The 6 Best NAD+ Supplements of 2025, Reviewed by Experts

Disclaimer: This article is for informational purposes only and does not constitute medical advice. The products reviewed have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before starting any new supplement regimen.

NAD supplements are marketed to help restore cellular energy levels, mental clarity, and slow down biological aging, but you have to pick formulas that have research to back up the claims.

The problem is figuring out which NAD+ boosters are clinically effective and which are expensive placebos. The vast majority of products rely on one precursor and hope for the best. The most effective formulas work on cellular energy from multiple angles.

Your cells need NAD+ (nicotinamide adenine dinucleotide), a coenzyme that helps drive energy production, DNA repair, and metabolic function. NAD levels in your body naturally decline by about 50% between the ages of 40 and 60. This decline is linked to chronic fatigue, brain fog, and delayed recovery from exercise and illness.

Our team tested and reviewed the best NAD supplements of 2025 to find out which formulas give real results. In this guide we cover the clinical research, third-party testing, and which ingredients actually boost cellular energy.

Best NAD+ Supplements in 2025 Reviewed

Best Overall & Best for Energy: Jinfiniti Vitality ↑® NAD+ Booster

NAD+ precursor per serving: 900 mg (NMN, Niacinamide)
Additional ingredients: Creatine Monohydrate, D-Ribose
Form: Powder
Certifications: Third-party tested, cGMP-certified, made in USA

Jinfiniti Vitality ↑® NAD+ Booster earns both our top overall pick and best for energy because it’s the only formula clinically shown to get 85% of users to optimal NAD+ levels in just 4 weeks while simultaneously supporting ATP production for sustained cellular energy.

Most NAD+ supplements rely on a single precursor and hope for the best. Vitality takes a different approach with a patent-pending 4-ingredient formula that works through multiple metabolic pathways simultaneously.

The formula combines 900mg of NAD+ precursors (NMN and niacinamide) with creatine monohydrate and D-ribose. This multi-pathway design addresses a problem most companies ignore: your cells need more than just NAD+ precursors to sustain elevated levels and maximize energy output.

Creatine supports ATP regeneration (adenosine triphosphate, the cellular energy currency), helping maintain the energy boost from increased NAD+. D-ribose provides the building blocks your cells need to produce both NAD+ and ATP efficiently. Together, they create sustained energy that doesn’t crash.

Clinical trials on this exact formula showed participants averaged a 100% increase in NAD+ levels alongside improvements in energy and mental clarity. The formula outperformed standalone NAD+ precursors by 3x and delivered results comparable to IV NAD+ therapy at a fraction of the cost.

Users report sustained mental clarity through the afternoon, better workout recovery, and the ability to handle stress without the usual energy drain. The energy boost appeared within the first two weeks and continued building through week 8.

Dr. Jin-Xiong She, who developed Vitality after years of dedicated research, explains, “Relying on a single NAD+ booster overlooks just how intricate cellular energy metabolism truly is. When we support several processes at once—such as NAD+ production, ATP generation, and the cell’s overall fuel supply—we see more consistent and lasting benefits, rather than short-lived increases.”

The powder format dissolves easily in water or your morning coffee. Two scoops daily (one morning, one evening) deliver the full clinical dose.

Jinfiniti backs the formula with over 5 years of safety data from hundreds of doctors and thousands of users. Third-party testing verifies purity and potency for every batch.

✓ Pros	✗ Cons
Clinical trial proving 85% reach optimal NAD+ in 4 weeks	Requires mixing (not grab-and-go like capsules)
Multi-pathway formula 3x more effective than single precursors	Premium pricing compared to basic NR supplements
Combines NAD+ precursors with ATP support	Two servings daily for full benefits
Created by scientist with 400+ published papers
Third-party tested with published results
Outperforms IV NAD+ at lower cost

Best for: People looking to boost NAD+ levels with proven results and full support for cellular energy, including both NAD+ and ATP production. This is especially helpful for those who often feel tired or experience low energy in the afternoon.

Best Budget Option: Life Extension NAD+ Cell Regenerator

NAD+ precursor per serving: 300 mg Nicotinamide Riboside (NR)
Additional ingredients: None
Form: Vegetarian capsule
Certifications: Non-GMO certified, GMP-compliant facility

Check Price →

Life Extension NAD+ Cell Regenerator offers a straightforward, clinically validated dose of Niagen (patented NR) without extras or inflated pricing.

This is pure NR supplementation done right. Each capsule delivers 300mg of Niagen, the specific form of nicotinamide riboside used in the majority of published NAD+ research.

NR converts to NAD+ through the salvage pathway (your body’s primary NAD+ recycling system responsible for 85% of production). Studies show 300mg daily can measurably increase blood NAD+ levels within weeks.

The formula’s simplicity is its strength. No proprietary blends, no underdosed “kitchen sink” ingredients, no unnecessary fillers. You get exactly what decades of research say works for NAD+ elevation.

This makes it ideal if you’re building your own supplement stack or want to avoid potential interactions with other formulas. You control what goes in your body beyond the NR.

Life Extension has operated since 1980 and maintains rigorous quality standards. The company provides Certificates of Analysis upon request and manufactures in GMP-compliant facilities.

The one-capsule serving makes dosing simple. Take it in the morning with breakfast for consistent absorption.

✓ Pros	✗ Cons
Clean, single-ingredient formula	No supporting ingredients for sustained NAD+ levels
Uses clinically studied Niagen brand NR	May plateau after 8-12 weeks without methyl donors
Accessible price point for daily use	Single pathway approach vs multi-pathway formulas
40+ years of company quality reputation	Lower precursor dose than some competitors
Easy one-capsule serving
Non-GMO certified

Best for: Budget-conscious people who want an affordable NAD+ supplement as a basic option, or those who like to add other ingredients to their routine on their own.

Best NAD+ Supplement for Women: Tru Niagen Beauty

NAD+ precursor per serving: 200 mg Nicotinamide Riboside (NR)
Additional ingredients: Hyaluronic Acid, Astaxanthin, Biotin, Grape Seed Extract, Vitamin E
Form: Capsules
Certifications: NSF Certified for Sport, third-party tested by Alkemist Labs

Check Price →

Tru Niagen Beauty is our pick for women because it addresses cellular aging alongside the visible signs of aging that matter to many women—skin elasticity, hydration, and hair health.

Most NAD+ supplements only target cellular energy. Tru Niagen Beauty goes further by adding nutrients that support both NAD+ and healthy skin, hair, and nails.

The formula pairs 200mg of Niagen (the patented NR used in multiple clinical trials) with hyaluronic acid, a molecule that holds up to 1,000 times its weight in water. Your skin’s natural hyaluronic acid declines with age, leading to dryness and loss of volume.

Astaxanthin (a powerful antioxidant from marine algae) protects skin cells from oxidative stress and UV damage. Studies show it can improve skin texture and reduce fine lines when taken consistently.

Biotin supports hair growth and nail strength. Grape seed extract and vitamin E provide additional antioxidant protection against environmental stressors that accelerate skin aging.

The result is a supplement that works on two levels: boosting cellular NAD+ for energy and metabolic function while delivering compounds specifically chosen for skin, hair, and nail health.

The standard serving is 2 capsules (200mg NR), though you can take up to 4 capsules daily (400mg) for higher NAD+ support.

Tru Niagen maintains NSF Certified for Sport status across its product line, meaning every batch undergoes rigorous third-party testing for banned substances and label accuracy.

✓ Pros	✗ Cons
Combines NAD+ boosting with beauty-specific nutrients	Lower NR dose than dedicated NAD+ formulas
Hyaluronic acid for skin hydration and elasticity	Premium pricing for the category
NSF Certified for Sport testing standards	Multiple capsules per serving
Addresses both cellular and visible aging	Beauty benefits take 8-12 weeks to appear
Antioxidant protection from astaxanthin
Flexible dosing (2-4 capsules)

Best for: Women seeking cellular energy support who also want targeted benefits for skin hydration, elasticity, and overall radiance from a formula designed with beauty outcomes in mind.

Best with Resveratrol: Thorne ResveraCel

NAD+ precursor per serving: 415 mg Nicotinamide Riboside (NR)
Additional ingredients: Trans-Resveratrol (150mg), Quercetin Phytosome (250mg), Betaine (85mg)
Form: Capsules (2 per serving)
Certifications: NSF Certified for Sport, TGA Certified (Australia)

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Thorne ResveraCel is our top pick for resveratrol because it combines a robust NAD+ precursor dose with synergistic longevity compounds that work through complementary pathways.

Think of this as a complete aging support system in one formula. The 415mg of Niagen provides strong NAD+ elevation, while resveratrol and quercetin activate sirtuins (proteins that regulate cellular health and longevity).

Sirtuins require NAD+ to function. By boosting both NAD+ levels and sirtuin activity simultaneously, ResveraCel creates conditions for enhanced cellular repair and metabolic regulation.

The 150mg dose of trans-resveratrol matches amounts used in longevity research. Resveratrol has shown potential for cardiovascular protection, improved insulin sensitivity, and activation of genes associated with lifespan extension in animal models.

Quercetin phytosome (quercetin bound to phospholipids for better absorption) adds anti-inflammatory and antioxidant activity. Studies suggest quercetin may help clear senescent cells (damaged cells that refuse to die and contribute to aging).

Betaine serves as a methyl donor, supporting the methylation reactions needed to sustain NAD+ production. This addresses the plateau effect seen in some NAD+ supplementation where levels rise then fall after 8-12 weeks.

Thorne maintains exceptional quality standards with NSF Certified for Sport testing and TGA certification from Australia’s strict regulatory authority.

The two-capsule serving makes it easy to split the dose (one morning, one evening) or take together.

✓ Pros	✗ Cons
High-dose NR (415mg) plus longevity compounds	More expensive than single-ingredient options
Resveratrol activates sirtuins that work with NAD+	Two capsules per serving
Quercetin for senolytic and anti-inflammatory effects	Complex formula may make it harder to isolate benefits
Betaine supports sustained NAD+ production
NSF Certified for Sport and TGA certified
Targets multiple aging pathways simultaneously

Best for: Users looking for all-in-one longevity support from a single supplement, offered by a company recognized for clinical-grade formulations.

Best Liposomal: Codeage Liposomal NAD+ ULTRA

NAD+ per serving: 500 mg (pure NAD+, not precursor)
Additional ingredients: Trans-Resveratrol, Quercetin, Betaine, Riboflavin (B2), Vitamin B12
Form: Liposomal Capsules (3 per serving)
Certifications: cGMP certified, Non-GMO, Vegan, third-party tested

Check Price →

Codeage Liposomal NAD+ ULTRA uses a different method by providing real NAD+ molecules, not just precursors. These molecules are wrapped in liposomes to help your body absorb them better.

Most NAD+ supplements give you NMN or NR, which your body then converts to NAD+. This formula skips that conversion entirely and delivers 500mg of pure NAD+ directly.

The challenge with taking NAD+ orally has always been bioavailability. NAD+ molecules are large and break down quickly in the digestive system. That’s why precursors like NMN and NR became the standard approach.

Codeage addresses this through liposomal encapsulation. The NAD+ molecules are wrapped in phospholipid bubbles (derived from non-GMO sunflower oil) that protect them through digestion and allow cellular uptake.

Studies on liposomal delivery systems show they can increase bioavailability by 20-25% compared to standard formulations. Whether this advantage is enough to make direct NAD+ delivery superior to precursors remains debated, but the technology is promising.

The formula includes supporting ingredients that make sense: trans-resveratrol for sirtuin activation, quercetin for antioxidant support, betaine for methylation, and B vitamins that participate in NAD+ metabolism.

The three-capsule serving allows flexibility. You could start with two capsules and increase to three as needed.

Codeage manufactures in a cGMP-certified facility in the USA and subjects batches to third-party testing for purity and potency.

✓ Pros	✗ Cons
Delivers pure NAD+ directly (not precursors)	Three capsules per serving
Liposomal technology for enhanced absorption	Direct NAD+ approach has less research than precursors
Includes resveratrol, quercetin, and B vitamins	Higher price point
Non-GMO, vegan formulation	Effectiveness compared to precursors still debated
Made in USA cGMP facility
Third-party tested

Best for: People interested in cutting-edge NAD+ delivery technology who want to bypass the precursor conversion step, though this approach has less clinical validation than NMN/NR supplementation.

Best Sublingual: Jinfiniti Vitality ↑® NAD+ Lozenge

NAD+ precursor per serving: 900 mg (NMN, Niacinamide)
Additional ingredients: Creatine Monohydrate, D-Ribose
Form: Sublingual Lozenge
Certifications: Third-party tested, cGMP-certified

Shop Vitality ↑® Lozenge

The Vitality ↑® Lozenge delivers the same clinically proven formula as the powder but in a sublingual format that may enhance absorption through oral mucosa.

Sublingual delivery (under the tongue) allows compounds to enter your bloodstream directly through the rich capillary network in your mouth. This bypasses first-pass metabolism in the liver, potentially increasing bioavailability.

While most NAD+ research uses oral capsules, there’s growing interest in sublingual formats. The theory is sound: NAD+ precursors absorbed through the mouth could reach cells faster and avoid degradation in the digestive tract.

The lozenge dissolves under your tongue in about 2-3 minutes. You get the same 4-ingredient, multi-pathway formula that proved 85% of users reached optimal NAD+ levels in 4 weeks.

The format offers convenience advantages. No mixing required, portable enough for travel, and easy to take at work or on the go. Just let it dissolve and you’re done.

Some users report noticing effects slightly faster with the lozenge compared to the powder, though this remains anecdotal rather than clinically proven.

The lozenge uses the same rigorous third-party testing and quality standards as all Jinfiniti products. Each batch is verified for purity and potency.

Two lozenges daily (one morning, one evening) deliver the full clinical dose.

✓ Pros	✗ Cons
Same proven formula as Best Overall pick	Limited research on sublingual NAD+ delivery
Sublingual absorption may enhance bioavailability	Takes 2-3 minutes to fully dissolve
No mixing required (grab-and-go convenience)	More expensive than powder per serving
Portable and travel-friendly	May not suit people who dislike lozenges
Backed by clinical trial showing 85% reach optimal levels
Third-party tested

Best for: People who want the clinically proven Vitality formula in a convenient sublingual format that doesn’t require mixing, ideal for busy schedules or frequent travel.

Top NAD+ Supplements Comparison Table

Product	NAD+ Precursor	Other Ingredients	Form	Third-Party Tested	Key Feature
Jinfiniti Vitality	900mg NMN + Niacinamide	Creatine, D-Ribose	Powder	Yes	Clinical validation: 85% reach optimal NAD+
Life Extension Cell Regenerator	300mg NR (Niagen)	None	Capsule	Yes	Clean single-ingredient formula
Tru Niagen Beauty	200mg NR (Niagen)	Hyaluronic Acid, Biotin, Astaxanthin	Capsule	Yes	Beauty-focused with skin nutrients
Thorne ResveraCel	415mg NR (Niagen)	Resveratrol, Quercetin, Betaine	Capsule	Yes	Complete longevity pathway support
Codeage Liposomal NAD+	500mg pure NAD+	Resveratrol, Quercetin, B vitamins	Liposomal Capsule	Yes	Direct NAD+ delivery (not precursor)
Jinfiniti Vitality Lozenge	900mg NMN + Niacinamide	Creatine, D-Ribose	Sublingual Lozenge	Yes	Sublingual absorption for convenience

Testing and formulations current as of December 2025. Always verify current specifications on product pages.

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. It’s a vital molecule that supports hundreds of cellular processes.

Your mitochondria (the cellular powerplants) need NAD+ to convert food into ATP, the energy currency your body runs on. Without adequate NAD+, energy production slows down^[1].

NAD+ also controls DNA repair, circadian rhythms, and metabolic processes that keep cells functioning properly.

The problem? NAD+ levels decline dramatically with age.

Research shows a 50% drop between ages 40 and 60. By age 80, some studies report 80% reductions from youthful levels.

Lower NAD+ means:

• Less energy production
• Slower DNA repair
• Impaired metabolism
• Reduced cellular cleanup (autophagy, the process cells use to remove damaged components)
• Compromised mitochondrial health

NAD+ itself can’t be absorbed well as a supplement. It’s too big and breaks down in your stomach before it can help your cells.

That’s why NAD+ supplements use precursors—smaller molecules your body can turn into NAD+ through natural processes.

How Do NAD+ Supplements Work?

NAD+ supplements give your body the building blocks it needs to make more NAD+.

You can’t take NAD+ directly because it breaks down in your stomach before reaching your cells. Instead, you take smaller molecules called precursors that your body converts into NAD+.

Think of it like this: you can’t deliver a fully assembled car to your cells, but you can deliver the parts and let your cells build it.

The two main precursors are:

• NMN (nicotinamide mononucleotide): Converts directly to NAD+ inside your cells. This is a short, efficient path.
• NR (nicotinamide riboside): Converts to NMN first, then to NAD+. This takes one extra step but works just as well.

Your body mainly produces NAD+ through recycling. About 85% of your NAD+ comes from breaking down and rebuilding old NAD+ molecules. This recycling system is where supplemental NMN and NR work.

Your body can also make NAD+ from vitamin B3 (niacin), but this often causes skin flushing at the doses needed to meaningfully raise NAD+.

Most NAD precursors use NMN or NR because they plug directly into your body’s main NAD+ production system. Both have proven effective in clinical trials.

NMN vs NR: Which Should You Choose?

Both NR and NMN raise NAD+ levels effectively. The differences are smaller than supplement companies want you to believe.

NMN (Nicotinamide Mononucleotide)

• One step away from becoming NAD+
• Slightly newer, with growing research
• Effective dose: 300-900mg daily
• Some studies show benefits for sleep quality

NR (Nicotinamide Riboside)

• Two steps away from becoming NAD+ (converts to NMN first, then to NAD+)
• More published human studies
• Effective dose: 250-500mg daily
• Research shows benefits for brain health markers

For specific guidance, see our detailed breakdown of optimal NMN dosage based on current research.

Which one wins?

Honestly, both work. Your cells convert either one into NAD+ efficiently.

The better questions are: What’s the dose? Is it third-party tested? Does the formula include supporting ingredients?

Studies show safe doses up to 2,000mg for NR and 1,200mg for NMN. Both have excellent safety records.

The best approach? Try both and see which your body responds to best.

Health Benefits of NAD+ Supplements

Studies on NAD+ supplements have found several possible benefits. However, most research in people has only lasted for a few weeks or months.

Energy and Metabolism Support

NAD+ is required for the electron transport chain in mitochondria—the process that converts nutrients into ATP.

Higher NAD+ levels improve mitochondrial efficiency, leading to better energy production^[2].

Studies in middle-aged and older adults taking NMN or NR have reported improved fatigue scores and better physical endurance. One trial showed amateur runners taking 1,000mg NMN daily improved their aerobic capacity compared to placebo^[3].

For people experiencing chronic fatigue linked to low NAD+ levels, supplementation may help restore cellular energy production.

Cognitive Function

Your brain uses roughly 20% of your body’s energy despite making up only 2% of body weight.

This energy demand makes brain function particularly sensitive to NAD+ status.

Research shows NAD+ precursors may protect neurons from oxidative stress, support neurotransmitter production, and improve markers associated with cognitive decline.

A 2022 study found NR supplementation improved biomarkers related to neurodegenerative pathways in adults over 55^[4].

Cellular Repair and Healthy Aging

NAD+ activates sirtuins, a family of proteins that regulate cellular health, DNA repair, and stress resistance.

Sirtuins can’t function without NAD+. Declining NAD+ levels may accelerate aging.

Animal research shows NAD+ supplementation can extend both lifespan and healthspan (years lived in good health). Human trials are shorter but show improvements in biological aging markers, inflammation levels, and cellular stress response^[5].

Cardiovascular Health

NAD+ supports endothelial function (the health of blood vessel linings), blood pressure regulation, and vascular flexibility.

Studies in older adults have found NMN supplementation improved arterial stiffness and blood pressure readings.

Research shows NAD+ plays a critical role in heart health by supporting energy production in cardiac muscle cells and protecting against oxidative stress.

Research published in 2024 examining adults over 40 found 250mg NMN daily for 12 weeks reduced blood pressure and arterial stiffness compared to baseline^[6].

Exercise Performance and Recovery

NAD+ helps your muscles use energy, supports healthy mitochondria in muscle cells, and assists with recovery after exercise.

Athletes and active individuals often report faster recovery times and better workout performance with NAD+ supplementation.

A 2021 study in amateur runners showed NMN supplementation enhanced aerobic capacity during training, suggesting improved oxygen utilization and energy production in working muscles^[7].

How to Choose a NAD+ Supplement

Selecting the right NAD+ supplement means understanding a few key factors that separate effective formulas from expensive placebos.

NAD+ Precursor Type and Dosage

Single vs. Multi-Pathway Formulas

Simple NMN or NR supplements work by feeding one pathway. Multi-ingredient formulas like Jinfiniti’s Vitality support NAD+ production through multiple pathways while also addressing ATP synthesis and methylation.

Research shows single-pathway supplements can plateau around 8-12 weeks as the body adapts or runs short on cofactors needed to sustain production.

Multi-pathway formulas help prevent this plateau.

Effective Dose Ranges

Clinical trials show 250-500mg daily for NR and 300-900mg for NMN as effective starting doses.

Higher doses up to 2,000mg NR and 1,200mg NMN have proven safe in studies. For detailed guidance on proper NAD+ dosage and frequency, research-backed recommendations can help you find your optimal intake.

Lower doses under 200mg may not provide enough precursor for meaningful NAD+ elevation, especially in people over 50 with depleted baseline levels.

Absorption Enhancement

Liposomal Technology: Wrapping NAD+ or precursors in lipid bubbles may increase absorption by protecting them through digestion. Research shows roughly 20-25% improvement in bioavailability. Learn more about liposomal NAD+ delivery and the science behind this technology.

Sublingual Formats: Lozenges and powders designed to dissolve under the tongue bypass digestive breakdown. They deliver precursors directly to the bloodstream through oral mucosa. The debate between sublingual NMN vs capsules continues as research emerges on optimal delivery methods.

With or Without Food: Some precursors absorb better with dietary fat. Check product recommendations, but many work well taken with morning meals.

The challenge with novel delivery methods? Limited clinical data. Most published NAD+ research uses standard capsules, so dosing guidance for liposomal or sublingual formats remains unclear.

Supporting Ingredients for Sustained NAD+ Elevation

TMG/Betaine (Trimethylglycine): Acts as a methyl donor. NAD+ production creates a byproduct called homocysteine that requires methyl groups to process safely. The combination of NMN and TMG hasbeen studied for supporting methylation.

Creatine Monohydrate: Supports ATP regeneration, complementing the energy boost from NAD+. When your cells have both elevated NAD+ and efficient ATP recycling, energy production remains high under stress.

D-Ribose: Provides the sugar backbone needed to build new ATP molecules. Research shows 5g daily can reduce fatigue and improve energy recovery^[8].

Resveratrol and Quercetin: These polyphenols activate sirtuins and support antioxidant systems that work with NAD+ for cellular health. They don’t boost NAD+ directly but may enhance the benefits. Research on NAD+ combined with resveratrolshows potential synergistic effects for longevity.

Third-Party Testing and Quality

NAD+ precursors can degrade in heat or humidity. Quality manufacturers test every batch to verify:

• Purity (no contaminants or heavy metals)
• Potency (actual NAD+ precursor content matches label claims)
• Stability (product maintains potency through shelf life)

Look for companies that publish Certificates of Analysis or have NSF Certified for Sport testing, which screens for banned substances and verifies label accuracy.

Form and Convenience

• Capsules: Most convenient, consistent dosing, easy to travel with. The most-researched format.
• Powders: Allow flexible dosing, can be mixed into drinks, sometimes more cost-effective per serving.
• Lozenges/Sublingual: Bypass digestive breakdown, convenient, may have faster absorption.
• Liposomal Liquids: Enhanced absorption technology, though clinical dosing data remains limited.

How We Tested

We evaluated NAD+ supplements using a systematic methodology designed to identify formulas with clinical backing, quality manufacturing, and real-world effectiveness.

Formula Analysis

We examined each product’s ingredient list against published NAD+ research to verify:

• Precursor dosing aligns with amounts shown effective in clinical trials (250-2,000mg for NR, 300-1,200mg for NMN)
• Supporting ingredients have evidence for enhancing or sustaining NAD+ production
• No proprietary blends that hide actual ingredient amounts
• Absence of unnecessary fillers or underdosed “window dressing” ingredients

We gave preference to formulas addressing multiple aspects of cellular energy metabolism rather than relying on a single precursor alone.

Quality Verification

We checked each brand’s commitment to quality through:

• Third-party testing status: Do they test batches independently for purity and potency?
• Certificate of Analysis availability: Can customers access actual test results?
• Manufacturing standards: GMP-certified facilities? NSF Certified for Sport?
• Contamination screening: Testing for heavy metals, microbes, and other contaminants?

Brands that make test results publicly available or easily accessible scored highest for transparency.

Clinical Evidence Review

We researched whether product formulations matched research protocols:

• Does the NMN or NR dose align with human clinical trials?
• Are combination ingredients supported by NAD+ metabolism research?
• Have the specific branded ingredients (like Niagen) been studied independently?
• Does the company reference legitimate peer-reviewed research or rely on marketing claims?

Real-World Testing Factors

We considered practical use factors:

• Serving size: Number of capsules/scoops required
• Mixing requirements: For powders, how easily they dissolve
• Taste: For flavored formats
• Travel convenience: Can you easily take it on the go?
• Dosing flexibility: Can you adjust intake based on your needs?

Value Assessment

We compared cost-effectiveness accounting for:

• Actual precursor amount per dollar spent
• Inclusion of supporting ingredients that may enhance or sustain results
• Bulk purchasing or subscription discounts
• Shipping costs and policies

The cheapest option isn’t always the best value if it requires higher doses or lacks ingredients for sustained effectiveness.

Frequently Asked Questions

What is the best NAD+ supplement?

Jinfiniti Vitality ↑® NAD+ Booster is our top pick because it’s the only formula with clinical data showing 85% of users reach optimal NAD+ levels in 4 weeks. The multi-pathway approach combining NMN, niacinamide, creatine, and D-ribose outperformed single-ingredient NAD+ boosters by 3x in trials.

Should I take NMN or NR?

Both NMN and NR effectively raise NAD+ levels in clinical trials. NMN is one metabolic step closer to NAD+, while NR has more published human research. Rather than choosing, consider formulas that combine both to potentially access a wider range of benefits.

What’s the optimal NAD+ dosage?

Clinical research shows effective daily doses of 250-500mg for NR and 300-900mg for NMN. Higher doses up to 2,000mg NR and 1,200mg NMN have proven safe in human trials. Start at the lower end and increase based on your response and healthcare provider guidance.

How long does it take to see results from NAD+ supplements?

Blood NAD+ levels typically increase within 1-2 weeks of consistent supplementation. Subjective energy improvements often appear by weeks 2-4. Full benefits for cellular health markers may take 8-12 weeks to develop. Results vary based on baseline NAD+ status, age, and overall health.

Users report noticeable improvements in energy, mental clarity, and recovery following a similar timeline in this NMN before and after analysis of real-world results.

Can I take NAD+ with other supplements?

NAD+ supplements generally combine safely with most other supplements. They pair well with antioxidants, B vitamins, omega-3s, and other longevity-focused nutrients. Always consult your healthcare provider before combining supplements, especially if you take prescription medications.

Are there side effects from NAD+ supplements?

NAD+ precursors (NMN and NR) are well-tolerated at research doses. Mild side effects reported in some studies include nausea, headache, or digestive discomfort, typically when starting at high doses. These effects are rare and usually resolve with continued use or dose adjustment.

Should NAD+ be taken with food?

Research protocols vary. Some studies used fasted dosing, others with meals. NAD+ precursors are fat-soluble, so taking them with food containing healthy fats may improve absorption. Follow product-specific recommendations or take with your morning meal for consistent absorption.

What time of day should I take NAD+?

Most research uses morning dosing to align with natural circadian rhythms and energy needs. Some formulas recommend split dosing (morning and evening) for sustained NAD+ elevation. Avoid taking close to bedtime as increased cellular energy might interfere with sleep for some users.

How does NAD+ compare to NMN?

NAD+ is the end product your cells need. NMN is a precursor your body converts to NAD+. Taking NMN orally is more effective than taking NAD+ directly because NMN has better bioavailability and cellular uptake. Your body efficiently converts NMN to NAD+ once absorbed.

Will NAD+ supplements help with weight loss?

NAD+ supports metabolism and mitochondrial function, which influence energy expenditure. Some research shows NAD+ precursors may improve insulin sensitivity and metabolic health markers.

NAD+ supplements aren’t weight loss drugs. Benefits for body composition appear as part of improved overall metabolic health.

Research examining NMN and weight loss shows the connection between NAD+ metabolism and body composition is more nuanced than simple calorie burning.

Important Medical Disclaimer

This article provides educational information about NAD+ supplements based on current scientific research. It should not replace medical advice from qualified healthcare professionals.

Consult Your Healthcare Provider

Always speak with your doctor before starting NAD+ supplementation, especially if you:

• Have existing medical conditions
• Take prescription medications
• Are pregnant, nursing, or planning pregnancy
• Have a personal or family history of cancer
• Are scheduled for surgery
• Take blood thinners or immunosuppressant drugs

Research Limitations

While human trials show NAD+ precursors safely increase NAD+ levels and cellular function markers, long-term studies (multiple years) remain limited. Most research examines weeks to months of supplementation.

Cancer research has shown tumor cells require NAD+ for growth, raising theoretical concerns about NAD+ supplementation in people with active cancer or high cancer risk. This relationship needs more research to fully understand.

FDA Status

Dietary supplements like NAD+ boosters are not evaluated by the FDA for safety or efficacy. These products are not intended to diagnose, treat, cure, or prevent any disease.

Individual Variation

Response to NAD+ supplementation varies based on age, baseline NAD+ status, genetics, overall health, and lifestyle factors. Results from research studies represent group averages and may not reflect your personal experience.

Testing Recommended

Consider testing your NAD+ levels before and during supplementation to verify the supplement is working for your biochemistry.

Jinfiniti offers the world’s only consumer NAD+ test processed in a CLIA-certified laboratory.

Learn how to test NAD+ levels accurately and what the results mean for your supplementation strategy.

For personalized guidance about NAD+ supplementation and dosing appropriate for your health status, consult a qualified healthcare provider familiar with longevity medicine.