to our website from real customers. In their words,  and for a variety of health conditions, here’s what people are saying about how it feels to be NAD optimized.


“Just minutes ago, I was standing at my kitchen counter and could barely hold my head up. After two scoops of Vitality Boost, I was online looking at tile at Home Depot and about to bolt out the door. Wildest thing.”

-Kathyrn, best selling author, mom, and speaker who was two days into having Covid at the time.

Parkinson’s Disease

“I’m extremely happy with my latest nad test done January 18. Current levels are 58.9
Here is the progress starting with April 16, 2022: 24.9, 23.4, 34, 33.6, 42, 58.9

Your nmn and testing works. Even with Parkinson’s my energy levels are good.”

-David, retired professor and noted health expert.

Running and Exercise

“I recently purchased the Vitality Boost in October of 2023 and have used it since…I didn’t know that it could increase energy and improve performance, and being in the Military while on deployment has given me that extra boost to get me through my long days. 

…This product couldn’t have come at a better time since I was preparing for the Athens Marathon in Greece on November 12th, 2023. I finished 608th of 21,598, averaging a pace of 7:30 seconds for a distance of 26.2 miles. For proof, check out my Instagram @ _mas_oficial, which shows my race results! This was my first marathon, and being a 31-year-old male, I felt like I was in my early 20s. I feel more energized and focused throughout the day while in the field. Regarding gym exercise, I’ve been improving my bench, squat, and deadlift.” 

—Emmanuel C. 

Chasing Kids

“I’m almost done with my first jar and I can’t believe how my energy levels have improved. I’m finding myself smiling more often and feeling overall much more relaxed. My boyfriend’s nieces and nephew roped me into playing a basketball game with them over Christmas and despite having done no cardio or regular workout sessions for a few years now, I had plenty of energy even after running back and forth across the gym for probably a solid half hour before the kids finally got bored. The energy improvement is very tangible. The mood improvement is subtle but still noteworthy”

—Emily P. 

Walking, Stamina, Drive

“I have used other NAD products but at 75 years old, I was still testing just low normal, and not feeling able to complete my normal day and workouts with vigor. After six weeks using Jinfiniti’s Accuri Vitality Boost I am back living like I was 25 years ago… 5 -10 mile hikes, full days of meetings and studying… and having fun again!. My wife is also back to our expected normal activity levels…” thank you Dr. She from both of us! “

—Bruce Ross

Anxiety & Mental Health

“I felt like my brain was broken. I was so tired. I battled high levels of anxiety, having panic attacks three times a week, I felt fatigued all the time and needed 400 mg of caffeine and 2 naps per day just to function. It felt like a single setback could slide me off the cliff.

Initially, I did a big round of NAD IV, which was $4000, but I was desperate. It gave me a lot of energy and mental lift, but it wasn’t sustainable. A few months later, I was feeling the same. And then I discovered Jinfiniti. My NAD levels were sorely deficient. 

Within several months of taking the Vitality Boost, my energy is much higher, my mental health and anxiety is so much better, and I’ve even lost some of the unwanted stubborn weight that wouldn’t go away. And my NAD levels are now optimal at 55.4 thanks to Vitality Boost.

My husband and I feel we have our lives back and I know Jinfinti’s been a huge part of that.”

—Sarah W., one of our monthly subscribers of Vitality Boost.

Mental Clarity, Postpartum, Recovery

“After Dante was born, I still regularly experienced higher than normal levels of fatigue (like my cells were tired). I didn’t wake up as energized as I used to and my recovery wasn’t as good after a workout. I had some lingering brain fog and lack of mental clarity. Metabolism seemed to be lower. 

After two weeks of taking Vitality Boost, my brain fog has lifted, my metabolism is coming back and I’ve even felt some of that postpartum baby fat shedding faster. I feel better, happier, and more alert when I wake up. I am bouncing back faster and better from workouts. I am back to myself, which feels amazing.”

—Dr. Jennifer Fraboni (Doc Jen)

Severe Fatigue

“Over the last year, I started experiencing really debilitating fatigue in the afternoon. About six months ago, I did the NAD test and got shockingly low results coming in deficient. I’m perfectly healthy. I don’t have any diagnosed medical conditions. I exercise regularly, I eat well, and I’m not overweight. 

I was so appalled and determined to start taking the supplements regularly. 

Two weeks into taking the NAD supplement, the fatigue disappeared. I was absolutely astonished. I’m not going to stop taking the supplements to see if the fatigue comes back. I’d recommend the Vitality boost to anyone who needs extra energy.”

—Dr. James Goodwin, Director of Brain Health Network, London, UK.


“I have been using the supplement for the last 2 months. During this time I have increased my movement and feel strong and energized over the whole day. I’m a full time working mum and love all kinds of exercise. The best thing is the even energy all day so I can train/exercise/move whenever.”

—Louise N.

Overall Vitality

When my friend gifted me Vitality Boost I was skeptical however this skepticism has turned into gratitude for Jinfiniti. Vitality Boost has exceeded my expectations as a comprehensive wellness supplement. The promised benefits of increased energy, enhanced performance, improved sleep quality, and reduced inflammation have been noticeable in my daily life. 

I’ve experienced a significant reduction in muscle and joint pains, and the positive impact on allergic and asthmatic symptoms is truly remarkable. The supplement’s influence on mental clarity and dementia symptoms adds an extra layer of appeal. The promise of improved health functions, including the liver, kidney, heart, and thyroid, provides a sense of overall well-being. Vitality Boost lives up to its claims, making it a valuable addition to my wellness routine.”

—Shannon O.

Research news: NAD is showing significant promise in treatment neurodegenerative diseases, traumatic brain injury, diabetes, stroke and other health challenges from this research paper

“The preservation of cognitive ability by increasing nicotinamide adenine dinucleotide(NAD+) levels through supplementation with NAD+precursors has been identified as a promising treatment strategy for a number of conditions; principally, age-related cognitive decline (includingAlzheimer’s disease and vascular dementia), but also diabetes, stroke, and traumatic brain injury.”

Reading these reviews warms our hearts and reignites our passion for what we’re doing here at Jinfiniti with our groundbreaking NAD tests, biomarker panels and Vitality Boost (which we back with a 60-day Money Back Guarantee).

Do you have results to share? You can leave us a review by going to the product page here, scrolling down and clicking the “Write a review button.”

We’re always thrilled to hear how Jinfiniti has helped you optimize your life or any questions you may have.


-Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts with NAD+ and it’s Precursors to Prevent Cognitive Decline across Disease Context

-Importance of NAD Anabolism in Metabolic, Cardiovascular, and Neurodegenerative Disorders.”

Six Warning Signs of Low NAD

There are six warning signs of low NAD levels that that can help you know when you need to optimize. These signs are often the prerequisite to more serious diseases, but fortunately there are simple ways to treat them all.

Do you have any of these? 

1. Fatigue

Every day we hear from our customers about this common health complaint. Just this week, one of our customers in Europe told us that when he began taking our Accuri® Vitality Boost, he didn’t notice much at first.

He’d been battling extremely difficult fatigue for awhile. And although nothing changed at first, after just two weeks without changing anything else about his lifestyle or health habits, the fatigue went away. It simply evaporated. 

Here at Jinfiniti, we would think this an aberration if it wasn’t something we hear all the time

One of our recent case studies, Dr. Dominic Fraboni, whom I spoke with on the podcast, The Optimal Body, was already very healthy and fit, but after adjusting to life with a newborn, lack of sleep and plummets in his energy and stamina, he was more than ready for a drastic change. 

After taking Accuri® Vitality Boost for just seventeen days, Dr. Fraboni tripled his NAD levels and noticed a massive difference in his energy levels and stamina. 

2. Muscle Soreness 

If you’ve struggled with low cellular-level energy for a long time, you’ve probably struggled with fatigue. The good news is that you can gain back muscle recovery that you had in your twenties. 

NAD is a linchpin in the metabolic machinery, steering the complex dance of energy production and cellular repair. It acts like the conductor of a symphony, directing processes that are crucial for our body’s performance. Emerging research reveals that NAD plays a large role in mitigating muscle soreness and aiding the body to recuperate after strenuous physical activity.

When our levels of NAD decline (due to age, excessive stress or unhealthy habits) the harmonious balance within the cellular symphony is disrupted, leading to a delayed recovery process and, of course, really sore muscles. 

Faster recovery times are another thing Dr. Fraboni (among thousands of our other customers) noticed after taking Accuri® Vitality Boost

3. Low Stamina

When our NAD levels wane, the energy stores within our cells face a shortage, and that leaves us lacking the endurance we probably took for granted during our youth when our NAD levels were likely higher. 

NAD is essential for converting the food we consume into the energy our cells need to perform everything from the beating of our hearts to the movement of our muscles. Low NAD levels disrupt this energy equilibrium, leaving us feeling drained and sapping our stamina. 

Low NAD levels are like running on an almost-empty gas tank with the engine sputtering and struggling to keep up with the demands of a fast-paced world. 

This is one reason NAD just might hold the key to unlocking a future where stamina never declines even though our age increases. 

4. Unwanted Weight Gain 

When we have fat in places that we just can’t shake, it’s because our metabolisms are suffering. But it turns out that maintaining optimal intracellular NAD levels might be the key to tipping the scales in our favor. 

NAD acts as a coenzyme in pivotal processes like glycolysis and oxidative phosphorylation—which are fancy descriptions for processes that essentially convert nutrients into usable energy. Intracellular NAD levels are the thing that influence how efficiently this energy is produced and utilized. When our NAD levels fall, metabolic pathways become less efficient, which can lead to a decreased ability to burn calories, and thus, an excess storage of fat. 

Although we don’t guarantee weight loss, many of our customers have experienced weight loss as a welcome side effect of optimizing their metabolic health with Accuri® Vitality Boost

5. Brain Fog/ Long Covid 

NAD operates as a neurotransmitter in the brain. This may be why recent studies suggest that NAD depletion could be a key contributor to brain fog—a symptom that has lately been attributed to a number of health concerns, including the debilitating illness of long Covid. Mitochondrial decline within brain cells leads to lower communication between neurons as well as lower energy production. This simply means that if your NAD levels are low, you could experience symptoms under the label of “Brain Fog”—which includes, but isn’t limited to: memory recall, attention span, and mental fatigue.

Optimizing our NAD levels is a promising strategy for not only combating brain fog, but also for promoting long-term brain health and vitality even as we age. 

6. Poor Sleep Quality 

In addition to energy metabolism, NAD plays a multifaceted role in the regulation of our sleep-wake cycles. It’s a critical cofactor in the production of ATP (adenosine triphosphate), the molecule that fuels our cells, as well as sirtuins, including those related to sleep regulation. Optimal NAD levels ensure that we enjoy well-functioning circadian rhythms, which recycle into a restored physical system. 

On the flip side, however, chronic sleep deprivation or poor sleep quality is a cyclical issue that leads to further depletion of NAD reserves. With declining NAD levels, energy production within cells further falters, affecting stamina and hindering the body’s ability to rejuvenate and repair. 

But the good news is that we’ve discovered that by optimizing our NAD levels, we’re able to bolster sleep quality and interrupt the cycle of depletion. As a matter of fact, improved sleep is one of the first changes our customers notice once they begin taking our Accuri® Vitality Boost

And we all know the effect a poor night’s sleep versus a good night’s sleep can have on our brains, bodies and daily activities. It could be argued that sleep is the most important ingredient our bodies need in order to repair. 

Are you experiencing any of the signs on this list? 

So have most of us. 

As unpleasant as they might be, these signs serve as reminders when our NAD levels are suffering, and consequently, our entire health system. 

Thankfully, we know from thousands of tests (from everyday people as well as leading scientists, biohackers, MDs and health professionals) that our formula will optimize, not just improve, intracellular NAD for 90% of people alone, which no other NAD supplement can come close to promising.

No other supplement brand on the market offers the ability to take their supplement and test to see if it’s working. 

And that’s because no other brand on the market compares to the efficacy and transparency of Jinfiniti

In fact, we believe in our Accuri® Vitality Boost so much that we back it with a 60-day Money Back and Efficacy Guarantee.

Try it for yourself to experience how good you can feel. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Why Optimized, Precision Medicine is the Future
  2. Andrew Huberman is Wrong About NAD, NMN & Longevity
  3. What Does Peak Performance Look Like? 
  4. 9 Powerful Benefits of Optimizing Your NAD

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).