{"id":31633,"date":"2025-04-16T08:10:22","date_gmt":"2025-04-16T12:10:22","guid":{"rendered":"https:\/\/www.jinfiniti.com\/blog\/?p=31633"},"modified":"2025-07-16T15:30:41","modified_gmt":"2025-07-16T19:30:41","slug":"nicotinamide-riboside-vs-niacinamide","status":"publish","type":"post","link":"https:\/\/www.jinfiniti.com\/blog\/nicotinamide-riboside-vs-niacinamide\/","title":{"rendered":"Nicotinamide Riboside vs. Niacinamide: Which is Better?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">When it comes to Vitamin B3 supplements, the options can get confusing. You&#8217;ve probably heard about niacin, but what about nicotinamide riboside (NR) and niacinamide (NAM)?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These less-familiar forms of Vitamin B3 have been gaining attention for their potential health benefits. Research suggests they might support cellular energy, improve skin health, and potentially promote longevity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">But which one is right for you? Let&#8217;s break down the similarities and differences between these two <a href=\"https:\/\/www.jinfiniti.com\/blog\/nad-precursors\/\">NAD+ precursors<\/a> to help you make an informed choice.<\/p>\n\n\n<style>.kadence-column31633_6c11e8-ea > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-right:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);padding-left:var(--global-kb-spacing-md, 2rem);}.kadence-column31633_6c11e8-ea > .kt-inside-inner-col{border-top:1px solid #000000;border-right:1px solid #000000;border-bottom:1px solid #000000;border-left:1px solid #000000;}.kadence-column31633_6c11e8-ea > .kt-inside-inner-col,.kadence-column31633_6c11e8-ea > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column31633_6c11e8-ea > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column31633_6c11e8-ea > .kt-inside-inner-col{flex-direction:column;}.kadence-column31633_6c11e8-ea > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column31633_6c11e8-ea > .kt-inside-inner-col{background-image:linear-gradient(135deg,rgba(230,234,245,0.3) 0%,rgb(211,216,236) 100%);}.kadence-column31633_6c11e8-ea > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column31633_6c11e8-ea{position:relative;}@media all and (max-width: 1024px){.kadence-column31633_6c11e8-ea > .kt-inside-inner-col{border-top:1px solid #000000;border-right:1px solid #000000;border-bottom:1px solid #000000;border-left:1px solid #000000;flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column31633_6c11e8-ea > .kt-inside-inner-col{border-top:1px solid #000000;border-right:1px solid #000000;border-bottom:1px solid #000000;border-left:1px solid #000000;flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column31633_6c11e8-ea\"><div class=\"kt-inside-inner-col\">\n<h3 class=\"wp-block-heading\">Key Takeaways<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Both NR and NAM are forms of Vitamin B3 that boost NAD+ levels, but they work through different metabolic pathways<\/li>\n\n\n\n<li>Niacinamide (NAM) has stronger clinical evidence for skin health benefits, with decades of research backing its effectiveness<\/li>\n\n\n\n<li>Nicotinamide Riboside (NR) shows promising potential for anti-aging and metabolic health, but human clinical evidence is still emerging<\/li>\n\n\n\n<li>Your choice should depend on your goals: NAM for established skin benefits at lower cost, NR for potential metabolic and anti-aging benefits at premium pricing<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">What Are NR and NAM?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Nicotinamide riboside and niacinamide are both <a href=\"https:\/\/www.jinfiniti.com\/blog\/nad-vs-niacin-vs-niacinamide-vitamin-b3-differences\/\">forms of Vitamin B3<\/a>. Your body uses these to make NAD+ (nicotinamide adenine dinucleotide), a molecule vital for energy production.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Niacinamide (NAM) <\/strong>is the amide form of nicotinic acid&nbsp;found naturally in foods like meat, fish, beans, nuts, and grains. &#8220;Niacinamide&#8221; and &#8220;nicotinamide&#8221; refer to the same molecule. Beauty products usually use &#8220;niacinamide,&#8221; while research papers and supplements use &#8220;nicotinamide.&#8221;<\/li>\n\n\n\n<li><strong>Nicotinamide Riboside (NR)<\/strong> is a more advanced form of Vitamin B3. It combines a nicotinamide molecule with a ribose sugar. Small amounts exist in cow&#8217;s milk, yeast, and beer, but most people get it from supplements.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The key difference is simple: NR contains that extra ribose component, which makes it structurally closer to NAD+.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/Nicotinamide-vs-Niacinamide-1024x1024.png\" alt=\"Infographic showing the differences between Nicotinamide Riboside and Niacinamide\" class=\"wp-image-31635\" title=\"\" srcset=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/Nicotinamide-vs-Niacinamide-1024x1024.png 1024w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/Nicotinamide-vs-Niacinamide-480x480.png 480w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/Nicotinamide-vs-Niacinamide-150x150.png 150w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/Nicotinamide-vs-Niacinamide-768x768.png 768w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/Nicotinamide-vs-Niacinamide-300x300.png 300w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/Nicotinamide-vs-Niacinamide-600x600.png 600w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/Nicotinamide-vs-Niacinamide-100x100.png 100w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/Nicotinamide-vs-Niacinamide.png 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">Why NAD+ Matters<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Before comparing supplements, we should understand <a href=\"https:\/\/www.jinfiniti.com\/what-is-nad-plus\/\">why NAD+ is important<\/a> enough to consider boosting it.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">NAD+ is a coenzyme found in every cell of your body and serves several key functions:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Energy Production<\/strong>: NAD+ helps your cells convert food into energy through processes like glycolysis and mitochondrial oxidative phosphorylation.<\/li>\n\n\n\n<li><strong>DNA Repair<\/strong>: NAD+ supports enzymes that repair DNA damage, helping maintain genetic stability.<\/li>\n\n\n\n<li><strong>Signaling and Regulation<\/strong>: NAD+ is used by enzyme families called <a href=\"https:\/\/www.jinfiniti.com\/blog\/what-are-sirtuins\/\">sirtuins<\/a> that regulate metabolism, stress responses, and possibly influence aging.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Research shows our <a href=\"https:\/\/www.jinfiniti.com\/blog\/nad-levels-by-age\/\">NAD+ levels tend to drop as we get older<\/a>. This decrease may contribute to various age-related conditions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The decline happens because our bodies either produce less NAD+ or use more of it due to factors such as DNA damage and inflammation.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/www.jinfiniti.com\/product\/vitality-nad-plus-booster-supplement-powder\/\" target=\"_blank\" rel=\" noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"330\" height=\"550\" src=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/02\/Vitality-\u2191\u00ae-Vertical-CTA-1.png\" alt=\"Vitality NAD+ Booster promotional image\" class=\"wp-image-28037\" title=\"\"><\/a><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">How They Work: Different Paths to the Same Goal<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">NR and NAM both help create NAD+, but they follow different metabolic pathways to accomplish their goal.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Niacinamide Pathway<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">NAM creates NAD+ through what scientists call the &#8220;salvage pathway.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This is how it happens:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>An enzyme called Nicotinamide Phosphoribosyltransferase (NAMPT) converts NAM to Nicotinamide Mononucleotide (NMN).<\/li>\n\n\n\n<li>Enzymes called Nicotinamide Mononucleotide Adenylyltransferases (NMNATs) then convert NMN to NAD+.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">NAMPT is the rate-limiting enzyme in this process. This means it can become a bottleneck that slows down NAD+ production. This problem may get worse as we age because NAMPT activity often decreases over time.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Nicotinamide Riboside Pathway<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">NR follows a different route:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Enzymes called Nicotinamide Riboside Kinases (NRKs) add a phosphate group to NR, creating Nicotinamide Mononucleotide (NMN).<\/li>\n\n\n\n<li>Like in the NAM pathway, NMNAT enzymes then convert NMN to NAD+.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">The main advantage of NR is that it skips the NAMPT step, potentially offering a more direct path to NAD+.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, it is important to know that NR can also be broken down into NAM in the body, which would then go through the standard NAM pathway.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"438\" src=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/pexels-lastly-808465-1.jpg\" alt=\"Brown Wooden Path Surrounded With Green Grass Near Mountain\" class=\"wp-image-31640\" title=\"\" srcset=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/pexels-lastly-808465-1.jpg 640w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/pexels-lastly-808465-1-480x329.jpg 480w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/pexels-lastly-808465-1-600x411.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">Benefits of Nicotinamide Riboside vs Niacinamide<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Now for the big question: Which one is better? The answer isn&#8217;t straightforward and depends largely on what health goals you&#8217;re trying to achieve.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Nicotinamide Riboside Benefits<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Research on NR has largely focused on cellular energy, mitochondrial function, and potential anti-aging effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NAD+ Boosting<\/strong>: Human studies consistently show that oral NR supplementation effectively <a href=\"https:\/\/www.jinfiniti.com\/blog\/increase-nad-levels\/\">increases NAD+ levels<\/a> in the blood, with increases ranging from 40-90% with regular dosing.<sup data-fn=\"81bd4b68-9bcf-4a93-941e-62742ea930ac\" class=\"fn\"><a id=\"81bd4b68-9bcf-4a93-941e-62742ea930ac-link\" href=\"#81bd4b68-9bcf-4a93-941e-62742ea930ac\">1<\/a><\/sup><\/li>\n\n\n\n<li><strong>Mitochondrial Function<\/strong>: Studies highlight NR&#8217;s capacity to enhance mitochondrial function and potentially promote mitochondrial biogenesis (creation of new mitochondria).<sup data-fn=\"cdca709d-8487-43a0-8783-1cae36313e15\" class=\"fn\"><a id=\"cdca709d-8487-43a0-8783-1cae36313e15-link\" href=\"#cdca709d-8487-43a0-8783-1cae36313e15\">2<\/a><\/sup><\/li>\n\n\n\n<li><strong>Sirtuin Activation<\/strong>: NR is associated with activation of sirtuins, particularly SIRT1 and SIRT3, which are involved in regulating metabolism and longevity pathways.<sup data-fn=\"2408e4cc-98b3-452a-9ff4-01165ea8e810\" class=\"fn\"><a id=\"2408e4cc-98b3-452a-9ff4-01165ea8e810-link\" href=\"#2408e4cc-98b3-452a-9ff4-01165ea8e810\">3<\/a><\/sup><\/li>\n\n\n\n<li><strong>Promising Preclinical Evidence<\/strong>: Animal studies suggest benefits for metabolic health, neurodegenerative diseases, muscle disorders, and even potential lifespan extension in some models.<sup data-fn=\"ba9002d7-ca5d-47d7-a921-7328511bda24\" class=\"fn\"><a id=\"ba9002d7-ca5d-47d7-a921-7328511bda24-link\" href=\"#ba9002d7-ca5d-47d7-a921-7328511bda24\">4<\/a><\/sup><\/li>\n\n\n\n<li><strong>Mixed Human Evidence<\/strong>: While NR reliably increases blood NAD+ levels in humans, clinical evidence for downstream health benefits has been inconsistent. Some studies show modest improvements in blood pressure or aortic stiffness in specific populations<sup data-fn=\"d7b3d91b-f79c-47c8-8227-76727c815d06\" class=\"fn\"><a id=\"d7b3d91b-f79c-47c8-8227-76727c815d06-link\" href=\"#d7b3d91b-f79c-47c8-8227-76727c815d06\">5<\/a><\/sup>, potential neuroprotective effects in Parkinson&#8217;s disease<sup data-fn=\"4b706661-e598-4c69-a177-d5a78c3e5ebd\" class=\"fn\"><a id=\"4b706661-e598-4c69-a177-d5a78c3e5ebd-link\" href=\"#4b706661-e598-4c69-a177-d5a78c3e5ebd\">6<\/a><\/sup>, and possible benefits for conditions like non-alcoholic fatty liver disease (NAFLD) when combined with other compounds.<sup data-fn=\"9997afaa-451e-41a4-837d-1efc899b620e\" class=\"fn\"><a id=\"9997afaa-451e-41a4-837d-1efc899b620e-link\" href=\"#9997afaa-451e-41a4-837d-1efc899b620e\">7<\/a><\/sup><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Niacinamide Benefits<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">NAM has a longer history of research and established applications, particularly in dermatology:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Skin Health<\/strong>: NAM has well-documented benefits for skin, supported by numerous clinical studies using both topical and oral forms:\n<ul class=\"wp-block-list\">\n<li><strong>Acne<\/strong>: Topical NAM (4% creams\/gels) has shown effectiveness comparable to topical antibiotics.<sup data-fn=\"67d463e0-64ab-4a57-9ebf-02b8d42f1c41\" class=\"fn\"><a id=\"67d463e0-64ab-4a57-9ebf-02b8d42f1c41-link\" href=\"#67d463e0-64ab-4a57-9ebf-02b8d42f1c41\">8<\/a><\/sup><\/li>\n\n\n\n<li><strong>Rosacea<\/strong>: Its anti-inflammatory effects help manage redness and inflammation.<sup data-fn=\"1197dd44-c07b-4567-bf56-93e9064d88d8\" class=\"fn\"><a id=\"1197dd44-c07b-4567-bf56-93e9064d88d8-link\" href=\"#1197dd44-c07b-4567-bf56-93e9064d88d8\">9<\/a><\/sup><\/li>\n\n\n\n<li><strong>Skin Aging<\/strong>: Topical application (5% concentration) improves various signs of photoaging, including reducing fine lines, wrinkles, and hyperpigmentation.<sup data-fn=\"6dfef5d1-fc9c-4ff5-9a05-13497762a19f\" class=\"fn\"><a id=\"6dfef5d1-fc9c-4ff5-9a05-13497762a19f-link\" href=\"#6dfef5d1-fc9c-4ff5-9a05-13497762a19f\">10<\/a><\/sup><\/li>\n\n\n\n<li><strong>Skin Cancer Prevention<\/strong>: A landmark clinical trial (ONTRAC) demonstrated that oral NAM (500mg twice daily) significantly reduced the rate of new non-melanoma skin cancers in high-risk individuals.<sup data-fn=\"e86cf554-2db0-4d12-ab23-1d4bd09817bf\" class=\"fn\"><a id=\"e86cf554-2db0-4d12-ab23-1d4bd09817bf-link\" href=\"#e86cf554-2db0-4d12-ab23-1d4bd09817bf\">11<\/a><\/sup><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Other Potential Benefits<\/strong>:\n<ul class=\"wp-block-list\">\n<li><strong>Osteoarthritis<\/strong>: Higher doses (3g\/day) may improve joint flexibility and reduce pain and swelling.<sup data-fn=\"b6cdb823-dcb2-431e-9988-1bcd2aa61019\" class=\"fn\"><a id=\"b6cdb823-dcb2-431e-9988-1bcd2aa61019-link\" href=\"#b6cdb823-dcb2-431e-9988-1bcd2aa61019\">12<\/a><\/sup><\/li>\n\n\n\n<li><strong>Type 1 Diabetes<\/strong>: May help slow disease progression in newly diagnosed individuals by preserving pancreatic beta-cell function.<sup data-fn=\"be510f14-31b8-4081-8832-ad856a7cadb5\" class=\"fn\"><a id=\"be510f14-31b8-4081-8832-ad856a7cadb5-link\" href=\"#be510f14-31b8-4081-8832-ad856a7cadb5\">13<\/a><\/sup><\/li>\n\n\n\n<li><strong>Hyperphosphatemia<\/strong>: Can help lower high blood phosphate levels in kidney failure patients on dialysis.<sup data-fn=\"3d7c0e8a-db36-4d15-b274-2a7858f391fa\" class=\"fn\"><a id=\"3d7c0e8a-db36-4d15-b274-2a7858f391fa-link\" href=\"#3d7c0e8a-db36-4d15-b274-2a7858f391fa\">14<\/a><\/sup><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">A critical distinction emerges when comparing the evidence. NAM has established human clinical data, including large randomized controlled trials, supporting its use for specific conditions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In contrast, while NR shows promising results in preclinical models and reliably boosts NAD+ in humans, strong clinical evidence confirming specific health outcomes in humans is often lacking or inconsistent.<\/p>\n\n\n\n\n\n<h2 class=\"wp-block-heading\">Bioavailability and Safety Profiles<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Bioavailability<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Both NR and NAM are effective at increasing NAD+ levels, but there are some differences in how efficiently they do so:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>NR<\/strong>: Human studies show that NR supplementation (100-1000 mg daily) effectively raises blood NAD+ levels, with increases ranging from 40-90%. However, a significant portion of orally ingested NR may be converted to NAM in the digestive tract or circulation.<\/li>\n\n\n\n<li><strong>NAM<\/strong>: Readily absorbed, primarily in the small intestine, and is generally considered more bioavailable than niacin (NA) due to its more direct pathway to NAD+.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">One interesting finding is that NR supplementation leads to substantial increases in a molecule called NAAD, even when NAD+ levels don&#8217;t show a significant rise. This suggests NR undergoes unique metabolic processing, the implications of which are still being investigated.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"428\" src=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/pexels-cristian-rojas-10042928.jpg\" alt=\"Fit Woman Drinking from Thermos\" class=\"wp-image-31638\" title=\"\" srcset=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/pexels-cristian-rojas-10042928.jpg 640w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/pexels-cristian-rojas-10042928-480x321.jpg 480w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2025\/04\/pexels-cristian-rojas-10042928-600x401.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\">Safety and Side Effects<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Both supplements are generally considered safe, but they have different characteristics at higher doses:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>NR<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Generally well-tolerated up to 1000-2000 mg\/day in studies<\/li>\n\n\n\n<li>Typical side effects, when they occur, include nausea, bloating, fatigue, headache, diarrhea, and skin discomfort<\/li>\n\n\n\n<li>May lower blood pressure, requiring caution for those on antihypertensive medications<\/li>\n\n\n\n<li>Long-term safety data in humans is still relatively limited compared to NAM<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>NAM<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Excellent tolerability, particularly at nutritional and common therapeutic doses<\/li>\n\n\n\n<li>A major advantage over nicotinic acid (niacin) is the lack of the uncomfortable &#8220;niacin flush&#8221;<\/li>\n\n\n\n<li>At typical supplement doses (up to 900-1500 mg\/day), side effects are usually mild and may include stomach discomfort, dizziness, headache, or rash<\/li>\n\n\n\n<li>High doses (&gt;3 g\/day) may cause reversible liver issues, increased blood sugar, or worsen gallbladder disease or peptic ulcers<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Dosage Recommendations from Human Studies<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The effective dosage depends on what you&#8217;re trying to achieve:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>NR<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>For NAD+ boosting: 250-1000 mg per day<\/li>\n\n\n\n<li>250 mg\/day has been shown to increase blood NAD+ by about 40%<\/li>\n\n\n\n<li>500 mg\/day increased blood NAD+ by approximately 90%<\/li>\n\n\n\n<li>1000 mg\/day increased NAD+ in white blood cells by about 60%<\/li>\n\n\n\n<li>Higher doses (2000 mg\/day) have been used in studies on obesity\/insulin resistance and heart failure<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>NAM<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Basic nutritional needs (RDA): 14-16 mg per day for adults<\/li>\n\n\n\n<li>Skin cancer prevention: 500 mg once or twice daily (total 500-1000 mg\/day)<\/li>\n\n\n\n<li>Osteoarthritis: 3 grams per day, typically divided into multiple doses<\/li>\n\n\n\n<li>Acne (oral): 750 mg per day<\/li>\n\n\n\n<li>Topical applications: Usually 4-5% concentration in creams or serums<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Making Your Choice: Which is Better for You?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The &#8220;better&#8221; option really depends on your specific health goals:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Consider NR if<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>You&#8217;re primarily interested in boosting overall NAD+ levels for potential metabolic, mitochondrial, or &#8220;anti-aging&#8221; benefits<\/li>\n\n\n\n<li>You&#8217;re specifically interested in sirtuin activation (NAM can actually inhibit sirtuins at higher doses)<\/li>\n\n\n\n<li>You&#8217;re willing to pay more for a supplement with promising preclinical evidence but less established human clinical outcomes<\/li>\n\n\n\n<li>You&#8217;re comfortable with a newer supplement that has less long-term safety data<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Consider NAM if<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>You&#8217;re focused on skin health (acne, rosacea, photoaging, hyperpigmentation)<\/li>\n\n\n\n<li>You&#8217;re at high risk for non-melanoma skin cancers and looking for preventive measures<\/li>\n\n\n\n<li>You&#8217;re seeking a more budget-friendly option with a longer history of use<\/li>\n\n\n\n<li>You prefer a supplement with more established clinical evidence for specific conditions<\/li>\n\n\n\n<li>You&#8217;re concerned about long-term safety and want a more extensively studied option<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Takeaway on Niacinamide vs Nicotinamide Riboside<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Both nicotinamide riboside and niacinamide are valuable forms of Vitamin B3 that can boost NAD+ levels, albeit through different pathways.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">They share the fundamental goal of supporting cellular NAD+ pools but have distinct profiles regarding established benefits, research evidence, and cost.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">NAM boasts a longer history of use, established clinical benefits (particularly for skin health), and a well-understood safety profile at a more affordable price point.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">NR offers a theoretically more direct pathway to NAD+ and promising preclinical evidence for metabolic and anti-aging benefits, but at a higher cost and with less definitive human outcome data.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For those looking to optimize their NAD+ levels, a comprehensive approach may be most effective. Jinfiniti&#8217;s <a href=\"https:\/\/www.jinfiniti.com\/product\/vitality-nad-plus-booster-supplement-powder\/\">Vitality \u2191\u00ae NAD+ Booster<\/a> offers a clinically validated formula combining NMN (another NAD+ precursor) with niacinamide, D-ribose, and creatine monohydrate.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This synergistic blend is designed to support NAD+ levels, boost energy production, and improve sleep quality and overall cellular function.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">What sets this approach apart is the combination of multiple pathways to NAD+ enhancement, rather than relying on a single precursor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The inclusion of niacinamide provides the established benefits discussed throughout this article, while the additional ingredients work together to maximize cellular energy production.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Remember that supplements should complement, not replace, a healthy lifestyle. Proper nutrition, regular exercise, quality sleep, and stress management remain the foundations of health and may themselves support healthy NAD+ levels.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As with any supplement, it&#8217;s always advisable to consult with a healthcare professional before starting either NR or NAM, especially if you have existing health conditions or are taking medications.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">FAQs<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Are nicotinamide and niacinamide the same thing?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Nicotinamide and niacinamide refer to the exact same molecule. The terms are often used interchangeably, with &#8220;niacinamide&#8221; being more common in cosmetics and skincare products, while &#8220;nicotinamide&#8221; is more frequently used in research and supplement nomenclature.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Why is nicotinamide riboside so much more expensive than niacinamide?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Nicotinamide riboside is more expensive primarily because it&#8217;s a newer, more complex compound that requires special manufacturing processes. The higher cost also reflects marketing around NR&#8217;s potential anti-aging benefits and the costs of ongoing research.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can I take both nicotinamide riboside and niacinamide together?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">While the document doesn&#8217;t specifically address taking both supplements together, there&#8217;s no indication that combining them would be harmful. However, since NR can be converted to NAM in the body anyway, taking both might be redundant. As with any supplement combination, it&#8217;s best to consult with a healthcare provider before starting such a regimen.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Does niacinamide cause flushing like niacin?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">No, unlike niacin (nicotinic acid), niacinamide does not cause the uncomfortable &#8220;niacin flush&#8221; \u2013 a skin reaction characterized by redness, warmth, and itching. This is one of the major advantages of niacinamide over niacin. Nicotinamide riboside also doesn&#8217;t cause flushing.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Which form of Vitamin B3 is best for anti-aging purposes?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Based on current research, nicotinamide riboside has more theoretical potential for overall &#8220;anti-aging&#8221; benefits due to its efficient NAD+ boosting capabilities and association with sirtuin activation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, for specific skin anti-aging benefits (reducing wrinkles, hyperpigmentation, etc.), topical niacinamide (at 4-5% concentration) has stronger clinical evidence.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For internal anti-aging effects, NR shows promise in animal studies, but conclusive human evidence is still emerging.<\/p>\n\n\n<ol class=\"wp-block-footnotes\"><li id=\"81bd4b68-9bcf-4a93-941e-62742ea930ac\"><a href=\"https:\/\/www.nature.com\/articles\/s41514-017-0016-9\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.nature.com\/articles\/s41514-017-0016-9<\/a> <a href=\"#81bd4b68-9bcf-4a93-941e-62742ea930ac-link\" aria-label=\"Jump to footnote reference 1\">\u21a9\ufe0e<\/a><\/li><li id=\"cdca709d-8487-43a0-8783-1cae36313e15\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24071780\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24071780\/<\/a> <a href=\"#cdca709d-8487-43a0-8783-1cae36313e15-link\" aria-label=\"Jump to footnote reference 2\">\u21a9\ufe0e<\/a><\/li><li id=\"2408e4cc-98b3-452a-9ff4-01165ea8e810\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10459282\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10459282\/<\/a> <a href=\"#2408e4cc-98b3-452a-9ff4-01165ea8e810-link\" aria-label=\"Jump to footnote reference 3\">\u21a9\ufe0e<\/a><\/li><li id=\"ba9002d7-ca5d-47d7-a921-7328511bda24\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7352172\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7352172\/<\/a> <a href=\"#ba9002d7-ca5d-47d7-a921-7328511bda24-link\" aria-label=\"Jump to footnote reference 4\">\u21a9\ufe0e<\/a><\/li><li id=\"d7b3d91b-f79c-47c8-8227-76727c815d06\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-018-03421-7\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.nature.com\/articles\/s41467-018-03421-7<\/a> <a href=\"#d7b3d91b-f79c-47c8-8227-76727c815d06-link\" aria-label=\"Jump to footnote reference 5\">\u21a9\ufe0e<\/a><\/li><li id=\"4b706661-e598-4c69-a177-d5a78c3e5ebd\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-43514-6\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.nature.com\/articles\/s41467-023-43514-6<\/a> <a href=\"#4b706661-e598-4c69-a177-d5a78c3e5ebd-link\" aria-label=\"Jump to footnote reference 6\">\u21a9\ufe0e<\/a><\/li><li id=\"9997afaa-451e-41a4-837d-1efc899b620e\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0925443919302029\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0925443919302029<\/a> <a href=\"#9997afaa-451e-41a4-837d-1efc899b620e-link\" aria-label=\"Jump to footnote reference 7\">\u21a9\ufe0e<\/a><\/li><li id=\"67d463e0-64ab-4a57-9ebf-02b8d42f1c41\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28220628\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28220628\/<\/a> <a href=\"#67d463e0-64ab-4a57-9ebf-02b8d42f1c41-link\" aria-label=\"Jump to footnote reference 8\">\u21a9\ufe0e<\/a><\/li><li id=\"1197dd44-c07b-4567-bf56-93e9064d88d8\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25399625\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/25399625\/<\/a> <a href=\"#1197dd44-c07b-4567-bf56-93e9064d88d8-link\" aria-label=\"Jump to footnote reference 9\">\u21a9\ufe0e<\/a><\/li><li id=\"6dfef5d1-fc9c-4ff5-9a05-13497762a19f\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11857428\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11857428\/<\/a> <a href=\"#6dfef5d1-fc9c-4ff5-9a05-13497762a19f-link\" aria-label=\"Jump to footnote reference 10\">\u21a9\ufe0e<\/a><\/li><li id=\"e86cf554-2db0-4d12-ab23-1d4bd09817bf\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10050186\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10050186\/<\/a> <a href=\"#e86cf554-2db0-4d12-ab23-1d4bd09817bf-link\" aria-label=\"Jump to footnote reference 11\">\u21a9\ufe0e<\/a><\/li><li id=\"b6cdb823-dcb2-431e-9988-1bcd2aa61019\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8841834\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/8841834\/<\/a> <a href=\"#b6cdb823-dcb2-431e-9988-1bcd2aa61019-link\" aria-label=\"Jump to footnote reference 12\">\u21a9\ufe0e<\/a><\/li><li id=\"be510f14-31b8-4081-8832-ad856a7cadb5\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10097894\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/10097894\/<\/a> <a href=\"#be510f14-31b8-4081-8832-ad856a7cadb5-link\" aria-label=\"Jump to footnote reference 13\">\u21a9\ufe0e<\/a><\/li><li id=\"3d7c0e8a-db36-4d15-b274-2a7858f391fa\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1051227624000360\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1051227624000360<\/a> <a href=\"#3d7c0e8a-db36-4d15-b274-2a7858f391fa-link\" aria-label=\"Jump to footnote reference 14\">\u21a9\ufe0e<\/a><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>When it comes to Vitamin B3 supplements, the options can get confusing. You&#8217;ve probably heard about niacin, but what about nicotinamide riboside (NR) and niacinamide (NAM)? These less-familiar forms of Vitamin B3 have been gaining attention for their potential health benefits. Research suggests they might support cellular energy, improve skin health, and potentially promote longevity. [&hellip;]<\/p>\n","protected":false},"author":10909,"featured_media":31637,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"[{\"content\":\"<a href=\\\"https:\/\/www.nature.com\/articles\/s41514-017-0016-9\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/www.nature.com\/articles\/s41514-017-0016-9<\/a>\",\"id\":\"81bd4b68-9bcf-4a93-941e-62742ea930ac\"},{\"content\":\"<a href=\\\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24071780\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24071780\/<\/a>\",\"id\":\"cdca709d-8487-43a0-8783-1cae36313e15\"},{\"content\":\"<a href=\\\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10459282\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10459282\/<\/a>\",\"id\":\"2408e4cc-98b3-452a-9ff4-01165ea8e810\"},{\"content\":\"<a href=\\\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7352172\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7352172\/<\/a>\",\"id\":\"ba9002d7-ca5d-47d7-a921-7328511bda24\"},{\"content\":\"<a href=\\\"https:\/\/www.nature.com\/articles\/s41467-018-03421-7\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/www.nature.com\/articles\/s41467-018-03421-7<\/a>\",\"id\":\"d7b3d91b-f79c-47c8-8227-76727c815d06\"},{\"content\":\"<a href=\\\"https:\/\/www.nature.com\/articles\/s41467-023-43514-6\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/www.nature.com\/articles\/s41467-023-43514-6<\/a>\",\"id\":\"4b706661-e598-4c69-a177-d5a78c3e5ebd\"},{\"content\":\"<a href=\\\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0925443919302029\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0925443919302029<\/a>\",\"id\":\"9997afaa-451e-41a4-837d-1efc899b620e\"},{\"content\":\"<a href=\\\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28220628\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28220628\/<\/a>\",\"id\":\"67d463e0-64ab-4a57-9ebf-02b8d42f1c41\"},{\"content\":\"<a href=\\\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25399625\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pubmed.ncbi.nlm.nih.gov\/25399625\/<\/a>\",\"id\":\"1197dd44-c07b-4567-bf56-93e9064d88d8\"},{\"content\":\"<a href=\\\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11857428\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11857428\/<\/a>\",\"id\":\"6dfef5d1-fc9c-4ff5-9a05-13497762a19f\"},{\"content\":\"<a href=\\\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10050186\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10050186\/<\/a>\",\"id\":\"e86cf554-2db0-4d12-ab23-1d4bd09817bf\"},{\"content\":\"<a href=\\\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8841834\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pubmed.ncbi.nlm.nih.gov\/8841834\/<\/a>\",\"id\":\"b6cdb823-dcb2-431e-9988-1bcd2aa61019\"},{\"content\":\"<a href=\\\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10097894\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pubmed.ncbi.nlm.nih.gov\/10097894\/<\/a>\",\"id\":\"be510f14-31b8-4081-8832-ad856a7cadb5\"},{\"content\":\"<a href=\\\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1051227624000360\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1051227624000360<\/a>\",\"id\":\"3d7c0e8a-db36-4d15-b274-2a7858f391fa\"}]"},"categories":[351,352],"tags":[],"class_list":["post-31633","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nad-supplement-interventions","category-nad-precursors"],"_links":{"self":[{"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/posts\/31633","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/users\/10909"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/comments?post=31633"}],"version-history":[{"count":0,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/posts\/31633\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/media\/31637"}],"wp:attachment":[{"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/media?parent=31633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/categories?post=31633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/tags?post=31633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}