{"id":12161,"date":"2025-05-15T11:45:17","date_gmt":"2025-05-15T15:45:17","guid":{"rendered":"https:\/\/www.jinfiniti.com\/blog\/?p=12161"},"modified":"2025-05-15T12:51:33","modified_gmt":"2025-05-15T16:51:33","slug":"nad-and-cancer","status":"publish","type":"post","link":"https:\/\/www.jinfiniti.com\/blog\/nad-and-cancer\/","title":{"rendered":"NAD and Cancer: What We Know and What We Don&#8217;t"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Cancer remains one of the most complex challenges in modern medicine. As scientists search for new treatments, one molecule keeps appearing in research: NAD+ (nicotinamide adenine dinucleotide).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This essential coenzyme plays crucial roles in energy production, DNA repair, and cell survival. But its relationship with cancer is complicated.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Some studies suggest NAD+ could help fight cancer. Others raise concerns about feeding tumor growth. So what should you know about NAD and cancer risk?<\/p>\n\n\n<style>.kadence-column12161_26494d-59 > .kt-inside-inner-col{padding-top:var(--global-kb-spacing-sm, 1.5rem);padding-right:var(--global-kb-spacing-sm, 1.5rem);padding-bottom:var(--global-kb-spacing-sm, 1.5rem);padding-left:var(--global-kb-spacing-md, 2rem);}.kadence-column12161_26494d-59 > .kt-inside-inner-col{border-top:1px solid #000000;border-right:1px solid #000000;border-bottom:5px solid #000000;border-left:1px solid #000000;}.kadence-column12161_26494d-59 > .kt-inside-inner-col,.kadence-column12161_26494d-59 > .kt-inside-inner-col:before{border-top-left-radius:10px;border-top-right-radius:10px;border-bottom-right-radius:10px;border-bottom-left-radius:10px;}.kadence-column12161_26494d-59 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column12161_26494d-59 > .kt-inside-inner-col{flex-direction:column;}.kadence-column12161_26494d-59 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column12161_26494d-59 > .kt-inside-inner-col{background-color:rgba(230, 234, 245, 0.35);}.kadence-column12161_26494d-59 > .kt-inside-inner-col:before{opacity:0.3;}.kadence-column12161_26494d-59{position:relative;}@media all and (max-width: 1024px){.kadence-column12161_26494d-59 > .kt-inside-inner-col{border-top:1px solid #000000;border-right:1px solid #000000;border-bottom:5px solid #000000;border-left:1px solid #000000;flex-direction:column;justify-content:center;}}@media all and (max-width: 767px){.kadence-column12161_26494d-59 > .kt-inside-inner-col{border-top:1px solid #000000;border-right:1px solid #000000;border-bottom:5px solid #000000;border-left:1px solid #000000;flex-direction:column;justify-content:center;}}<\/style>\n<div class=\"wp-block-kadence-column kadence-column12161_26494d-59\"><div class=\"kt-inside-inner-col\">\n<h3 class=\"wp-block-heading\">Key Takeaways<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Scientists can target NAD+ metabolism to starve cancer cells while NAD+ supports your immune system&#8217;s natural cancer-fighting abilities.<\/li>\n\n\n\n<li>Studies show NAD+ supplements don&#8217;t increase cancer risk in healthy people and may improve overall health and longevity.<\/li>\n\n\n\n<li>Your immune cells need adequate NAD+ levels to effectively hunt down and destroy cancer cells.<\/li>\n\n\n\n<li>If you have active cancer or genetic risk factors, consult your healthcare provider before taking NAD+ supplements.<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">How NAD+ Works in Your Body<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.jinfiniti.com\/what-is-nad-plus\/\">NAD+<\/a> is like a cellular currency. Your cells use it for hundreds of different processes every day.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Think of it as fuel for cellular repair and energy production. Without enough NAD+, your cells struggle to function properly.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As you age, your <a href=\"https:\/\/www.jinfiniti.com\/blog\/nad-levels-by-age\/\">NAD levels naturally decline<\/a>. By age 50, you might have half the NAD+ you had at 20.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This decline affects everything from energy levels to DNA repair mechanisms. It&#8217;s one reason why cancer risk increases with age.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lower NAD+ levels are also linked to increased inflammation and are often observed in chronic inflammatory conditions<sup data-fn=\"3aa28b0d-5d16-4c9b-9137-6ab1692f0a96\" class=\"fn\"><a id=\"3aa28b0d-5d16-4c9b-9137-6ab1692f0a96-link\" href=\"#3aa28b0d-5d16-4c9b-9137-6ab1692f0a96\">1<\/a><\/sup>. Chronic inflammation can promote tumor growth, increase treatment resistance, and suppress your immune system.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Your Immune System and NAD+<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Your body&#8217;s ability to fight cancer depends heavily on immune cells called CD8+ T cells. These are your cellular warriors that hunt down and destroy cancer cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Recent research reveals that NAD+ is essential for these T cells to function properly<sup data-fn=\"74682209-5f68-49fa-b78c-d5c57e7cdb98\" class=\"fn\"><a id=\"74682209-5f68-49fa-b78c-d5c57e7cdb98-link\" href=\"#74682209-5f68-49fa-b78c-d5c57e7cdb98\">2<\/a><\/sup>. Without adequate NAD+, your immune system can&#8217;t mount an effective anti-cancer response.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The kynurenine pathway, which produces NAD+, helps maintain T cell fitness in tumor environments. This suggests that supporting NAD+ levels might boost your natural cancer defenses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studies show that targeting NAD+ metabolism can improve T cell function and enhance their ability to kill cancer cells<sup data-fn=\"ed467252-35fc-4812-b8e8-d148c68be0ce\" class=\"fn\"><a id=\"ed467252-35fc-4812-b8e8-d148c68be0ce-link\" href=\"#ed467252-35fc-4812-b8e8-d148c68be0ce\">3<\/a><\/sup>. This creates an interesting paradox in cancer treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Targeting NAD Metabolism in Cancer Treatment<\/h2>\n\n\n<style>.kb-image12161_46a11e-52 .kb-image-has-overlay:after{opacity:0.3;border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;}.kb-image12161_46a11e-52 img.kb-img, .kb-image12161_46a11e-52 .kb-img img{border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;}<\/style>\n<div class=\"wp-block-kadence-image kb-image12161_46a11e-52\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/national-cancer-institute-BxXgTQEw1M4-unsplash-1.jpg\" alt=\"Closeup of woman holding a cancer patient&#039;s hand\" class=\"kb-img wp-image-33881\" title=\"\" srcset=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/national-cancer-institute-BxXgTQEw1M4-unsplash-1.jpg 640w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/national-cancer-institute-BxXgTQEw1M4-unsplash-1-480x320.jpg 480w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/national-cancer-institute-BxXgTQEw1M4-unsplash-1-600x400.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Cancer cells have a dirty secret. They&#8217;re energy hogs that consume massive amounts of NAD+ to fuel their rapid growth.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Scientists have found ways to exploit this weakness. By blocking NAD+ production in cancer cells, they can starve tumors of essential nutrients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Research shows that targeting key enzymes like NAMPT (nicotinamide phosphoribosyltransferase) can effectively kill cancer cells<sup data-fn=\"852ebfb1-d80a-4688-9fa4-812ed0b07c1a\" class=\"fn\"><a id=\"852ebfb1-d80a-4688-9fa4-812ed0b07c1a-link\" href=\"#852ebfb1-d80a-4688-9fa4-812ed0b07c1a\">4<\/a><\/sup>. When you cut off their NAD+ supply, tumors struggle to repair DNA damage and maintain energy production.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PARP inhibitors represent another promising approach. These drugs block an enzyme that uses NAD+ for DNA repair. Studies demonstrate that PARP inhibitors improve survival rates in certain cancers, especially those with BRCA mutations<sup data-fn=\"1f82ab38-1655-47c5-bfef-25b34013a340\" class=\"fn\"><a id=\"1f82ab38-1655-47c5-bfef-25b34013a340-link\" href=\"#1f82ab38-1655-47c5-bfef-25b34013a340\">5<\/a><\/sup>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, these treatments work by depleting NAD+ in cancer cells. This raises important questions about NAD+ supplementation during cancer treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">NAD+ Supplements: Are They Safe?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Here&#8217;s where things get interesting. Despite concerns about feeding cancer cells, research on <a href=\"https:\/\/www.jinfiniti.com\/blog\/best-nad-supplements\/\">NAD+ supplements<\/a> tells a different story.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Long-term studies in mice found that nicotinamide mononucleotide (<a href=\"https:\/\/www.jinfiniti.com\/blog\/what-is-nmn\/\">NMN<\/a>, a popular NAD+ precursor) didn&#8217;t increase cancer risk<sup data-fn=\"463946ee-76c1-40b7-a378-98a3c751ce8a\" class=\"fn\"><a id=\"463946ee-76c1-40b7-a378-98a3c751ce8a-link\" href=\"#463946ee-76c1-40b7-a378-98a3c751ce8a\">6<\/a><\/sup>. In fact, supplemented mice lived longer and healthier lives.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The mice showed improved metabolic health and reduced frailty. No increase in tumor formation was observed over their lifespans.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This suggests that normal NAD+ supplementation doesn&#8217;t necessarily fuel cancer growth. The difference might lie in how healthy cells versus cancer cells use NAD+.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Potential Concerns in Cancer Metabolism<\/h2>\n\n\n<style>.kb-image12161_3e67ce-c2 .kb-image-has-overlay:after{opacity:0.3;border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;}.kb-image12161_3e67ce-c2 img.kb-img, .kb-image12161_3e67ce-c2 .kb-img img{border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;}<\/style>\n<div class=\"wp-block-kadence-image kb-image12161_3e67ce-c2\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"416\" src=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/national-cancer-institute-JxoWb7wHqnA-unsplash.jpg\" alt=\"female scientist looking through an inverted microscope at cancer cells that have been grown in culture media\" class=\"kb-img wp-image-33882\" title=\"\" srcset=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/national-cancer-institute-JxoWb7wHqnA-unsplash.jpg 640w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/national-cancer-institute-JxoWb7wHqnA-unsplash-480x312.jpg 480w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/national-cancer-institute-JxoWb7wHqnA-unsplash-600x390.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Cancer cells are remarkably adaptable. They can sometimes find ways around treatments that target NAD+ metabolism.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Some cancers develop resistance by altering their metabolic pathways<sup data-fn=\"aefbf460-1809-4fd7-8da2-1f4ea9463ada\" class=\"fn\"><a id=\"aefbf460-1809-4fd7-8da2-1f4ea9463ada-link\" href=\"#aefbf460-1809-4fd7-8da2-1f4ea9463ada\">7<\/a><\/sup>. They essentially rewire themselves to survive NAD+ depletion.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For example, cancer cells might inactivate certain enzymes to protect themselves from NAD+ depletion strategies. This can make treatments less effective over time.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There&#8217;s also theoretical concern that <a href=\"https:\/\/www.jinfiniti.com\/blog\/increase-nad-levels\/\">boosting NAD+ levels<\/a> could support cancer cell metabolism. Cancer cells have high energy demands and efficient DNA repair mechanisms.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, cancer biology often defies simple explanations. Some tumors are &#8220;cold&#8221; &#8211; they hide from your immune system with few attacking T cells. Others are &#8220;hot&#8221; with active immune responses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Interestingly, increased tumor cell growth can sometimes transform cold tumors into hot ones. This may actually improve your response to chemotherapy and lead to better survival outcomes<sup data-fn=\"b81d61f3-b8d5-4306-8263-61fdf15fe824\" class=\"fn\"><a id=\"b81d61f3-b8d5-4306-8263-61fdf15fe824-link\" href=\"#b81d61f3-b8d5-4306-8263-61fdf15fe824\">8<\/a><\/sup>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Current research hasn&#8217;t shown increased cancer risk from NAD+ supplementation in healthy individuals.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the Research Shows<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Let&#8217;s look at what different studies have found about NAD+ and cancer:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th><strong>Approach<\/strong><\/th><th><strong>Potential Benefit<\/strong><\/th><th><strong>Concern\/Risk<\/strong><\/th><\/tr><\/thead><tbody><tr><td><strong>NAD+ Metabolism Targeting<\/strong><\/td><td>Inhibits tumor growth and survival<\/td><td>Cancer cell adaptation, therapy resistance<\/td><\/tr><tr><td><strong>Sirtuin Modulation<\/strong><\/td><td>May improve health, delay aging<\/td><td>Impact on tumor biology not fully understood<\/td><\/tr><tr><td><strong>NAD+ Precursor Supplementation<\/strong><\/td><td>No increased tumor burden in mice<\/td><td>Theoretical risk of supporting tumor metabolism<\/td><\/tr><tr><td><strong>PARP Inhibitors<\/strong><\/td><td>Improved survival in DNA repair-deficient cancers<\/td><td>Risk of secondary malignancies<\/td><\/tr><tr><td><strong>Genetic Factors (e.g., SDHx)<\/strong><\/td><td>N\/A<\/td><td>Increased cancer risk via NAD+ pathway<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The data shows a complex picture. NAD+ can both help and hinder cancer depending on the context.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Who Should Be Cautious?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Certain genetic factors can affect how NAD+ impacts cancer risk. Mutations in genes like SDHx can destabilize tumor suppressor proteins like p53<sup data-fn=\"e081df2d-4e9b-4007-9a52-a02b2be58973\" class=\"fn\"><a id=\"e081df2d-4e9b-4007-9a52-a02b2be58973-link\" href=\"#e081df2d-4e9b-4007-9a52-a02b2be58973\">9<\/a><\/sup>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These genetic changes alter <a href=\"https:\/\/www.jinfiniti.com\/blog\/nad-vs-nadh\/\">NADH\/NAD+<\/a> metabolism in ways that may increase cancer risk. If you have a family history of certain cancers, genetic testing might provide useful information.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PARP inhibitor treatments, while beneficial for some cancers, can increase the risk of secondary blood cancers<sup>2<\/sup>. This risk appears higher in certain genetic backgrounds.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">People undergoing cancer treatment should discuss the <a href=\"https:\/\/www.jinfiniti.com\/blog\/nad-supplement-benefits\/\">potential benefits NAD+ supplementation<\/a> with their oncologist. The timing and type of treatment matter.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What We Still Don&#8217;t Know<\/h2>\n\n\n<style>.kb-image12161_21191c-2e .kb-image-has-overlay:after{opacity:0.3;border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;}.kb-image12161_21191c-2e img.kb-img, .kb-image12161_21191c-2e .kb-img img{border-top-left-radius:30px;border-top-right-radius:30px;border-bottom-right-radius:30px;border-bottom-left-radius:30px;}<\/style>\n<div class=\"wp-block-kadence-image kb-image12161_21191c-2e\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"427\" src=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/lumiere-rezaie-439p_v4m-ao-unsplash.jpg\" alt=\"A woman with short hair contemplating outdoors\" class=\"kb-img wp-image-33883\" title=\"\" srcset=\"https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/lumiere-rezaie-439p_v4m-ao-unsplash.jpg 640w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/lumiere-rezaie-439p_v4m-ao-unsplash-480x320.jpg 480w, https:\/\/www.jinfiniti.com\/blog\/wp-content\/uploads\/2024\/02\/lumiere-rezaie-439p_v4m-ao-unsplash-600x400.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Research on NAD+ and cancer is still evolving. Many questions remain unanswered.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We don&#8217;t fully understand how different types of cancer respond to NAD+ modulation. Some might be more sensitive than others.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The optimal timing of NAD+ interventions remains unclear. Should you boost NAD+ before, during, or after cancer treatment?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Long-term effects of NAD+ supplementation in cancer survivors need more study. Most research has focused on short-term outcomes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Individual genetic variations likely affect NAD+ metabolism and cancer risk. Personalized approaches may become important in the future.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The Bottom Line<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">NAD+ plays a crucial role in both cancer development and treatment. The relationship is nuanced and depends on many factors.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Current evidence suggests that NAD+ supplementation doesn&#8217;t increase cancer risk in healthy individuals. Animal studies support this finding.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, people with active cancer or genetic predispositions should consult healthcare providers before taking NAD+ supplements. Treatment context matters enormously.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The most promising applications involve targeting NAD+ metabolism in cancer cells while supporting immune function. This dual approach may offer the best of both worlds.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As research continues, we&#8217;ll likely develop more sophisticated ways to use NAD+ in cancer prevention and treatment. The key is understanding when to boost it and when to block it.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For now, supporting healthy NAD+ levels through lifestyle factors like exercise, sleep, and proper nutrition remains a safe approach for most people. Supplementation can be considered based on individual circumstances and medical guidance.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The future of NAD+ and cancer research looks promising. But like many aspects of cancer biology, the answers are complex and highly individual.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Referenced Sources<\/h3>\n\n\n<ol class=\"wp-block-footnotes\"><li id=\"3aa28b0d-5d16-4c9b-9137-6ab1692f0a96\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10893221\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10893221\/<\/a> <a href=\"#3aa28b0d-5d16-4c9b-9137-6ab1692f0a96-link\" aria-label=\"Jump to footnote reference 1\">\u21a9\ufe0e<\/a><\/li><li id=\"74682209-5f68-49fa-b78c-d5c57e7cdb98\"><a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(23)01530-9\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(23)01530-9<\/a> <a href=\"#74682209-5f68-49fa-b78c-d5c57e7cdb98-link\" aria-label=\"Jump to footnote reference 2\">\u21a9\ufe0e<\/a><\/li><li id=\"ed467252-35fc-4812-b8e8-d148c68be0ce\"><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00432-022-04124-9\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/link.springer.com\/article\/10.1007\/s00432-022-04124-9<\/a> <a href=\"#ed467252-35fc-4812-b8e8-d148c68be0ce-link\" aria-label=\"Jump to footnote reference 3\">\u21a9\ufe0e<\/a><\/li><li id=\"852ebfb1-d80a-4688-9fa4-812ed0b07c1a\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11206297\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11206297\/<\/a> <a href=\"#852ebfb1-d80a-4688-9fa4-812ed0b07c1a-link\" aria-label=\"Jump to footnote reference 4\">\u21a9\ufe0e<\/a><\/li><li id=\"1f82ab38-1655-47c5-bfef-25b34013a340\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35212587\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35212587\/<\/a> <a href=\"#1f82ab38-1655-47c5-bfef-25b34013a340-link\" aria-label=\"Jump to footnote reference 5\">\u21a9\ufe0e<\/a><\/li><li id=\"463946ee-76c1-40b7-a378-98a3c751ce8a\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10738395\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10738395\/<\/a> <a href=\"#463946ee-76c1-40b7-a378-98a3c751ce8a-link\" aria-label=\"Jump to footnote reference 6\">\u21a9\ufe0e<\/a><\/li><li id=\"aefbf460-1809-4fd7-8da2-1f4ea9463ada\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37190889\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37190889\/<\/a> <a href=\"#aefbf460-1809-4fd7-8da2-1f4ea9463ada-link\" aria-label=\"Jump to footnote reference 7\">\u21a9\ufe0e<\/a><\/li><li id=\"b81d61f3-b8d5-4306-8263-61fdf15fe824\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10458686\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10458686\/<\/a> <a href=\"#b81d61f3-b8d5-4306-8263-61fdf15fe824-link\" aria-label=\"Jump to footnote reference 8\">\u21a9\ufe0e<\/a><\/li><li id=\"e081df2d-4e9b-4007-9a52-a02b2be58973\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3276278\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3276278\/<\/a> <a href=\"#e081df2d-4e9b-4007-9a52-a02b2be58973-link\" aria-label=\"Jump to footnote reference 9\">\u21a9\ufe0e<\/a><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>NAD plays an active role in potentially helping prevent cancer. NAD also boosts anti-tumor immunity.<\/p>\n","protected":false},"author":10909,"featured_media":33880,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"[{\"content\":\"<a href=\\\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10893221\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10893221\/<\/a>\",\"id\":\"3aa28b0d-5d16-4c9b-9137-6ab1692f0a96\"},{\"content\":\"<a href=\\\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(23)01530-9\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(23)01530-9<\/a>\",\"id\":\"74682209-5f68-49fa-b78c-d5c57e7cdb98\"},{\"content\":\"<a href=\\\"https:\/\/link.springer.com\/article\/10.1007\/s00432-022-04124-9\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/link.springer.com\/article\/10.1007\/s00432-022-04124-9<\/a>\",\"id\":\"ed467252-35fc-4812-b8e8-d148c68be0ce\"},{\"content\":\"<a href=\\\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11206297\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11206297\/<\/a>\",\"id\":\"852ebfb1-d80a-4688-9fa4-812ed0b07c1a\"},{\"content\":\"<a href=\\\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35212587\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35212587\/<\/a>\",\"id\":\"1f82ab38-1655-47c5-bfef-25b34013a340\"},{\"content\":\"<a href=\\\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10738395\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10738395\/<\/a>\",\"id\":\"463946ee-76c1-40b7-a378-98a3c751ce8a\"},{\"content\":\"<a href=\\\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37190889\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37190889\/<\/a>\",\"id\":\"aefbf460-1809-4fd7-8da2-1f4ea9463ada\"},{\"content\":\"<a href=\\\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10458686\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10458686\/<\/a>\",\"id\":\"b81d61f3-b8d5-4306-8263-61fdf15fe824\"},{\"content\":\"<a href=\\\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3276278\/\\\" target=\\\"_blank\\\" rel=\\\"noreferrer noopener\\\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3276278\/<\/a>\",\"id\":\"e081df2d-4e9b-4007-9a52-a02b2be58973\"}]"},"categories":[351,322],"tags":[],"class_list":["post-12161","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nad-supplement-interventions","category-cancer-health-conditions"],"_links":{"self":[{"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/posts\/12161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/users\/10909"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/comments?post=12161"}],"version-history":[{"count":0,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/posts\/12161\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/media\/33880"}],"wp:attachment":[{"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/media?parent=12161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/categories?post=12161"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jinfiniti.com\/blog\/wp-json\/wp\/v2\/tags?post=12161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}