Boosting NAD levels has been shown to improve your health span. But there’s never been a way to measure NAD easily and accurately.
An intracellular NAD test gives you actionable data that you can use to create an effective program for boosting NAD levels and living your best life.
Nicotinamide adenine dinucleotide is a necessary molecule for maintaining life.
It is found inside every cell.
NAD deficiency is involved in five out of the nine hallmarks of aging and can increase the risks of age-related diseases such as stroke, heart disease, diabetes, kidney, neurodegenerative and infectious diseases.
Studies have shown that elevating NAD levels can increase
telomre length. NAD is also essential for the functions of many proteins involved in regulating gene expression.
Proteostasis is the ability of a cell to make stable, functioning proteins.
Mitochondria generate energy in the form of the ATP molecule via the Krebs cycle and oxidative phosphorylation. These processes are called respiration and produce free radicals that can harm the cell. As we age our mitochondria become dysfunctional by producing less ATP and more free radicals.
Senescent cells are zombe-like cells that stopped dividing and do not function normally. While senescece plays some imortant roles in normal physiology, increased senescence, as observed in many patients with diseases and people with old age, is harmful because senescent cells secrete large amounts of pro-inflammatory molecules and contribute to many age-related diseases.
Cells respond to the abundance of nutrients in the diet through different pathways. When nutrient sensing is deregulated, cells don’t respond well to nutrients which can lead to conditions such as insulin insensitivity.
Several NAD+ precursors can be used by cells as building blocks to make NAD+. As a one-step precursor to NAD, nicotinamide mononucleotide (NMN) is the most efficacious supplement to elevate NAD+ levels. Nicotinamide riboside (NR), vitamin B3 including nicotinic acid (NA) and nicotinamide (NAM) may also boost NAD+ in some people.
NAD+ or NADH have also been used through different routes (IV, subcutaneous & oral) to elevate NAD levels and treat certain diseases and health conditions.
NAD is constantly consumed by many enzymes. CD38, which is increased by inflammation and during aging, is the key enzyme that degrades NAD. Several supplements have been shown to efficiently inhibit CD38 activity in test tubes.
Certain supplements, diet and exercise can potentially increase the activities of NAD-synthesizing enzymes and thus elevate NAD levels. This strategy could be very useful when combined with NAD precursors.