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AgingSOS™: NAD and SA-β-gal dual test

Measure total NAD and Senescence

Unique tests that measure circulating NAD and senescence - key aging factors that can lead to a decline in health. Find out what you can do to maintain healthy levels.



Nicotinamide adenine dinucleotide (NAD) is a necessary molecule for maintaining life and is found in every cell. Insufficient NAD is involved in five out of the nine hallmarks of aging and can increase the risks of age-related such as cancer, stroke, heart disease, and diabetes.

It is thought that the surface protein on immune cells, CD38, increases with age and is the biggest reason why NAD levels decline with age.

Risk factors for sub-optimal NAD levels
  • Age.
  • NADases like CD38.
  • DNA damage that causes PARP activation.

If you are deficient, you can optimize your NAD levels by supplementing with NAD precursors NR or NMN which have been shown to raise levels in animals as well as humans.

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An isoform of beta-galactosidase is a marker for cellular senescence, a hallmark of aging. Senescent cells do not divide or work properly and release a variety of pro-inflammatory factors. Senescence can be a healthy process that prevents cancer cells from dividing, but with enough senescent cells, a condition called secretory-associated senescence phenotype (SASP) emerges that contributes to physical dysfunction of tissues. We developed the first ever assay to reliably measure senescence-associated beta-galactosidase (SA-beta-gal) to track and optimize your senescence levels to prevent SASP.

Risk factors for high SA-beta-gal levels
  • Senescent cells accumulate with age.
  • Oxidative stress can damage cells and induce senescence..
  • Short telomeres can induce replicative senescence.

Senolytic are supplements or drugs like quercetin and dasatinib that are being investigated for clearing senescent cells while preserving healthy ones. Fasting activates autophagy and may clear our senescent cells.

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