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7 Common Symptoms of Autoimmune Diseases You Shouldn’t Ignore

NAD for autoimmune diseases

Do you struggle with an autoimmune disease that affects your health and daily life?

Autoimmune diseases are more common than you might think.

In fact, approximately 8% of people in the United States are diagnosed with autoimmune diseases, affecting virtually any part of their body, from the joints and skin to the organs and nervous system.

78% of autoimmune disease sufferers are women, especially during their childbearing years. 

While the precise reasons for this gender imbalance remain unclear, researchers suggest that sex hormones may influence the development and progression of these conditions. 

What is evident is that the immune system is behaving abnormally, deviating from its usual function.

The Immune System

The immune system is a complex network of cells and chemicals that work together to protect the body from harmful invaders such as bacteria, viruses, and other pathogens. 

Under normal circumstances, the immune system can distinguish between foreign substances and the body’s cells, launching an attack only when necessary to maintain health.

However, in the case of autoimmune diseases, this delicate balance is disrupted. 

The immune system mistakenly identifies your tissues and organs as foreign invaders and mounts an attack against them.

This misguided immune response leads to the production of autoantibodies, proteins that target and attack healthy cells, causing inflammation, tissue damage, and a range of symptoms.

Some autoimmune diseases, such as type 1 diabetes, specifically target one organ, while others, like systemic lupus erythematosus (lupus), can affect multiple systems throughout the body.

Despite ongoing research efforts, the exact cause of autoimmune diseases remains unknown. 

However, several factors are believed to contribute to their development, including genetic predisposition, environmental triggers, and lifestyle factors such as smoking and obesity.

Antibodies vs Autoantibodies 

NAD for autoimmune diseases

Antibodies and autoantibodies are critical components of the immune system, but they have distinct roles and functions in the body’s defense against pathogens and its response to autoimmune diseases.

Antibodies, also known as immunoglobulins, are proteins produced by specialized white blood cells called B cells. Their primary function is to recognize and neutralize foreign invaders, such as bacteria, viruses, and other harmful substances known as antigens.

When an antigen enters the body, it triggers B cells to multiply and differentiate into plasma cells. These plasma cells secrete large quantities of antibodies circulating in the bloodstream and other body fluids.

Antibodies specifically target antigens by binding to them, marking them for destruction by other immune cells, or rendering them harmless.

On the other hand, autoantibodies are antibodies that mistakenly target and attack the body’s tissues and cells

Unlike antibodies, which target foreign invaders, autoantibodies target normal proteins in the body’s cells, leading to inflammation, tissue damage, and a range of symptoms.

The presence of autoantibodies in the blood is often used as a diagnostic marker for autoimmune diseases, as it indicates an immune response against the body’s tissues.

Most individuals naturally have low levels of autoantibodies. However, elevated levels often suggest the presence of an autoimmune disease.

Diagnosing an autoimmune disease can be challenging. 

According to Ana-Maria Orbai, M.D., M.H.S., a rheumatologist at the Johns Hopkins Arthritis Center, diagnosing the condition requires a combination of symptoms, specific blood markers, and sometimes even a tissue biopsy.

Speaking of symptoms, below are seven of the common symptoms people with autoimmune diseases experience.

Fatigue

NAD for autoimmune diseases

Fatigue is a common and often debilitating symptom experienced by individuals with autoimmune diseases. 

Unlike normal tiredness, fatigue associated with autoimmune diseases is not relieved by rest and can significantly affect daily life.

People with autoimmune diseases have an overactive immune system resulting in elevated levels of cytokines and increased inflammation, which can contribute to fatigue.

Cytokines are vital proteins that regulate the growth and function of immune system cells and blood cells.

When these proteins are released, they act as signals that prompt the immune system to carry out its functions. 

This includes the regulation of the growth of various blood cells and other cells involved in the body’s immune and inflammatory responses.

In a recent survey conducted by the Autoimmune Association, it showed the profound impact of fatigue on individuals with autoimmune diseases.

Over 1,000 respondents reported that fatigue negatively affects their quality of life, family relationships, mental health, and ability to work and parent.

The constant immune activity in autoimmune diseases can be exhausting, making simple tasks challenging. 

Additionally, fatigue can impair cognitive function, affecting concentration and memory.

The neuroendocrine system, which regulates energy metabolism and stress response, can also be disrupted in autoimmune diseases, contributing to fatigue. 

Sleep disturbances, such as insomnia, are common in autoimmune diseases and can further exacerbate fatigue.

Malabsorption and nutrient deficiencies, which are prevalent in autoimmune diseases, can also contribute to the feeling of extreme tiredness.

Joint Pain and Stiffness

NAD for autoimmune diseases

Joint pain and stiffness are hallmark symptoms of autoimmune diseases, stemming from the immune system’s misdirected attack on the body’s tissues. 

In autoimmune conditions, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), the immune system targets the synovium, a thin membrane lining the joints, leading to inflammation and subsequent pain and stiffness.

As the autoimmune response persists, the inflammation can damage the cartilage and bone within the joint. 

Cartilage, which cushions the ends of bones, can deteriorate, leading to friction between bones and further exacerbating pain and stiffness. 

Additionally, chronic inflammation can promote the formation of osteophytes, or bone spurs, which can impede joint movement and cause additional discomfort.

The nervous system also plays a role in the experience of joint pain and stiffness in autoimmune diseases.

The immune response can disrupt the normal function of nerves in the joints, resulting in heightened sensitivity to pain and altered pain perception. 

That’s why you can experience severe pain if you have autoimmune joint conditions.

Skin Changes

NAD for autoimmune diseases

Skin changes are a common manifestation of autoimmune diseases, reflecting the complex interplay between the immune system and skin cells. 

Autoimmune skin conditions are characterized by an overactive immune response that targets the skin’s cells, resulting in inflammation and the formation of skin lesions. 

These lesions can vary in appearance and severity, ranging from red, scaly patches in psoriasis to butterfly-shaped rashes across the cheeks and nose in lupus.

The mechanisms underlying skin changes in autoimmune diseases are multifactorial.

In psoriasis, for example, immune cells called T cells become overactive, leading to the rapid turnover of skin cells and thick, scaly plaques. 

In lupus, the immune system produces antibodies that target the skin, leading to inflammation and tissue damage.

Skin changes in autoimmune diseases can also be influenced by genetic and environmental factors.

Certain genetic variations can predispose individuals to develop autoimmune skin conditions, while environmental factors such as sunlight exposure and stress can trigger or exacerbate symptoms.

Digestive Issues

NAD for autoimmune diseases

Digestive issues are a common concern for individuals grappling with autoimmune diseases, impacting the gastrointestinal tract and manifesting in a spectrum of symptoms.

These symptoms can include abdominal pain, bloating, diarrhea, constipation, nausea, vomiting, and difficulty swallowing, along with fluctuations in weight.

A variety of autoimmune diseases can affect the digestive system, such as Inflammatory Bowel Disease (IBD), including Crohn’s disease and ulcerative colitis, which cause inflammation along the digestive tract. 

Celiac Disease, triggered by gluten ingestion, damages the small intestine.

Autoimmune Hepatitis targets liver cells, leading to inflammation and damage.

Primary Biliary Cholangitis (PBC) and Primary Sclerosing Cholangitis (PSC) are chronic autoimmune conditions affecting the bile ducts in the liver.

The immune system’s assault on the gastrointestinal tract underpins these digestive symptoms, resulting in inflammation, tissue harm, and functional impairment. 

Several mechanisms contribute to these symptoms:

Chronic inflammation in the digestive tract can damage the intestinal lining, affecting nutrient and water absorption, and causing issues like diarrhea, malabsorption, and nutrient deficiencies.

Alterations in the gut microbiota, the community of bacteria in the gut, can also lead to inflammation and digestive symptoms.

Moreover, autoantibodies in some autoimmune diseases target proteins in the digestive tract, leading to tissue damage and dysfunction. For instance, in celiac disease, autoantibodies attack the lining of the small intestine in response to gluten.

Disruption of the gut-brain axis, which regulates gut motility, sensation, and secretion, can also occur in autoimmune diseases, contributing to digestive symptoms.

Muscle Weakness

NAD for autoimmune diseases

Muscle weakness is a common symptom in autoimmune diseases, arising from the immune system’s attack on healthy muscle tissue. 

This immune response triggers inflammation, which can damage muscles and hinder their normal function. 

This damage can culminate in muscle weakness and fatigue over time.

As a result, simple everyday activities like walking, climbing stairs, or lifting objects can become unmanageable due to muscle weakness. 

Additionally, tasks requiring precision become a challenge due to compromised fine motor skills.

Beyond physical limitations, muscle weakness can exact a psychological toll, leading to feelings of frustration, loss of independence, and diminished quality of life.

Chronic inflammation can also impede muscle function, fostering muscle weakness. It can also inflict damage on muscle fibers, disrupting their usual structure and operation, leading to weakness and diminished strength.

Furthermore, autoimmune diseases can interfere with energy production in muscle cells, precipitating fatigue and weakness, particularly during periods of physical exertion.

Fever and Inflammation

NAD for autoimmune diseases

Fever, an elevation in body temperature often accompanied by sweating, chills, and fatigue is a common symptom in autoimmune diseases. 

Inflammation, the body’s response to injury or infection, characterized by redness, swelling, heat, and pain, is also prevalent in these conditions. 

Both fever and inflammation arise from the immune system’s misguided attack on healthy tissues.

Generally, these symptoms result from immune system dysfunction, producing inflammatory proteins known as cytokines. 

These cytokines can provoke inflammation throughout the body, manifesting as fever, swelling, and pain.

Additionally, external factors such as infections can trigger fever and inflammation in autoimmune diseases by stimulating the immune system.

When the immune system erroneously attacks the body’s tissues as foreign and launches an immune response against them. This process entails the production of autoantibodies and the activation of immune cells like T cells and macrophages.

Immune cells release pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).

In response to inflammation, the liver produces acute-phase proteins like C-reactive protein (CRP) and fibrinogen. 

While these proteins help modulate the immune response and facilitate tissue repair, they can also contribute to fever and inflammation.

Brain Fog and Cognitive Issues

NAD for autoimmune diseases

Brain fog and cognitive issues in autoimmune diseases are thought to stem from inflammation, immune system dysfunction, and neurotransmitter imbalances. 

The immune system can erroneously attack healthy tissues, resulting in chronic inflammation.

This inflammation can compromise the blood-brain barrier, a protective barrier that regulates the passage of substances between the bloodstream and the brain.

When the blood-brain barrier is compromised, immune cells and inflammatory molecules can enter the brain, triggering an inflammatory response that impairs cognitive function.

Additionally, imbalances in neurotransmitters—chemical messengers that transmit signals between nerve cells in the brain—have been implicated in brain fog and cognitive issues. 

Moreover, microglia, immune cells in the brain, play a crucial role in the brain’s immune response. 

If you have autoimmune diseases, your microglia can become overactivated, releasing pro-inflammatory cytokines and other molecules that damage neurons and disrupt normal brain function. 

This neuroinflammation is believed to contribute to cognitive problems such as brain fog and memory loss. 

NAD and Autoimmune Diseases

NAD for autoimmune diseases

NAD (nicotinamide adenine dinucleotide) is a coenzyme found in all living cells and is essential for various biological processes, including energy metabolism, DNA repair, and gene expression. 

Recent research has highlighted the potential connection between NAD levels and autoimmune diseases.

One emerging area of interest is the role of NAD in regulating immune responses.

NAD levels have been linked to the function of immune cells, such as T cells and macrophages, which play a crucial role in the development and progression of autoimmune diseases. 

Studies suggest that NAD may influence immune cell activation, proliferation, and cytokine production, all of which are key factors in autoimmune responses.

Additionally, NAD is involved in regulating the activity of sirtuins, a class of proteins that play a role in cellular stress responses, inflammation, and aging. 

Sirtuins have been implicated in autoimmune diseases, and their activity may be influenced by NAD levels. 

Some research suggests that boosting NAD levels or activating sirtuins could have therapeutic potential in treating autoimmune diseases by modulating immune responses and reducing inflammation.

To help optimize your NAD levels to support a healthy immune system and minimize or avoid the symptoms associated with autoimmune disease, here are two things you can do:

1. Optimize your NAD Levels

NAD for autoimmune diseases

First, you need to identify your NAD levels, whether they’re low, borderline, or high, so you can get actionable data to help you find an effective and affordable product and the correct dosage to optimize your NAD level.

The Intracellular NAD® Test is the first and only NAD test that can help you determine if you are deficient in NAD, if your NAD supplement is working, or if you are taking the optimal dosage for your supplement. 

This test provides you with the information you need to optimize your NAD levels without the guessing game.

2. The Only NAD Supplement We Trust

NAD for autoimmune diseases

Second, if there’s one supplement we trust to support healthy levels of NAD in your body, it’s none other than Vitality Boost by Jinfiniti

Vitality Boost is a clinically validated formulation consisting of NAD precursor, Creatine monohydrate, D-Ribose, and Nicotinamide that work synergistically. 

This supplement supports healthy NAD levels to revitalize your cells and body, just as it did for Mia, who began taking Vitality Boost to address her autoimmune issues.

“I’ve struggled with autoimmune issues from a young age, trying numerous supplements that were both costly and ineffective. Despite various treatments, blood draws, and hospital visits, we couldn’t find a solution that worked for my body.

A few months ago, I started taking Boost and noticed an immediate increase in energy. My sleep improved, and I felt more energized during workouts and throughout the day. My lab results also saw a significant improvement, which hadn’t happened with any other treatment.”

Vitality Boost is a patent-pending NAD formulation guaranteed to optimize NAD and contains four high-purity and natural ingredients, to help you…

  • Boost energy and improve performance
  • Improve sleep quality
  • Support inflammation, muscle, and joint pains
  • Support healthy allergic and asthmatic symptoms
  • Improve mental clarity and dementia symptoms
  • Support functions of many organs (liver, kidney, heart, thyroid, fertility)…

Therefore, if you’re looking to support a healthy immune system to avoid the risk of autoimmune diseases or finally break free from the symptoms that are trapping you from living a normal life…

You can also try out Intracellular NAD® Test and Vitality Boost

The NAD Optimization® Bundles — 2 Intracellular NAD® tests and 1 Accuri® Vitality Boost supplement — and get 1 free supplement and free consultation. 

This package allows you to reveal your current NAD level, the optimal dosage for NMN supplements, and health benefits from optimized NAD levels

We work with you to optimize your NAD level.

If you want to avoid the risk of autoimmune diseases or finally break free from the symptoms that are stopping you from living a normal life…

Stock up Vitality Boost now!

Why Peter Attia is Wrong About NAD

Dr. Peter Attia’s name has become synonymous with longevity and health with his podcast and recent book, Outlive. And while he is right about so many things and overall we are aligned, there are a few things we disagree with him on, and for substantial reasons. 

Before we do that, let’s start out with the difference between an MD and a PHD. An MD is specifically authorized to treat and advise a variety of health conditions, though with an area of specialty who practices medicine with a limited focus on research. A PHD is a specialist who researches a particular area or areas of study, mine for example is genetics, disease treatments, and disease prevention. 

Attia’s an MD who reads research, but I’m a researcher who does the research that MD’s read.

A PHD scientific researcher would be more knowledgeable than an MD in research, understanding the research, but MD’s are more equipped to advise treatments on a variety of common diseases. 

So this is where we the rub is with Attia: he speaks as if he is an authority on longevity research when he’s far less knowledgeable than true researchers like Dr. David Sinclair or myself. Attia’s Google Scholar rank (the ranking based on number of scientific publications and citations) is a 19, mine is a 76, and Dr. David Sinclair’s is a 119. I have almost 400% more research credentials than Attia and Sinclair has 600% more than Attia. 

So when Dr. Peter Attia believes that NAD’s effect on lifespan or longevity is essentially nonexistent because he cites a couple of limited and outdated studies, he’s really speaking out of turn. He feels that NAD requires more research, and while this is true (more research is always better), there are so many studies I can cite that confirm our understanding of NAD and its immense effects on the human body that he doesn’t acknowledge. 

If you’re operating on a low level of NAD supply, you are more likely to contribute to the main causes of disease. Cellular senescence, for instance, is a condition where your blood stream becomes toxic with zombie cells. However, if your NAD is optimized, your entire body will be in a healthier state, you’ll have less zombie cells and be more able to fight off the main causes of disease, brought on by things such as cellular senescence, oxidative stress, inflammation, and glycation. 

NAD counteracts all six root causes of aging, also known as the six root causes of disease, because aging is actually just that: a disease. 

While Peter Attia is undeniably a prominent figure in the realm of longevity and health optimization, his views are not without critique. Attia often emphasizes the importance of lifestyle interventions, such as diet, exercise, and sleep, in extending lifespan.

And while we agree that these factors play a crucial role, Attia’s dismissal of NAD’s powerful effects on the entire human system is where his perspective falls short because he’s not seeing the link between NAD and the other key biomarkers of aging, which my team and I get to see everyday, especially when our clients are utilizing our most robust test, the Aging SOS test which allows us to test for 17 biomarkers.

Attia’s viewpoint, while grounded in personal experiences, observations, and some research experience, might sometimes overlook the bigger picture painted by scientific research. For example, we have firsthand experience of having tested 20,000 individuals and having seen the powerful effects of NAD optimization on many of the key biomarkers of aging (of which he would agree that are vital to combating aging). 

Plus, I don’t think he really understands the role of NAD in cellular repair as fully as he should.  NAD acts as a cofactor for various enzymes involved in DNA repair, stress response, and cell signaling pathways crucial for maintaining cognitive function. NAD helps protect neurons from damage and promotes overall body health by scavenging free radicals and reducing inflammation—the leading, underlying cause of all disease. 

And if you happen to be 50+ years old, your NAD levels are likely not optimal unless you’ve been taking our Vitality Boost for quite some time. According to extensive research, the average healthy 50-year-old has already lost 50% of their NAD levels. 

At Jinfiniti, our flagship NAD supplement, the Vitality Boost, is a patent-pending formulation that has been extensively tested in clinical studies by  hundreds of clinics and by thousands of consumers. It allows optimization of NAD in approximately 90% of users, a figure incomparable to any other NAD supplementation on the market. 

Because here’s the big, evidence-backed truth that Attia doesn’t realize: No other molecule comes close to helping your cells function optimally as much as NAD. 

This means that pain, inflammation, fatigue and brain fog all decrease while mental clarity, stamina, recovery, energy, and youthfulness and vitality all increase when NAD is optimized.

The Crucial Role of Optimizing NAD in Treating, & Reversing Long Covid

Long Covid has emerged as a significant health concern for individuals who have recovered from the acute phase of Covid-19 but continue to experience debilitating symptoms. While the exact mechanisms behind Long Covid are not yet fully understood, scientists and researchers have been investigating various potential treatments. One avenue of investigation is the role of NAD+ in managing Long Covid.

What is Long Covid?

Long Covid, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), refers to a condition where individuals experience persistent symptoms after recovering from the initial phase of COVID-19. These symptoms can include fatigue, shortness of breath, cognitive impairment, and joint pain, among others. The duration of Long Covid can vary from a few weeks to several months, significantly impacting individuals’ quality of life.

Long Covid is a complex and multifaceted condition that continues to puzzle medical professionals and researchers alike. The long-lasting effects of the virus on the body can manifest in various ways, making it challenging to pinpoint a specific set of symptoms that define Long Covid. However, understanding the symptoms and impact of this condition is crucial in providing appropriate care and support to those affected.

Symptoms and Impact of Long Covid

The symptoms of Long Covid can be diverse and affect multiple organ systems. While fatigue is the most commonly reported symptom, individuals with Long Covid may also experience neurological symptoms such as brain fog and difficulties with memory and concentration. These cognitive impairments can be frustrating and debilitating, affecting individuals’ ability to perform daily tasks and engage in work or social activities.

Respiratory symptoms like persistent cough and shortness of breath are also frequently reported among Long Covid patients. These symptoms can persist long after the initial infection has resolved, making it difficult for individuals to regain their pre-COVID level of physical activity and overall well-being. The constant feeling of breathlessness can be distressing and limit an individual’s ability to exercise or perform simple tasks.

In addition to cognitive and respiratory symptoms, individuals with Long Covid may experience musculoskeletal symptoms, such as joint and muscle pain. These symptoms can be persistent and affect mobility, making it challenging for individuals to engage in physical activities they once enjoyed. Furthermore, Long Covid can also present cardiovascular symptoms like heart palpitations, adding another layer of complexity to the condition.

Long Covid can profoundly impact individuals’ lives, preventing them from returning to work, participating in daily activities, and maintaining relationships. The lingering symptoms can lead to a decreased quality of life and mental health issues, including depression and anxiety. The frustration and uncertainty surrounding Long Covid can also contribute to feelings of isolation and helplessness.

Prevalence and Demographics of Long Covid

The prevalence of Long Covid varies, with estimates ranging from 10% to 80% of people who have had Covid-19. This wide range can be attributed to various factors, including the severity of the initial infection, age, underlying health conditions, and vaccination status. While Long Covid is more commonly observed in individuals who had severe initial infections, it can also affect those with mild or even asymptomatic cases of Covid-19.

Long Covid does not discriminate and can affect individuals of all ages, genders, and ethnic backgrounds. It is not limited to a specific demographic group, highlighting the need for comprehensive research and support for all those affected. The long-term consequences of Long Covid on individuals’ physical and mental well-being emphasize the importance of early detection, proper management, and ongoing care.

Further research is necessary to identify risk factors and potential treatments for Long Covid. The medical community is actively investigating the underlying mechanisms of this condition, exploring potential therapies, and developing strategies to support individuals on their journey to recovery.

An Overview of NAD+

NAD+”…also helps enzymes that repair DNA and prevent damage to our cells.” Kathryn Piper, Registered Dietician/Nutritionist

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the body that plays a crucial role in various biological processes. It is involved in energy production, DNA repair, cellular signaling, and regulation of gene expression. NAD+ levels naturally decline with age, and this decline has been associated with various age-related conditions.

The Biological Role of NAD+

NAD+ is a key player in cellular energy metabolism. It is involved in the conversion of nutrients into adenosine triphosphate (ATP), the primary fuel for cellular processes. NAD+ also functions as a cofactor for enzymes involved in DNA repair, assisting in maintaining genomic integrity. Furthermore, NAD+ is involved in regulating cellular processes related to aging, inflammation, and stress response.

One fascinating aspect of NAD+ is its ability to modulate the activity of sirtuins, a class of proteins that have been linked to longevity and healthspan. Sirtuins require NAD+ as a cofactor to carry out their enzymatic activities, and their function is thought to be influenced by NAD+ availability. These proteins play diverse roles in regulating cellular metabolism, aging, and stress response. By interacting with sirtuins, NAD+ can have a profound impact on cellular health and homeostasis.

Research has shown that NAD+ levels can be influenced by various factors, including diet, exercise, and certain molecules like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). Strategies that boost intracellular NAD+ levels have gained attention for their potential role in promoting health and disease prevention.

Turn to NAD instead of the normal medicines to treat Long Covid

NAD+ and Cellular Health

NAD+ is essential for maintaining cellular health and homeostasis. It plays a pivotal role in cellular processes such as DNA repair, mitochondrial function, and cellular defense mechanisms. By supporting these critical processes, NAD+ can help optimize cellular function and protect against various stresses.

Furthermore, NAD+ has been implicated in the regulation of cellular aging. As we age, NAD+ levels naturally decline, leading to a decline in cellular function and an increased susceptibility to age-related conditions. By replenishing NAD+ levels, it may be possible to slow down the aging process and promote healthier aging.

Emerging research has also suggested a potential link between NAD+ and Long Covid, a condition characterized by persistent symptoms following a Covid-19 infection. It is hypothesized that NAD+ supplementation could help alleviate some of the symptoms associated with Long Covid by supporting cellular function and promoting recovery.

In conclusion, NAD+ is a vital coenzyme that plays a crucial role in various biological processes. Its involvement in energy production, DNA repair, cellular signaling, and regulation of gene expression highlights its significance in maintaining cellular health and homeostasis. Understanding the intricate mechanisms by which NAD+ influences cellular processes opens up exciting possibilities for therapeutic interventions and disease prevention.

The Connection Between NAD+ and Long Covid

Emerging evidence suggests that NAD+ may play a crucial role in the management of Long Covid. Several mechanisms have been proposed to explain this connection. Long Covid, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), refers to the persistent symptoms experienced by some individuals even after recovering from the acute phase of COVID-19. These symptoms can include fatigue, brain fog, shortness of breath, and muscle weakness, among others. Understanding the underlying mechanisms of Long Covid is essential for developing effective treatments.

The Impact of NAD+ on Immune Response

The immune system plays a vital role in combating viral infections, including SARS-CoV-2. NAD+ has been shown to influence immune cell function and response. It can regulate the production of pro-inflammatory cytokines, which are involved in the immune response to viral infections. By modulating immune cell activity, NAD+ may help optimize immune response and reduce the severity and duration of Long Covid symptoms.

Moreover, NAD+ is involved in the repair and maintenance of DNA, which is crucial for the proper functioning of immune cells. Adequate levels of NAD+ can support the immune system’s ability to recognize and eliminate viral particles, preventing the persistence of the virus and the subsequent development of Long Covid symptoms.

NAD+ and Viral Infections

Research has indicated that NAD+ may have antiviral properties and can enhance the immune response against viral infections. NAD+ can activate various cellular defense mechanisms, including the production of antiviral proteins and enhancing the activity of natural killer cells. These effects suggest that boosting NAD+ levels may support the body’s ability to fight viral infections, including the persistent nature of Long Covid.

In addition to its direct antiviral effects, NAD+ also plays a role in mitochondrial function. Mitochondria are the powerhouses of cells and are responsible for generating energy. Viral infections, including SARS-CoV-2, can disrupt mitochondrial function, leading to cellular dysfunction and the persistence of symptoms. NAD+ supplementation has been shown to improve mitochondrial function and restore cellular energy production, potentially alleviating the symptoms of Long Covid.

Furthermore, NAD+ is involved in the regulation of inflammation, a key component of the immune response. Excessive inflammation can contribute to tissue damage and the development of chronic conditions. By modulating the inflammatory response, NAD+ may help prevent the long-term consequences of COVID-19, reducing the risk of developing Long Covid.

Overall, the connection between NAD+ and Long Covid is an area of active research. 

Understanding the role of NAD+ in immune response, viral infections, and mitochondrial function can provide valuable insights into potential therapeutic strategies for managing Long Covid. Further studies are needed to elucidate the precise mechanisms involved and to determine the optimal approaches for NAD+ supplementation in Long Covid patients.

Potential Benefits of NAD+ for Long Covid Patients

The potential benefits of NAD+ supplementation for Long Covid patients are being explored in clinical and preclinical studies.

Improving Energy Levels and Reducing Fatigue

Fatigue is one of the most common and debilitating symptoms of Long Covid. NAD+ plays a vital role in cellular energy production, and its decline with age or illness can contribute to fatigue and reduced stamina. By replenishing NAD+ levels, it is possible that energy production can be enhanced, leading to improved energy levels and reduced fatigue in Long Covid patients.

Enhancing Cognitive Function

Cognitive impairment, often referred to as “brain fog,” is another prominent symptom of Long Covid. NAD+ is involved in maintaining brain health, supporting neuronal function, and facilitating neurotransmitter synthesis. By optimizing NAD+ levels, cognitive function may be improved, potentially alleviating the cognitive impairments experienced by Long Covid patients.

Current Research and Future Perspectives

Current research is actively investigating the role of NAD+ in managing Long Covid, aiming to provide more insights into its potential benefits and limitations.

Ongoing Studies on NAD+ and Long Covid

Several clinical and preclinical studies are underway to evaluate the efficacy of NAD+ supplementation or NAD+ precursor molecules in managing Long Covid. These studies aim to determine the optimal dosage, treatment duration, and potential side effects of NAD+ interventions in Long Covid patients. The results of these studies have the potential to guide future treatment strategies.

Potential Challenges and Limitations

While NAD+ shows promise in managing Long Covid, some challenges and limitations need to be addressed. The optimal dosage and treatment duration have yet to be determined, and the long-term effects of NAD+ supplementation are not fully understood. Additionally, further research is needed to identify potential interactions with other medications and treatments commonly used in Long Covid management.

Conclusion

In conclusion, understanding the role of NAD+ in managing Long Covid is a relevant and promising avenue of research. NAD+ plays a crucial role in cellular health, mitochondrial function, immune response, and energy production. Its potential benefits in managing Long Covid, such as improving energy levels, reducing fatigue, and enhancing cognitive function, make it an intriguing area of exploration. Raise your NAD levels and improve energy and performance with Accuri® Vitality Boost

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Why Optimized, Precision Medicine is the Future
  2. Andrew Huberman is Wrong About NAD, NMN & Longevity
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. What Does Peak Performance Look Like? 

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order)

NAD Optimization: Real People, Real Results

Over the last 30 days we’ve received amazing messages, reviews, and conversations with customers over text, social media, email and comments added to our website from real customers. In their words,  and for a variety of health conditions, here’s what people are saying about how it feels to be NAD optimized.

Covid

“Just minutes ago, I was standing at my kitchen counter and could barely hold my head up. After two scoops of Vitality Boost, I was online looking at tile at Home Depot and about to bolt out the door. Wildest thing.”

-Kathyrn, best selling author, mom, and speaker who was two days into having Covid at the time.

Parkinson’s Disease

“I’m extremely happy with my latest nad test done January 18. Current levels are 58.9
Here is the progress starting with April 16, 2022: 24.9, 23.4, 34, 33.6, 42, 58.9
.

Your nmn and testing works. Even with Parkinson’s my energy levels are good.”

-David, retired professor and noted health expert.

Running and Exercise

“I recently purchased the Vitality Boost in October of 2023 and have used it since…I didn’t know that it could increase energy and improve performance, and being in the Military while on deployment has given me that extra boost to get me through my long days. 

…This product couldn’t have come at a better time since I was preparing for the Athens Marathon in Greece on November 12th, 2023. I finished 608th of 21,598, averaging a pace of 7:30 seconds for a distance of 26.2 miles. For proof, check out my Instagram @ _mas_oficial, which shows my race results! This was my first marathon, and being a 31-year-old male, I felt like I was in my early 20s. I feel more energized and focused throughout the day while in the field. Regarding gym exercise, I’ve been improving my bench, squat, and deadlift.” 

—Emmanuel C. 

Chasing Kids

“I’m almost done with my first jar and I can’t believe how my energy levels have improved. I’m finding myself smiling more often and feeling overall much more relaxed. My boyfriend’s nieces and nephew roped me into playing a basketball game with them over Christmas and despite having done no cardio or regular workout sessions for a few years now, I had plenty of energy even after running back and forth across the gym for probably a solid half hour before the kids finally got bored. The energy improvement is very tangible. The mood improvement is subtle but still noteworthy”

—Emily P. 

Walking, Stamina, Drive

“I have used other NAD products but at 75 years old, I was still testing just low normal, and not feeling able to complete my normal day and workouts with vigor. After six weeks using Jinfiniti’s Accuri Vitality Boost I am back living like I was 25 years ago… 5 -10 mile hikes, full days of meetings and studying… and having fun again!. My wife is also back to our expected normal activity levels…” thank you Dr. She from both of us! “

—Bruce Ross

Anxiety & Mental Health

“I felt like my brain was broken. I was so tired. I battled high levels of anxiety, having panic attacks three times a week, I felt fatigued all the time and needed 400 mg of caffeine and 2 naps per day just to function. It felt like a single setback could slide me off the cliff.

Initially, I did a big round of NAD IV, which was $4000, but I was desperate. It gave me a lot of energy and mental lift, but it wasn’t sustainable. A few months later, I was feeling the same. And then I discovered Jinfiniti. My NAD levels were sorely deficient. 

Within several months of taking the Vitality Boost, my energy is much higher, my mental health and anxiety is so much better, and I’ve even lost some of the unwanted stubborn weight that wouldn’t go away. And my NAD levels are now optimal at 55.4 thanks to Vitality Boost.

My husband and I feel we have our lives back and I know Jinfinti’s been a huge part of that.”

—Sarah W., one of our monthly subscribers of Vitality Boost.

Mental Clarity, Postpartum, Recovery

“After Dante was born, I still regularly experienced higher than normal levels of fatigue (like my cells were tired). I didn’t wake up as energized as I used to and my recovery wasn’t as good after a workout. I had some lingering brain fog and lack of mental clarity. Metabolism seemed to be lower. 

After two weeks of taking Vitality Boost, my brain fog has lifted, my metabolism is coming back and I’ve even felt some of that postpartum baby fat shedding faster. I feel better, happier, and more alert when I wake up. I am bouncing back faster and better from workouts. I am back to myself, which feels amazing.”

—Dr. Jennifer Fraboni (Doc Jen)

Severe Fatigue

“Over the last year, I started experiencing really debilitating fatigue in the afternoon. About six months ago, I did the NAD test and got shockingly low results coming in deficient. I’m perfectly healthy. I don’t have any diagnosed medical conditions. I exercise regularly, I eat well, and I’m not overweight. 

I was so appalled and determined to start taking the supplements regularly. 

Two weeks into taking the NAD supplement, the fatigue disappeared. I was absolutely astonished. I’m not going to stop taking the supplements to see if the fatigue comes back. I’d recommend the Vitality boost to anyone who needs extra energy.”

—Dr. James Goodwin, Director of Brain Health Network, London, UK.

Movement

“I have been using the supplement for the last 2 months. During this time I have increased my movement and feel strong and energized over the whole day. I’m a full time working mum and love all kinds of exercise. The best thing is the even energy all day so I can train/exercise/move whenever.”

—Louise N.

Overall Vitality

When my friend gifted me Vitality Boost I was skeptical however this skepticism has turned into gratitude for Jinfiniti. Vitality Boost has exceeded my expectations as a comprehensive wellness supplement. The promised benefits of increased energy, enhanced performance, improved sleep quality, and reduced inflammation have been noticeable in my daily life. 

I’ve experienced a significant reduction in muscle and joint pains, and the positive impact on allergic and asthmatic symptoms is truly remarkable. The supplement’s influence on mental clarity and dementia symptoms adds an extra layer of appeal. The promise of improved health functions, including the liver, kidney, heart, and thyroid, provides a sense of overall well-being. Vitality Boost lives up to its claims, making it a valuable addition to my wellness routine.”

—Shannon O.

Research news: NAD is showing significant promise in treatment neurodegenerative diseases, traumatic brain injury, diabetes, stroke and other health challenges from this research paper

“The preservation of cognitive ability by increasing nicotinamide adenine dinucleotide(NAD+) levels through supplementation with NAD+precursors has been identified as a promising treatment strategy for a number of conditions; principally, age-related cognitive decline (includingAlzheimer’s disease and vascular dementia), but also diabetes, stroke, and traumatic brain injury.”


Reading these reviews warms our hearts and reignites our passion for what we’re doing here at Jinfiniti with our groundbreaking NAD tests, biomarker panels and Vitality Boost (which we back with a 60-day Money Back Guarantee).

Do you have results to share? You can leave us a review by going to the product page here, scrolling down and clicking the “Write a review button.”

We’re always thrilled to hear how Jinfiniti has helped you optimize your life or any questions you may have.

Citations:

-Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts with NAD+ and it’s Precursors to Prevent Cognitive Decline across Disease Context

-Importance of NAD Anabolism in Metabolic, Cardiovascular, and Neurodegenerative Disorders.”

The shocking truth about fertility and NAD levels

Given the modern world’s accelerated human aging conditions, most of us know at least one person who has struggled or is struggling with fertility issues. 

But did you know that low fertility has recently been linked in academic studies to declining NAD levels? (Research link is at the bottom of the blog.) 

Here’s the nitty-gritty. 

The ovary—the crucial organ for female reproductive function—has a limited lifespan determined by the number of primordial follicles it possesses, established early in development. As females age, this ovarian reserve naturally decreases, leading to diminished fertility in the late 30s and menopause. 

Cells in the ovary require energy for folliculogenesis (which is just a fancy word for the process by which cells develop into a fertilizable egg). NAD plays a vital role in that energy generation, as well as cell signaling and tissue repair, so the decline in ovarian NAD levels with age is linked to reduced fertility. 

Understanding NAD and Ovarian Function: 

While NAD is a crucial component in the energy metabolism of ovarian cells—including those responsible for folliculogenesis and oocyte maturation—during ovulation, there’s a heightened demand for NAD to support various processes, including follicular rupture and DNA damage repair. The balance of NAD is essential for maintaining these ovarian functions. With decline in NAD levels due to health issues or simple aging, ovaries experience a decrease in egg quantity and quality. 

Role of CD38 in Ovarian NAD and Metabolism: 

One factor contributing to age-related decline in NAD levels is the gene CD38. CD38 is known for its diverse roles in regulating immune cell function and metabolic processes. As we age, an increase of CD38 gene expression and activity negatively correlates with tissue NAD levels in various organs. 

In mice studies, when mice lose the CD38 gene’s function, their ovaries have more resources and increased fertility when they’re young. But as they age, the levels of CD38 in ovaries go up, leading to decreased energy production and fertility. 

Which brings us to NAD. 

CD38 is a regulator that controls how much NAD is used in the ovaries, and NAD is crucial for reproductive functions. So when we look at mice without the CD38 gene, we notice that they have improved reproductive abilities, including more follicles and increased fertility. This led us to believe that these mice might have higher levels of NAD, and when we checked their ovaries, we discovered that the NAD levels were significantly higher in the mice without the CD38 gene compared to regular mice, especially in their reproductive prime. 

In summary, as we begin to understand the molecular mechanisms behind ovarian NAD loss, new avenues for enhancing reproductive longevity open up to us. 

We already knew that targeting NAD metabolism would have a dramatic effect on nearly every cellular process in the human body, but this new evidence is pointing us to potential solutions within one of the most challenging and heartbreaking conditions besieging our modern world: infertility. 

If someone you know is struggling with infertility, forward this email to them. NAD is integrally involved in over 500 cellular processes in the human body and is the foundational molecule of life. It should come as no surprise that we now see evidence of low NAD levels leading to infertility. 

Here at Jinfiniti, our flagship NAD supplement, the Accuri® Vitality Boost, is a patent-pending formulation that has been extensively tested in clinical studies by  hundreds of clinics and by thousands of consumers. It allows optimization of NAD in approximately 90% of users, a figure incomparable to any other NAD supplementation on the market. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. Why Optimized, Precision Medicine is the Future
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. Andrew Huberman is Wrong About NAD, NMN & Longevity

Research Citation:

CD38 regulates ovarian function and fecundity via NAD+ metabolism from National Institute of Health.

What Does Peak Performance Aging Look Like? Is Cognitive Aging Really a Fact of Life?

Peak performance aging is a radical concept that throws a pie in the face of traditional aging. The traditional theory of aging is that there is little that we can do to stop the slide. 

We’ve all heard accepted-aging statements: “Well, there’s nothing you can do about it. I guess we’re just getting old.” “Can’t teach an old dog new tricks.” “Aches and pains are all part of getting old.” “Aging comes for us all.” 

One leading thinker, Steven Kotler, a noted expert in the field of peak performance begs to differ.

Aging is a fact of life, but old is all a mindset.”

A NY Times bestselling author, journalist and flow researcher, Kotler explains further about the myth of uncontrollable aging in his research and his recent book, Gnar Country: Growing Old, Staying Rad.

“Ageism is the most socially acceptable stereotype in the world,” he said. “But it has radical consequences.”  He further explains, aging is a mindset,”A proper mindset towards aging is also a growth mindset. If you have a fixed mindset around aging, everything about lifelong learning is going to be worthless.”

When psychologist Mihaly Cskiszentmihalyi coined the term Flow in the 70s to explain the peak performance zone he discovered people could tap into, he discovered a unique psychological state like any other and inadvertently helped catalyze the positive psychology movement. 

When it comes to aging, the latest research indicates that not only is regularly activating flow state a key factor in long-term life satisfaction, it is also neuro-protective against cognitive decline (see George Valliant’s research at Harvard-citations will be on our blog). 

You may be wondering what all this may have to do with Jinfiniti, and we’ll get to that in a second. 

But first, here are a few things that happen when your body is in Flow State: 

  1. All six positive neurochemical cocktails are released.
  2. Life satisfaction goes up. 
  3. Cognitive decline slows and even reverses. 

The long slow route theory of aging states that skills decline as you age, therefore cognitive decline is inevitable. But new research that supports peak performance aging flys in the face of that with practical guidance on how to achieve peak performance aging. 

To avoid cognitive decline, the research says that you need to:  

  1. Solve the crisis of identity by the time you’re 30.
  2. Have match/fit quality by the time you’re in your 40s.
  3. In your 50s, you need to combat two things:
    1. Risk aversion. If you are risk averse, you are fearful which releases norephedrine, which then blocks . You need challenging, creative social experiences and should remain open, curious and explorative. 
    2. Physical fragility. According to Kotler, you do this through “challenging social activities that involve deliberate dynamic play in novel outdoor environments.” To protect against cognitive decline, you need neurogenesis, the birth of new neurons. You have 700 new neurons being made daily, with the majority of them being made in the hippocampus. 

So why is this important? In the hippocampus, your brain remembers novel outdoor experience as that is what your brain has been trained to do for thousands of years. 

What does a positive, even a growth mindset around aging look like?

Six neurochemical cocktails released in flow:

1. DOPAMINE

Drives desire, excitement, enthusiasm, sexual desire, curiosity, to test your limits

2. NOREPINEPHRINE

Brain’s version of adrenaline. Produces a huge increase in energy and alertness. When you’re obsessed with an idea, can’t stop thinking about the person you just met, then it’s activated

3. OXYTOCIN

Produces love, trust, friendship. It’s pro social. Underpins everything from long term bliss to cooperative businesses and relationships.

4. SEROTONIN

Calming, peaceful. Gives a mood lift. Shows up post meal with the desire to take a nap. Important for satisfaction and contentment

5 & 6. ENDORPHINS & ANANDAMIDE

Heavy duty stress & pain relievers. Replaces the weight of the day with euphoric happiness.

Kotler identifies five categories of functional fitness that need to be trained and maintained: strength, stamina, agility, balance and flexibility.

“These are all use it or lose it skills, if we want to retain our physical abilities late in life,” he said.

He noted a study about aging conducted by Yale professor Becca Levy that proved there was a significant correlation in how people thought about aging and viewed themselves when exposed to negative stereotypes.

“This could be people saying, ‘You’re too old for this s- -t,’ or you telling yourself ‘You’re too old for this s- -t,’” he explained. “By the time they were 60, we see a 30% greater memory decline in people who have been exposed to negative stereotypes around aging. Literally, we’re killing each other with these ideas.”

So here’s how peak performance aging ties into what we’re about at Jinfiniti:

If you are suffering in one of the vital biomarkers that can precipitate and accelerate aging, then it dramatically diminishes your potential longevity and healthspan.

Just this week, I met a 35-year-old with significant health issues whom we may be able to help pre-empt by testing and more precisely diagnosing while also optimizing NAD levels, so it can happen at almost any age.

NAD deficiency affects your energy, which in turn, affects your drive and motivation to engage in peak-performance, anti-aging related activities. The sooner you start ensuring your NAD is optimized, the sooner you throttle back aging, thereby extending your healthspan immediately. 

If you happen to be 50+ years old, your NAD levels are likely not optimal unless you’ve been taking our vitality boost for quite some time. According to extensive research, the average healthy 50-year-old has already lost 50% of their NAD levels. 

Here at Jinfiniti, our flagship NAD supplement, the Accuri® Vitality Boost, is a patent-pending formulation that has been extensively tested in clinical studies by  hundreds of clinics and by thousands of consumers. It allows optimization of NAD in approximately 90% of users, a figure incomparable to any other NAD supplementation on the market. 

No other molecule comes close to helping your cells function optimally as much as NAD. 

This means that pain, inflammation, fatigue, brain function (obstacles to Flow State & peak performance aging) all decrease while mental clarity, stamina, recovery, energy, and youthfulness (ingredients of Flow State) all increase when NAD is optimized.

Hence why NAD optimization plays an inextricable link in achieving peak performance aging at the molecular level.

Whether you’re a pro athlete or you’re working in the corporate world, building a business, or raising a family, taking care of your cellular vitality is paramount to how you feel, how you perform but also how and whether or not you age.

That’s why NAD is  arguably the foundational molecule for all of life. Plus, if you are over 40 years old your NAD levels are essentially guaranteed to be deficient. So get one of our NAD tests and a bottle of Vitality Boost to tune up your NAD levels. Better, yet, our NAD starter kit is a terrific value as it’s 2 tests and 2 Vitality Boosts, so within two months we can verify that your NAD levels are up to optimal levels.

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Andrew Huberman is Wrong About NAD, NMN & Longevity
  2. What Does Peak Performance Look Like? 
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. Why Optimized, Precision Medicine is the Future

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).

Citations:

Why Optimized, Precision Medicine is the Future of Health

Optimized, precision medicine is the future of health because no one person is the same, and when it comes to your health, shortcuts can be costly and even deadly.

Imagine you are about to board a flight and the pilot makes the following announcement: “I have an important update about today’s flight. There’s a five percent chance that you will land in the wrong city. Additionally, there’s another five percent chance that you will not safely make it to your destination and may perish onboard. Boarding will begin in approximately five minutes.”

We expect 100% precision for landing in the right city safely every time we board a flight. No exceptions. We expect 100% precision from Starbucks when we order our favorite beverage. We expect 100% successful delivery from our Amazon.com order, don’t we?

But astonishingly, when it comes to our health, we’ve become used to accepting far less precision, even when there are far more serious consequences than getting the wrong Frappuccino. 

Take cancer, for example. 

In the US alone, 86,500 cancer patients (5%) are misdiagnosed every year, leading to wrong treatments, accidental deaths, and unnecessary suffering. I don’t know about you, but if it’s my loved one who’s dealing with cancer and there’s a 5% chance of misdiagnosis, that’s far too high. Plus, by the time you’ve got cancer, you’ve got a full-blown problem that often would have been preventable with more advanced testing. 

All this to say: which diseases could you prevent with a greater precision approach to your health?

Just like when it comes to getting on an airplane, when it comes to my health or the health of my loved ones, I never want to “wing” it. 

But sadly, most Americans have more data on their social media profiles than they have on their health and vitality. 

And, regardless of what Apple or Fitbit may want you to believe, steps-per-day is not a biomarker. 

A real biomarker anticipates potential issues that can become full-blown diseases. It’s common sense that when your body is functioning optimally, you are less likely to get diseases and experience significant health issues. 

This is the promise of the advanced health tests we offer at Jinfiniti. Our Advanced Aging Panel tests for 22 key biomarkers, half of which are not available via any other test in the world, and all of which are contributing factors to creating disease states in your body. 

Step trackers, sleep monitors, and glucose monitors are all helpful, but none are as vital, precise, or comprehensive as our Aging SOS panels (both the standard and the advanced).

Since NAD is the primary fuel source for no less than 500 cellular processes and since having optimal levels of NAD is vital to peak energy, health and slowing aging, this is the easiest and most affordable testing option to begin extending the good years of your life. 

Jinfiniti’s NAD test is $248 and can be done from the comfort of your home. (Use the code optimal20 to get 20% off your first order.) If you are purchasing one of our Aging SOS biomarker panels, please note that NAD testing is already included with those. 

In the Western world, “normal health” isn’t healthy. Optimal is healthy. So never settle for normal when you can be optimal. 

And if you’re 50+ years old, your NAD levels are likely not optimal unless you’ve been taking our vitality boost for quite some time. According to extensive research, the average healthy 50-year-old has lost 50% of their NAD levels. 

Is there someone you want to be healthy and feeling optimal for? 

I do. I have two young girls and I want to be in optimal health for them for as long as possible. 

This is a huge part of our mission here at Jinfiniti: Living in prime, optimal health so we can enjoy our time with loved ones, doing all the things that make life worth living.

And that’s why precision medicine matters.

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Why Optimized, Precision Medicine is the Future
  2. 9 Powerful Benefits of Optimizing Your NAD
  3. Andrew Huberman is Wrong About NAD, NMN & Longevity
  4. What Does Peak Performance Look Like? 

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).

Andrew Huberman is Wrong About NAD, NMN, NR & Longevity

Recently, Stanford neuroscientist Dr. Andrew Huberman (who has one of the top health podcasts in the world) did a 16-minute Q&A segment on NAD and its precursors. Overall, I respect his commitment to scientific accuracy and his standard of excellence with his approach. However, I consider him under-informed and not a subject matter expert in this particular arena. Here’s where Huberman is wrong about NAD, NMN, NR and longevity.

Let’s start out with where we agree with Dr. Huberman:

  1. NAD provides a noticeable increase in energy: Dr. Huberman takes NMN and NR daily because of the very noticeable improvement in energy. In his words, “It gives me a lot of sustainable physical and mental energy throughout the day. I noticed a decrease in energy when I stopped taking NR and NMN. While I wasn’t totally depleted, my energy was noticeably lower. As a 48-year-old, having great energy is important to me.”
  2. We need more data and research. There are countless studies, tens of millions of dollars and many different types of clinical trials underway and completed. But because NAD shows enormous promise and potential, we can’t do enough research fast enough. Plus, it takes years for many trials and studies to be completed. 

However, there are a few important points where I disagree with Dr. Huberman. I believe he is seeing an incomplete picture with regards to NAD and its role in so many of our body’s systems. 

Here’s where we disagree: 

  1. Optimal Levels of NAD Increase Lifespan by Increasing Healthspan: While there haven’t been conclusive studies done on humans to demonstrate that NAD extends lifespan, you’d be hard pressed to find any conclusive clinical trials and studies on any molecule or nutrient that slows aging.  Furthermore, the six root causes of aging that are central to long term health all are influenced, if not directly affected, by NAD. If your NAD levels are deficient, your metabolic function suffers significantly, which we know intensifies and accelerates your aging as well as your likelihood of disease. 
  1. Supplements are  fundamental to optimal health: He claims that supplements are NOT fundamental to life/health, which is obviously wrong. Most of us are deficient in multiple nutrients for one reason or another and supplementation is an invaluable way to boost and support our health, improving our healthspan and thereby extending our lifespan.
  1. NMN clearly elevates NAD levels (especially Vitality Boost): Huberman says he does not know if NMN can elevate NAD.  He is ignoring all the publications and consumer data that NMN can elevate NAD, and the functional / clinical benefits. His statement is contradictory to his own experience that it gives him more energy with cellular energy being a fundamental aspect of good health. We see thousands of test results every year that conclusively demonstrate that your intracellular levels can be substantially increased, especially with our Vitality Boost, of which no other supplement comes close to increasing NAD levels as effectively. .
  1. NAD IV. There’s much that we don’t know about the effectiveness of intravenous NAD, but one thing we do know is that it has no measurable impact of raising your NAD levels in your blood. Within hours of getting an IV, your system has flushed out the NAD from your bloodstream. Huberman seems to believe that your NAD levels increase with NAD IV, which is not the case at least intracellularly though they do seem to increase in your plasma. Here’s a feature that RaisingNAD.com did on me where we discussed the research that indicates no perceptible impact to intracellular NAD though your cellular plasma NAD levels do seem to increase.

See our Youtube video this week comparing NAD IV vs. Vitality Boost.

Many people do notice an increase in energy and reduction in anxiety for a time period ranging from several days to several weeks after an IV, and we also agree that NAD IVs are a very expensive (and even painful) way to increase NAD

Dr. Huberman deserves a thumbs-up for his overall approach and standard of scientific rigor. As a fellow scientist, I have served as a Division Chief of Experimental Pathology and Director of Research and was the founding Director for Biotechnology and Genomic Medicine, as well as the director of two core research facilities in Genomics, Proteomics and Mass Spectrometry. Additionally, I discovered many important genes during my research, such as the type 1 diabetes gene which influences what we do today. 

As a genetics researcher for over 40+ years, I have reviewed thousands of intracellular NAD tests, authored over 400-peer reviewed papers with an H-index of 76 and over 19,000 citations, and secured over $100 million dollars in research grants.

Here at Jinfiniti, our flagship NAD supplement, the Accuri® Vitality Boost, is a patent-pending formulation that has been extensively tested in clinical studies by hundreds of clinics and by thousands of consumers. It allows optimization of NAD in approximately 90% of users, a figure incomparable to any other NAD supplementation on the market. 

I strongly disagree with both Dr. Andrew Huberman’s assessment of NAD and its precursors. His  understanding of NAD and its precursors are far less than what’s currently available. He hasn’t had the privilege of  being a genomics researcher for 40+ years, nor has he reviewed thousands of intracellular NAD tests. 

As someone who has a deep and integral knowledge of NAD and its precursors, I have a much more expansive data set and perspective when it comes to NAD and its role in our health. It is my primary area of focus. 

With regards to neuroscience, Huberman is the expert. But as far as genetics and NAD are concerned, that’s my field of expertise

Accuri® Vitality Boost optimizes—not just improves—intracellular NAD for 90% of people alone, which no other NAD supplement can come close to promising. While other brands increase NAD levels by 20-40% at best, we often see levels increase by 200-300% like we did with Doc Jen, a prominent doctor of physical therapy who loves the Vitality Boost. We back it with a 60-day Money Back and Efficacy Guarantee. That’s because we back up our Vitality Boost with testing, where all of the proof lies! 

I highly recommend testing your NAD levels to see where your levels are at and how much they need to be optimized. Jinfiniti’s intracellular NAD test is the only one of its kind in the world, and if you don’t already know where your levels are at, it’s the best place to begin your optimization journey. 

Here are a few of our recent blog posts that you may be interested in reading regarding some of the science behind NAD, NAD precursors, and optimization leading to longevity: 

Lastly, as much as we know about NAD and it’s role in our health, there’s substantially more to be discovered, so I consider us very much in the early days of figuring out how to extend lifespan. From the research and the experiential evidence I see every week with countless customers, NAD plays a vital role in extending our healthspan, life quality, and cellular vitality.

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. 9 Powerful Benefits of Optimizing Your NAD
  2. Why Optimized, Precision Medicine is the Future
  3. Andrew Huberman is Wrong About NAD, NMN & Longevity
  4. What Does Peak Performance Look Like? 

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).

The Brain’s Powerful Weapon Against Fatigue, Addiction and Disease

Did you know that the brain’s most powerful weapon against fatigue, neurodegenerative diseases, mental health, and addiction is a coenzyme that you were born with?

Noted brain health expert, Dr. James Goodwin, the author of Supercharge Your Brain, was recently suffering with debilitating fatigue. He took our NAD test and, surprise, his NAD levels came in severely deficient. 

He shares his story here:

“Over the last year, I started experiencing really debilitating fatigue in the afternoon. About six months ago, I did the NAD test and got shockingly low results coming in deficient. I’m perfectly healthy. I don’t have any diagnosed medical conditions. I exercise regularly, I eat well, and I’m not overweight. 

I was so appalled and determined to start taking the supplements regularly. 

Two weeks into taking the NAD supplement, the fatigue disappeared. I was absolutely astonished. I’m not going to stop taking the supplements to see if the fatigue comes back. I’d recommend the Vitality boost to anyone who needs extra energy.”

-Dr. James Goodwin, Director of Brain Health Network, London, UK.

NAD is essential to almost every cellular process in the human body. But with all the focus we put on our brain health (and how often we’re using that organ) you may be fascinated to know exactly what NAD is doing for your thinker. 

1. Enhanced Mental Clarity & Performance 

NAD plays a key role in the health of brain cells, boosting the production of PGC-1-alpha, a protein that protects brain cells against mitochondrial dysfunction & oxidative stress. Additionally, it acts as a neurotransmitter. Your brain is 3% of your body weight, but it uses 20% of your calories. Therefore, when your body is deficient in NAD, your brain is especially so.

Anecdotally, we have seen many clients experience significant reductions in brain fog and fatigue when they boost their NAD levels with our state-of-the-art, high performing Accuri® Vitality Boost

2. Addiction Treatment (Recreational drugs including marijuana, alcohol, opioids & other drugs): 

In early studies & data tracking, Springfield Wellness Center (the first NAD+ clinic in America) found that NAD+ has a nearly 400% better success rate than normal rehab clinics because NAD+ infusions help the brain chemistry heal while reducing or eliminating cravings for addictive substances. 

NAD+ IV coupled with NAC and other vital nutrients and minerals helps rewire neural pathways, detox and optimize your mitochondrial energy, and eliminate chemical cravings. Participants in the study who began with very high cravings for drugs or alcohol still had essentially no cravings two years after the treatments. See NADResearch.org and the Cravings Study here. 

3. Depression, PTSD and Anxiety:

When your brain experiences trauma, especially prolonged trauma such as PTSD or C-PTSD, it dramatically changes your brain structure. Since trauma is something that many of us have experienced and since we haven’t figured out how to time travel yet, how do we heal our brains and get back to good mental health? 

According to conventional medical understanding, depression has no cure. But in our opinion and armed with thousands of clinical studies, we believe that diseases & ailments conventional medicine have called lost causes actually have potential solutions. 

In our labs, we have seen many, many clients experience significant improvements in their mental health when their NAD levels are optimized. 

“For over 2 years, my mental health suffered. I battled high levels of anxiety, having panic attacks three times a week, I felt fatigued all the time and needed 400 mg of caffeine and 2 naps per day just to function. It felt like a single setback could slide me off the cliff.

Initially, I did a big round of NAD IV, which was $4000, but I was desperate. It gave me a lot of energy and mental lift, but it wasn’t sustainable. A few months later, I was feeling the same. And then I discovered Jinfiniti. My NAD levels were sorely deficient. 

Within several months of taking Vitality boost, my energy is much higher, my mental health and anxiety is so much better, and I’ve even lost some of the unwanted stubborn weight that wouldn’t go away. And my NAD levels are now optimal at 55.4 thanks to Vitality Boost.

My husband and I feel we have our lives back and I know Jinfinti’s been a huge part of that.”

-Sarah, one of our monthly subscribers of Vitality Boost.

4. Neurodegenerative Diseases Such as Alzheimers & Parkinson’s:

Early research indicates that some of the most prominent neurodegenerative diseases can be effectively treated with NAD. Brain chemistry and brain functioning—specifically metabolic deficiencies—are central problems with neurological diseases. 

Springfield Wellness center experts have treated many patients who have dementia or Parkinson’s, and when they receive NAD+ treatments, their symptoms often go into remission. Of course, the earlier the treatment begins, the better and quicker the results. 

**Unfortunately, there have not been enough clinical trials done to test NAD’s effects on neurodegenerative diseases to empirically state these. 

Yes, we are biased towards Jinfiniti’s Accuri® Vitality Boost, but that’s primarily because we’re biased towards documentable, scientific results and our Vitality boost is the only NAD optimization supplement on the market. The others only increase NAD levels at best, we optimize NAD levels. 

Other supplements that should be on your short list for brain health:

  • Vitamin D: plays a vital role in maintaining healthy cognitive function and deficiencies may accelerate aging. 
  • Creatine: The most important function of Creatine is that it serves as a battery or reserve to store ATP, which most people do not discuss. Additionally, it increases muscle mass and improves brain function
  • 1000 MG of EPA Fatty Acids: Healthy brain fats, especially EPA fatty oils (ideally 1000 mg per day for mental health and longevity). Dr. Andrew Huberman, the noted Stanford neuroscientist speaks candidly about how 1000 mg of EPA fatty acids have the equivalent effect of an anti-depressant for over 70% of people!

To additionally heal your brain and increase your mental health, avoid or minimize these neurotoxins (Yes, this is a bold claim, but they create so much brain dysfunction that they can safely be labeled such):  

  1. Conventionally fried foods
  2. Sugar and alcohol
  3. Processed foods

If you needed a quick reminder to restock on your Accuri® Vitality Boost, here it is! Don’t forget that our subscription option is always the best deal and will keep you from running out. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. Andrew Huberman is Wrong About NAD, NMN & Longevity
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. Why Optimized, Precision Medicine is the Future

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).

The Six Root Reasons of Aging

If you can slow your aging, can you delay disease? If you delay disease, can you can delay death?

“The loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old, but not when we are young.”

-Dr. David Sinclair, Harvard Medical School, Lifespan

It’s the supposed, inevitable decline that will swallow each and every one of us. Or will it?

Have you ever noticed that some people display vastly different health statuses, sometimes even in the same family? 

Prominent researchers in the last few decades have come to cautiously agree to a rough consensus of aging hallmarks. While it is very debatable how many hallmarks there are, I believe that these six are the primary hallmarks of aging as the others can be traced back to these six core hallmarks in one form or another. 

The six core reasons of aging are as follows: 

1. NAD and Other Micronutrient Deficiencies

Since NAD arguably acts as the most important enzyme in your body and is such a foundational building block of nearly every cellular process, it’s vital to keep your NAD levels optimal to slow the tides of aging. Unfortunately,  the average adult is heading towards a significant NAD deficiency by their early 40s. But thankfully, with our patent-pending Vitality boost, the most effective NAD-optimizing supplement ever developed, you can boost your NAD levels to optimal as fast as a couple weeks (did you see Doc Jen’s results?). 

2. Oxidative Stress and DNA Damage


When human cells experience oxidative stress, it’s the equivalent of a Roman army putting down its shields and turning their backs on the attackers as they attack.  Since your cells always have attackers swimming around in the bloodstream, when they let their guard down due to fatigue (hint: NAD deficiency is the primary cause of this) the DNA goes under attack. When your cells are too tired to fight the invaders, they lose their DNA and aging accelerates, plus, cells with broken DNA that continue to multiply can form tumors.

3. Glycation and Blood Sugar

When your levels of insulin resistance increase, it’s because your cells have experienced an overwhelming amount of glucose and fructose pulsating through your bloodstream. And when that happens, your cells begin to brown, like the sugar crumbles on top of creme brûlée. This is a process called glycation. In other words, you don’t want his happening to your cells. I don’t know about you, but burnt cells don’t sound very enticing to me. 

4. Chronic Inflammation

Foreign invaders (e.g., viruses and bacteria) damage cells directly, so our bodies have developed an inflammatory response, which recruits white blood cells to release toxins like oxygen radicals and cytokines (peptides with killing activity) to destroy the invaders.

Inflammatory responses are meant to be temporary, but unfortunately there are complications when you’re perpetually living in an inflamed state, like one the average American lives in. Normal tissues can experience long term damage from an inflammatory response; your tissues can also be mistaken for a foreign invader (e.g. kidney disease), and a prolonged bad bacterial overgrowth in the gut can lead to breaks in the intestinal barrier (e.g. leaky gut). Inflammation is good in the short run, but awful for you in the long run.

5. Cellular Senescence

When your cells don’t function properly, some of them have the potential to turn into what we like to call zombie cells. Zombie cells are old cells that refuse to die; but not only that, they also travel in your blood and damage healthy cells, spreading toxicity and inflammatory proteins. If your body is functioning properly, it’s designed to get rid of zombie cells. If not, your disease chances and illness symptoms will only increase as you age. 

6. Metabolic Dysfunction

NAD is central to the regulation of cellular energy production, but inadequate NAD levels can impede energy-producing pathways and result in reduced cellular energy production, contributing to conditions like metabolic syndrome. And what is metabolic syndrome? Metabolic syndrome is a cluster of conditions stemming from metabolic dysfunction and leading to heart disease. 

NAD deficiency can also disrupt the balance between anabolic and catabolic processes in the body, which leads to disturbances in body weight, insulin sensitivity and overall metabolic health. 

Lastly, NAD is intricately involved in maintaining mitochondrial function and cellular repair mechanisms. Reduced NAD levels can impair mitochondrial respiration and increase oxidative stress, and oxidative damage and DNA mutations can further exacerbate metabolic dysfunction and increase the risk of chronic diseases like diabetes and obesity. 

If you, like us, are astounded at how interconnected all six of these causes of aging are, we strongly advocate for testing not just your NAD, but up to 23 biomarkers with our advanced panel, one of the most advanced biomarker tests available in the world. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. 9 Powerful Benefits of Optimizing Your NAD
  2. Andrew Huberman is Wrong About NAD, NMN & Longevity
  3. What Does Peak Performance Look Like? 
  4. Why Optimized, Precision Medicine is the Future

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).

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