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Tag: NAD

The Big Lie We Believe About Our Health

You’ve been told you’re healthy…but let’s be honest, you may not feel as great as you did when you were 30, assuming you were a healthy 30-year-old. The big lie that most of us believe is that we’re “healthy” when actually we’re just normal.

And in America, the harsh truth is that “normal” isn’t very healthy at all.

Normal isn’t healthy. Optimal is healthy. Don’t settle for normal when you can be optimal. And if you’re 50+ years old, your NAD levels are likely not optimal unless you’ve been taking our vitality boost for quite some time.

Did you know that according to extensive research, the average healthy 50-year-old has lost 50% of their NAD levels? 

Even individuals with high activity levels usually have lower cellular NAD than the average person their age.

That’s because NAD is fuel for cellular function (over 500 cellular processes, in fact). And whether you’re exercising your body or just aging gracefully, you are definitely burning fuel. 

The good news is that you can get your NAD levels optimized and experience all that your body will offer you from an optimized state. And there’s never been a better time to begin than now. 

If you’re curious about where your NAD levels are, you can grab the only NAD test available [here.] 

If you need to re-stock on our evidence-backed NAD+ supplement, Accuri® Vitality Boost, the only supplement backed by both a 30-day Money Back and Efficacy Guarantee, you can do so here.

Our Accuri® Vitality Boost subscription offer is our best value and keeps you stocked on your favorite supplement. Activate your monthly subscription here and save $20 per month. 

No other company backs their products with the opportunity to verify the results. Just us. 

Plus, a little known secret we should let you in on is that most supplement companies are not research-driven, so they’re shooting in the dark with their dosage suggestions.  

We’re not shooting in the dark.

Instead, we give you precision with actionable, data driven insights with the only NAD test available plus the only NAD optimization supplement. We’ve studied thousands of test results, tried and tested the dosage and ingredients, and discovered, based on scientific evidence, what works for 90% of the population.

Your body will thank you. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Why Optimized, Precision Medicine is the Future
  2. What Does Peak Performance Look Like?
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. Andrew Huberman is Wrong About NAD, NMN & Longevity

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).

NAD and age-related diseases

What is NAD?

Nicotinamide adenine dinucleotide (NAD) is a necessary molecule for maintaining life and is found in every cell. NAD is involved in redox reactions and comes in two forms: NAD+ and NADH. Insufficient NAD is involved in five out of the nine hallmarks of aging and can increase the risks of age-related diseases such as cancer, stroke, heart disease, diabetes, and neurodegenerative diseases.

Energy metabolism

NAD is necessary for major energy pathways such as glycolysis, the Krebs cycle, and oxidative phosphorylation. All of these pathways produce the body’s energy currency: ATP. When NAD is not available, cells can’t produce enough ATP to sustain important biological processes which leads to suboptimal health.

Sirtuins: aging regulators

Sirtuins are enzymes that require NAD+ to function and are involved in five hallmarks of aging. When there are healthy amounts of sirtuins and NAD+ cofactors, they inhibit the hallmarks: epigenetic alterations, mitochondrial dysfunction, deregegulated nutrient sensing, genomic instability, and cellular senescence.

DNA repair

The PARP enzymes use NAD to repair DNA to prevent genomic instability, a hallmark of aging.

The sirtuin enzymes also help prevent genomic instability by helping FOXO transcription factors to bind to DNA and express antioxidant enzymes to protect cells from oxidative stress.

NAD deficiency accelerates the hallmarks of aging

When the body does not have enough NAD, all of the above roles are harmed. Without enough NAD, genomic instability, epigenetic alterations, deregulated nutrient sensing, and poor energy metabolism hurt wellness and promote aging. NAD declines with age because it is consumed by enzymes, mainly CD38.

Hallmarks of aging affected by NAD
Hallmark Description NAD’s role
Epigenetic alteration Each of you cells share the same DNA. Epigenetics is what decides which pieces of DNA to use to make proteins and is the reason we have different cell types. With age, our cells become confused and lose some of their ability to function properly within their cell types.
Loss of proteostasis Proteostasis is the ability of a cell to make stable, functioning proteins. As we age, some cells lose the ability to do this well. Instead, they make ineffective or harmful proteins.
Mitochondrial dysfunction Mitochondria generate energy in the form of the ATP molecule via the Krebs cycle and oxidative phosphorylation. These processes are called respiration and produce free radicals that can harm the cell in large numbers. As we age our mitochondria become dysfunctional by producing less ATP and more free radicals.
Senescence Senescent cells are those that stop dividing. This is a good mechanism for preventing cancer, but it can be harmful because it causes cells to release inflammatory molecules into the body and contribute to chronic inflammation.
Deregulated nutrient sensing Cells respond to the availability of nutrients in the diet through different pathways. When nutrient sensing is deregulated, cells don’t respond well to nutrients which can lead to conditions such as insulin insensitivity.

What are the risk factors for NAD deficiency?

NAD declines with age and contributes to disease

Obesity is also a risk factor for NAD depletion, possibly because it contributes to chronic inflammation, which causes DNA damage, requires NAD+-consuming PARP hyperactivation.

NAD deficiency is a common central pathological factor of a number of diseases and aging: cerebral ischemia, myocardial ischemia, diabetes, cancer, metabolic, neurodegenerative diseases, and other age-associated pathologies.

How can you optimize your NAD levels?

Supplementation

NAD precursor supplements such as NR and NMN have been shown to raise NAD levels in humans.

Diet and exercise

Obesity is associated with reduced expression of NAD and sirtuins, whereas weight loss increases NAD and sirtuin expression.

Exercise has been shown to increase activity of an NAD-synthesizing enzyme called NAMPT.

NAD pathways
Reprinted from “Srivastava S. Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders. Clin Transl Med. 2016;5(1):25. doi:10.1186/s40169-016-0104-7”

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Why Optimized, Precision Medicine is the Future
  2. What Does Peak Performance Look Like? 
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. Andrew Huberman is Wrong About NAD, NMN & Longevity

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).

Antioxidants and the TAC assay

Article topics

What is TAC?

Our total antioxidant capacity (TAC) test measures the ability of the blood to blunt the harmful effects of oxidative stress. Although it does not include all of the body’s antioxidant defenses like intracellular enzymes such as superoxide dismutase, it provides a valuable measure of a person’s antioxidant capacity that can be used to identify antioxidant deficiencies and to guide to optimal levels.

Antioxidants blunt the effects of oxidative stress by stopping free radicals from damaging cellular DNA, proteins, and lipids. Stopping free radicals improves immune function, increases healthspan, and reduces DNA damage that contributes to cancer and aging. Combined with the d-ROMs assay, TAC provides a picture of how well you are protected from the harmful effects of oxidative stress.

antioxidants and free radicals
Antioxidants donate electrons to free radicals and stop cell damage.

What are the risk factors for antioxidant deficiency?

Environmental and internal stresses that produce free radicals deplete the body’s antioxidant stores. If you chronically expose yourself to stressors like pollution or a an inflammatory diet, then you will overuse your antioxidant reserves and risk becoming deficient.

Some causes of antioxidant deficiencies:

  • Diets low in antioxidants
  • Alcohol
  • Smoking
  • Radiation
  • Pollution
  • Infections
  • Obesity
  • Chronic inflammation
  • Excessive iron, magnesium, copper, or zinc
  • Excessive antioxidant supplementation

How can you optimize your antioxidant levels?

A word of caution on supplements

While reducing oxidative stress is a good thing, heavy use of supplements like over-the-counter vitamin C and vitamin E can be harmful. In a meta-analysis of 14 clinical trials (n=170,525), antioxidant supplementation was not found to prevent gastrointestinal cancer, but may have increased risk instead.

Many more studies on antioxidant supplementation failed to find beneficial effects:

  • A meta-analysis of 19 randomized clinical trials (n=135,967) concluded that high-dose vitamin E supplements may increase all-cause mortality.
  • A meta-analysis of 53 randomized trials (n=241,833) found an increased risk of all-cause mortality after supplementing with antioxidants.

Diet

Contrary to supplemental antioxidants, dietary antioxidants have a positive effect on health. A study (n=521,457) on the effects of dietary antioxidant compounds found a reduced risk of gastric cancer. Another study surveyed cancer patients and controls suggests eating antioxidant-rich whole foods lowers the risk of cancers like non-Hodgkin’s lymphoma.

Why might whole foods have an effect on cancers while individual supplements may not? The answer may be that there is a synergistic antioxidant effect from eating whole foods that lowers the risks of developing age-related diseases.

Aside from mortality risk, antioxidants can improve cognitive ability. Lutein and zeaxanthin are antioxidants that cross the blood-brain barrier and reduce oxidative stress in the brain. They are found in green leafy vegetablesand can improve cognitive function in older adults

A diverse, non-exhaustive list of high antioxidant foods:

  • Beverages
    • Green tea
    • Coffee
    • Red wine
  • Nuts
    • Walnuts
    • Sunflower seeds
  • Berries, fruits, and vegetables
  • Spices and herbs
    • Cloves
    • Oregano
    • Thyme
antioxidant foods diet

Conclusion

Antioxidants are an integral part of a healthy diet. If you believe you are deficient, try adding more some spices into your meals like allspice, oregano, or cloves, and increase your intakes of fruits and vegetables. Try to get all your antioxidants from whole foods if possible. If you have an allergy to fruits and find it difficult to take in antioxidants from whole foods or spices, then consider small-dose supplements while monitoring your biomarkers so you don’t take high doses.

References

  • Tan BL, Norhaizan ME, Liew WP, Sulaiman Rahman H. Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases. Front Pharmacol. 2018;9:1162. Published 2018 Oct 16. doi:10.3389/fphar.2018.01162
  • Singh AK, Pandey P, Tewari M, Pandey HP, Gambhir IS, Shukla HS. Free radicals hasten head and neck cancer risk: A study of total oxidant, total antioxidant, DNA damage, and histological grade. J Postgrad Med. 2016;62(2):96-101. doi:10.4103/0022-3859.180555
  • Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757-772. Published 2018 Apr 26. doi:10.2147/CIA.S158513
  • Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet. 2004;364(9441):1219-1228. doi:10.1016/S0140-6736(04)17138-9
  • Miller ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142(1):37-46. doi:10.7326/0003-4819-142-1-200501040-00110
  • Bjelakovic G, Nikolova D, Gluud C. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?. PLoS One. 2013;8(9):e74558. Published 2013 Sep 6. doi:10.1371/journal.pone.0074558
  • Serafini M, Jakszyn P, Luján-Barroso L, et al. Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study. Int J Cancer. 2012;131(4):E544-E554. doi:10.1002/ijc.27347
  • Holtan SG, O’Connor HM, Fredericksen ZS, et al. Food-frequency questionnaire-based estimates of total antioxidant capacity and risk of non-Hodgkin lymphoma. Int J Cancer. 2012;131(5):1158-1168. doi:10.1002/ijc.26491
  • Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr. 2003;78(3 Suppl):517S-520S. doi:10.1093/ajcn/78.3.517S
  • Eisenhauer B, Natoli S, Liew G, Flood VM. Lutein and Zeaxanthin-Food Sources, Bioavailability and Dietary Variety in Age-Related Macular Degeneration Protection. Nutrients. 2017;9(2):120. Published 2017 Feb 9. doi:10.3390/nu9020120
  • Hammond BR Jr, Miller LS, Bello MO, Lindbergh CA, Mewborn C, Renzi-Hammond LM. Effects of Lutein/Zeaxanthin Supplementation on the Cognitive Function of Community Dwelling Older Adults: A Randomized, Double-Masked, Placebo-Controlled Trial. Front Aging Neurosci. 2017;9:254. Published 2017 Aug 3. doi:10.3389/fnagi.2017.00254
  • Carlsen MH, Halvorsen BL, Holte K, et al. The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J. 2010;9:3. Published 2010 Jan 22. doi:10.1186/1475-2891-9-3
  • Zhao T, Sun Q, Marques M, Witcher M. Anticancer Properties of Phyllanthus emblica (Indian Gooseberry). Oxid Med Cell Longev. 2015;2015:950890. doi:10.1155/2015/950890

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. 9 Powerful Benefits of Optimizing Your NAD
  2. Andrew Huberman is Wrong About NAD, NMN & Longevity
  3. What Does Peak Performance Look Like? 
  4. Why Optimized, Precision Medicine is the Future

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code welcome20 if you’re a new customer for 20% off your 1st order).