The 6 Best Fisetin Supplements of 2025, Reviewed by Experts

Disclaimer: This article is for informational purposes only and does not constitute medical advice. The products reviewed have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before starting any new supplement regimen.

If you feel like your energy is lower than it used to be, it takes longer for you to bounce back from workouts or stress, or you just aren’t as mentally sharp as you were 10 years ago, it could be that your cells are accumulating damage more quickly than your body can repair it and get rid of it.

Dead and dying cells that aren’t cleared from your body efficiently (known as senescent cells) are clogging up your body and hastening your rate of aging right now.

Fisetin is a natural plant molecule that helps your body recognize and remove these “zombie cells” before they produce inflammation, exhaustion, and brain fog that make you feel ancient.

The top fisetin supplement can enhance your body’s natural cellular renewal process to help you feel like the younger, stronger, more vibrant version of yourself that you once were.

We’ve evaluated and researched the best fisetin supplements of 2025 so you don’t have to. We used criteria like dosage, absorption technology, ingredient synergy, and third-party testing to determine which fisetin supplements provide the most potent support for your cells.

Best Fisetin Supplements in 2025 Reviewed

Best Overall: Jinfiniti SenoAid™ Senolytic Complex

Fisetin per serving: 170 mg
Additional ingredients: Quercetin (1000 mg), Bromelain, Green Tea Extract, Piperine
Form: Capsules
Certifications: Third-party tested, GMP-certified

Jinfiniti SenoAid™ earns our top pick because it combines clinically-dosed fisetin with quercetin, creating a powerful senolytic formula that addresses cellular aging through multiple pathways.

SenoAid’s 170 mg dose of high-quality fisetin per capsule falls within the studied dosing window, and its 1000 mg quercetin is backed by its own body of senolytic research. Studies have demonstrated that quercetin supports the clearance of senescent cells, and in clinical trials, quercetin and fisetin have been shown to boost each other’s effects^[1][2].

SenoAid boosts the absorption of fisetin and quercetin with piperine (extract of black pepper). Bromelain is added to improve the formula’s anti-inflammatory properties, while green tea extract provides additional antioxidant support.

SenoAid is formulated by genomic scientist and professor Dr. Jin-Xiong She, who has published over 400 research papers. The precision of the formula is the result of years of scientific experience and knowledge in the industry. The supplement is manufactured in a CLIA-certified lab and subject to third-party testing to verify purity and potency.

“The problem of cellular senescence is multi-faceted and requires a multi-pathway approach,” says Dr. She. “Pairing fisetin with quercetin and absorption enhancers results in a more complete formula for cellular renewal than single-ingredient supplements.”

✓ Pros	✗ Cons
Combines fisetin with quercetin for multi-pathway support	Premium pricing compared to single-ingredient options
Includes piperine for potential absorption benefits	Requires 2 capsules per serving
Bromelain may provide additional inflammation support	Some users may experience mild digestive adjustment initially
Formulated by genomic scientist with extensive research background
Third-party tested for purity
May support multiple health aspects (cellular health, inflammation management, healthy uric acid levels)

Best for: People seeking a comprehensive approach to cellular health who want a research-informed formula that combines multiple beneficial compounds in one supplement.

Best High-Absorption Formula: Life Extension Bio-Fisetin

Fisetin per serving: 8 mg (enhanced with galactomannan fibers)
Form: 1 vegetarian capsule
Certifications: Non-GMO, Vegetarian, Gluten-free

Check Current Price →

Life Extension Bio-Fisetin takes a unique approach with a lower fisetin dose enhanced by fenugreek-derived galactomannan fibers that the company states may increase bioavailability up to 25 times compared to standard fisetin.

The proprietary coating is designed to protect fisetin through the digestive system, potentially allowing more of the active compound to reach the bloodstream. This absorption technology suggests the 8 mg dose may provide benefits comparable to higher doses of unformulated fisetin, according to the manufacturer.

Research published in the Journal of Nutritional Science examined this galactomannan-enhanced formula and reported improved fisetin absorption and circulation time in human subjects^[3].

The one-capsule serving makes this convenient to add to any supplement routine. Life Extension’s long-standing reputation and commitment to third-party testing support their product quality claims.

✓ Pros	✗ Cons
Proprietary technology designed for enhanced bioavailability	Lower fisetin milligram amount per dose
Budget-friendly option	Single-ingredient formula without additional compounds
Convenient one-capsule serving	Cost per milligram of fisetin may be higher due to absorption technology
Absorption technology supported by published research
Established brand with quality testing protocols

Best for: People who prioritize absorption technology and prefer a simple, single-ingredient formula at an accessible price point.

Best Pure Fisetin: Doctor’s Best Fisetin with Novusetin

Fisetin per serving: 100 mg
Form: 1 veggie capsule
Certifications: Non-GMO, Gluten-Free, Soy-Free, Vegan

Check Current Price →

Doctor’s Best provides pure fisetin as Novusetin®, a standardized extract from Rhus succedanea (wax tree) designed to provide consistent potency in every capsule.

The 100 mg dose aligns with amounts used in human clinical trials examining fisetin’s effects on cellular health markers. This straightforward formula contains no unnecessary additives or fillers.

According to the product information, Doctor’s Best emphasizes fisetin’s role in supporting glutathione levels (an important cellular antioxidant) and cellular function. These mechanisms are areas of ongoing research in the healthy aging field.

The brand’s vegan-friendly formulation and allergen-free approach make this suitable for people with dietary restrictions or sensitivities.

✓ Pros	✗ Cons
Research-supported fisetin dose	Does not include absorption enhancers
Standardized Novusetin® extract for consistency	Single-ingredient formula
Suitable for vegan and allergen-restricted diets	Moderate pricing for a pure fisetin product
Simple, minimal-ingredient formula
Well-established supplement brand

Best for: People who prefer single-ingredient supplements and want a clean, vegan-friendly fisetin formula from an established brand.

Best Budget Option: Swanson Ultra Fisetin

Fisetin per serving: 100 mg
Form: 1 vegan capsule
Certifications: Vegan, Non-GMO

Check Current Price →

Swanson Ultra Fisetin offers the same Novusetin® extract used in premium brands at a competitive price point, making it an accessible way to try fisetin supplementation.

The formula is straightforward—pure fisetin extract in a vegan capsule. Swanson’s 100% Money Back Guarantee removes financial risk for those wanting to explore fisetin supplements without a large commitment.

With a 4.4-star rating from customer reviews, this product has built a track record among users seeking senolytic support. Customer feedback suggests satisfaction with the product quality and value.

Swanson has operated in the supplement industry since 1969, bringing decades of manufacturing experience and quality protocols to their product line.

✓ Pros	✗ Cons
Competitive pricing for 100 mg fisetin	Does not include absorption enhancers
Uses same Novusetin® extract as premium options	Basic single-ingredient formulation
100% Money Back Guarantee	Standard 30-capsule bottle size
Vegan and Non-GMO certified
Decades of industry experience

Best for: Budget-conscious consumers who want quality fisetin at a competitive price, or those new to fisetin supplements wanting to try it affordably.

Best Value Per Serving: Double Wood Fisetin

Fisetin per serving: 100 mg
Form: 1 capsule
Certifications: Soy-Free, Gluten-Free, Non-GMO, Vegan

Check Current Price →

Double Wood Fisetin stands out for offering 60 capsules per bottle (compared to 30 for most competitors), providing better long-term value for consistent supplementation.

Multi-bottle purchasing options can reduce the per-serving cost even further for those committed to ongoing cellular health support. This pricing structure makes sense given that fisetin’s research suggests benefits may accumulate over time with consistent use.

Double Wood sources their fisetin from Cotinus coggygria (smoke tree) and publishes both Certificates of Analysis and third-party test results on their website. This transparency around testing builds confidence in product quality and purity.

The company recommends starting with 100 mg daily with meals and suggests not exceeding 300 mg per day, which aligns with current research on studied fisetin doses.

✓ Pros	✗ Cons
60 capsules per bottle (double most competitors)	Does not include absorption enhancers
Volume purchasing options available	Best results when taken with food
Publicly available COA and third-party test results	Single-ingredient formulation
Clean, minimal-ingredient formula
Clear dosing guidance based on research

Best for: People planning consistent long-term supplementation who want transparent third-party testing and good value for extended use.

Best Combination Formula: Dr. Mercola Fisetin and Spermidine

Fisetin per serving: 125 mg
Spermidine per serving: 1.2 mg
Form: 1 capsule
Certifications: Non-GMO, Gluten-Free, Soy-Free

Check Current Price →

Dr. Mercola Fisetin and Spermidine combines two longevity-focused compounds in one formula, with fisetin supporting cellular health and spermidine supporting autophagy (the body’s natural cellular maintenance process).

The 125 mg fisetin dose is higher than many single-ingredient supplements, while the 1.2 mg spermidine comes from rice germ extract rather than wheat sources. This makes it suitable for those avoiding gluten or preferring rice-derived ingredients.

According to the product description, spermidine’s role in supporting autophagy may complement fisetin’s cellular effects. Together, these compounds address aspects of cellular aging through distinct but potentially related pathways.

The formulation emphasizes ingredients that may cross the blood-brain barrier, which may be of interest to those focused on cognitive health aspects of aging.

✓ Pros	✗ Cons
Combines two longevity-focused compounds	Premium price point
Higher fisetin dose (125 mg) per serving	Spermidine dose is lower than dedicated spermidine supplements
Rice-derived spermidine suitable for gluten-sensitive individuals	Does not include absorption enhancers
Formulated with brain health focus	Combination approach may not suit those wanting only fisetin
Clean formulation without unnecessary fillers

Best for: People interested in both cellular health and autophagy support who want a combination formula with an emphasis on cognitive health aspects.

Top Fisetin Supplements Comparison Table

Product	Fisetin Dose	Additional Ingredients	Price	Key Feature	Third-Party Tested
Jinfiniti SenoAid	170 mg	Quercetin (1000mg), Bromelain, Green Tea, Piperine	Check Price	Multi-compound formula with absorption enhancer	Yes
Life Extension Bio-Fisetin	8 mg	Galactomannan fibers	Check Price	Proprietary absorption technology	Yes
Doctor’s Best Fisetin	100 mg	None	Check Price	Pure Novusetin® standardized extract	Yes
Swanson Ultra Fisetin	100 mg	None	Check Price	Budget-friendly option	Yes
Double Wood Fisetin	100 mg	None	Check Price	60 capsules per bottle for better value	Yes
Dr. Mercola Fisetin + Spermidine	125 mg	Spermidine (1.2mg)	Check Price	Dual-compound longevity formula	Yes

Pricing subject to change. Click links for current pricing and availability.

What is Fisetin?

Fisetin is a natural flavonoid (plant-based compound) found in strawberries, apples, grapes, onions, and cucumbers. The body does not make it, so it must come from food or supplements.

The problem with getting fisetin from food is that you would have to eat hundreds of strawberries every day to achieve the fisetin doses used in studies. One cup of strawberries has less than 0.2 mg of fisetin, while study protocols have used between 100 and 500 mg of fisetin.

This has been why supplementation is the most reasonable approach for those looking to study fisetin’s potential for supporting cellular health.

Fisetin is one of a group of compounds that are known as senolytics, which are believed by researchers to potentially support the body’s natural ability to manage senescent cells. Senescent cells are those that have stopped dividing and don’t go through the normal process of cell death, so they can accumulate.

In a study published in The Lancet’s EBioMedicine, researchers reported that fisetin showed senolytic activity in laboratory experiments, with effects in senescent cells under research conditions^[4].

How Does Fisetin Work?

Fisetin works at the cellular level through several key mechanisms that researchers believe may support healthy aging. Laboratory and animal studies suggest it acts as both a senolytic compound (supporting the body’s management of senescent cells) and a cellular protector.

The main mechanisms of action are:

• Senolytic activity: May support the body’s natural processes for managing damaged cells that accumulate with age^[4]
• Antioxidant properties: Studies show potential to support glutathione levels and protect against oxidative stress^[5]
• Crosses the blood-brain barrier: Can reach brain tissue directly, unlike many other compounds^[6]
• Multiple pathway effects: Research indicates fisetin influences inflammatory signaling, cellular stress responses, and metabolic pathways simultaneously^[7]

Health Benefits of Fisetin

Research into fisetin’s health effects is ongoing, with most studies conducted in animals or laboratory settings. More human trials are needed to confirm these potential benefits.

Cellular Aging Support

Research in animal models suggests fisetin may help extend both lifespan and healthspan. In one notable study, older mice given fisetin lived longer and showed improved health markers compared to untreated mice^[4].

• Human longevity studies are currently underway
• Cellular mechanisms observed in animals are being studied for potential human relevance

Cognitive and Brain Health

Animal research has shown associations between fisetin supplementation and improved memory and learning performance. Studies found maintained cognitive function in older animal subjects^[6].

• Human clinical trials examining cognitive benefits are in progress
• May support brain health through reduced neuroinflammation and cellular protection

Inflammation Management

Laboratory studies indicate fisetin may influence inflammatory signaling molecules through multiple cellular pathways, including effects on NF-κB activation^[8].

• May support healthy inflammatory responses
• Observed effects in cell studies need confirmation in human trials

Cardiovascular Health

Animal research has examined fisetin’s potential effects on blood vessel health and circulation markers, likely related to its antioxidant properties^[9].

• Studies show potential benefits for maintaining healthy blood vessels
• Human cardiovascular research is currently limited

Metabolic Function

Preliminary research suggests fisetin might influence blood sugar metabolism and insulin sensitivity^[10].

• Studies examined effects on insulin-producing cells^[11]
• More research needed to determine practical applications for human metabolic health

How to Choose a Fisetin Supplement

When comparing fisetin supplements, several factors may help you identify products that align with current research and quality standards.

Fisetin Dosage

Research in humans has examined doses ranging from 100 mg to 500 mg daily. Most clinical trials studying fisetin’s cellular effects use doses in the 100-300 mg range.

Lower doses (under 50 mg) may not provide the levels studied in senolytic research, while very high doses (over 500 mg) haven’t been extensively studied in humans for long-term safety.

Research protocols have commonly used 100-200 mg daily for consistent supplementation, with some studies examining higher doses for shorter periods (a few days per month) rather than continuous daily intake.

Absorption Enhancement

Fisetin has relatively poor bioavailability on its own in standard supplement form. Some formulas address this through:

• Piperine (black pepper extract): Research suggests this may enhance absorption of various plant compounds
• Galactomannan fibers: Designed to protect compounds through digestion
• Liposomal delivery: Encapsulates compounds in lipid molecules
• Taking with fats: Consuming with meals containing healthy fats may improve uptake

Synergistic Ingredients

While pure fisetin has been studied independently, some research examines it in combination with other compounds.

Quercetin is frequently studied alongside fisetin in senolytic research. Studies have examined these two flavonoids together, suggesting they may work through complementary pathways.

Other compounds sometimes combined with fisetin include:

• Bromelain: May support absorption and has been studied for inflammatory responses
• Spermidine: Studied for its potential effects on autophagy processes
• Green tea extract: Provides additional antioxidant compounds
• Resveratrol: Another compound studied in longevity research

Third-Party Testing

Because supplements are not pre-approved by the FDA, independent verification can help verify product quality. Consider brands that:

• Test batches for purity and potency
• Publish Certificates of Analysis (COAs) showing test results
• Use GMP-certified manufacturing facilities
• Screen for heavy metals, pesticides, and contaminants

Reputable brands typically make this testing information accessible on their website or available upon request.

Source and Standardization

Fisetin supplements typically use one of two plant sources:

• Cotinus coggygria (smoke tree): Most common source
• Rhus succedanea (wax tree): Used in Novusetin® standardized extract

Standardized extracts (like Novusetin) guarantee a specific percentage of active fisetin in every batch, ensuring consistency from bottle to bottle.

Form and Convenience

Consider your preferences around:

• Capsule count per serving: Some require 1 capsule daily, others need 2-3
• Capsule size: Larger doses may mean bigger pills
• Vegan options: Look for plant-based capsules if this matters to you
• Serving frequency: Daily dosing versus pulse dosing (a few days per month)

How We Tested

Independent Evaluation Disclaimer: The products reviewed in this article were evaluated independently based on publicly available information, published research, and product specifications. We have no affiliation with any of the brands mentioned except Jinfiniti, and product inclusion does not constitute endorsement by any manufacturer. Our evaluations represent our analysis only.

We evaluated these fisetin supplements using a systematic methodology designed to identify formulas that align with current research on cellular health compounds.

Formula Analysis

We examined each product’s ingredient list, focusing on:

• Fisetin dosage: Does it fall within research-studied ranges?
• Absorption support: What technologies or ingredients may enhance bioavailability?
• Additional compounds: Are combination ingredients supported by research?
• Ingredient quality: Are there unnecessary additives or common allergens?

We compared formulations against published research to verify that doses and combinations align with studied protocols.

Quality Verification

We checked each brand’s commitment to quality through:

• Third-party testing status: Do they test batches independently?
• COA availability: Can customers access test results?
• Manufacturing standards: Are facilities GMP-certified?
• Contamination screening: Do they test for heavy metals and impurities?

We gave preference to brands that make their testing data readily accessible.

Value Assessment

We considered the cost-effectiveness of each product, accounting for:

• Absorption enhancement technologies that may affect effective dosing
• Additional beneficial ingredients beyond fisetin alone
• Capsule count and actual supply duration
• Available discounts for bulk or subscription purchases

Brand Reputation

We considered:

• Years in business and company track record
• Customer reviews and ratings across platforms
• Scientific expertise in formulation
• Transparency around sourcing and manufacturing
• Return policies and customer satisfaction guarantees

Research Alignment

We evaluated whether each formula’s approach reflects current longevity research, including:

• Single-ingredient versus combination formulas
• Dosing strategies studied in research
• Mechanisms of action examined in studies
• Supporting evidence for formula design choices

The TAO Standard

At Jinfiniti, our TAO philosophy emphasizes Test, Act, Optimize as the most effective approach to healthy aging.

While we couldn’t conduct biomarker testing on every product (that would require extensive controlled trials), we evaluated how well each formula’s design might support measurable cellular health improvements based on existing research literature.

We believe effective supplementation works best as part of a comprehensive approach that includes biomarker testing to verify whether supplements are supporting your individual health goals.

Frequently Asked Questions

What is the optimal fisetin dosage?

Most clinical trials use 100-300 mg daily. Starting with 100 mg is common, with adjustments based on your healthcare provider’s guidance.

Should I take fisetin daily or use pulse dosing?

Both approaches have been studied. Daily dosing provides consistent supplementation, while pulse dosing (300-500 mg for 2-3 days monthly) reflects some research protocols. Consult your healthcare provider about which suits your situation.

How long does it take to see benefits from fisetin?

Individual responses vary. Some report changes within 2-4 weeks, but cellular effects likely develop over longer periods. Biomarker testing can provide objective data on your individual response.

Can I take fisetin with other supplements?

Yes, fisetin has been studied alongside other compounds, particularly quercetin. Always check with your healthcare provider before combining supplements, especially if you take prescription medications.

Are there any side effects of fisetin?

Fisetin appears well-tolerated with few reported side effects at studied doses. Some may experience mild digestive discomfort initially. Consult your doctor if you take blood thinners. Pregnant or nursing women should avoid fisetin.

Does fisetin need to be taken with food?

Taking fisetin with a meal containing healthy fats may improve absorption since it’s fat-soluble. This is particularly relevant for formulas without absorption enhancers.

How does fisetin compare to quercetin?

Both are flavonoids studied for effects on senescent cells through different mechanisms. Fisetin may have stronger senolytic activity in lab tests, while quercetin has more extensive research for allergic responses. Research often examines them together—this is why SenoAid includes both.

Will fisetin interact with medications?

Fisetin may interact with blood thinners and medications metabolized by certain liver enzymes. Consult your healthcare provider before adding fisetin if you take prescription medications, especially before surgery.

Can I get enough fisetin from food?

No. You’d need several pounds of strawberries daily to reach research doses of 100-500 mg. Supplementation is the only practical way to reach studied levels.

Is fisetin safe for long-term use?

Animal research shows good tolerance, but human studies beyond several months are limited. Current evidence suggests 100-200 mg daily appears well-tolerated for studied durations. Work with a healthcare provider if planning extended use.

Important Medical Disclaimer

This article is intended for informational and educational purposes only and should not be construed as medical advice. The information provided is based on currently available research and product specifications, but individual results may vary.

Consult Your Healthcare Provider: Always consult with a qualified healthcare professional before starting any new supplement regimen, especially if you:

• Have existing medical conditions
• Take prescription medications
• Are pregnant, nursing, or planning pregnancy
• Are scheduled for surgery
• Have bleeding disorders or take blood thinners

Not FDA Evaluated: The dietary supplements discussed in this article have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Research Limitations: Much of the fisetin research referenced involves animal studies or laboratory research. Human clinical trials are ongoing, and results from animal studies may not translate directly to human health outcomes. More research is needed to fully understand fisetin’s effects in humans.

Brand Independence: This article provides independent product analysis based on publicly available information. Except for Jinfiniti products, we have no affiliation with the manufacturers mentioned. Product inclusion does not constitute brand endorsement or medical recommendation. The companies mentioned have not paid for inclusion in this review.

Individual Results Vary: Responses to supplementation can vary significantly based on individual factors including age, health status, genetics, diet, lifestyle, and other variables. Results mentioned in research studies represent group averages and may not reflect your personal experience.

Testing Recommended: We recommend working with a healthcare provider and considering appropriate biomarker testing before and during supplementation to monitor your individual response and ensure supplements are appropriate for your health situation.

Pricing and Availability: Prices and product availability are subject to change. Please verify current pricing and product specifications on manufacturer websites before purchasing.

For personalized health advice and supplement recommendations tailored to your individual needs, please consult a licensed healthcare professional.