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Tag: Inflammation

NAD: A New Cure for Seasonal Allergies

Allergy season is just beginning and more than 81 million Americans are suffering. Could NAD be a new cure?

As the spring season unfurls its vibrant colors and the air fills with the gentle buzz of life, many individuals brace themselves for the less welcome arrival of pollen season. For those with allergies, this time of year can be particularly challenging, with symptoms ranging from mild discomfort to severe reactions that significantly impact daily life. However, emerging research into the molecular and cellular mechanisms of nicotinamide adenine dinucleotide (NAD) offers a glimmer of hope for managing these seasonal woes more effectively.

Understanding NAD and Its Role in the Immune System

NAD is a coenzyme present in all living cells, essential for numerous metabolic processes, including those that convert food into energy. It also plays a critical role in repairing DNA, regulating protein functions, and maintaining cellular health. Recent studies have begun to shed light on how NAD influences immune responses, particularly in the context of allergies.

1. Regulation of Immune Cells

The immune system is a complex network of cells and proteins that defends the body against infection. However, in people with allergies, this system misidentifies harmless substances like pollen as dangerous invaders, triggering an allergic reaction. NAD influences the function and regulation of various immune cells, including T cells, B cells, and macrophages. These cells are pivotal in orchestrating the body’s response to allergens. By modulating the activity and differentiation of these cells, NAD can potentially alter the immune system’s reactivity to allergens, offering a new avenue for allergy management.

2. Reduction of Inflammatory Response

Inflammation is a hallmark of allergic reactions, manifesting as redness, swelling, and discomfort. NAD plays a role in the signaling pathways that regulate inflammation. By influencing these pathways, NAD can potentially modulate the body’s inflammatory response to allergens. This modulation could lead to a reduction in the severity of allergic symptoms, making pollen season more bearable for those affected.

3. Regulation of Sirtuin Activity

Sirtuins are a family of enzymes dependent on NAD, known for their role in promoting cellular health, longevity, and stress resistance. They also play a crucial part in regulating inflammation and immune responses. Activation of sirtuins could help mitigate the inflammatory processes associated with allergic reactions. Since sirtuins require NAD to function, maintaining optimal NAD levels is crucial for their activity. This connection highlights another pathway through which NAD can influence allergic responses.

4. NAD Precursors Suppress Hyper Allergic Reactions

In 2022, an article published on NMN.com explains that researchers in Korea identified a lot of hope in hyper allergic responses in mice using NAD precursors. “Animal research has shown that the nicotinamide adenine dinucleotide (NAD+) precursor, nicotinamide, inhibits the release of pro-inflammatory proteins called histamines from white blood cells called mast cells. Since mast cell histamine release is a hallmark of the anaphylactic response, this finding provides a glimmer of hope for boosting NAD+ to ward off these allergic reactions. 

The researchers summarize their findings: “The findings showing that NMN or NR treatment reduces the mast cell release of the proinflammatory proteins, histamine and IL-6 begs the question of whether NAD+ precursors could help with common allergies. Anaphylaxis is on the severe end of the allergic response spectrum, and many of the same cellular processes occurring in anaphylaxis happen in common allergies. Namely, histamine and IL-6 release occur frequently and to varying degrees with common allergies. Future human trials could look at the effects of NMN or NR supplementation on blood inflammatory factor levels or examine the severity of symptoms in people with common allergies to, for example, tree pollen.”

For the full article go here.

Jinfiniti’s Vitality Boost: Proven Relief for Allergy Sufferers

Jinfiniti’s Vitality Boost has emerged as a beacon of hope for those suffering from allergies. Vitality Boost has established itself as the most powerful NAD optimizing substance on the market, but many people are experiencing significant reduction in those nagging springtime allergies. As allergies are subsiding, you’re then able to enjoy the beauty of nature and potentially the pets you adore without the headaches of sneezing and sniffling.

“I originally bought this supplement for its longevity support, but to my surprise, it helped with my allergies! We have a dog who sadly gives me lots of sneezing fits, stuffy noses, and occasional asthmatic reactions.
I have taken everything under the sun that the doctor has prescribed. Some of those things have helped mildly, others not so much, but I know every pharmaceutical comes with a cost.  I am happy to say I am now able to nix the daily Zyrtec that was previously needed to cope after a month of using Vitality and am using only Singulair and my emergency inhaler. 
Next up, I will try to ease out of a Singulair. Wish me luck! And thanks for the great product!”

-Emily P wrote on our website on 1/28/24.

Conclusion

As we navigate the beauty and challenges of spring, understanding the intricate relationship between NAD and allergies offers a new perspective on managing seasonal allergies. The regulation of immune cells, reduction of inflammatory responses, and regulation of sirtuin activity are just the beginning of unraveling NAD’s full potential in allergy management. With Jinfiniti’s Vitality Boost demonstrating tangible benefits for individuals, including those at the helm of its creation and promotion, NAD boosting emerges as a proven and effective strategy for enhancing quality of life during allergy season. As research continues to evolve, the promise of NAD in allergy management shines brighter, offering hope and relief to those seeking to enjoy the spring season to its fullest.

You may also want to read some of our other recent blogs below:

Additional citations and research on allergies that may be useful:

The Significance of Inflammatory Biomarkers in Health and Longevity

Inflammation is a physiological response that occurs in the body to protect against harmful stimuli. In recent years, the field of medical science has placed increasing importance on the study of inflammatory biomarkers. These biomarkers serve as indicators of inflammation within the body and can provide valuable insights into disease processes, prognosis, and treatment response. Medical professionals can better diagnose and manage various conditions by understanding the role and significance of inflammatory biomarkers.

ALT TXT IMG: Inflammation

Defining Inflammatory Biomarkers

Inflammatory biomarkers are specific molecules or substances that are released in response to inflammation. These biomarkers can be found in various body fluids, such as blood, urine, or cerebrospinal fluid. Common examples of inflammatory biomarkers include C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).

The Biological Role of Inflammatory Biomarkers

Inflammatory biomarkers play a crucial role in the body’s immune response. When an inflammatory trigger is detected, immune cells release these biomarkers to initiate and amplify the inflammatory process. This protective response helps to eliminate pathogens, repair damaged tissue, and restore homeostasis. By measuring the levels of inflammatory biomarkers, healthcare professionals can assess the severity and progression of inflammation. This information is particularly valuable in chronic inflammatory conditions such as rheumatoid arthritis or inflammatory bowel disease.

For example, when an infection occurs, the body’s immune system recognizes the presence of harmful microorganisms and responds by releasing inflammatory biomarkers. These biomarkers act as signals, attracting immune cells to the site of infection. Once at the site, immune cells release additional biomarkers, triggering a cascade of events that destroy the invading pathogens. Inflammatory biomarkers also play a role in tissue repair, as they stimulate the production of growth factors and other molecules that aid in the healing process.

Furthermore, inflammatory biomarkers can have both local and systemic effects. Locally, they contribute to the redness, swelling, and heat commonly associated with inflammation. Systemically, they can induce fever, increase heart rate, and alter blood flow to prioritize immune cell recruitment. These systemic effects help ensure the body’s immune response is robust and effective.

The Clinical Significance of Inflammatory Biomarkers

“Inflammation that’s not specifically from an infection or injury often doesn’t manifest into a lot of clear symptoms,” said Dr. Ketan Amin, a physician with Novant Health Presbyterian Internal Medicine. “It just kind of smolders in the background.”

Inflammatory biomarkers have significant clinical implications across a wide range of medical specialties. Elevated levels of certain biomarkers can indicate active inflammation, infection, or tissue injury. By monitoring these biomarkers, physicians can monitor disease activity, assess treatment response, and make informed decisions regarding therapeutic interventions. For example, in cardiovascular disease, elevated levels of CRP have been associated with an increased risk of heart attack or stroke. By identifying high-risk patients based on biomarker measurements, preventive measures, and targeted therapies can be implemented.

In addition to their diagnostic and prognostic value, inflammatory biomarkers serve as therapeutic targets. Researchers are actively exploring ways to modulate the levels or activity of these biomarkers to treat various inflammatory conditions. For instance, drugs targeting pro-inflammatory cytokines like IL-6 or TNF-alpha have been developed and successfully used in diseases such as rheumatoid arthritis and psoriasis. By blocking the action of these biomarkers, the inflammatory response can be dampened, leading to symptom relief and improved patient outcomes.

Moreover, inflammatory biomarkers are not limited to rheumatology or immunology. They have relevance in other medical specialties as well. In oncology, for example, certain biomarkers can indicate the presence of inflammation within tumors, which can influence treatment decisions and prognosis. Inflammatory biomarkers also play a role in infectious diseases, where their levels can help differentiate between viral and bacterial infections, guide antibiotic therapy, and monitor treatment response.

Overall, the study and understanding of inflammatory biomarkers continue to expand, uncovering their intricate roles in health and disease. As research progresses, new biomarkers may be discovered, offering even greater insights into the complex mechanisms of inflammation and paving the way for more targeted and personalized approaches to patient care.

ALT TXT IMG: Terminally ill

The Interplay between Inflammation and Disease

Inflammation is closely intertwined with various diseases, contributing to their onset, progression, and resolution. It is a complex biological response that occurs when the body’s immune system detects harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammatory biomarkers play a crucial role in elucidating this intricate relationship and pave the way for improved diagnosis and treatment strategies.

When inflammation occurs, the body releases a cascade of molecules, including cytokines, chemokines, and acute-phase proteins. These biomarkers act as signals, attracting immune cells to the site of inflammation and triggering a series of events to eliminate the threat and promote tissue repair.

Inflammatory Biomarkers and Chronic Diseases

Chronic diseases such as diabetes, cardiovascular disease, and autoimmune disorders are characterized by persistent inflammation. Inflammatory biomarkers can provide valuable insights into disease activity and help guide treatment decisions. For example, in diabetes, elevated levels of C-reactive protein (CRP) and interleukin-6 (IL-6) have been associated with insulin resistance and increased risk of complications. By monitoring these biomarkers, healthcare professionals can intervene early, implement targeted interventions, and potentially reduce the burden of chronic diseases.

Moreover, research has shown that chronic inflammation can contribute to the development and progression of atherosclerosis, the underlying cause of many cardiovascular diseases. Inflammatory biomarkers like high-sensitivity CRP (hs-CRP) and fibrinogen can help identify individuals at higher risk of cardiovascular events, allowing for timely interventions and preventive measures.

In autoimmune disorders like rheumatoid arthritis and inflammatory bowel disease, inflammatory biomarkers like erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) can indicate disease activity and guide treatment decisions. Monitoring these biomarkers can help healthcare professionals assess the effectiveness of medications and make adjustments as needed.

Inflammatory Biomarkers in Acute Illnesses

Inflammatory biomarkers are also valuable in the context of acute illnesses. Infections, trauma, or surgical procedures can activate the body’s inflammatory response, leading to the release of specific biomarkers. Measuring these biomarkers can aid in diagnosing the underlying cause of the acute illness, monitoring disease progression, and assessing the effectiveness of treatment.

For instance, elevated levels of procalcitonin have been used as a marker of bacterial infections, enabling prompt initiation of appropriate antibiotics. This biomarker helps differentiate between bacterial and viral infections, guiding clinicians in selecting the most effective treatment approach.

Inflammatory biomarkers like C-reactive protein (CRP) and interleukin-6 (IL-6) are also commonly measured in the context of sepsis, a life-threatening condition characterized by a dysregulated inflammatory response. Monitoring these biomarkers can assist in early detection, risk stratification, and guiding the intensity of treatment in septic patients.

Furthermore, in the field of surgery, measuring inflammatory biomarkers such as interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) can help assess the extent of tissue damage and predict postoperative complications. By closely monitoring these biomarkers, healthcare professionals can optimize patient care and improve surgical outcomes.

In conclusion, the interplay between inflammation and disease is a complex and multifaceted relationship. Inflammatory biomarkers provide valuable insights into disease processes, allowing for early intervention, targeted treatments, and improved patient outcomes. Continued research in this field holds great promise for further understanding the role of inflammation in various diseases and developing innovative therapeutic strategies.

The Process of Identifying Inflammatory Biomarkers

Identifying and validating inflammatory biomarkers is an intricate process that requires meticulous research and validation. It involves a series of steps and techniques to discover and measure specific molecules that indicate the presence or progression of inflammation in the body.

One of the key aspects of this process is the selection of appropriate techniques for biomarker detection. A variety of techniques are employed to detect and measure inflammatory biomarkers. These techniques include enzyme-linked immunosorbent assays (ELISA), polymerase chain reaction (PCR), flow cytometry, and mass spectrometry, among others. Each technique has its advantages and limitations and is selected based on the specific biomarker and sample type.

Enzyme-linked immunosorbent assays (ELISA) are commonly used in biomarker research. They involve the use of specific antibodies that bind to the biomarker of interest, allowing for its detection and quantification. PCR, on the other hand, amplifies specific DNA sequences, making it useful for detecting genetic biomarkers associated with inflammation. Flow cytometry enables the analysis of individual cells, providing valuable information about cell surface markers and intracellular biomarkers. Mass spectrometry, a powerful analytical technique, can identify and quantify biomarkers based on their mass-to-charge ratio.

Advances in technology have also led to the development of point-of-care testing, allowing for rapid biomarker measurement at the bedside. This has significant implications for the early detection and monitoring of inflammatory conditions, as it eliminates the need for time-consuming laboratory analysis.

Despite the progress made in identifying inflammatory biomarkers, several challenges remain. Biomarker research involves rigorous validation studies emphasizing sensitivity, specificity, and reproducibility. It is essential to ensure that the biomarker accurately reflects the presence or severity of inflammation and is not influenced by other factors. Complex diseases may involve multiple biomarkers, requiring a comprehensive approach to diagnosis and monitoring. Identifying and validating a panel of biomarkers that collectively provide a more accurate assessment of inflammation is an ongoing area of research.

Standardization of biomarker assays and variability between laboratories pose additional challenges. It is crucial to establish consistent protocols and quality control measures to ensure reliable and comparable results across different research settings. This is particularly important when biomarkers are used in clinical practice, as accurate and reproducible measurements are essential for making informed decisions about patient care.

Advancements in bioinformatics and big data analysis hold promise in addressing these challenges and facilitating biomarker discovery. Analyzing large datasets and integrating various types of biological information can help identify patterns and associations that may not be apparent through traditional analysis methods. This can lead to the identification of novel biomarkers and the development of more accurate diagnostic and prognostic tools.

In conclusion, the process of identifying inflammatory biomarkers is a complex and ongoing endeavor. It requires the careful selection of techniques, rigorous validation studies, and the overcoming of various challenges. However, advancements in technology and data analysis offer exciting opportunities for further understanding and utilizing these biomarkers in the diagnosis, monitoring, and treatment of inflammatory conditions.

The Future of Inflammatory Biomarkers in Medical Science

As technology advances, inflammatory biomarkers are expected to gain even more prominence in medical science.

Potential Applications of Inflammatory Biomarkers

Inflammatory biomarkers have the potential to revolutionize personalized medicine, allowing for targeted interventions and individualized treatment plans. By understanding the unique biomarker profiles of different diseases and their response to specific therapies, healthcare professionals can tailor treatment strategies, leading to improved outcomes and reduced healthcare costs.

The Impact of Technological Advancements on Biomarker Research

Technological advancements, such as next-generation sequencing, proteomics, and metabolomics, are expanding the possibilities for biomarker discovery. These advancements enable the identification of novel biomarkers, uncovering new pathways and mechanisms underlying disease processes. Moreover, the integration of artificial intelligence and machine learning algorithms allows for the analysis of vast data sets, leading to the development of more accurate diagnostic and prognostic models.

Conclusion

Inflammatory biomarkers are crucial in medical science, providing valuable insights into the complex interplay between inflammation and disease. By understanding the role and significance of inflammatory biomarkers, healthcare professionals can improve diagnosis, monitor disease activity, and tailor treatment strategies. As technology advances, the future of inflammatory biomarkers holds promise for personalized medicine and improved patient outcomes. Detect inflammation in your body with the AgingSOS® Starter Panel.

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Why Optimized, Precision Medicine is the Future
  2. Andrew Huberman is Wrong About NAD, NMN & Longevity
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. What Does Peak Performance Look Like? 

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order)

The 24 Hottest Biohacking Trends in 2024

One question we get asked a lot is, what are the latest biohacking trends? So today we want to breakdown the 24 hottest biohacking trends in 2024. Which of the hottest trends stand out as the most important for you? 

According to our research here at the Jinfiniti, the following biohacking trends stand out, though there’s some that we’ve missed undoubtedly: 

1. A shift towards efficacy-based science.

Mindbody and Class Pass’s annual prediction details a shift in 2024’s consumers from misinformation toward science-based, performance-driven products and services. The report explains that consumers are using clinical studies and research as a metric in their wellness choices, while becoming increasingly savvy about what they put in their bodies and who they listen to for advice. 

2. NAD.

NAD, believe it or not, is still in the early stages of becoming mainstream. It will at least be another year before it leaps into larger adoption by the public. However, early adopters are already big believers in its 360 ability to optimize the human body. NAD plays a crucial role in the human body by serving as a coenzyme involved in over 500 cellular processes, including energy production and DNA repair.

3. Metabolic function.

Most health disorders and diseases stem from some type of metabolic dysfunction. In 2024, understanding and optimizing metabolic function is gaining prominence as a crucial health trend because it directly impacts energy levels, weight management, and overall well-being. This is why it’s one of the six root causes of aging

4. Stem cell innovations.

Stem cell treatments show a lot of promise for treating different types of cancer and other joint/physical pain (although it is largely unvalidated through clinical trials). Whole body stem cell treatments are gaining popularity as well as other specific-use cases, though you’ll likely have to travel outside of the US to get treatments. If you do this, proceed with caution and do your research. 

5. Brain optimization.

Nootropics, NAD, brain exercise devices and at-home neurofeedback such as Apollo Neuro and Sensai are becoming extremely popular among the biohacking community. There is an uphill movement around getting mentally sharper as you age, something science supports as entirely possible.  

6. Inflammation.

Inflammation and Pain innovations:  One of the top five health issues, it affects millions of people. Innovations are happening with the use of sound based devices like StemWave that activate stem cells in your body to reduce pain and even the use of psychedelics like ketamine and psilocybin to treat pain. Additionally, expect more high powered turmeric based supplements with other anti-inflammatory nutrients to emerge. As we learn more about how inflammation induces disease states, we’re accelerating ways to combat inflammation (NAD optimization, for instance, significantly reduces inflammation). Here at Jinfiniti, we have a new inflammation test and product coming out in the 1st half of the year to help combat one of the six root causes of aging.

7. Optimized gut health.

Gut health has become a major health trend because a balanced and thriving gut not only aids in effective digestion, but also influences aspects of overall well-being, from immune function to mood regulation. Supplements like Seed are groundbreaking in creating important innovations in probiotic delivery. 

8. Red light therapy.

Red light therapy is gaining popularity for its abilities to promote cellular repair, reduce inflammation, and enhance skin health. As the spectrum of colors expands, so does our depth of understanding.

9. Mental health breakthroughs with psychedelics.

The use of psychedelics is showing promising breakthroughs by offering unique therapeutic perspectives, potentially bringing mental health breakthroughs to illnesses such as depression and PTSD through profound and transformative experiences. MDMA and psilocybin in particular are expected to be federally decriminalized in 2024, according to pioneers of the movement. 

10. The use of psychedelics to accelerate physical recovery and pain reductio.

Psychedelics are also being explored for physical rehab, with some studies suggesting their potential to assist in pain management and rehabilitation by altering perception and enhancing the mind-body connection. Rehabilitation for stroke victims (see here) and research is currently being done for dealing with pain (ketamine, for example, is being used with success to help treat chronic pain). 

11. Organ supplements.

Organ meats, used for most of humankind history and loaded with essential vitamins and minerals, stopped being part of our regular diet after WWII, which contributes to missing elements in our diets. This article makes the case for it. If you’re looking for a great brand, Ancestral Supplements is one of the best brands for grass-fed organ supplements on the market.

12. Cold therapy.

Cold plunges and cryotherapy will continue to rise in popularity because of their abilities to reduce inflammation, accelerate muscle recovery, ramp up immune systems and regulate brain chemistry.

13. Hot therapy.

Hot saunas, including red light saunas, are on the rise, for not only providing a relaxing moment in your day, but also for promoting cardiovascular health, detoxing and losing weight and easing muscle tension. 

14. Advanced pain relieving fibers.

Companies like Intelligent Threads are working with quantum principles and theoretical physicists to develop fibers that work with your body’s skeletal system and send signals to your muscles to relax. One of our team members bought a shirt at A4M and noticed an immediate relaxation effect in his body. 

15. Peptides.

While facing stiff regulatory challenges, you can expect that peptides will continue to occupy a prominent place in our minds, partly because of their effectiveness (and risk as well). Peptides act as versatile signaling molecules that can influence various physiological processes, making them essential for functions ranging from immune response to tissue repair to hormonal balance. 

16. Mitochondrial function.

As more products come out that improve and elevate this vital component of our body’s health (our Vitality Boost, for instance, gives a huge improvement to mitochondrial function because NAD is used), we understand more and more that optimal mitochondrial health is crucial. These cellular powerhouses not only generate energy but also impact overall cellular function, influencing everything from metabolism and aging to disease resilience.

17. Biomarker testing.

You can expect an increase in awareness and usage of biomarker tests in our culture, because they offer personalized insights into individual health profiles and enable proactive wellness by assessing specific indicators that go far beyond traditional diagnostics. Plus, new tests will be coming out (we have several of our own).

18. EMS body suits for workouts.

These are expanding in popularity because of the potential to get the equivalent of a two-hour workout in 20 mins (+ 20 mins to get the suit on!). These workouts will leave you dripping with sweat. See this story for more information. 

19. New wearable health tech.

Sleep trackers, glucose monitors, step counters and smartwatches won’t be the only games in town for long, but you can expect these to expand in their abilities as well. I expect to see more at-home, wearable brain-optimization devices like Neurovizor or Sensai to gain traction.

20. Glucose monitoring.

Glucose monitoring is important for managing overall health—and not just for individuals with diabetes. Monitoring your blood sugar levels reduces the risk of later complications. Levels is arguably the best app on the market for this.

21. AI.

The use of helpful AI to give health insight, data, and recommendations will continue to accelerate as AI gets smarter every minute, literally. We can see a future where it’s recommending supplements, adjusting foods, recommending exercises, and helping you actively prevent disease.

22. Alcohol alternatives.

The rising popularity of foregoing alcohol reflects a trend towards cleaner, low-carb alternatives that align with a healthier lifestyle while offering a mindful approach to socializing. Hard ketones in particular are gaining popularity and improving in taste. Ketonaid has a tasty piña colada. Kratom is another supplement/drink that is gaining popularity with Kratom bars popping up around many parts of the country. 

23. Women’s health issues taking centerstage.

Did you know that almost all drug testing and development is done primarily with the white male in mind? This means that half of our species—with their unique hormone biochemistry makeup—is left out, not to mention the diversity of ethnicities who also get left out, and other individuals with unique DNA profiles, gut microbiome differences and more. This is a change we look forward to seeing take place all over the globe. 

24. Wellness retreats.

The rising trend of wellness retreats underscores a collective desire for much more holistic well-being. People in the biohacking space crave rejuvenating escapes that are not only fun, but combine self-care practices, mindfulness activities, and healthy lifestyle choices, usually set in an idyllic setting. 

Additional Resources:

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Why Optimized, Precision Medicine is the Future
  2. Andrew Huberman is Wrong About NAD, NMN & Longevity
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. What Does Peak Performance Look Like? 

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order)

The Scary Causes of Oxidative Stress and Inflammation & Disease States

“Inflammation plays a central role in healing, but left to run wild, this process can lead to arthritis, heart disease, and Alzheimer’s.” Harvard Health Publication, April 12, 2021

Oxidative stress and inflammation are two interconnected processes that play crucial roles in the development and progression of various diseases. While they are distinct entities, they often work hand in hand, perpetuating a cascade of events that can lead to tissue damage, chronic diseases, and impaired physiological functions. This article will delve into the intricate relationship between oxidative stress and inflammation, exploring the underlying mechanisms, causes, and potential therapeutic approaches. Through a comprehensive understanding of these processes, you can gain valuable insights into the importance of maintaining a balanced state in your body’s biological systems.

Understanding Oxidative Stress: A Comprehensive Overview

ALT TXT IMG: Inflammation

Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to detoxify or repair the resulting damage. ROS, including free radicals and non-radical molecules, are natural byproducts of cellular metabolism and are usually kept in check by endogenous antioxidant defenses. However, when the production of ROS overwhelms the body’s antioxidant capacity, oxidative stress ensues, leading to cellular dysfunction and damage.

Oxidative stress can have a profound impact on various tissues and organs, including the cardiovascular system, nervous system, liver, and lungs. In the cardiovascular system, oxidative stress can contribute to the development of atherosclerosis, a condition characterized by the buildup of plaque in the arteries. This plaque can restrict blood flow and increase the risk of heart attacks and strokes. 

In the nervous system, oxidative stress has been implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. In the liver, oxidative stress can impair the organ’s ability to detoxify harmful substances, leading to liver damage and dysfunction. In the lungs, oxidative stress can contribute to the development of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma.

Defining Oxidative Stress

Oxidative stress is a physiological condition characterized by the presence of an excess of ROS that surpasses the body’s detoxification and repair mechanisms. It can occur in various tissues and organs, including the cardiovascular system, nervous system, liver, and lungs. The delicate balance between ROS production and antioxidant defenses is crucial for maintaining normal cellular function and preventing oxidative damage.

When oxidative stress occurs, excessive ROS can react with and damage important cellular components, including lipids, proteins, and DNA. This damage can disrupt normal cellular processes and contribute to the development of various diseases. For example, oxidative damage to lipids can lead to the formation of lipid peroxides, which can further propagate oxidative stress and cause cellular dysfunction. Oxidative damage to proteins can alter their structure and function, impairing their ability to carry out vital cellular processes. Oxidative damage to DNA can result in mutations and genomic instability, increasing the risk of cancer development.

The Biological Impact of Oxidative Stress

Oxidative stress has far-reaching implications on cellular homeostasis and overall health. Prolonged exposure to high levels of ROS can lead to oxidative damage to lipids, proteins, and DNA, triggering a cascade of molecular events that impair cellular function and contribute to the development of numerous diseases, including cardiovascular diseases, neurodegenerative disorders, and cancer.

In cardiovascular diseases, oxidative stress plays a key role in the initiation and progression of atherosclerosis. Excessive ROS can promote the oxidation of low-density lipoproteins (LDL), leading to the formation of oxidized LDL particles. These oxidized LDL particles can then trigger an inflammatory response and the recruitment of immune cells, ultimately resulting in the formation of plaque in the arteries. Additionally, oxidative stress can also promote the proliferation and migration of smooth muscle cells, further contributing to the development of atherosclerosis.

In neurodegenerative disorders, oxidative stress can contribute to the accumulation of abnormal protein aggregates, such as beta-amyloid plaques in Alzheimer’s disease and alpha-synuclein aggregates in Parkinson’s disease. These protein aggregates can disrupt normal cellular function and lead to neuronal dysfunction and cell death. Furthermore, oxidative stress can also impair mitochondrial function, leading to energy deficits and increased production of ROS, creating a vicious cycle of oxidative damage and cellular dysfunction.

In cancer, oxidative stress can promote the development and progression of tumors. Excessive ROS can cause DNA damage and mutations, which can lead to the activation of oncogenes and the inactivation of tumor suppressor genes. Additionally, oxidative stress can also promote angiogenesis, the formation of new blood vessels that supply nutrients and oxygen to the growing tumor. This increased blood supply can facilitate tumor growth and metastasis.

Common Causes of Oxidative Stress

Oxidative stress can arise from a variety of internal and external factors. Endogenous sources of ROS include normal metabolic processes, inflammation, and mitochondrial dysfunction. During normal cellular metabolism, ROS are produced as byproducts of energy production. Inflammation, whether acute or chronic, can also increase ROS production as part of the immune response. Mitochondrial dysfunction, which can occur due to genetic mutations or environmental factors, can lead to an increase in ROS production.

Exogenous sources of ROS include exposure to environmental toxins, pollutants, radiation, and certain medications. Environmental toxins and pollutants, such as heavy metals and pesticides, can generate ROS and contribute to oxidative stress. Radiation, whether from natural sources like the sun or medical procedures like X-rays, can also generate ROS and cause oxidative damage. Certain medications, such as chemotherapeutic agents and some antibiotics, can induce oxidative stress as a side effect of their therapeutic action.

ALT TXT IMG: Ashtray with used cigarettes

Lifestyle factors can also contribute to oxidative stress. Smoking, for example, exposes the body to a multitude of harmful chemicals and free radicals, overwhelming the body’s antioxidant defenses. Poor diet, especially one high in processed foods and low in fruits and vegetables, can lead to nutrient deficiencies and a reduced intake of antioxidants. Excessive alcohol consumption can increase ROS production and impair antioxidant defenses. Chronic stress, whether psychological or physical, can also contribute to oxidative stress by disrupting normal cellular processes and increasing inflammation.

In conclusion, oxidative stress is a complex phenomenon that can have profound implications on cellular homeostasis and overall health. Understanding the causes and consequences of oxidative stress is crucial for developing strategies to mitigate its detrimental effects and promote optimal health.

The Role of Inflammation in the Body

Inflammation is a complex biological response that is the body’s natural defense mechanism against injury, infection, and foreign invaders. It is an essential process for tissue repair and healing. However, when inflammation becomes chronic or dysregulated, it can lead to detrimental effects and promote the development and progression of various diseases.

The Inflammatory Response: A Double-Edged Sword

The inflammatory response is a precisely orchestrated process that involves the recruitment of immune cells, release of inflammatory mediators, and activation of signaling pathways. Acute inflammation is beneficial as it helps eliminate pathogens and initiate tissue repair. However, when inflammation persists or becomes excessive, it can lead to tissue damage, dysfunction, and the production of additional ROS, perpetuating a cycle of oxidative stress and chronic inflammation.

Chronic Inflammation: A Silent Threat

Chronic inflammation is characterized by long-lasting low-grade inflammation that persists even in the absence of an infection or injury. It often goes unnoticed as it is not associated with overt symptoms but can silently contribute to the development and progression of chronic diseases, including cardiovascular diseases, diabetes, obesity, and certain cancers. Chronic inflammation acts as a driving force in the link between oxidative stress and inflammation.

Inflammation and Disease: An Undeniable Connection

Mounting evidence suggests that inflammation plays a pivotal role in the pathogenesis of various diseases. In the context of oxidative stress, chronic inflammation can promote excessive ROS production and impair the body’s antioxidant defenses, leading to a vicious cycle of oxidative stress and inflammation. This interconnectedness between oxidative stress and inflammation has been implicated in diseases ranging from atherosclerosis and neurodegenerative disorders to metabolic syndrome and cancer.

Unraveling the Connection Between Oxidative Stress and Inflammation

While oxidative stress and inflammation are distinct biological processes, they are intricately linked, feeding into each other and amplifying their detrimental effects. Several mechanisms underlie the connection between oxidative stress and inflammation, highlighting their interdependent nature.

The Biochemical Interplay

Oxidative stress can activate various signaling pathways involved in inflammation, such as nuclear factor-kappa B (NF-kB), mitogen-activated protein kinases (MAPKs), and inflammasomes. These pathways, in turn, promote the release of pro-inflammatory cytokines and chemokines, perpetuating the inflammatory response. Additionally, inflammation can induce the production of ROS, further exacerbating oxidative stress.

Oxidative Stress as a Trigger for Inflammation

Excessive ROS can directly damage cellular components and activate signaling pathways that promote inflammation. The oxidation of lipids, proteins, and DNA triggers the release of damage-associated molecular patterns (DAMPs), which act as danger signals and initiate the immune response. This immune response can result in the recruitment of immune cells, release of inflammatory mediators, and perpetuation of inflammation.

Inflammation and Its Role in Oxidative Damage

Chronic inflammation produces high levels of ROS and reactive nitrogen species (RNS) as byproducts of immune cell activation. These reactive species can further promote oxidative stress, leading to DNA damage, lipid peroxidation, and protein modification. The resulting oxidative damage contributes to tissue injury, organ dysfunction, and the pathophysiology of inflammatory diseases.

Potential Therapeutic Approaches

The intricate relationship between oxidative stress and inflammation offers potential avenues for therapeutic intervention. By targeting both oxidative stress and inflammation, various strategies aim to restore the delicate balance and prevent or attenuate the progression of chronic diseases.

Antioxidants: Nature’s Defense Against Oxidative Stress

Antioxidants are molecules that neutralize ROS and reduce oxidative stress. They can be endogenous, produced by the body, or exogenous, obtained through dietary sources or supplementation. Foods rich in antioxidants include fruits, vegetables, nuts, and seeds. Emerging research suggests that antioxidant-rich diets and antioxidant supplementation may help mitigate oxidative stress and reduce inflammation, potentially preventing or managing certain diseases.

Anti-Inflammatory Drugs and Their Potential

Anti-inflammatory drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids, are commonly used to manage inflammation and its associated symptoms. These drugs work by inhibiting the production or action of inflammatory mediators and can provide symptomatic relief in acute and chronic inflammatory conditions. However, long-term use of these drugs may have side effects, and their efficacy in preventing or treating chronic diseases associated with oxidative stress and inflammation is still under investigation.

The Promise of Combined Therapies

Given the intricate interplay between oxidative stress and inflammation, combined therapeutic approaches targeting both processes simultaneously hold promise for more effective disease prevention and management. For example, interventions that aim to enhance endogenous antioxidant defenses while modulating the inflammatory response may achieve better outcomes in chronic diseases characterized by both oxidative stress and inflammation.

In conclusion, the link between oxidative stress and inflammation is a complex and bidirectional relationship that underlies the pathophysiology of various diseases. Oxidative stress can trigger inflammation, and chronic inflammation can promote oxidative stress, perpetuating a cycle of damage and dysfunction. Understanding the interplay between these processes is crucial for the development of targeted therapeutic strategies that aim to restore balance and prevent or manage chronic diseases effectively. By exploring the intricate relationship between oxidative stress and inflammation, we can gain valuable insights into the complexities of our body’s biological systems and pave the way for a healthier future.

Reduce inflammation with Accuri® Vitality Boost!

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. Andrew Huberman is Wrong About NAD, NMN & Longevity
  3. Why Optimized, Precision Medicine is the Future
  4. 9 Powerful Benefits of Optimizing Your NAD

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).

Unveiling the Secrets: Are You Aging Faster than You Think? Surprising Body Signals You Should Not Ignore

It’s easy for time to slip away in today’s fast-paced world. Do you often find yourself looking in the mirror, wondering where all those years went? But have you ever stopped to consider that you might be aging faster than you think? The body has a way of sending signals, subtle hints that it’s time to take notice and make some changes. This article will explore the surprising body signals you should not ignore and delve into the science behind the aging process.

ALT TXT IMG: A close-up view of a stopwatch, providing a detailed look at its features and design

Understanding the Aging Process

Before uncovering the secrets of aging, it’s essential to understand the process itself. Aging is a natural part of life, a result of the body’s cells gradually losing their ability to function optimally. As you age, your body goes through various changes that affect your physical appearance, energy levels, and overall health.

One of the key factors in the aging process is the gradual decline in the production of collagen and elastin, two proteins responsible for maintaining the elasticity and firmness of the skin. This decline leads to the formation of wrinkles, sagging skin, and age spots. Additionally, the production of natural oils in the skin decreases, resulting in dryness and a loss of radiance.

Another aspect of aging is the decline in the body’s ability to repair and regenerate cells. This can lead to a slower healing process and an increased susceptibility to diseases and infections. The immune system also weakens with age, making it harder for the body to fight off illnesses.

Biological vs. Chronological Age

Chronological age refers to the number of years you have been alive. On the other hand, biological age takes into account various factors such as genetics, lifestyle choices, and overall health. It’s not uncommon to find individuals who are biologically older or younger than their chronological age suggests. So, while your birth certificate may say one thing, your body might reveal another truth.

Factors such as genetics can play a significant role in determining your biological age. Some people are blessed with genes that allow them to age gracefully and maintain a youthful appearance for longer. On the other hand, certain genetic variations can make individuals more prone to premature aging.

Lifestyle choices also have a profound impact on biological age. Regular exercise, a balanced diet, and stress management techniques can help slow down the aging process. On the contrary, unhealthy habits such as smoking, excessive alcohol consumption, and a sedentary lifestyle can accelerate aging.

ALT TXT IMG: A plate filled with an assortment of healthy vegetables

Factors Accelerating the Aging Process

Although aging is a natural process, certain factors can expedite it. Lifestyle choices play a significant role in how fast you age. Smoking, excessive sun exposure, poor nutrition, and high-stress levels can all contribute to premature aging. Smoking, in particular, has been linked to accelerated skin aging, as it damages collagen and elastin fibers, leading to wrinkles and a dull complexion.

Excessive sun exposure is another major factor in premature aging. Ultraviolet (UV) rays from the sun can penetrate the skin and cause DNA damage, leading to the breakdown of collagen and elastin. This can result in the development of fine lines, wrinkles, and age spots.

Poor nutrition can also contribute to the aging process. A diet lacking essential nutrients, antioxidants, and healthy fats can deprive the body of the building blocks needed for cell repair and regeneration. Additionally, a diet high in processed foods and sugar can promote inflammation, which is linked to accelerated aging.

High-stress levels can take a toll on the body and accelerate the aging process. Chronic stress triggers the release of stress hormones, such as cortisol, which can lead to inflammation and damage to body cells. Prolonged stress can also disrupt sleep patterns, impair immune function, and contribute to the development of chronic diseases.

Additionally, chronic conditions such as diabetes and cardiovascular disease can also accelerate the aging process. These conditions put a significant strain on the body and can lead to oxidative stress, inflammation, and damage to cells and tissues.

It’s essential to be aware of these factors and take proactive steps to mitigate their effects. Adopting a healthy lifestyle, protecting the skin from sun damage, and managing stress levels can slow aging and improve overall well-being.

Recognizing the Subtle Signs of Aging

“The basis of anti-aging is finding and fixing nutrient, hormonal and light deficiencies that occur with age.”

Steven Magee, Author & Scientist

As you age, the body will undergo various changes. Some of these signs are more apparent than others. Here are some subtle indications that you might be aging faster than you think.

Did you know that the aging process affects not only your physical appearance but also your internal systems? It’s fascinating how the body adapts and transforms as time goes by.

Changes in Skin and Hair

One of the most noticeable signs of aging is changes in the skin and hair. Fine lines, wrinkles, and age spots may start to appear. Your hair may become thinner, drier, or show signs of graying. These changes occur due to decreased collagen production and the gradual breakdown of elastin in the skin. It’s important to take care of the skin by adopting a skincare routine and protecting it from the harmful effects of the sun.

Collagen, the protein responsible for maintaining the elasticity of the skin, starts to decline as you age. This reduction leads to the formation of wrinkles and sagging skin. Additionally, the breakdown of elastin, which allows the skin to snap back into place, contributes to the loss of firmness and resilience.

When it comes to the hair, the pigment-producing cells gradually decrease in number, resulting in the appearance of gray or white strands. The hair follicles also shrink, leading to thinner and more brittle hair. Embracing these changes and finding ways to enhance your natural beauty can be empowering.

Shifts in Energy Levels and Sleep Patterns

Another telling sign of aging is a shift in energy levels and sleep patterns. When you age, the body naturally requires less sleep, and experiencing occasional bouts of fatigue is normal. However, if you find yourself feeling constantly drained or having trouble falling or staying asleep, it may be a sign of an underlying issue. It’s crucial to address these changes and seek medical advice if necessary.

Various factors, including hormonal changes, lifestyle choices, and overall health can influence energy levels. It’s essential to listen to your body and provide it with the care it needs. Sometimes, a simple adjustment in your daily routine, such as incorporating regular exercise or practicing stress-reducing techniques, can make a significant difference in your energy levels.

Sleep patterns can also be affected by age-related changes. Sleep quality may decline, leading to difficulty achieving a restful night’s sleep. Creating a relaxing bedtime routine, ensuring a comfortable sleep environment, and avoiding stimulants before bed can help improve sleep quality.

Alterations in Memory and Cognitive Function

Many individuals notice changes in their memory and cognitive function as they age. Forgetfulness and difficulty focusing may become more prevalent. These changes occur due to a decline in brain cell communication and reduced blood flow to the brain. Engaging in mentally stimulating activities, maintaining a healthy diet, and getting regular exercise can help support cognitive function as you age.

The brain, like any other organ, changes as you grow older. The connections between brain cells may weaken, affecting memory and cognitive abilities. Additionally, reduced blood flow to the brain can impact its overall function. However, it’s important to note that cognitive decline is not inevitable and can be influenced by various lifestyle factors.

Engaging in activities that challenge the brain, such as puzzles, reading, or learning new skills, can help maintain cognitive function. A well-balanced diet rich in nutrients, especially those known to support brain health, can also play a significant role in preserving cognitive abilities. Regular physical exercise has been shown to enhance blood flow to the brain and promote overall brain health.

Body Signals You Should Not Ignore

Now that you’ve explored some of the subtle signs of aging, it is time to discuss the body signals you should never ignore. These signals may indicate an underlying issue that requires immediate attention.

Unexplained Weight Changes

If you notice significant and unexplained weight changes, it’s essential to investigate further. Sudden weight loss could be a sign of an underlying medical condition, such as thyroid problems or an undiagnosed illness. On the other hand, unexplained weight gain may be an indication of hormonal imbalances or an unhealthy lifestyle. It’s crucial to listen to your body and consult a healthcare provider if necessary.

Persistent Fatigue and Lack of Energy

Feeling persistently tired and lacking energy, despite getting adequate rest, can be a sign of an underlying issue. Chronic fatigue can result from various causes, including anemia, depression, or chronic conditions such as fibromyalgia. It’s important to pay attention to these signals and seek medical advice to address any underlying concerns.

Frequent Illness or Slow Healing

If you find yourself falling ill frequently or notice that your wounds take longer to heal, it may be a sign that your immune system isn’t functioning optimally. Aging compromises the immune system, making you more susceptible to infections and viruses. However, if you notice a significant decline in your immune function, it’s crucial to consult a healthcare professional to rule out any underlying health conditions.

The Science Behind Aging and Body Signals

Now, it is time to talk about the science behind aging. Two key factors that play a significant role in the aging process are telomeres, inflammation, and oxidative stress.

The Role of Telomeres in Aging

Telomeres are protective caps at the end of chromosomes that shorten with each cell division. As telomeres shorten, your cells age, leading to a decline in functionality. This process contributes to the overall aging of the body. While you cannot stop telomeres from shortening, certain lifestyle choices, such as regular exercise and stress management, can help slow down this process.

Inflammation and Aging

Inflammation, although a natural response to injury or infection, can also contribute to the aging process. Chronic inflammation, often influenced by poor diet and lifestyle choices, can lead to accelerated aging and increased risk of chronic diseases. Following an anti-inflammatory diet, engaging in regular physical activity, and managing stress can help reduce inflammation and slow down the aging process.

Oxidative Stress and its Impact on Aging

Oxidative stress occurs when there is an imbalance between free radicals and antioxidants in the body. Free radicals are unstable molecules that can cause damage to the cells and DNA. Over time, this damage accumulates, contributing to the aging process. Antioxidants, found in fruits, vegetables, and certain vitamins, can help neutralize free radicals. By adopting a diet rich in antioxidants, you can mitigate the effects of oxidative stress and slow down aging.

Conclusion

In conclusion, it’s important to pay attention to the subtle signals the body sends as you age. By recognizing these signs and taking proactive steps, you can identify potential health issues and make the necessary changes to live a healthier, more vibrant life. Understanding the science behind aging and implementing lifestyle modifications can help slow down the aging process and improve overall well-being. So, next time you look in the mirror, remember, that you have the power to take control of your aging journey and embrace the wisdom that comes with it. Are you aging faster than you think? Find out by measuring your epigenetic age. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. 9 Powerful Benefits of Optimizing Your NAD
  3. Why Optimized, Precision Medicine is the Future
  4. Andrew Huberman is Wrong About NAD, NMN & Longevity

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order)

3 Foods for Curing Pain and Inflammation

Pain and inflammation act as our bodies’ dynamic duo, stepping in for defense and repair. In the immediate aftermath of an injury or infection, pain signals serve as red flags, directing our attention to the site of trouble and urging caution. At the same time, inflammation mobilizes the immune system, dispatching cells and biochemical warriors to neutralize threats and initiate the healing process. 

But in the long-term, persistent inflammation can become a double-edged sword, damaging healthy tissues and contributing to the development of chronic conditions. The very mechanisms designed to protect us in the short run can, if left unchecked, turn into saboteurs, wreaking havoc on the body’s delicate balance, creating chronic illness and debilitating physical symptoms. 

In this blog, I’ll be covering the three foods that create pain and inflammation, three foods you can eat to rapidly decrease (and potentially eliminate it), and several bonus tools to integrate into your life that will help you heal from it and prevent it from occurring in the future. 

Let’s go. 

Three Foods That Decrease Inflammation 

Fish Oils 

Fish oils, renowned for their health benefits, are particularly esteemed for their remarkable ability to reduce inflammation in the body. Packed with omega-3 fatty acids (specifically EPA and DHA), fish oils exert potent anti-inflammatory effects at the cellular level. These fatty acids serve as precursors to specialized molecules called resolvins and proteins, which actively work to resolve inflammation and promote tissue repair. Additionally, they inhibit the production of pro-inflammatory cytokines. 

Turmeric

Turmeric, renowned for its vibrant hue and distinctive flavor, packs a powerful punch when it comes to addressing inflammation. The secret weapon within turmeric is curcumin, a bioactive compound with potent anti-inflammatory properties. Curcumin works by targeting multiple pathways at the molecular level, inhibiting the activity of inflammatory enzymes and reducing the production of pro-inflammatory cytokines. Its effectiveness is akin to a skilled conductor orchestrating a symphony of anti-inflammatory responses within the body. 

Studies have shown that curcumin’s impact rivals that of some anti-inflammatory drugs, sans the potential side effects. Incorporating turmeric into one’s diet or opting for curcumin supplements can be a flavorful and natural strategy to help quell inflammation, providing a holistic approach to promoting overall health and well-being.

NAD

NAD—the coenzyme we speak about so much—is a pivotal player in cellular energy production and wields a multifaceted influence on inflammatory processes. NAD’s role in supporting sirtuins is particularly noteworthy. NAD acts as a molecular maestro in over 500 cellular processes in the human body, healing run down metabolic systems and orchestrating an intricate dance that suppresses pro-inflammatory signals. NAD’s effect also extends to immune modulation, ensuring a balanced and controlled response to external threats and reducing your chances of chronic illness. 

Three Foods That Create Inflammation 

Alcohol 

Alcohol, a favorite social elixir, unfortunately wreaks havoc on various physiological systems, triggering an inflammatory response as the body attempts to cope with the assault. The liver, in particular, bears the brunt of alcohol metabolism, leading to the release of inflammatory chemicals and the formation of oxidative stress. This inflammatory cascade can extend beyond the liber, affecting other organs and tissues throughout the body. Alcohol also disrupts the balance of gut bacteria, contributing to intestinal inflammation that may exacerbate overall systemic inflammation. 

While an occasional toast might not be cause for concern, chronic and excessive alcohol consumption can turn the celebration into a symphony of inflammation, potentially leading to long-term health consequences. 

Sugar

Sugar, particularly in the form of refined carbohydrates, can set off a cascade of events that fuel inflammation in the human body. High sugar intake releases pro-inflammatory cytokines and activates inflamed pathways, contributing to a state of chronic inflammation. This inflammatory response permeates many physiological systems such as joints, organs and even the nervous system. 

Sugar consumption is also linked to insulin resistance, a condition that not only disrupts glucose metabolism, but also additionally exacerbates inflammation. 

Pasteurized Dairy 

The dairy pasteurization process involves heating milk to kill harmful bacteria but unfortunately also alters the structure of proteins and enzymes in the milk. For some people, especially those with lactose intolerance or dairy protein sensitivity, these changes trigger an inflammatory response. 

Additionally, pasteurized dairy lacks the beneficial enzymes and probiotics presented in raw varieties, which play a role in aiding digestion and maintaining gut health. 

The inflammatory potential of dairy varies from person to person, and while many individuals tolerate it well, some find relief from inflammation by exploring alternative sources of dairy or opting for fermented dairy products that may be less inflammatory and more digestible.

Three Tools to Reduce Inflammation: 

  • Infrared sauna
  • Cryotherapy 
  • Cold plunges
  • Egoscue (to reduce pain and help balance)— popularized by Tim Farris and also used by Tony Robbins 

For extra resources, see Josh Axe’s blog for anti-inflammation supplements.

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. Andrew Huberman is Wrong About NAD, NMN & Longevity
  3. Why Optimized, Precision Medicine is the Future
  4. 9 Powerful Benefits of Optimizing Your NAD

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).

9 Powerful Benefits of Optimizing Your NAD

No other molecule comes close to helping your cells function optimally as much as NAD. While there is still extensive research being done on all the benefits of NAD, we see nine benefits of optimizing your NAD constantly in test results at the Jinfiniti labs.

There are the given benefits right off the bat: the decrease of pain, inflammation and fatigue and the increase of mental clarity, stamina, recovery, energy, and youthfulness. But keep reading to discover how else the wonderful coenzyme of NAD can benefit you.

NAD is arguably the foundational molecule for all of life. Sadly, it declines as we age, but we can bring our NAD levels back to levels most of us haven’t experienced since we were teenagers, thus giving us a trickle-down effect for many of our age-related diseases (see graph below).

If you’re into health, peak performance, biohacking, or you’re just interested in feeling great, what I’m sharing today is relevant for you. Let’s dive into the cellular functions impacted by NAD.

9 Powerful Benefits of Optimizing Your NAD 

1. TELOMERE SHORTENING

Telomere shortening and NAD+ levels are intricately connected in the context of cellular aging and health. Telomeres are the protective caps at the end of our chromosomes, and their gradual shortening over time is a hallmark of the aging process. As telomeres shorten, cells may lose their ability to divide and function properly. NAD+ plays a crucial role in this process by supporting the activity of enzymes called sirtuins, which are involved in DNA repair and maintenance. Sirtuins require NAD+ as a coenzyme to function effectively, and a decline in NAD+ levels can impair their ability to promote telomere stability and repair.

2. DEREGULATED NUTRIENT SENSING

Deregulated nutrient sensing and NAD+ levels are closely intertwined in the context of metabolic health and aging.  NAD+ serves as a critical cofactor of enzymes like sirtuins (sirtuins + NAD are intricately connected to many aspects of aging), which are key regulators of nutrient sensing pathways. When nutrient sensing becomes dysregulated, often due to overnutrition and sedentary lifestyles, it can lead to metabolic dysfunction and age-related diseases. Maintaining adequate NAD+ levels is crucial to support sirtuin activity and restore balance in nutrient sensing.

3. STEM CELL EXHAUSTION

Stem cell exhaustion and NAD+ levels are intimately interconnected in the context of aging and tissue homeostasis. Stem cells are essential for the regeneration and repair of various tissues, and their capacity to divide and differentiate declines with age. NAD plays a pivotal role in maintaining stem cell function by supporting critical processes like DNA repair and energy production. When NAD levels are low, it contributes to reduced sirtuin activity, leading to inefficient DNA repair and genomic instability within stem cells, which in turn accelerates stem cell exhaustion and compromises tissue repair. By bolstering NAD levels, it’s possible to enhance sirtuin function and potentially rejuvenate stem cell activity.

4. DISABLED MICROAUTOPHAGY

Disabled microautophagy and NAD levels are intricately related in the context of cellular quality control and overall health. Microautophagy is a cellular process responsible for degrading and recycling damaged organelles and proteins through direct engulfment by lysosomes. NAD plays a crucial role in regulating the activity of sirtuins, which are involved in the maintenance of cellular quality control mechanisms, including autophagy. When NAD levels decline, sirtuin activity may be compromised, impacting microautophagy and other autophagic processes. This can result in the accumulation of cellular debris, impaired organelle quality, and ultimately contribute to cellular dysfunction and aging. By sustaining optimal NAD levels, it may be possible to support the efficient functioning of microautophagy and maintain cellular health, offering potential beefits for overall well-being and longevity.

5. INFLAMMAGING

Inflammaging, the chronic low-grade inflammation that accompanies the aging process, is closely intertwined with NAD levels in the context of immune function and age-related diseases. NAD is a critical cofactor for enzymes known as sirtuins, which play a pivotal role in regulating inflammation and immune responses. As NAD levels naturally decline with age, sirtuin activity may decrease, leading to a state of chronic inflammation. This persistent low-grade inflammation is associated with a range of age-related conditions, including neurodegenerative diseases, cardiovascular issues, and metabolic disorders. By replenishing NAD levels, it is possible to potentially enhance sirtuin-mediated anti-inflammatory mechanisms and mitigate inflammaging, offering a promising approach to promote healthier aging and reduce the risk of age-related diseases.

6. MITOCHONDRIAL DYSFUNCTION

Mitochondrial dysfunction and NAD levels are intricately linked in the realm of cellular energy production and overall health. Mitochondria are the powerhouse of our cells, responsible for generating ATP, the cellular energy currency. NAD plays a critical role as a coenzyme in the electron transport chain, a fundamental process in mitochondrial ATP synthesis. However, as NAD levels decline with age, the efficiency of mitochondrial function may deteriorate, leading to impaired energy production and an increase in oxidative stress. By maintaining optimal NAD levels, it’s possible to support the function of key enzymes involved in mitochondrial energy production, potentially mitigating mitochondrial dysfunction, and promoting cellular vitality, which is crucial for overall health and longevity.

7. CELLULAR SENESCENCE

Cellular senescence and NAD levels are interconnected in the context of aging and tissue function. Cellular senescence is a state where cells lose their ability to divide and function properly, often as a response to various stressors or DNA damage contributing to aging-related diseases and tissue dysfunction. Sirtuins, which play a crucial role in regulating and controlling the process of senescence. Declining NAD levels with age can impair sirtuin function, potentially promoting the accumulation of senescent cells in tissues. These senescent cells release proinflammatory signals.

8. LOSS OF PROTEOSTASIS

Loss of proteostasis, the failure to maintain the correct balance of properly folded and functional proteins, is intricately connected with NAD levels in the context of cellular health and aging. NAD is essential for the activity of sirtuins so by replenishing NAD levels, it may be possible to enhance sirtuin-mediated protein quality control mechanisms and maintain proteostasis, potentially mitigating age-related protein aggregation and related diseases, thus supporting overall cellular health.

9. ALTERED CELLULAR COMMUNICATION

Altered cellular communication and NAD levels are closely linked in the context of aging and age-related diseases. NAD plays a pivotal role in the regulation of intercellular signaling and communication processes. As NAD levels naturally decline with age, sirtuin activity may diminish, disrupting the finely tuned cellular communication network. By maintaining optimal NAD levels, it is possible to support sirtuin-mediated mechanisms that help restore proper cellular communication and signaling pathways, potentially mitigating age-related cellular dysfunction and promoting healthier aging.

Additional blogs you may enjoy:

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. 9 Powerful Benefits of Optimizing Your NAD
  3. Why Optimized, Precision Medicine is the Future
  4. Andrew Huberman is Wrong About NAD, NMN & Longevity

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).

3 Things That Age You Quickly

Here at Jinfiniti, we often talk about the things we can do to optimize our health and increase our longevity. But there are also 3 things that can age you quickly unless you actively avoid them.

Let’s dive into the first one. 

  1. POOR SLEEP 

The National Council on Aging discovered that even just one night of lost sleep activates genes related to aging in older adults. They also found that regularly sleeping less than six hours per night may be linked to dementia and stroke-related brain changes as early as middle age.

Lack of sleep may contribute to early onset of many chronic conditions, including dementia, cardiovascular disease, osteoporosis, and diabetes. 

As we age, our body tissues naturally experience some damage and our immune system has a way to remove these damaged cells. Sleep is pivotal to this system because it regulates the immune system and its inflammatory response, helping to remove the damaged cells. So if you’re not getting at least seven hours of sleep per night, your body will show accumulation of inflammation and tissue damage. 

So what’s the solution? Better and longer sleep, of course. But how do we achieve that? 

Here are a few tips: 

  1. Avoid screens for an hour before bedtime. 
  2. Keep your bedroom temperature cool (65°F (18°C) is ideal). 
  3. Avoid caffeine (especially coffee) in the afternoon and minimize alcohol in the evening. 
  4. Keep your bedroom as dark as possible to keep light from interfering with your melatonin production. 
  1. CHRONIC STRESS

Long-term stress is a three-stage killer.

It begins with the release of the hormones cortisol and adrenaline (which cause inflammation and damage to both DNA and cells if they flood your body for a prolonged period of time). It continues with oxidative stress, which is something we talk about quite a bit here at Jinfiniti.

Like stress hormones, oxidative stress also damages cells and DNA, but  it also damages proteins—all of which lead to premature aging. 

Finally, chronic stress affects telomeres, which are the protective caps on the end of your chromosomes that are thought to be a marker of biological aging. Chronic stress is associated with shorter telomeres, which is a serious stage in the problem of premature aging.

So that’s the bad news about stress.

The good news is that if chronic levels of stress are removed, the human body is able to recover and its once-damaged processes can return to healthy levels of functioning.

The body has mechanisms that can repair damaged cells and tissues, and these mechanisms become more high-functioning as the stress is constantly reduced. 

Here are a few of our ideas to reduce chronic stress:

  1. Take a brisk walk. Even a 10-minute walk when you’re feeling stressed can help “burn off” stress hormones and release your body’s feel-good chemicals, which promote relaxation and counter all the physical symptoms associated with stress. 
  2. Try mindfulness. Many people think of mindfulness as a meditation practice, and maybe that’s what you love to do. If not, a simple act of listening to a relaxing song while taking your morning shower or holding a warm beverage while sitting on your front porch, listening to the birds sing, can be acts of mindfulness as well. 
  3. Laugh more. Dr. William Fry refers to laughter as ‘internal jogging’ because it reduces stress hormones and becomes an aperture of joy and hope through which you can look at your life. Whether it’s your children or grandchildren that make you laugh or your favorite TV show, incorporate more opportunities for joy and laughter in your life. 
  1. POOR DIET CHOICES

Aging is a culinary tale, and in this tale, inflammatory foods are the villain.

The havoc that ensues from inflammatory foods accelerates the aging process, leaving a trail of oxidative stress and cellular damage. 

Mitochondria (the energy powerhouses of our cells) has to burn the food we eat to produce ATP (energy), but if we’re eating rice, fried foods or any sugars, (and especially if our mitochondria is already not functioning properly) we’re going to produce free radicals—and free radicals are a big cause of disease and aging. 

Glycation—or, the modification of proteins—is another physiological process that comes out of our diet choices, and it’s a major cause of aging. Not to be confused with glucose (which measures how much sugar is in your blood) glycation measures how much sugar is turning into proteins. 

If you eat a chocolate bar, you’ll experience high levels of glycation (GSP). But it’s not only about how much sugar you eat—it’s also the interaction of your specific genes in combination with the sugar you’re intaking.

Since the foods we consume can either be allies in the battle against time or unwitting accomplices in hastening the aging process, let’s look at the foods that are best left on the shelf: 

  1. Sugar. The Big Bad Guy of inflammatory foods, excessive sugar intake causes glycation, one of the cornerstone causes of premature aging (as explained above). 
  2. Trans Fats. Found in many processed and fried foods, trans fats are notorious for wreaking havoc on our cells. They increase inflammation and contribute to oxidative stress. Check ingredient labels diligently and steer clear of foods that list “partially hydrogenated oils.” 
  3. Processed Meats. Laden with preservatives and additives, processed meats can be detrimental to our attempts to defy aging. Instead, choose lean protein sources like poultry, fish, legumes and nuts instead.
  4. Refined Grains. Often found in white bread, white rice and various processed foods, refined grains cause rapid spikes in blood sugar levels. This triggers a cascade of events leading to inflammation and increased free radicals—in other words, premature aging. Opt instead for unrefined grains or nut and seed options.
  5. Alcohol. NAD levels plummet within the first hour of drinking alcohol, so be mindful of if, when and how you consume alcohol.

Feeling overwhelmed?

Don’t be.

We all eat our favorite (not-so-healthy) treats from time-to-time. Sometimes we get stressed. Other times we don’t get the sleep we need. And that’s okay. 

The most important thing we can do is monitor our biomarker levels in case any of our important physiological processes are malfunctioning in a dangerous way. 

Here at Jinfiniti we recommend testing with one of our biomarker panels because they are the most complete biomarker tests in the world. There are many biomarker tests on the market, but there are none as complete or accurate as Jinfiniti’s. 

Fifty percent of the biomarkers we test for aren’t testable anywhere else in the world! A thorough, comprehensive panel (we have two, priced for your needs) can reveal to you where your body is doing well and where it needs help. 

And if you need to re-stock or purchase our evidence-backed NAD optimization supplement, Accuri® Vitality Boost (backed by our 30-day Money Back Guarantee) you can do so here.

No matter where you’re at on your journey to defy aging and optimize your health, we are here to support you in reaching your goals.

After all, we’re on the same journey as you. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Andrew Huberman is Wrong About NAD, NMN & Longevity
  2. 9 Powerful Benefits of Optimizing Your NAD
  3. Why Optimized, Precision Medicine is the Future
  4. What Does Peak Performance Look Like? 

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).